助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   rb gene mutations 的翻译结果: 查询用时:0.18秒
图标索引 在分类学科中查询
所有学科
眼科与耳鼻咽喉科
更多类别查询

图标索引 历史查询
 

rb gene mutations
相关语句
  rb基因突变
     THE CHARACTERISTICS OF Rb GENE MUTATIONS IN 108 CASES OF RETINOBLASTOMA.
     108例视网膜母细胞瘤Rb基因突变的特征
短句来源
     GENE DIAGNOSIS AND GENETIC COUNSELLING OF Rb GENE MUTATIONS IN RETINOBLASTOMA PATIENTS AND THEIR FAMILY MEMBERS
     RB患者及家庭成员Rb基因突变和患病风险的基因诊断及遗传咨询
短句来源
     Objective:To determine the accurate position and composition of Rb gene mutations,analyze its significance in the pathogenesis of laryngeal neoplasma and provide evidence for gene diagnosis and gene therapy.
     目的 :检测喉鳞状细胞癌组织中 Rb基因突变的具体位置和内容 ,分析其在喉癌发生发展中的意义 ,为基因诊断和基因治疗提供依据。
短句来源
  “rb gene mutations”译为未确定词的双语例句
     Analysis and Clinical Implication of Ha-ras, p53 and RB Gene Mutations and Infection of Bladder Cancer with Papillomavirus
     膀胱癌人乳头瘤病毒感染与Ha-ras、p53、RB基因变异及其临床意义的研究
短句来源
  相似匹配句对
     THE EXPRESSION OF Rb GENE IN RETINOBLASTOMA
     视网膜母细胞瘤Rb基因表达
短句来源
     RB Gene and Tumor Suppression .
     RB基因与肿瘤抑制
短句来源
     Conclusions: The occurrence of Rb is the result of multiple gene mutations.
     结论:Rb的发生与多个细胞凋亡调控基因异常有关。
短句来源
     THE CHARACTERISTICS OF Rb GENE MUTATIONS IN 108 CASES OF RETINOBLASTOMA.
     108例视网膜母细胞瘤Rb基因突变的特征
短句来源
     Mutations analysis of RB1 gene in Chinese patients with retinoblastoma
     国人视网膜母细胞瘤患者RB1基因突变的特性
短句来源
查询“rb gene mutations”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。
  rb gene mutations
Two mechanisms may be involved in the inactivation of pRb: one is through Rb gene mutations, and the other is by cyclin D1 overexpression.
      
Among the remaining 15 thyroid carcinoma samples, 11 were found previously to have Rb gene mutations.
      
Six of them were found in carcinomas without Rb gene mutations.
      
We have previously found Rb gene mutations in 55% of malignant thyroid tumors.
      
Production of truncated protein product or fulllength mutant protein product has been reported in association with certain RB gene mutations.
      
更多          


To detect the relation of p53 and Rb genes to the development of lung cancer,we used PCR and SSCP methods to analyse the mutations of p53 gene exons 5-8 and Rb gene exons 14-16,22-23 regions in 41 human lung cancer samples.The results showed that 16 cases had p53 gene mutations(39%)in exons 5-7;4 cases were Rb abnormal(9.8%),among whom,2 cases had a large fragment loss in exons 14-16 and the other 2 cases had mutations in exons 22-23.In the mutation...

To detect the relation of p53 and Rb genes to the development of lung cancer,we used PCR and SSCP methods to analyse the mutations of p53 gene exons 5-8 and Rb gene exons 14-16,22-23 regions in 41 human lung cancer samples.The results showed that 16 cases had p53 gene mutations(39%)in exons 5-7;4 cases were Rb abnormal(9.8%),among whom,2 cases had a large fragment loss in exons 14-16 and the other 2 cases had mutations in exons 22-23.In the mutation samples,a small cell lung cancer had two p53 gene mutations in exons 5 and 7 respectively;another small cell lung cancer had p53 gene(exon 6)and Rb gene(exon 22-23)mutations.Sequencing of 5 p53 mutation samples showed that each had a single base substitution or insertion in one or three codons of p53 gene,which result in producing abnormal p53.These evidences indicate that p53 and Rb genes mutations are closely related to the development of lung cancers,especially to small cell lung cancers.

为探讨肺癌发生的分子遗传学机理,采用聚合酶链反应及聚合酶链反应-单链构象多态性技术,对41例人肺癌组织中p53基因外显子5~8及Rb基因外显子14~16、22~23进行了突变分析。结果显示:p53基因突变16例(16/41,39%),分布于外显子5~7;Rb基因异常4例(4/41,9.8%),其中外显子14~16区域部分缺失和外显子22~23区域突变各2例;在9例小细胞肺癌标本中,7例发生p53及R5基因的突变,其中1例存在p53基因两个外显子突变,另1例同时存在p53及Rb基因的突变。对部分p53基因突变标本序列分析,均在1个或3个密码子上存在导致p53蛋白异常的单碱基置换或插入突变。以上结果表明:肺癌、特别是小细胞肺癌的发生可能与p53及Rb基因的突变有关。

Aberrations of chromosome 9 p21 22 are involved in the genesis of many forms of cancer.The gene p16 and p15 have been assigned to this region.Both p16 and p15 are an inhibitor of cyclin D cdk4,cyclin D cdk6 complex and have been implicated in a wide variety of cancer types,including the germline of patients with familial melanoma.In order to investigate and compare the status of p16,p15 gene in primary tumors and cell lines,we...

Aberrations of chromosome 9 p21 22 are involved in the genesis of many forms of cancer.The gene p16 and p15 have been assigned to this region.Both p16 and p15 are an inhibitor of cyclin D cdk4,cyclin D cdk6 complex and have been implicated in a wide variety of cancer types,including the germline of patients with familial melanoma.In order to investigate and compare the status of p16,p15 gene in primary tumors and cell lines,we examined 357 primary tumors and 29 cell lines derived from diverse tumor types.In addition to analysis of these primary tumors and cell lines,blood specimens from 91 patients either with sporadic multiple cancers or from cancer prone families were also analyzed.The data showed the following:1)Homozygous deletions of p16,p15 were comparatively rare and far less common than previously reported,although hemizygous deletions were observed in a significant fraction of many tumor types;2)the incidence of p16,p15 deletions(either homozygous deletions or heterozygous deletions)varied significantly among different tumor types;3)most deletions involved in both p16 and p15 genes;4)sequence variations in the coding sequence of p16,p15 were comparatively rare among these tumor types,though mutations and polymorphisms were identified;5)some tumors which showed LOH at 9p,containing p16 and p15 gene,did not show deletions or point mutations in the p16,p15 gene.6)In a subset of retinoblastoma and osteosarcoma where no Rb gene mutations were present a significant fraction was found to contain p16,p15 gene deletions.

INTRODUCTION  Cytogeneticandmoleculargeneticanalyseshaverevealedthatchromosome9p2122isinvolvedinthegenesisandorprogressionofmanydifferenttypesoftumors.Thechromosomalalterationsat9p2122,includinginversions,translocations,rearrangements,heterozygousa...

Objective:To determine the accurate position and composition of Rb gene mutations,analyze its significance in the pathogenesis of laryngeal neoplasma and provide evidence for gene diagnosis and gene therapy. Methods:Mutations in 20 th exon Rb gene was detected in 50 cases with laryngeal neoplasma and in 12 cases of normal control group by PCR SSCP DNA sequencing. Results:Rb mutation frequency was approximately 12%(6/50) observed in the laryngeal cancer and the point...

Objective:To determine the accurate position and composition of Rb gene mutations,analyze its significance in the pathogenesis of laryngeal neoplasma and provide evidence for gene diagnosis and gene therapy. Methods:Mutations in 20 th exon Rb gene was detected in 50 cases with laryngeal neoplasma and in 12 cases of normal control group by PCR SSCP DNA sequencing. Results:Rb mutation frequency was approximately 12%(6/50) observed in the laryngeal cancer and the point mutation was predominant. These mutations induced the changes of amino acids sequeces. There were no definite association of the mutation with tumor progressive stages, differentiation degree and lymph metastasis ( P >0.05). Conclusion: Non functional Rb protein produced by gene mutation was one cause in the development of laryngeal neoplasma, howerver, Rb gene mutation was not common in pathogenesis of human laryngeal neoplasma.

目的 :检测喉鳞状细胞癌组织中 Rb基因突变的具体位置和内容 ,分析其在喉癌发生发展中的意义 ,为基因诊断和基因治疗提供依据。方法 :应用 PCR- SSCP- DNA测序技术 ,选择 Rb基因第 2 0外显子的引物 ,对 5 0例喉鳞状细胞癌组织及 1 2例正常对照进行突变的检测。结果 :5 0例喉癌患者的喉癌组织中 Rb基因的突变率为 1 2 % ,突变以点突变为主 ,突变均引起氨基酸的改变。 Rb基因的突变与临床分期、病理分化程度及淋巴结转移间无相关性 ( P>0 .0 5 )。结论 :Rb基因突变导致的喉癌细胞不能产生有功能的 Rb蛋白可能是喉癌发生的原因之一 ,但 Rb基因的突变并不是喉鳞癌的常发事件。

 
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关rb gene mutations的内容
在知识搜索中查有关rb gene mutations的内容
在数字搜索中查有关rb gene mutations的内容
在概念知识元中查有关rb gene mutations的内容
在学术趋势中查有关rb gene mutations的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社