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release vehicle
相关语句
  释放载体
     Study on a Sustained Release Vehicle, PLF-127——Enhancement of therapeutic effects of certain biological response modifiers on a rat mammary carcinoma
     缓慢释放载体PLF-127的研究——对特定的生物学反应调节剂(BRM)抗肿瘤作用的增强
短句来源
  相似匹配句对
     vehicle;
     整车建模;
短句来源
     Influence of sodium hyaluronate as vehicle on chloramphenicol release
     以玻璃酸钠为媒介对氯霉素释放的影响
     NEW RELEASE
     新片推荐
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     release of the virus.
     组装病毒病毒颗粒;
短句来源
     When the vehicle reaches the preset speed, it begins to release the torpedo.
     载雷车达到预定速度后 ,释放空投鱼雷。
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  release vehicle
To determine the effect of hylan fluid (HA), a model slow release vehicle on the pharmacokinetic profile and efficacy of interleukin-1 receptor antagonist (IL-lra) in rats with established type II collagen arthritis.
      
Evaluation of Polyvinyl Alcohol Hydrogel as a Sustained-Release Vehicle for Rectal Administration of Indomethacin
      
Twelve hours after the last codeine injections, one injection of either a high or low dose of the zinc tannate salt of heroin, levo-alpha-acetylmethadol (LAAM) or hydromorphone in slow-release vehicle (SRV) was administered.
      
The latter is an incompletely defined collagenous substance which is believed to function as a slow release vehicle for BMP.
      


It has been shown that some biological response modifiers(BRM)mixed with PLF-127, a sustained release vehicle, were more effective against the growth of tumors. In this paper we studied the effect of interleukin-2(IL-2)in PLF-127 combined with transfer of LAK cells on the pulmonary metastasis of a mammary carcinoma in SHR rats. An enhancement of antimetastasis effect of the LAK+IL-2 therapy was observed by applying PLF-127. After lentinan,a T cell oriented BRM, which showed definitive antimetastasis effect...

It has been shown that some biological response modifiers(BRM)mixed with PLF-127, a sustained release vehicle, were more effective against the growth of tumors. In this paper we studied the effect of interleukin-2(IL-2)in PLF-127 combined with transfer of LAK cells on the pulmonary metastasis of a mammary carcinoma in SHR rats. An enhancement of antimetastasis effect of the LAK+IL-2 therapy was observed by applying PLF-127. After lentinan,a T cell oriented BRM, which showed definitive antimetastasis effect when it was administered alone, was mixed with PLF-127, such enhancement of antimetastasis effect could not. be demonstrated. The results suggest that the diversity of the effect of PLF-127 on IL-2 and lentinan may be due to the different ability of them to stimulate and modify the immunity of hosts.

本文报告了缓慢释放载体PLF-127对香菇多糖(lentinan)和IL-2并用LAK细胞抗SHR大鼠乳腺癌肺转移作用的影响,分析讨论了PLF-127对生物学反应调节剂(BRM)的可能作用。

Objective:To enhance therapeutic effects and reduce adverse effects of norcantharidin (NCFD) on anti-tumor. Methods:Poloxamer 407 (P407) gel was used as a sustained-release vehicle for topical administration of NCTD.The tox- icity of different preparations of NCTD in mice were observed,respectively.The anti-tumor effects of NCTD or NCTD in P407 (NCTD/P) on SD rats implanted with W_(256) carcinoma were also studied.Results:(1) The toxicity of the sus- tained-release preparation of NCTD in P407 gel...

Objective:To enhance therapeutic effects and reduce adverse effects of norcantharidin (NCFD) on anti-tumor. Methods:Poloxamer 407 (P407) gel was used as a sustained-release vehicle for topical administration of NCTD.The tox- icity of different preparations of NCTD in mice were observed,respectively.The anti-tumor effects of NCTD or NCTD in P407 (NCTD/P) on SD rats implanted with W_(256) carcinoma were also studied.Results:(1) The toxicity of the sus- tained-release preparation of NCTD in P407 gel was lower than that of free NCTD.(2) There were significantly slower tumor growth,more extensive tumor necrosis and longer survival time in SD rats treated with NCTD/P than those treated with free NCTD.Conclusion:The NCTD in P407 gel appeared to be less toxic and have more tumoricidal effects than that equivalent dose of free NCTD,mainly because NCTD in P407 might stay in the injected location for a longer time and produce a lower peak level in plasma than free NCTD.

目的:探讨增强去甲斑蝥素的抗癌效果,减轻其毒副反应。方法:选择泊洛沙姆407作为去甲斑蝥素局部用药的载体,将去甲斑蝥素制成缓释剂型,比较不同剂型去甲斑蝥素的毒性及对荷 W(256)肿瘤大鼠的抗肿瘤效果。结果:(1)去甲斑蝥素缓释剂型的毒性明显低于单纯去甲斑蝥素;(2)去甲斑蝥素缓释剂型治疗组大鼠肿瘤生长受到显著抑制,肿瘤组织坏死广泛,治疗后平均生存期延长(与单纯去甲斑蝥素比较,P<0.05);综合疗效优于单纯去甲斑蝥素组。结论:去甲斑蝥素-泊洛沙姆407缓释制剂瘤内注射,通过延缓药物释放,保持肿瘤内有效药物浓度,并避免峰值血药浓度出现而起到增效减毒作用。

Objective: To study the toxic and pharmocodynamic effects of sustained release preparation of norcantharidin (NCTD). Methods: Poloxamer 407 (P407) gel was used as a sustained release vehicle for topical administration of NCTD. The toxicity of different preparations of NCTD in mice were observed. The antitumor effects of NCTD or NCTD and P407 (NCTD/P407) on SD rats implanted with W256 carcinoma were also studied. Results: (1) The sustained release preparation of norcantharidin in Poloxamer 407 (NCTD/P407)...

Objective: To study the toxic and pharmocodynamic effects of sustained release preparation of norcantharidin (NCTD). Methods: Poloxamer 407 (P407) gel was used as a sustained release vehicle for topical administration of NCTD. The toxicity of different preparations of NCTD in mice were observed. The antitumor effects of NCTD or NCTD and P407 (NCTD/P407) on SD rats implanted with W256 carcinoma were also studied. Results: (1) The sustained release preparation of norcantharidin in Poloxamer 407 (NCTD/P407) might stay in the liver at least for 4 h after injection. (2) The toxicity of the sustained release preparation of NCTD in P407 gel was lower than that of free NCTD. (3) There were significant slower tumor growth, more extensive tumor necrosis and longer survival in SD rats treated with NCTD/P407 than those treated with free NCTD. Conclusion: The NCTD in P407 gel is less toxic and have more tumoricidal effects than the equivulent dose of free NCTD, mainly because NCTD in P407 may stay in the injecting location and act with the tumor cells for a longer time.

目的:初步探讨去甲斑蝥素缓释制剂的减毒增效作用。方法:选择泊洛沙姆407 作为去甲斑蝥素局部用药的载体,将去甲斑蝥素制成缓释剂型,在初步证实该制剂兔肝内注射后确能缓慢释放的前提下,比较不同剂型的去甲斑蝥素的毒性及对荷 W 256 肿瘤大鼠的抗肿瘤效果。结果:(1)去甲斑蝥素缓释制剂肝内注射后在局部至少能停留4 h;(2)去甲斑蝥素缓释制剂的毒性明显低于单纯去甲斑蝥素;(3)去甲斑蝥素缓释剂型治疗组大鼠肿瘤生长受到显著抑制,肿瘤组织坏死广泛,治疗后平均生存期延长(与单纯去甲斑蝥素组相比, P< 0.05),综合疗效优于单纯去甲斑蝥素组。结论:去甲斑蝥素缓释制剂肝内局部注射能够通过延缓去甲斑蝥素的释放速度,增加其与肿瘤细胞直接作用的时间等途径达到减毒增效的目的。

 
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