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nizatidine tablets
相关语句
  尼扎替丁片
     The relative bioavailability of nizatidine tablets was 97.4%.
     尼扎替丁片的相对生物利用度为 97 4%。
短句来源
     Objective To study the pharmacokinetics and relative bioavailability of nizatidine tablets in healthy volunteers.
     目的 研究尼扎替丁片在健康人体的药代动力学和生物等效性。
短句来源
  “nizatidine tablets”译为未确定词的双语例句
     In this paper, nizatidine tablets and capsules were overall syudied on formulation design, optimization of preparation, establishment of quality control criteria and stability investigation.
     本文从处方筛选、制备工艺优化、质量控制标准的建立、稳定性考察等方面对尼杂替丁片剂及胶囊剂进行了全面的研究。
短句来源
     First, using the method of single factor investigation, the formulation and preparation of nizatidine tablets and capsules were optimized and decided considering synthetically several evaluation quotas.
     采用单因素考察的方法,综合多个评价指标,筛选确定了尼杂替丁片剂及胶囊剂的处方及制备工艺。
短句来源
     According to 2000 edition of Chinese Pharmacopoeia, the quality criteria of nizatidine tablets and capsules was studied on the basis of its physical and chemical property and the feature of tablets and capsules.
     根据尼杂替丁的理化性质和片剂及胶囊剂的特点,参照中国药典2000版,进行了尼杂替丁片剂及胶囊剂的质量标准研究。 研究内容包括性状、鉴别试验、有关物质检查、溶出度测定、含量测定等。
短句来源
     Methods Nizatidine tablets or nizatidine capsules at the single dose of 150 mg were administered orally in 22 healthy volunteers in an open randomized cross-over test. The plasma levels of nizatidine were measured by high performance liquid chromatography (HPLC).
     方法 采用随机开放双交叉自身对照试验 ,2 2名健康自愿者单剂量口服尼扎替丁 (片或胶囊 ) 15 0mg ,用高效液相色谱法测定尼扎替丁在血浆中的浓度。
短句来源
     The statistical analysis for AUC 0-Tn, C max, and T max showed that there was no significant difference between nizatidine tablets and capsules (P>0.05).
     统计检验结果表明各药动学参数间均无显著性差异 (P >0 0 5 )。
短句来源
  相似匹配句对
     The relative bioavailability of nizatidine tablets was 97.4%.
     尼扎替丁片的相对生物利用度为 97 4%。
短句来源
     Weianlin Tablets
     唯安林片
短句来源
     Meptin Tablets
     美喘清片
短句来源
     Objective To study the pharmacokinetics and relative bioavailability of nizatidine tablets in healthy volunteers.
     目的 研究尼扎替丁片在健康人体的药代动力学和生物等效性。
短句来源
     IMPROVED SYNTHESIS OF NIZATIDINE
     尼扎替丁的合成改进
短句来源
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Objective To study the pharmacokinetics and relative bioavailability of nizatidine tablets in healthy volunteers. Methods Nizatidine tablets or nizatidine capsules at the single dose of 150 mg were administered orally in 22 healthy volunteers in an open randomized cross-over test. The plasma levels of nizatidine were measured by high performance liquid chromatography (HPLC). Results The pharmacokinetic parameters of nizatidine tablets were: AUC 0-Tn (3 832.598±431.311) ng·h·ml...

Objective To study the pharmacokinetics and relative bioavailability of nizatidine tablets in healthy volunteers. Methods Nizatidine tablets or nizatidine capsules at the single dose of 150 mg were administered orally in 22 healthy volunteers in an open randomized cross-over test. The plasma levels of nizatidine were measured by high performance liquid chromatography (HPLC). Results The pharmacokinetic parameters of nizatidine tablets were: AUC 0-Tn (3 832.598±431.311) ng·h·ml -1, C max (1 105.626±187.378) ng·ml -1, and T max (1.261±0.366) h, and the pharmacokinetic parameters of nizatidine capsule were: AUC 0-Tn (3 978.227±611.387) ng·h·ml -1, C max (1 371.916±280.980) ng·ml -1, and T max (1.091±0.382) h. The statistical analysis for AUC 0-Tn, C max, and T max showed that there was no significant difference between nizatidine tablets and capsules (P>0.05). The relative bioavailability of nizatidine tablets was 97.4%. Conclusion The bioavailability of nizatidine tablets is equal to that of nizatidine capsules.

目的 研究尼扎替丁片在健康人体的药代动力学和生物等效性。方法 采用随机开放双交叉自身对照试验 ,2 2名健康自愿者单剂量口服尼扎替丁 (片或胶囊 ) 15 0mg ,用高效液相色谱法测定尼扎替丁在血浆中的浓度。结果 尼扎替丁片达峰时间为 (1 2 61± 0 3 66)h ,峰浓度为 (110 5 62 6± 187 3 78)ng/ml ,曲线下面积为 (3 83 2 5 98± 43 1 3 11)ng·h·ml-1,尼扎替丁胶囊达峰时间为 (1 0 91± 0 3 82 )h ,峰浓度为 (13 71 916± 2 80 980 )ng/ml,曲线下面积为 (3 978 2 2 7± 611 3 87)ng·h·ml-1。统计检验结果表明各药动学参数间均无显著性差异 (P >0 0 5 )。尼扎替丁片的相对生物利用度为 97 4%。结论 健康人单剂量口服 15 0mg尼扎替丁片与尼扎替丁胶囊生物等效。

Objective To evaluate the pharmacokinetics and bioequivalence of two nizatidine preparations in Chinese healthy volunteers. Methods According to a randomized cross-over design, a single oral dose of 300 mg of nizatidine test or reference preparation was given to 20 Chinese healthy young volunteers. After dosing, serial blood samples were collected for a period of 8.5 h. Nizatidine concentration in plasma was analyzed by HPLC. Results The main pharmacokinetic parameters of nizatidine...

Objective To evaluate the pharmacokinetics and bioequivalence of two nizatidine preparations in Chinese healthy volunteers. Methods According to a randomized cross-over design, a single oral dose of 300 mg of nizatidine test or reference preparation was given to 20 Chinese healthy young volunteers. After dosing, serial blood samples were collected for a period of 8.5 h. Nizatidine concentration in plasma was analyzed by HPLC. Results The main pharmacokinetic parameters of nizatidine preparations were as follow: t max were (1.49±0.48) and (1.38±0.58) h,C max were (2319±511) and (2408±572) ng·mL -1 ,MRT were(3.08±0.44) and (2.97±0.46) h,t 1/2 were (1.55±0.33) and (1.51±0.21) h, AUC 0-t were (6625±964) and (6725± 1078) ng·h ·mL -1 ,AUC 0-∞ were (6836±973) and (6928±1114) ng·h·mL -1 for imported tablets and domestic tablets respectively. The relative bioavailability of nizatidine tablet F 0-8.5h was (99.67±13.93)%.Conclusion The test and reference preparations were bioequivalent.

目的 研究进口与国产尼扎替丁在健康人体的药代动力学,并评价2种制剂的生物等效性。方法 用双交叉试验设计, 20名健康志愿者口服国产尼扎替丁片剂和进口胶囊剂,服药后0~8. 5h内间隔取血,用HPLC法测定血药浓度。计算主要药代动力学参数,并以胶囊剂为参比制剂,计算尼扎替丁片剂的相对生物利用度,判断其生物等效性。结果 国产片剂和进口胶囊剂的体内药代动力学参数分别为:tmax为(1. 49±0. 48), (1. 38±0. 58)h;Cmax为(2319±511), (2408±572)ng·mL-1;MRT为(3. 08±0. 44), (2. 97±0. 46)h;t1 /2为(1. 55±0. 33), (1. 51±0. 21)h; AUC0-t为(6625±964), (6725±1078)ng·h·mL-1;AUC0-∞为(6836±973), (6928±1114)ng·h·mL-1。尼扎替丁片剂的相对生物利用度F0-8. 5h为(99. 67±13. 93)%。结论 2种制剂具有生物等效性。

 
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