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quantitative injury
相关语句
  定量损伤
     Methods: The model of quantitative injury was established in rats with the weight drop apparatus with a laser compression recorder.
     方法 :利用激光束描记位移的重力打击装置 ,制备可靠的定量损伤模型 ;
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  相似匹配句对
     Injury;
     外伤;
短句来源
     Quantitative analysis on the maxillofacial injury
     颌面部损伤量化评分的临床研究
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     Quantitative evaluation of personality changes induced by craniocerebral injury
     颅脑损伤所致人格改变的量化评估
短句来源
     THE PANCREAS INJURY
     胰腺损伤(附7例报告)
短句来源
     Quantitative trabeculectomy
     定量滤过性小梁切除术
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Objective: To investigate the effects of the expression of exogenous brain derived neurotrophic factors (BDNF) on injured spinal cord following in vivo adenoviral gene transfer to the cord. Methods: The model of quantitative injury was established in rats with the weight drop apparatus with a laser compression recorder. The replicate defect recombinant adenoviral vector was transferred into the injured spinal cord through direct injection. The gene transfer was verified with X Ga1 staining and the...

Objective: To investigate the effects of the expression of exogenous brain derived neurotrophic factors (BDNF) on injured spinal cord following in vivo adenoviral gene transfer to the cord. Methods: The model of quantitative injury was established in rats with the weight drop apparatus with a laser compression recorder. The replicate defect recombinant adenoviral vector was transferred into the injured spinal cord through direct injection. The gene transfer was verified with X Ga1 staining and the changes in morphology of the injured axon were quantitatively determined. Meanwhile, the expression of BDNF mRNA and immunohistochemical reactivity of BDNF and NF in the injured spinal cord were investigated. Results: The spinal cord was infected by injection of the adenoviral vector and expressed the report gene. The loss of axons reduced following the in vivo infection of adenoviral vector carrying exogenous BDNF gene after SCI, while more positive axons in immunohistochemical reaction than that of normal spinal cord were seen. Conclusion: In vivo transfer of adenoviral vector into the foci can provide protection to some extent to injured axons through increasing local expression of exogenous BDNF and facilitate repair of the cytoskeleton in the injured neurons. These effects are important in gene therapy of SCI.

目的 :研究腺病毒介导的脑源性神经营养因子(BDNF)基因在大鼠损伤脊髓内的表达规律 ,观察外源性BDNF对损伤脊髓的作用。方法 :利用激光束描记位移的重力打击装置 ,制备可靠的定量损伤模型 ;以直接注射法将带有BDNF基因表达框的复制缺陷重组腺病毒载体直接转移至大鼠损伤脊髓 ,用X Gal染色检测基因转移有效性 ,并观察损伤轴突计量形态学改变 ,损伤脊髓BDNFmRNA表达 ,BDNF和神经中丝(Neurofilament,NF)免疫组化活性的改变。结果 :腺病毒载体直接引入脊髓可有效地感染脊髓组织和表达报告基因。直接转染BDNF腺病毒载体可明显减少伤后两周轴突丧失 ;同时 ,NF免疫反应阳性的轴突较正常增多。结论 :实验性腺病毒介导的BDNF基因损伤脊髓转移是可行的。在基因直接转移局部外源性BDNF过表达对神经具有保护作用 ,可减少轴突丧失 ,促进神经元骨架蛋白的修复。这种双重作用可能在脊髓损伤治疗中有重要的价值。

 
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