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hb virus
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  乙肝病毒
     Person-year infection rates of HB virus were 8.9%(8/89.9 person-years) for intradermal revaccination,significantly higher than 3.6%(12/337.2 person-years) in controls,and 4.3%(3/70.2 personyears) for intramuscular revaccination,approximated to that of controls,based on positive conversion of anti-HBc.
     用抗-HBc阳转作为感染指标计算乙肝病毒人年感染率,皮内复种者为8.9%(8/89.9人年),高于应答对照者的3.6%(12/337.2人年),而肌肉复种者为4.3%(3/70.2人年),与应答对照者接近。
短句来源
     Person-year infection rates of HB virus were 8.9% (8/ 89.9 person-years) for intradermal revaccinees, significantly higher than 3.6% (12/ 337.2 person-years) in controls, and 4.3% (3/ 70.2 person-years) for intramuscular revaccinees, approximating to that of controls, based on positive conversion of anti-HBc.
     用抗-HBc阳转作为感染指标计算乙肝病毒人年感染率,皮内复种者为8.9%(8/89.9人年),高于应答对照者的3.6%(12/337.2人年),而肌肉复种者为4.3%(3/70.2人年),与应答对照者接近。
短句来源
     The rate of carrying surface antigens (HBsAg) of HB virus was 7.55%, indicative of a high level of HBV infection.
     乙肝病毒表面抗原(HBsAg)携带率为7.5 5 % ,HBV感染仍处于较高水平。
短句来源
     Conclusions: A combination immunotherapy plan in which late-stage pregnant women are immunized by HBIG monthly and their newborns are injected with HB Vaccine 5 μg a time(0,1,6 project) and HBIG 200 IU a time(0,1/2,1 project) may help improve maternal-infantile HB virus transmission interruption rate significantly.
     结论:孕妇妊娠晚期乙肝高价免疫球蛋白被动免疫,继之所生婴儿基因乙肝疫苗5μg/次(0、1、6方案)加大剂量乙肝高价免疫球蛋白200 IU/次(0、1/2、1方案)联合免疫方案可明显提高乙肝病毒母婴垂直传播阻断率。
短句来源
     Results The positive rate of TSP-2expressio n in HBV-infected patients was56%and that in non-HBV-infected was24%,which was significantly different (P<0.05). Conclusions HB virus increases TSP-2expression in colorectal cancer and may play a ro le in the decrease of liver metastasis.
     结果乙肝病毒感染组癌组织中的TSP2阳性表达率为56%,明显高于非乙肝病毒感染组的24%(P<0.05。结论乙肝病毒感染者结直肠癌组织中的TSP2表达上调,从而可能降低结直肠癌肝转移的发生。
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  “hb virus”译为未确定词的双语例句
     Objective An expression vector for anti-HBsAg Fab fragment and interferon-αA(IFN-αA) fusion protein in E. coli was constructed in order to find a new immunobiotherapy drug targeted to HB virus.
     目的为深入研究乙型肝炎的生物导向治疗,构建以人抗乙型肝炎表面抗原(HBsAg)抗体Fab片段为导向作用、αA-干扰素(IFN-αA)为治疗作用的融合蛋白Fab/IFN-αA原核表达载体pHS/IFN-αA。
短句来源
     Conclusion: The success in construction and expression of fusion protein makes it possible to carry out further studies on its purification and the targeted therapy of gene-engineering pharmaceutic to HB virus.
     结论:融合蛋白ScFv-IL-2的成功构建及表达,为融合蛋白的纯化和研究开发新型的乙肝导向治疗的基因工程药物打下良好的基础。
短句来源
     Methods Peripheral blood was extracted from 103 hepatitis B (HB) virus-infected persons, including 11 cases of HB virus (HBV)-infected persons, 11 cases of acute HB, 81 cases of chronic HB, and 11 cases of asymptomatic HBV infection, and 25 healthy blood donors used as controls.
     方法 采用流式细胞分析技术对 10 3例乙肝患者 (包括HBV携带者 11例 ,慢性乙肝轻度 35例 ,中度 33例 ,重度 13例 ,急性乙肝11例 )和 2 5例健康人 (对照组 )的外周血DC2进行检测 ,同时检测患者血常规 ,计算出DC2绝对数 ;
短句来源
     Treatment group obviously surpassed control group in improving clinical symptoms, signs and hepatic function as well as the rate of HB virus turning to negative. There was obvious statistical significance (P<0.05), no serious adverse reactions.
     治疗组在临床症状及体征改善、肝功能改善 ,乙型肝炎病毒阴转率方面明显优于对照组 ,具有显著的统计学意义 (P <0 .0 5 ) ,且未见严重不良反应。
短句来源
     Result : The treatment group was obviously better than the control group in improving hepatic function, the rate of HB virus serum markers turning to negative as well as the situation of hepatic fibrogenesis. There was obvious statistical significance(P <0.01).
     结果:治疗组在改善肝功能、乙型肝炎病毒标志物阴转率、改善肝纤维化指标方面,明显优于对照组,具有统计学意义(P<0.01)。
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  相似匹配句对
     hardness was HB;
     硬度HB;
短句来源
     (e) infection by virus;
     病毒说:细菌感染或多病原说;
短句来源
     Virus counter
     病毒计数器
短句来源
     STUDIES ON THE CORRELATION OF,SF,Hb IN SERUM AFFECTED VIRUS HEPATITIS WITH RIA
     RIA法检测病毒性肝炎患者血清TF、SF、Hb含量和相关性研究
短句来源
     Monoclonal Antibodies for Detection of Strain HB of Potato Virus X(PVX-HB)
     用于检测马铃薯X病毒株系(PVX-HB)的单克隆抗体
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  hb virus
Cytotoxic T lymphocyte activity and HB virus mutant in chronic HB virus carriers
      
However, the generated amounts of IgG were not associated with the HB virus carrier state.
      
Studies on the effects of estrogen on antibody responses in asymptomatic hb virus carriers and non-responders to hb vaccine inoc
      
The relationship between the prognosis of the disease based on liver histology and HB virus (HBV) associated antigen/antibody systems was investigated in twenty seven patients with chronic active hepatitis (CAH).
      
A case of alpha-feto protein (AFP) positive hepatic cell carcinoma has been presented in which the appearance of a mono-clonal gammopathy can be explained by persistent infection with HB virus (HBV).
      
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hree serologic markers for screening beforehepatitis B vaccination were HBsAg,anti-HBsand anti-HBc. The data of HB virus infectionin eight cities were analysed in order to savetest cost and to achieve similar immune effect. For routine screening, anti-HBc is the only onemarker needed to be used. The neonates and chil-dren aged 0~3 years can be vaccinated directly without screening.

目前乙肝疫苗接种前要进行HBsAg、抗-HBs和抗-HBc三项指标的筛检。为了节省检验费用,并能达到一定的预防效果,我们对八个城市的乙肝感染情况进行了分析,在常规筛检时,只需筛检一项抗-HBc。新生儿和0~3岁幼儿可以直接接种。这样,即能节省费用又能达到一定预防效果,符合费用-效果原则。

Objective:This study was designed to construct a expression vector for antiHBsAg Fab fragment and interferonaA(IFNaA) fusion protein in E. coli.Methods:with PCR and molecular clone technique, the gene fragment of IFNaA was introducedinto the corresponding endonuclease sites and artificial Linker at 5,3termini, and then forming pHs/IFNaA recombining it with the vector in correct endonuclease sites. Results:After checking with enzymic hydrolysis, the human gene of IFNaA was correctly cloned to the vector,...

Objective:This study was designed to construct a expression vector for antiHBsAg Fab fragment and interferonaA(IFNaA) fusion protein in E. coli.Methods:with PCR and molecular clone technique, the gene fragment of IFNaA was introducedinto the corresponding endonuclease sites and artificial Linker at 5,3termini, and then forming pHs/IFNaA recombining it with the vector in correct endonuclease sites. Results:After checking with enzymic hydrolysis, the human gene of IFNaA was correctly cloned to the vector, and the sequence of the gene was confirmed correct.Conclusion:The success in construction of human antiHBsAg Fab fragment/IFNaA fusion protein expression vector makes it possible to carry out further studies on expressing in E.coli and targeted therapy polypeptide for HB virus.

目的:为深入开展乙型肝炎的生物导向治疗,我们构建了人抗乙肝表面抗原(HBsAg)抗体Fab片段/αA-干扰素(IFN-αA)融合蛋白原核表达载体pHS/IFN-α。方法:采用PCR方法,将IFN-αADNA两端引入酶切位点及5端引入-Linker,重组入抗HBsAg抗体Fab表达载体pHS相应酶切位点,酶切鉴定并筛选出阳性克隆pHS/IFN-αA,并对插入基因片段测序。结果:重组阳性克隆经酶切鉴定证实重组片段已正确插入载体相应酶位点,片段与PCR扩增片段大小相同,硷基序列正确。结论:pHS/IFN-αA的成功构建,为人抗HBsAg抗体Fab片段/αA-干扰素融合蛋白在大肠杆菌的表达打下基础

Objective An expression vector for anti-HBsAg Fab fragment and interferon-αA(IFN-αA) fusion protein in E.coli was constructed in order to find a new immunobiotherapy drug targeted to HB virus. Methods With PCR and molecular clone techniques, we amplify the gene fragment of IFN-αA with corresponding endonuclease sites and artificial linker at 5′, 3′ termini, and then forming pHS/IFN-αA by recombining it within the vector in correct endonuclease sites. Choosing the passive clone to transform into E.coli...

Objective An expression vector for anti-HBsAg Fab fragment and interferon-αA(IFN-αA) fusion protein in E.coli was constructed in order to find a new immunobiotherapy drug targeted to HB virus. Methods With PCR and molecular clone techniques, we amplify the gene fragment of IFN-αA with corresponding endonuclease sites and artificial linker at 5′, 3′ termini, and then forming pHS/IFN-αA by recombining it within the vector in correct endonuclease sites. Choosing the passive clone to transform into E.coli and introduced by IPTG to express the fusion protein. Results Enzymic hydrolysis and DNA sequence measurement confirmed that human gene of IFN-αA has correctly cloned to the vector and can express fusion protein in E.coli. Conclusion The success in construction and expression of the fusion protein makes it possible to carry out further studies on its purification and targeted therapy polypeptide to HB virus.

目的为深入研究乙型肝炎的生物导向治疗,构建以人抗乙型肝炎表面抗原(HBsAg)抗体Fab片段为导向作用、αA-干扰素(IFN-αA)为治疗作用的融合蛋白Fab/IFN-αA原核表达载体pHS/IFN-αA。方法用PCR体外扩增目的基因IFN-αA,并在其DNA两端引入酶切位点及5′端人工合成的Linker,重组人抗HBsAg抗体Fab片段表达载体pHS相应酶切位点,酶切和DNA测序鉴定筛选出阳性克隆,转化大肠杆菌,经IPTG诱导表达。结果目的基因正确正向插入载体,重组表达载体pHS/IFN-αA能在大肠杆菌表达出具有双重生物活性的融合蛋白Fab/IFN-αA。结论融合蛋白Fab/IFN-αA的成功构建及在大肠杆菌的表达,为融合蛋白的纯化及研制新一代乙型肝炎生物导向治疗的基因工程多肽类药物打下了基础。

 
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