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artemether capsule
相关语句
  蒿甲醚胶囊
     Study on Stabitily of the Artemether Capsule —A New Type of Antimalarial Drug
     抗疟新药——蒿甲醚胶囊稳定性的研究
短句来源
     Results: The SD 50 of AHESRG was 1.30 mg/kg, while that of the artemether capsule was 5.70 mg/kg. The antimalarial efficacy of AHESRG was approximately 4.4 times than that of the artemether capsule, and the parasitemia clearance time was shortened 12 h.
     结果:蒿甲醚高效缓释颗粒剂50%抑制剂量(SD50)为1.30mg/kg,对照品蒿甲醚胶囊SD50为5.70mg/kg,高效缓释颗粒剂的抗疟效价约为蒿甲醚胶囊的4.4倍,原虫血症清除时间快12h。
短句来源
     Methods: “Four days inhibitory therapy” was used to compare the antimalaria effects of AHESRG and artemether capsule.
     方法:采用4d抑制性治疗法,比较蒿甲醚高效缓释颗粒剂及对照品蒿甲醚胶囊的抗疟效价;
短句来源
     After parasitemia peak treatment, the parasites of the mice with 100, 50, 25mg/(kg·d) of AHESRG became clear at 2, 3, and 5 d respectively, without recrudesce within 30 d and with high survival rate. The therapeutic efficacy of AHESRG was higher than that of the artemether capsule in same dosages.
     经高峰治疗用药后,高效缓释颗粒剂100,50,25mg/(kg·d)3个剂量组的鼠原虫血症分别于第2,3,5天清除,30d内无复燃,病鼠存活率高,疗效明显高于蒿甲醚胶囊相应剂量对照组。
短句来源
     Methods Totally 213 Plasmodium falciparum malaria cases were treated with Quinimax(produced in France)in Africa(Quinimax Group)and another 213 Plasmodium falciparum malaria cases were,at the same time,treated with domestic artemether capsule(Artemether Group)for a course of 5 days. The results were compared.
     方法用法国生产Quinimax静脉注射治疗非洲恶性疟疾213例。 同时用国产蒿甲醚胶囊口服治疗恶性疟疾213例进行疗效比较,5d1疗程。
短句来源
  相似匹配句对
     Determination of Artemether soft capsule by HPLC
     HPLC测定蒿甲醚胶丸的含量
短句来源
     . and Ranjianduoji capsule.
     1、本草考证与文献考查
短句来源
     Study on Stabitily of the Artemether Capsule —A New Type of Antimalarial Drug
     抗疟新药——蒿甲醚胶囊稳定性的研究
短句来源
     THE SEA LANCE CAPSULE
     海长矛运载器
短句来源
     The effect of artemether is dose-dependent.
     蒿甲醚还呈现一定程度的剂量依赖性。
短句来源
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Objective: To observe the therapeutic efficacy of artemether high effect sustained release granules (AHESRG) against rodent malaria parasites, Plasmodium berghei. Methods: “Four days inhibitory therapy” was used to compare the antimalaria effects of AHESRG and artemether capsule. A peak parasitemia treatment method was used to observe the survival and cure rate of mice after treatment for 30 d. Results: The SD 50 of AHESRG was 1.30 mg/kg, while that of the artemether capsule was 5.70 mg/kg....

Objective: To observe the therapeutic efficacy of artemether high effect sustained release granules (AHESRG) against rodent malaria parasites, Plasmodium berghei. Methods: “Four days inhibitory therapy” was used to compare the antimalaria effects of AHESRG and artemether capsule. A peak parasitemia treatment method was used to observe the survival and cure rate of mice after treatment for 30 d. Results: The SD 50 of AHESRG was 1.30 mg/kg, while that of the artemether capsule was 5.70 mg/kg. The antimalarial efficacy of AHESRG was approximately 4.4 times than that of the artemether capsule, and the parasitemia clearance time was shortened 12 h. After parasitemia peak treatment, the parasites of the mice with 100, 50, 25mg/(kg·d) of AHESRG became clear at 2, 3, and 5 d respectively, without recrudesce within 30 d and with high survival rate. The therapeutic efficacy of AHESRG was higher than that of the artemether capsule in same dosages. Conclusion: AHESRG could enhance the antimalarial effects, prolong action time and reduce recrudescent rate of malaria parasites.

目的:观察蒿甲醚高效缓释颗粒剂对小鼠体内伯氏疟原虫的疗效。方法:采用4d抑制性治疗法,比较蒿甲醚高效缓释颗粒剂及对照品蒿甲醚胶囊的抗疟效价;采用高峰治疗法,观察用药后30d内的治愈率与病鼠存活率。结果:蒿甲醚高效缓释颗粒剂50%抑制剂量(SD50)为1.30mg/kg,对照品蒿甲醚胶囊SD50为5.70mg/kg,高效缓释颗粒剂的抗疟效价约为蒿甲醚胶囊的4.4倍,原虫血症清除时间快12h。经高峰治疗用药后,高效缓释颗粒剂100,50,25mg/(kg·d)3个剂量组的鼠原虫血症分别于第2,3,5天清除,30d内无复燃,病鼠存活率高,疗效明显高于蒿甲醚胶囊相应剂量对照组。结论:蒿甲醚高效缓释颗粒剂可增强抗疟效果,延长药物作用时间,并能降低疟原虫的复燃率

Objective:To establish HPLC method for the determination of artemether in artemether capsules.Methods:PUROSPHER(Merck)C 18 column(4 0 mm×125 mm,5 μm),with the mobile phase consisted of warter-acetonitrile(45∶55),detection wavelength at 210 nm and external standard method.Results:The average recovery of artemether was 100 8%,with RSD of 1 5%( n=6 ).Conclusion:The method is simple,rapid and the results is accurate and reliable.

目的 :建立测定蒿甲醚胶囊中蒿甲醚含量的高效液相色谱法。方法 :选用ODS分析柱 ,流动相 :水 -乙腈 (45∶5 5 ) ,检测波长 :2 10nm ,流速 :1 0mL·min-1,柱温 :室温 ,外标法定量。结果 :本法简便、准确、快速。线性范围 :5 0~ 2 5 0 μg (r =0 9998)。平均回收率为 10 0 8% ,RSD =1 5 % (n =6 )。 结论 :建立的方法利于蒿甲醚胶囊的质量控制。

Excipients and optimzing formulas were selected according to dissolution and the best prescription for the preparation of artemether was detected. The prepared capsules possess stable quality and correspond with its ChP standards. The prescription and preparation of artemether capsules are simple and suitable for industrial production.

以溶出度为主要考察指标,通过辅料的选择、处方的设计与优化,摸索出了一套最佳处方的蒿甲醚胶囊的制备方法.所制得的胶囊质量稳定,符合质量标准且其工艺简单,适合工业化生产.

 
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