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endotoxin injury
相关语句
  内毒素损伤
     Protection of endotoxin injury with antioxidants
     内毒素损伤和抗氧化剂的保护作用
短句来源
     Endotoxin injury in alcoholic liver disease
     酒精性肝病的内毒素损伤机制
短句来源
  “endotoxin injury”译为未确定词的双语例句
     Formulation of mechanism and experimental study of Gehua Xingjiu Yangwei granule (GHXJYWG) against endotoxin injury in rats alcoholic liver disease
     葛花醒酒养胃颗粒对酒精性肝病内毒素损伤的防治作用
短句来源
     Conclusion:Dachengqi decoction could inhibit lysosomal damage induced by endotoxin,preserve intracellular organelle and the gut barrier function,thus minimizing endotoxin injury to the organism.
     结论:大承气汤能够稳定肝、肠溶酶体膜,减少溶酶外逸,拮抗内毒素对机体的损害
短句来源
     This review focuses on the toxicity and pathogenic mechanism of the reactive oxygen and nitrogen species. The clinical use of antioxidants in the protection of the endotoxin injury is also discussed.
     阐述了活性氧和活性氮在内毒素毒性机制中的地位和作用,并讨论了抗氧化剂对内毒素损伤的保护作用及其临床应用前景。
短句来源
     Objective:To discuss action of Gahua Xingsiu yangwei gramule GHXJYWG against endotoxin injury in rats alcoholic liver disease.
     目的:探讨葛花醒酒养胃颗粒对酒精性肝病(ALD)内毒素损伤的防治作用。
短句来源
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In order to study the effect of DaChengQi decoction with protecting intracellular organelle,endotoxin was given to rabbits intravenously twice and produced generalized Shwartzman reaction(GSR).These animals were served as disseminated intravascular colagulation(DIC) model,serum and hepatic mitochondria lipid peroxides(LPO) were measured.The results showed LPO of DIC model group increased markedly than control group.Dexamethasone group was similar to control group,although DaChengQi decoction group was higher...

In order to study the effect of DaChengQi decoction with protecting intracellular organelle,endotoxin was given to rabbits intravenously twice and produced generalized Shwartzman reaction(GSR).These animals were served as disseminated intravascular colagulation(DIC) model,serum and hepatic mitochondria lipid peroxides(LPO) were measured.The results showed LPO of DIC model group increased markedly than control group.Dexamethasone group was similar to control group,although DaChengQi decoction group was higher than control group they had no statistical difference(P>0.05).Electronmicroscope result was in concordance with biochemical test.It indicate DaChengQi decoction can resist LPO damage induced by endotoxin and preserve intracellular organelle,reduce endotoxin injury to body.

采用内毒素所致家兔全身性Shwartzman反应作为DIC模型,检测肝线粒体及血清过氧化脂质(LPO)含量。结果表明:模型组LPO明显升高(p<0.05);地塞米松组与正常对照组相似,大承气汤组虽然较正常对照组稍高,但无统计学差异(p>0.05)。提示:大承气汤能够拮抗内毒素诱导的脂质过氧化损害,保护细胞器

Objective:To study the theoretical basis of Dachengqi decoction in protecting the gut barrier and treating endotoxemia.Methods:Wistar rats(n=6) were killed and livers were removed.Liver homogenates were made by routine assay,isolating lysosomes from hepatic homogenates by differential centrifugation.In vivo,endotoxin was given to rabbits intravenously twice,with an interval of 24 hours to induce generalized Shwartzman reaction(GSR).These animals were...

Objective:To study the theoretical basis of Dachengqi decoction in protecting the gut barrier and treating endotoxemia.Methods:Wistar rats(n=6) were killed and livers were removed.Liver homogenates were made by routine assay,isolating lysosomes from hepatic homogenates by differential centrifugation.In vivo,endotoxin was given to rabbits intravenously twice,with an interval of 24 hours to induce generalized Shwartzman reaction(GSR).These animals were served as disseminated intravascular coagulation(DIC) models and given various treatments.Acid phosphatase(ACP) in lysosomes were measured by 4 aminoantipyrine method.Results:In Dachengqi decoction group the lysosomal ACP activity was lowered markedly than in the DIC model group;when compared with the control group,there was no difference.In order to exclule the direct action of the medicine on ACP activity another experiment was carried out,namely different concentrations of Dachengqi decoction and endotoxin acting on calibrated acid phosphatase.The results showed simularities of ACP activity on either group( P >0.05).Conclusion:Dachengqi decoction could inhibit lysosomal damage induced by endotoxin,preserve intracellular organelle and the gut barrier function,thus minimizing endotoxin injury to the organism.

目的:探讨大承气汤保护肠道屏障功能、治疗内毒素血症的理论。方法:体外实验选用大鼠肝溶酶体,体内实验选用内毒素所致家兔全身性施瓦茨曼反应(GSR)作为弥漫性血管内凝血(DIC)模型,并给予不同处理,借测定溶酶体标志酶——酸性磷酸酶(ACP)活性,以判断溶酶体膜是否完整及大承气汤对其保护作用。结果:模型组动物肝、肠溶酶体ACP活性明显升高,而大承气汤治疗组则与正常对照组相似。结论:大承气汤能够稳定肝、肠溶酶体膜,减少溶酶外逸,拮抗内毒素对机体的损害

The heme oxygenase 1 (HO 1), a rate limiting enzyme in heme metabolism, has been recently defined as a novel stress stimulated protein, since the intracellular expression of HO 1 in response to various stimuli as oxidation, ischemia and endotoxin injury has been proved to be able to protect the cells from damage. In this study, a retroviral vector containing human HO 1 gene was constructed and transfected to rat vascular smooth muscle cells (VSMCs). Using Southern and Northern blot analyses, the...

The heme oxygenase 1 (HO 1), a rate limiting enzyme in heme metabolism, has been recently defined as a novel stress stimulated protein, since the intracellular expression of HO 1 in response to various stimuli as oxidation, ischemia and endotoxin injury has been proved to be able to protect the cells from damage. In this study, a retroviral vector containing human HO 1 gene was constructed and transfected to rat vascular smooth muscle cells (VSMCs). Using Southern and Northern blot analyses, the integration and mRNA expression of HO 1 gene in the transfected cells were confirmed. The profound protein expression of HO 1 as well as HO enzyme activity in the transfected cells increased by 1 8 fold and 2 0 fold respectively as compared with the non transfected cells. It was found that the HO 1 transfected VSMCs presented dominant resistance to toxicity produced by exposure to H 2O 2, as a significant protective effect of HO 1 marked by cell survival and LDH leakage was observed when 200, 400 and 600 μmol/L of H 2O 2 were used. The protection of HO 1 rapidly declined after the transfected VSMCs were pretreated 24 h with an HO 1 specific inhibitor (ZnPP IX). The results of this investigation suggest that the functional expression of HO 1 gene within VSMCs raises an alternative ability to protect the vascular cells against active oxygen injury.

本实验构建含人血红素加氧酶 1(hHO 1)基因的逆转录病毒载体XM 6/hHO 1,将其导入离体培养的大鼠血管平滑肌细胞 (vascularsmoothmusclecells,VSMC) ,观察外源性hHO 1基因在VSMC内的表达及其抗活性氧损伤作用。结果表明 :( 1)hHO 1基因可在靶细胞中明显表达 ,转染VSMC的HO 1蛋白表达和HO酶活性分别比非转染细胞高 1 8倍和 2 0倍 ;( 2 )转染hHO 1的VSMC可对抗大剂量H2 O2 对细胞的损伤作用 ,表现为细胞存活率增加和乳酸脱氢酶 (LDH)漏出减少 ,上述保护作用可被HO特异性抑制剂锌原卟啉IX (Zinc protoporphyrinIX ,ZnPP IX)所阻断。研究结果提示 ,外源性HO 1的过量表达可增加VSMC对抗氧化损伤的能力

 
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