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losartan tablets
相关语句
  氯沙坦
     Treatment of losartan tablets for 22 cases of early-phased diabetic nephropathy
     氯沙坦治疗早期糖尿病肾病22例分析
短句来源
     Methods Twenty two patients with early phased DN based on conventional therapy of diabetes were treated with losartan tablets (50 mg/d),and observed for 10~12 weeks.
     方法  2 2例早期 DN患者在抗糖尿病常规治疗的基础上加用氯沙坦 (5 0 mg/d) ,短期观察 10~ 12周。
短句来源
     Objective To evaluate the clinical effect of losartan tablets on excretion of urinary protein and kidney function in patients with early phased diabetic nephropathy (DN).
     目的 短期观察氯沙坦对早期糖尿病肾病 (DN)患者尿蛋白的排泄和肾功能的影响。
短句来源
     Conclusion Losartan tablets can decrease the excretion of urinary protein,inhibit progression of kidney damage,and keep normal renal function.
     结论 早期 DN的治疗中使用氯沙坦 ,可以降低尿蛋白排泄 ,阻止肾脏损害的发展 ,保护肾功能。
短句来源
  相似匹配句对
     Study on the formulation of losartan potassium tablets
     氯沙坦钾片剂的处方设计及其制备
短句来源
     Weianlin Tablets
     唯安林片
短句来源
     Aminoglutethimide Tablets
     治疗乳腺癌及皮质醇增多症特效药——氨鲁米特片
短句来源
     Treatment of losartan tablets for 22 cases of early-phased diabetic nephropathy
     氯沙坦治疗早期糖尿病肾病22例分析
短句来源
     Losartan was administered in the treatment group.
     血管紧张素Ⅱ受体拮抗剂选用Losartan。
短句来源
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This is an open randomized, two-period crossover study in 18 healthy male volunteers. Subjects receive a single oral dose of 50mg losartan tablet produced by Hangzhou-MSD and by U.K-MERCK .The plasma concentrations of unchanged losartan and its active metabolite, E-3174 are determined by using HPLC method. The main pharmacokinetic parameters are as follows: C_(max) of losartan (Hangzhou-MSD) and losartan (U.K.-MERCK) are 352.20 ± 196.09 and 291 .20 ± 124.41μg· L~(-1) Tab, are 0.91 ± 0.38...

This is an open randomized, two-period crossover study in 18 healthy male volunteers. Subjects receive a single oral dose of 50mg losartan tablet produced by Hangzhou-MSD and by U.K-MERCK .The plasma concentrations of unchanged losartan and its active metabolite, E-3174 are determined by using HPLC method. The main pharmacokinetic parameters are as follows: C_(max) of losartan (Hangzhou-MSD) and losartan (U.K.-MERCK) are 352.20 ± 196.09 and 291 .20 ± 124.41μg· L~(-1) Tab, are 0.91 ± 0.38 and 1.33 ± 0.69h, AUC_(0-∞) are 547.44 ± 226.77 and 499.52 ± 157.31 μg· h· L ~(-1), t_(1/2) are 1.89 ± 0.49 and 1.80 ± 0.51h, respectively; C_(max) of E-3174 (Hangzhou-MSD) and E-3174(U.K.-MERCK) are 545.07 ± 150.49 and 534.02 ± 142.88μg· L~(-1), T_(max), are 3.15 ± 1.07 and 3.37 ± 0.66h, AUC_(0-∞) are 3641.57 ± 637.17 and 3631.72 ± 687.94 μg· h· L~(-1), T_(1/2) are 8.33 ± 2.05 and 7.74 ± 1 .22h,respectively. According to statistic study, the differences of two parameters, C_(max) and T_(max) of unchanged losartan between two formulations are significant, but AUC_(0-∞) of unchanged losartan and three parameters, C_(max), T_(max), and AUC_(0-∞) of E-3174 show no significant difference between two formulations.

18名健康男性志愿者交叉单剂量口服杭州默沙东产50mg氯沙坦钾片和英国默克产50mg氯沙坦钾片,以HPLC-UV 法测定血浆中氯沙坦钾及其活性代谢产物E-3174的浓度,并对两种制剂进行生物等效性评价。试验结果表明:口服杭州产及默克产氯沙坦钾,氯沙坦钾C_(max)分别为352.201± 196.09和291.20±124.41μg·L~(-1),T_(max)分别为0.91±0.38和1.33±0.69h,AUCO_(0-∞)分别为547.44±226.77和499.52±157.31μg·h·L~(-1), T_(1/2);、分别为1.89±049和1.80±0.51h; E-3174 C_(max)分别为545.07±150.49和534.02±142.88μg·L~(-1),T_(max)分别为3.15±1.07和3.37±0.66h,AUC_(0-∞)分别为3641.57 ± 637.17和3631.72 ± 687.94μg·h·L~(-1),T_(1/2)分别为8.33±2.05和774±1.22h。统计分析表明,两制剂间氯沙坦钾的C_(max)、T_(max)有显著差异,而氯沙坦钾的AUC_(...

18名健康男性志愿者交叉单剂量口服杭州默沙东产50mg氯沙坦钾片和英国默克产50mg氯沙坦钾片,以HPLC-UV 法测定血浆中氯沙坦钾及其活性代谢产物E-3174的浓度,并对两种制剂进行生物等效性评价。试验结果表明:口服杭州产及默克产氯沙坦钾,氯沙坦钾C_(max)分别为352.201± 196.09和291.20±124.41μg·L~(-1),T_(max)分别为0.91±0.38和1.33±0.69h,AUCO_(0-∞)分别为547.44±226.77和499.52±157.31μg·h·L~(-1), T_(1/2);、分别为1.89±049和1.80±0.51h; E-3174 C_(max)分别为545.07±150.49和534.02±142.88μg·L~(-1),T_(max)分别为3.15±1.07和3.37±0.66h,AUC_(0-∞)分别为3641.57 ± 637.17和3631.72 ± 687.94μg·h·L~(-1),T_(1/2)分别为8.33±2.05和774±1.22h。统计分析表明,两制剂间氯沙坦钾的C_(max)、T_(max)有显著差异,而氯沙坦钾的AUC_(0-∞)、E-3174?

Objective To evaluate the clinical effect of losartan tablets on excretion of urinary protein and kidney function in patients with early phased diabetic nephropathy (DN).Methods Twenty two patients with early phased DN based on conventional therapy of diabetes were treated with losartan tablets (50 mg/d),and observed for 10~12 weeks.Result Changes of blood sugar,BUN,and Cr were not significant(all P>0.05).Excretion of urinary trace albumin decreased markedly,so did creatinine clearance (both...

Objective To evaluate the clinical effect of losartan tablets on excretion of urinary protein and kidney function in patients with early phased diabetic nephropathy (DN).Methods Twenty two patients with early phased DN based on conventional therapy of diabetes were treated with losartan tablets (50 mg/d),and observed for 10~12 weeks.Result Changes of blood sugar,BUN,and Cr were not significant(all P>0.05).Excretion of urinary trace albumin decreased markedly,so did creatinine clearance (both P<0.01).Conclusion Losartan tablets can decrease the excretion of urinary protein,inhibit progression of kidney damage,and keep normal renal function.

目的 短期观察氯沙坦对早期糖尿病肾病 (DN)患者尿蛋白的排泄和肾功能的影响。方法  2 2例早期 DN患者在抗糖尿病常规治疗的基础上加用氯沙坦 (5 0 mg/d) ,短期观察 10~ 12周。结果 病人治疗前后血糖均无明显改变 (P>0 .0 5 )。尿微量白蛋白下降 ,肌酐清除率 (Ccr)也明显降低 (P <0 .0 1) ,但尿素氮 (BU N)、肌酐 (Cr)无明显改变。结论 早期 DN的治疗中使用氯沙坦 ,可以降低尿蛋白排泄 ,阻止肾脏损害的发展 ,保护肾功能。

 
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