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predominant response
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     CONCLUSION:①At the early phase of acute trauma(especially at 6 hour after trauma),exogenous ADM shows a immune function modulation to adjust the proportion disequilibrium of Th1/Th2 by inhibiting Th1 predominant response.
     结论:①急性创伤早期(以创伤后6h为著),外源性肾上腺髓质素通过抑制Th1优势应答,具有校正Th1/Th2比例失衡的免疫调节作用。
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     Conclusion:The aged rats might associated with hyperapoptosis in lmphocytes,with the overexpression of Th1-Th2-Th3 and a relative Th2,Th3 predominant response,EF have a strong effect to adjust the unbalance proportionment of Th1-Th2-Th3 and restablish the new balance of Th1-Th2-Th3.
     结论:老龄大鼠脾淋巴细胞过度凋亡,Th1、Th2、Th3类细胞因子分泌增高,Th2、Th3类细胞因子优势应答; EF可以抑制淋巴细胞过度凋亡,校正老龄大鼠Th1、Th2、Th3类细胞因子之间的比例失衡,重塑Th1-Th2-Th3细胞免疫调节网络的良性平衡。
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     Recent studies show that granuloma is an irnmunopathology reaction with many kinds of inflammatory cells such as eosinophile granulocyte infiltrating which is mediated by Th2 predominant response induced by soluble egg antigen .
     近年来研究表明,血吸虫卵肉芽肿病变主要是由虫卵可溶性抗原诱导的以Th2型免疫优势应答介导的,以嗜酸性粒细胞等多种炎症细胞浸润为主的免疫病理反应。
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  “predominant response”译为未确定词的双语例句
     Respiratory syncytial virus (RSV) bronchiolitis had been identified as a risk factor for later recurrent wheezing and childhood asthma, in which an imbalance of CD4 helper T cell (Th) function, favoring a Th2 predominant response, is believed to be very important.
     由于呼吸道合胞病毒毛细支气管炎(RSV毛支)临床表现酷似哮喘,部分患儿可出现反复喘息,甚至发展为哮喘,而后者的发病被认为与CD4~+辅助性T淋巴细胞(Th)功能紊乱、Th2优势免疫应答密切相关,因而有人推测RSV毛支和哮喘可能存在共同的免疫机制,RSV毛支的发生与Th2优势免疫应答及局部强烈的Ⅱ型细胞因子反应有关。
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     Conclusion: There is a predominant response from Th1 to Th2 in Th1/Th2 balance of the immune system of patients with malignant tumors.
     结论:恶性肿瘤患者机体免疫系统存在T细胞亚群失调现象,Th2占优势。
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     Conclusion: The results suggested that yin-deficient status may be associated with the relative Th1 predominant response and the ZUOGUIWAN can reestablish the new balance of Th1/Th2. [
     结论:中医阴虚阳亢小鼠处于Th1相对优势状态,中药左归丸可重建Th1/Th2的平衡状态?
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     In patients with malignant tumors, Th1/Th2 balance changes. There is a predominant response from Th1 to Th2. It is unclear whether tumor vaccines and other immunotherapies play beneficial roles in tumor therapy through reversing the predominance.
     恶性肿瘤患者T细胞的Th1/Th2平衡多有改变,发生Th1向Th2漂移现象,瘤苗等免疫治疗是否通过逆转此漂移而有利于肿瘤治疗,尚待探讨。
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     Additionally, in BALF of the asthmatic group and BCG immunized group , the percentage of γδT cells were markedly higher than that in control group ( P <0.01). Conclusion The predominant response of Th2 cells are well related to the increased B lymphocytes, EOS, plasmacytes and neutrophils(they are all antigen presenting cell) as well as the high expression of CD2 + T cells in asthma.
     BCG组BALF中 ,CD2 + T细胞的百分率与正常组相比较无显著差异 (P >0 .0 5 ) ,其CD2 + T细胞的MFI显著高于正常组 (P <0 .0 5 )。
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     The Effect of Predominant Period on the Maximum of Response Spectrum
     卓越周期对反应谱最大值的影响
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     Response with B was similar to C.
     B和C组有效率相似。
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     Challenge and Response
     挑战与回应
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     The predominant period of the response spectrum is 0.45—0.51 s.
     反应谱的卓越周期为0.45—0.51s。
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     with the rule astigmatism is predominant.
     散光轴向分布以顺规散光为主(78.02%)。
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  predominant response
If glutamate was applied at distances of under 100 μ from the neurons the predominant response was one of excitation, evidently due to the direct action of the excitatory mediator.
      
In the streptozotocin-induced diabetic rats the predominant response indicative of healing was inhibitory.
      
A smaller percentage of cells was inhibited by progesterone, while the predominant response to testosterone was excitation.
      
It is suggested that changes in the predominant response of arcuate neurons to injection of estradiol in the course of the sex cycle are determined by the level of endogenous estrogens and pituitary gonadotropic hormones in the peripheral blood.
      
The predominant response of the willows to N fertilization was at the shoot-level, by production of greater leaf area per shoot.
      
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On isolated nonuniform stretched muscle preparation (INSMP) of rat diaphragm, it was found that the sustained depolarization (SD) in endplate area is the predominant response to repetitive stimu1ation after soman intoxication. Both the microelectrode intracellular recording and the extracellular acetylcholine (ACh) iontophoresis were used to investigate the mechanism of SD.The amplitude of ACh potential was used as the criterion of N-ACh receptor to ACh. ACh potential as well asendplate potential could...

On isolated nonuniform stretched muscle preparation (INSMP) of rat diaphragm, it was found that the sustained depolarization (SD) in endplate area is the predominant response to repetitive stimu1ation after soman intoxication. Both the microelectrode intracellular recording and the extracellular acetylcholine (ACh) iontophoresis were used to investigate the mechanism of SD.The amplitude of ACh potential was used as the criterion of N-ACh receptor to ACh. ACh potential as well asendplate potential could not be recorded during SD.ACh potential restored gradually after SD. A large depolarization response with 70 % duration dependent of the number ofiontophoresis pulse could be recorded in response to iontophoresis at 5-l0 Hz(1~58). After soman (5.5 μmol·L-1), it turned out to be a longlasting depolarization with 70% duration of 3.23±s 0.7s (n=6) independent of the number ofiontophoresis pulse. This response was the same asendplate potential induced SD in nature. On INSMPfrom rats pretreated with Botulinunl toxin A, in whichpresynaptic ACh release has been blocked, SD couldalso be recorded in response to 5-10 Hz AChiontophoresis after soman (5.5 μmol·L-1). It is con-cluded that SD is the result of postsynaptic responsesto ACh accumulated in the synaptic cleft after inhibi-tion of acetvlcholinesterase. The present results do notsupport the hypothesis that SD is the result ofpresynaptic“regenerative release”of ACh.

在离休大鼠膈肌标本上,细胞内记录终板区微电泳给乙酰胆碱(ACh)的电位,以ACh电位幅度为突触后反应性指标,观察了梭曼中毒后间接串刺激产生终板区持续性去极化反应的性质并分析了其产生的机理。持续性去极化过程中不仅串终板电位消失,ACh电位也消失,持续性去极化之后ACh逐渐恢复。在正常大鼠和肉毒毒素A中毒大鼠膈肌标本上,梭曼中毒后,串ACh电位(5-10Hz)也可诱发与持续性去极化性质相同的去极化反应,结果表明,持续性去极化主要是突触后N型ACh受体对高浓度ACh的一种反应,不支持突触前ACh“再生性”释放的假说。

Aim To explore the changes of cell composition in bronchoalveolar lavage fluid(BALF) in different Th1/Th2 cell immune response. Understand the mechanism of Th1/Th2 cell immune response at cellular and molecular levels. Methods Wistar rats ( n =10, for each group) were sensitized and challenged with ovalbumin to establish an asthmatic model, immunized with BCG vaccine to establish a immunized rat model. Cell composition in the BALF was detected by HE staining. The percentage and mean fluorescence intensity...

Aim To explore the changes of cell composition in bronchoalveolar lavage fluid(BALF) in different Th1/Th2 cell immune response. Understand the mechanism of Th1/Th2 cell immune response at cellular and molecular levels. Methods Wistar rats ( n =10, for each group) were sensitized and challenged with ovalbumin to establish an asthmatic model, immunized with BCG vaccine to establish a immunized rat model. Cell composition in the BALF was detected by HE staining. The percentage and mean fluorescence intensity (MFI) of CD2 +, CD28 + and γδTCR + T cells were detected by flow cytometry. The levels of IL 4 and IFN γ were determined by ELISA. The expressions of IL 4 mRNA and IFN γmRNA were determined by in situ hybridization. Results As compared to the control group , the sum of all lymphocytes, eosinophils (EOS), plasmacyte and neutrophils in BALF of asthmatic group significantly increased( P <0.01); the total lymphocytes and macrophages in BALF of the BCG immunized group also increased notably ( P <0.01). The percentage of CD2 + T cells decreased distinctly ( P <0.01), but the number of non CD2 + T cells increased in BALF of asthmatic group. The MFI of CD2 + T cells in BALF of asthmatic group was obviously more than those of control group and BCG immunized group. The percentage of CD2 + T cells had no significant difference ( P >0.05) but the MFI of CD2 + T cells was significantly higher ( P <0.01), compared between BCG immunized group and control group. As compared with control group, the percentage and MFI of CD28 + T cells in BALF of asthmatic group and BCG immunized group significantly increased ( P <0.01), while MFI of BCG immunized group was higher than that of the asthma group. Additionally, in BALF of the asthmatic group and BCG immunized group , the percentage of γδT cells were markedly higher than that in control group ( P <0.01). Conclusion The predominant response of Th2 cells are well related to the increased B lymphocytes, EOS, plasmacytes and neutrophils(they are all antigen presenting cell) as well as the high expression of CD2 + T cells in asthma. The predominant response of Th1 cells has relation to the increased T lymphocytes and macrophages as well as the high expression of CD28 + on T cells in BCG immunized group. γδT cells may also have a pattern of Th1/Th2 cell. They participate in both immunoregulation of BCG vaccine and pathogenesis of asthma, may being a initiatic cell which regulates Th0 cells to differentiate towards Th1/Th2 cells.

目的 探讨不同Th细胞优势应答下支气管肺泡灌洗液 (BALF)中的细胞学变化 ,了解Th1/Th2细胞免疫应答的细胞和分子机制。方法 用鸡卵清蛋白 (OVA)致敏Wistar大鼠 (每组 10只 ) ,制作致敏大鼠哮喘模型 ;用”冻干BCG”皮内注射制作BCG免疫大鼠模型。收集BALF并做HE染色 ,进行细胞分类计数。采用流式细胞术 ,测定BALF中 ,CD2 + 、CD2 8+ 及γδTCR+ T细胞占总淋巴细胞的百分率及平均荧光密度 (MIF)。用原位杂交法 ,检测肺组织中IL 4mRNA和IFN γmRNA的表达。用ELISA法检测血清IL 4和IFN γ的浓度。结果 哮喘组BALF中淋巴细胞、嗜酸性粒细胞 (EOS)、浆细胞和中性粒细胞的总数 ,均显著多于正常组 (P <0 .0 1) ;BCG免疫组BALF中 ,淋巴细胞和巨噬细胞的总数也显著高于正常组 (P <0 .0 1)。哮喘组BALF中 ,CD2 + T细胞占淋巴细胞的百分率明显少于正常组 (P <0 .0 1) ,非CD2 + 细胞明显增加。但哮喘组CD2 + T细胞的MFI显著高于正常组及BCG组 (P <0 .0 5 ) ;BCG组BA...

目的 探讨不同Th细胞优势应答下支气管肺泡灌洗液 (BALF)中的细胞学变化 ,了解Th1/Th2细胞免疫应答的细胞和分子机制。方法 用鸡卵清蛋白 (OVA)致敏Wistar大鼠 (每组 10只 ) ,制作致敏大鼠哮喘模型 ;用”冻干BCG”皮内注射制作BCG免疫大鼠模型。收集BALF并做HE染色 ,进行细胞分类计数。采用流式细胞术 ,测定BALF中 ,CD2 + 、CD2 8+ 及γδTCR+ T细胞占总淋巴细胞的百分率及平均荧光密度 (MIF)。用原位杂交法 ,检测肺组织中IL 4mRNA和IFN γmRNA的表达。用ELISA法检测血清IL 4和IFN γ的浓度。结果 哮喘组BALF中淋巴细胞、嗜酸性粒细胞 (EOS)、浆细胞和中性粒细胞的总数 ,均显著多于正常组 (P <0 .0 1) ;BCG免疫组BALF中 ,淋巴细胞和巨噬细胞的总数也显著高于正常组 (P <0 .0 1)。哮喘组BALF中 ,CD2 + T细胞占淋巴细胞的百分率明显少于正常组 (P <0 .0 1) ,非CD2 + 细胞明显增加。但哮喘组CD2 + T细胞的MFI显著高于正常组及BCG组 (P <0 .0 5 ) ;BCG组BALF中 ,CD2 + T细胞的百分率与正常组相比较无显著差异 (P >0 .0 5 ) ,其CD2 + T细胞的MFI显著高于正常组 (P <0 .0 5 )。哮喘组和BCG组BALF中 ,CD2 8+ 细胞占淋巴细胞的百分率显著多于正常组 (P <0 .0 1) ;BCG组CD2 8+ 细胞的MFI高于哮喘组 (P <0 .0 1

Objective To investigate the status of cellular immunity from Th cell polarization in pa-tients with different courses of condyloma acuminatum(CA).Methods The isolated PBMC were polarized by PHA and self-plasma for72hours,then followed by two-color immunofluorescent staining with anti-CD4-PE and anti-CCR5-FITC,or with anti-CD4-FITC and anti-CCR3-PE.Finally the stained cells were analyzed by flow-cytometry.Results The percentages of Th1/Th2cells of the short-course group and long-course group were(25.82±2.22)%/(14.80±1.14)%and(12.20±1.37)%/(13.74±0.99)%,respectively;the...

Objective To investigate the status of cellular immunity from Th cell polarization in pa-tients with different courses of condyloma acuminatum(CA).Methods The isolated PBMC were polarized by PHA and self-plasma for72hours,then followed by two-color immunofluorescent staining with anti-CD4-PE and anti-CCR5-FITC,or with anti-CD4-FITC and anti-CCR3-PE.Finally the stained cells were analyzed by flow-cytometry.Results The percentages of Th1/Th2cells of the short-course group and long-course group were(25.82±2.22)%/(14.80±1.14)%and(12.20±1.37)%/(13.74±0.99)%,respectively;the differ-ences between normal control and two CA groups were significant(P<0.05).The Th1/Th2cells ratios of short-course and long-course group were1.75±0.17or0.89±0.11,respectively.Conclusions It seems that there was Th1predominant response in CA patients with short-course and Th2predominant response in long-course group.These data indicate that there may be an possible switch from Th1to Th2response in CA pa-tient with long-course.

目的从辅助性T细胞(Th)极化情况,探讨不同病程尖锐湿疣患者的细胞免疫状态。方法取肝素抗凝血,用密度梯度离心法分离出血浆和外周血单一核细胞(PBMC)进行细胞培养和免疫荧光染色:PHA和自身血浆刺激PBMC诱导T细胞极化,72h后收获细胞,分别标记抗CD4鄄PE与抗CCR5鄄FITC和抗CD4鄄FITC与抗CCR3鄄PE,最后利用流式细胞仪对标记细胞进行分析。结果尖锐湿疣患者中,短病程组与长病程组Th1/Th2极化细胞百分率分别为(25.82±2.22)%/(14.80±1.14)%与(12.20±1.37)%/(13.74±0.99)%,两组极化细胞百分率分别与正常对照组比较差异均有显著性(P <0.05),短病程组Th1/Th2的比值为1.75±0.17,而长病程组为0.89±0.11。结论短病程尖锐湿疣患者机体呈现Th1型反应,而长病程者则以Th2型反应为主,存在Th1型反应向Th2型反应切换的现象。

 
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