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hyperleukocytosis syndrome
相关语句
  高白细胞综合征
     29 cases (48. 3%) developed leukooytosis and among them 9 developed hyperleukocytosis syndrome, which cleared up in 8 after having been treated with low-dose harringtonine or mitoxantrone or hydroxyurea in addition to ATRA.
     29例(483%)出现白细胞增多症,9例出现高白细胞综合征,加用小剂量三尖杉酯碱、羟基脲或米托蒽醌,8例症状消失。
短句来源
     Results:In the treatment of acute promyelocytic leukemia with all trans retinoic acid, the common toxic reactios are dry mouth, skin desiccation, desquamation, rhagadia (100%). 19 patients had gastro intestinal symptoms with higher ALT(50%),18 patients had hyperleukocytosis syndrome (47.5%), 16 patients had headache and dizziness (42.4%),8 patients had pain in muscle and joint (21.2%).
     结果 :APL在ATRA治疗过程中常见毒副反应有不同程度的口干、皮肤干燥、脱屑、皲裂 (10 0 % ) ,19例出现胃肠道症状伴谷丙转氨酶增高 (5 0 % ) ,18例高白细胞综合征(47 5 % ) ,16例出现头痛、头晕 (42 4 % ) ,8例有肌肉、关节疼痛 (2 1 2 % )。
短句来源
     Conclusions:The toxic reactions of all trans retinoic acid in the treatment of acute promyelocytic leukemia usually have dry mouth ,skin desiccation, desquamation, rhagadia, gastro intestine symptom with higher ALT, and hyperleukocytosis syndrome ets.
     结论 :ATRA治疗APL过程中常出现口干、皮肤干燥、脱屑、皲裂、胃肠道症状及高白细胞综合征等毒副反应。
短句来源
  相似匹配句对
     SYNDROME
     Noonan氏综合征(附2例报告)
短句来源
     Rowell's syndrome
     RoweIl综合征
短句来源
     COMPLICATION AND OUTCOME IN ACUTE LEUKEMIA WITH HYPERLEUKOCYTOSIS
     高白细胞急性白血病44例分析
短句来源
     STUDY ON MECHANISM OF HYPERLEUKOCYTOSIS INDUCED BY ATRA IN PATIENTS WITH APL
     APL经ATRA诱导后高白细胞征机制的进一步研究
短句来源
     LEUKAPHERESIS AND TELOMERASE TEST IN ACUTE LEUKEMIC PATIENTS WITH HYPERLEUKOCYTOSIS
     高白细胞性白血病患者细胞分离治疗及端粒酶检测
短句来源
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objective: To conclude experiences of treatment in acute promyelocytic leukemia(APL) with all-trans retinoic acid(ATRA) and to discuss how to reduce mortality of APL during treatment. Methods: Sixty patients with APL were selected to be treated with ATRA. Results: 53 cases (88. 3%)achieved complete remission. 29 cases (48. 3%) developed leukooytosis and among them 9 developed hyperleukocytosis syndrome, which cleared up in 8 after having been treated with low-dose harringtonine or mitoxantrone or hydroxyurea...

objective: To conclude experiences of treatment in acute promyelocytic leukemia(APL) with all-trans retinoic acid(ATRA) and to discuss how to reduce mortality of APL during treatment. Methods: Sixty patients with APL were selected to be treated with ATRA. Results: 53 cases (88. 3%)achieved complete remission. 29 cases (48. 3%) developed leukooytosis and among them 9 developed hyperleukocytosis syndrome, which cleared up in 8 after having been treated with low-dose harringtonine or mitoxantrone or hydroxyurea in addition to ATRA. Six patients developed retinoic acid syndrome (RS), which subsided after administration of methylprednisolone or dexamethasone with a lower dose of ATRA in four patients. Conclusion: Earlier recognition and appropriate treatment of hyper-leukocytosis and retinoic acid syndrome can reduce the mortality of APL during ATRA therapy.

目的:总结全反式维甲酸(ATRA)治疗急性早幼粒细胞白血病(APL)经验,探讨如何降低治疗中的早期死亡率。方法:选择60例确诊为APL的患者,采用ATRA治疗。结果:53例(883%)达完全缓解。29例(483%)出现白细胞增多症,9例出现高白细胞综合征,加用小剂量三尖杉酯碱、羟基脲或米托蒽醌,8例症状消失。6例出现维甲酸综合征,使用甲基强的松龙或地塞米松并用小剂量ATRA治疗后4例好转。结论:早期识别ATR毒副作用,尽早治疗,可以降低APL患者早期死亡率。

Purpose:To observe the toxic reactions of all trans retinoic acid in the treatment of acute promyelocytic leukemia. Methods:Analysis of toxic reaction was done for 38 patients who suffered from acute promyelocytic leukemia treated with all trans retinoic acid. Results:In the treatment of acute promyelocytic leukemia with all trans retinoic acid, the common toxic reactios are dry mouth, skin desiccation, desquamation, rhagadia (100%). 19 patients had gastro intestinal symptoms with higher ALT(50%),18 patients...

Purpose:To observe the toxic reactions of all trans retinoic acid in the treatment of acute promyelocytic leukemia. Methods:Analysis of toxic reaction was done for 38 patients who suffered from acute promyelocytic leukemia treated with all trans retinoic acid. Results:In the treatment of acute promyelocytic leukemia with all trans retinoic acid, the common toxic reactios are dry mouth, skin desiccation, desquamation, rhagadia (100%). 19 patients had gastro intestinal symptoms with higher ALT(50%),18 patients had hyperleukocytosis syndrome (47.5%), 16 patients had headache and dizziness (42.4%),8 patients had pain in muscle and joint (21.2%). The rare toxic reactions included 4/38 who had intracranial hypertension syndrome, 2/38 had hyperglycemia, 1/38 and hyperhistaminemia syndrome. Conclusions:The toxic reactions of all trans retinoic acid in the treatment of acute promyelocytic leukemia usually have dry mouth ,skin desiccation, desquamation, rhagadia, gastro intestine symptom with higher ALT, and hyperleukocytosis syndrome ets. THe treatment with lower dose of all trans retinoic acid(20~30 mg/d)for acute promyelocytic leukemia could decrease the toxic reactions without influencing its effectiveness.

目的 :研究全反式维甲酸 (ATRA)治疗急性早幼粒细胞白血病 (APL)常见及少见毒副反应。方法 :回顾分析 38例APL在ATRA治疗期间出现的毒副反应。结果 :APL在ATRA治疗过程中常见毒副反应有不同程度的口干、皮肤干燥、脱屑、皲裂 (10 0 % ) ,19例出现胃肠道症状伴谷丙转氨酶增高 (5 0 % ) ,18例高白细胞综合征(47 5 % ) ,16例出现头痛、头晕 (42 4 % ) ,8例有肌肉、关节疼痛 (2 1 2 % )。少见毒副反应包括高颅压综合征 4 / 38,血糖升高 2 / 38,高组胺综合征 1/ 38等。结论 :ATRA治疗APL过程中常出现口干、皮肤干燥、脱屑、皲裂、胃肠道症状及高白细胞综合征等毒副反应。使用小剂量ATRA(2 0~ 30mg/日 ) ,可减少毒副反应的发生而对疗效无明显影响。

 
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