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mouse
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     Mouse
     鼠标
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     CAT AND MOUSE
     猫和老鼠
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     Computer Mouse(1981)
     计算机鼠标(1981年)
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  mouse
Though only two esters showed antiinflammatory activity similar to that of the parent drug at equivalent dose levels, all the esters were equipotent to indomethacin in the mouse acetic acid-induced writhing assay for analgesic action.
      
Sublethally-irradiated NOD/SCID mice were transplanted with ex vivo expanded HSPCs with the dose of 8.5 × 106 cells per mouse.
      
Cytokines mRNA in bone marrow-derived dendritic cells in asthmatic mouse
      
Masking effect of different durations of forward masker sound on acoustical responses of mouse inferior collicular neurons to pr
      
Only one band was detected by Western-blotting, which is for the antibody released in mouse against purified DszC in the expression product of BL21 (DE3, paC5) and Rhodococcus sp.
      
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1. The albino mice were used for this study. The Golgi apparatus in the cells of the epididymis and the vas deferens of normal, starved, and refed animals were studied.2. The amount of the Golgi elements can be maintained by feeding, not only by the sex hormone.3. The Golgi apparatus may be regarded as a product of food assimilation, not a definite cell organ.4. It is suggested that the Golgi apparatus has similar organ with that of mitochondria and secretion granules, but with different quantity of lipoids....

1. The albino mice were used for this study. The Golgi apparatus in the cells of the epididymis and the vas deferens of normal, starved, and refed animals were studied.2. The amount of the Golgi elements can be maintained by feeding, not only by the sex hormone.3. The Golgi apparatus may be regarded as a product of food assimilation, not a definite cell organ.4. It is suggested that the Golgi apparatus has similar organ with that of mitochondria and secretion granules, but with different quantity of lipoids.

(1)本研究以白鼠为材料,就常态白鼠绝食及再餵之白鼠观察其副睾丸及输精管上皮细胞内之高基體。查得在绝食期内副睾上皮细胞之高基體逐渐減少,由网状體变为颗粒,先集于前端後卽散开,至三十六小时高基體绝少,再餵後復有颗粒出现於前端。 (2)输精管上皮细胞内高基體原作线状,列於细胞前部。绝食十三时後,变为颗粒。俟三十六小时後再餵,卽有许多小粒在细胞前端边缘或卽係高基體 (3)由此结果可知高基體之多寡,既视绝食与否而定,或可谓为食物同化之产物,非固定之细胞器官也。 (4)高基體之起源或与粒线體,及分泌粒同,但其所含类脂質之量不同。

A solution of crystalline ribonuclease was injected intraperitoneally andintravenously into the blood stream of the mouse. A depletion of the ribonucleicacid together with a decrease of the calcium ash was observed in the corticalportion of the liver cell 12 minutes after the injection until recovery of normaldistribution 122 hours later. The possible association of calcium with ribonucleicacid in the cytoplasm constituents of the liver cell is discussed.

核醣核酸酶结晶体的溶液由腹膜腔或血管注射到活鼠的体内可引肝细胞皮质部分的核醣核酸的分解和钙质的消失。这种作用在注射後12分钟开始到124小时後肝细胞恢复常态。关於在活体肝细胞内核醣核酸和钙结合的可能性予以充分的讨论。

A new method for the biological assay of vegetable purgatives based on the numbers of wet faeces excreted by groups of mice after dosing is described. The relation of the number of wet faeces per group of mice to the logarithm of the dose was found to be linear. A cage has been specially designed for this assay and it has been found advantageous to incorporate a definite proportion of water in the diet during test. 40 mice divided equally into 4 groups were used in each assay. 2 groups received...

A new method for the biological assay of vegetable purgatives based on the numbers of wet faeces excreted by groups of mice after dosing is described. The relation of the number of wet faeces per group of mice to the logarithm of the dose was found to be linear. A cage has been specially designed for this assay and it has been found advantageous to incorporate a definite proportion of water in the diet during test. 40 mice divided equally into 4 groups were used in each assay. 2 groups received the standard preparation and the other 2 groups received the test preparation. The standard deviation of a single determination based on 9 such assays was estimated to be 15.7 per cent. For rhubarb and its preparations, a“6-point”assay is advocated. With suitable restric-tion in the design of the assay, it is possible to calculate the potency by simple methods. Powdered crude drugs are used as laboratory standards in the assay of senna and rhubarb. The doses of cascara bark required to produce distinctive responses are too inconveniently large to be administered in suspension. It was found possible to use a potent extract of cascara in place of the powdered bark as a laboratory standard. Examples of the assay and the subsequent calculations are given. The method described is not only convenient in use but also gives a comparatively high degree of accuracy. The method has been successfully applied to senna leaf, senna fruit, rhubarb, cascara sagrada and extracts and commercial preparations made from these drugs, pure glycosides(sennosides A and B) and pure anthracene compounds(aloe emodin and aloe-emodine anthranol).

(1)本文详述植物性泻药的一种新的生物测定法,此法係用小白鼠在服药后所排出的濕粪数为基础,以定泻药的效价。(2)小白鼠服药後所排出的湿粪数与剂量指数的关係经证明为一直线。(3)本法所用鼠笼係特别设计,并证明在饲料内加入一定量的饮水,具有多种优点。(4)番泻效价的测定,每次用小白鼠4组,每组10只。2组给与标准品,另外2组给与试验品。根据9次试验的结果,试验的标准差是15.7%.(5)大黄效价的测定,以采用“6点”法为宜,即每次试验用小白鼠6组,3组给与标准品,另外3组给与试验品,所得的准确度与上述相仿。波希鼠李皮浸膏的效价测定,则用“4点”法或“6点”法均可。(6)所有试验一律采用粉状生药为实验室的比较标准,但是波希鼠李皮的效价太低,它的粉末不适於作为标准之用,可用波希鼠李皮乾浸膏来代替,作为比较标准。(7)本文对於效价测定及其计算方法都举例说明,并介绍了比较常法为简捷的相关效价计算法。(8)本法不但方便易行,而且有相当高的准确度;曾用在番泻、大黄、波希鼠李皮及其制剂,以及一些纯粹的蒽醌衍生物的效价测定,都获得了满意的结果。

 
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