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inflammatory activity
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  炎活性
     Thirteen compounds (II 1,3,5,8 13,15,18,19,23 ) exhibited marked anti inflammatory activity comparable to diclofenac sodium (DC) and rofecoxib (RC) in xylene induced mice ear swelling model, and twelve compounds (II 1,3,5,7,8,10 12,17,18,20,23 ) showed remarkable anti inflammatory activity comparable to DC and RC in carrageenan induced rat paw edema.
     角叉菜胶致大鼠足跖肿胀模型试验结果显示 ,12个化合物 (II1 ,3,5,7,8,1 0 1 2 ,1 7,1 8,2 0 ,2 3)的抗炎活性与双氯芬酸钠 (DC)和罗非昔布 (RC)相当 (P >0 0 5 )。
短句来源
     Compounds II 3 and II 9 showed anti inflammatory activity comparable to DC. Compound II 2 showed stronger anti inflammatory and analgesic activities and less GI side effect than DC, and released NO in vivo .
     II3和II9的抗炎活性与DC相当 ,II2 的抗炎镇痛活性强于DC ,胃肠道副作用小于DC ,并小于文献报道的硝酸酯类NO DC ,体内有明显的NO释放。
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     A series of 2 (E) (4 hydroxy 3 methoxybenzylidene) 5 (N substituted ami nomethyl) cyclopentanones was synthesized and evaluated for the anti inflammatory activity.
     本文合成了15种2(E)(3甲氧基4羟基苯亚甲基)环戊酮杂环胺Mannich碱盐酸盐和芳胺Mannich碱,并进行了初步的抗炎活性筛选。
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     The Design,Synthesis and Anti inflammatory Activity of β Aromaticamino Ketones
     β-芳胺酮类化合物的设计、合成及抗炎活性研究
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     OBJECTIVE To study the anti inflammatory activity and distribution patterns in tissues of dexamethasone acetate emulsion.
     目的 观察醋酸地塞米松静注乳剂的抗炎活性及在小鼠体内组织分布特征。
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  炎症活动
     AST, GGT, albumin, albumin/globulin, ALP, AFP, hyaluronic acid, N terminal procollagen Ⅲ(PⅢNP), collagen type Ⅳ(col Ⅳ), tissue inhibitors of metalloproteinases 1 (TIMP 1), alpha 2 macroglobulin, natural killer cells (NK), some parameters of Doppler ultrasonography, CT and/or MR imaging were related to the degree of inflammatory activity;
     AST、GGT、白蛋白、白 /球蛋白比、ALP、AFP、透明质酸、Ⅲ型前胶原肽、7S Ⅳ胶原、组织金属蛋白酶抑制物 1(TIMP 1)、α2 巨球蛋白、自然杀伤细胞 (NK )及B超、CT和 (或 )MR某些检测指标与炎症活动度有关。
短句来源
     There were no significant difference in levels of ALT, TBIL, ALB, γ-G, PTA, HBeAg, HBV-DNA positive rate in serum, the amount of HBV-DNA in serum, the severity of inflammatory activity grade and fibrosis, HBcAg positive rate and the morphologic feature of HBcAg expression in liver tissue between HGV-Ag positive and negative patients with CHB ( P >0.05).
     HGV Ag阳性与阴性患者血清丙氨酸转氨酶 (ALT)、总胆红素 (TBIL)、白蛋白(ALB)、电泳γ球蛋白 (γ G)、凝血酶原活动度 (PTA)水平、血清HBeAg、HBV DNA阳性率、血清HBV DNA定量水平及肝脏病理损害的炎症活动度与纤维化程度、肝组织HBcAg形态学表现、检出率等方面差异均无显著性 (P >0 .0 5 )。
短句来源
     The prevention and treatment with the Chinese Herbs could improve the steatosis of hepatocyte and inflammatory activity(P<0.01,P <0.05),and remarkably decrease the amounts of plasma TXB2 and the ratio of TXB_(2)/6-K-PGF1α. (P <0.01,P<0.05).
     应用不同剂量的理气化痰祛瘀法中药进行预防和治疗则能明显改善大鼠肝组织的脂肪变和炎症活动程度(P<0.01,P<0.05),显著降低血浆中TXB2含量和TXB2/6-K-PGF1α比值(P<0.01,P<0.05)。
短句来源
     Conclusion There is close correlation between liver fibrosis and inflammatory activity.
     结论 肝组织的炎症活动度与肝纤维化的分期呈明显的正相关 ;
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     ⑧ Scores of inflammatory activity in liver Those in model group and pingtang recipe group were higher than those in normal control group 16 weeks after modeling P < 0.01 but there was no significant difference between model group and pingtang recipe group.
     ⑧肝脏炎症活动度计分:造模后16周,模型组及二陈汤方加减组明显高于正常对照组(P<0.01),但模型组与二陈汤方加减组差异不明显。
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  炎作用
     Pentoxifylline (PTX) is a methyxanthine with selective anti inflammatory activity.
     己酮可可碱 (Pentoxifylline ,PTX)是甲基黄嘌呤的衍生物 ,具有选择性抗炎作用
短句来源
     Objective: To investigate the anti inflammatory activity of total polysaccharides of Anemarrhena asphodeloides Bunge (TPA) and discuss the mechanism roughly.
     目的:考察知母总多糖(TPA)的抗炎作用,并初步探讨其作用机制。
短句来源
     CONCLUSION:These findings indicated that FKS inhibited immediate hypersensitivity and the early phase of DTH mainly due to its stabilization of mast cell membrane and reduction of release of histamine,5 HT and other anaphylactic mediators,and inhibited the late phase of DTH maybe due to its anti inflammatory activity. Saponin was the active component of FKS responsible for its inhibition on DTH.
     结论 :地肤子可能主要通过稳定肥大细胞膜 ,减少组胺、5 HT等过敏介质的释放抑制速发型变态反应及DTH效应相的早期反应 ,其对DTH后期反应的抑制作用则可能与抗炎作用有关 ,地肤子皂苷为其抑制DTH的有效成分。
短句来源
     Analgesic effect and anti inflammatory activity were assessed in mice with means of the twisting test by acetic acid and the ear swelling by xylene.
     采用小鼠醋酸扭体、耳部肿胀法研究镇痛和抗炎作用
短句来源
     Inhaled corticosteroids (ICS) are the most effective anti-inflammatory agents available for the treatment of asthma and protect against fatal attacks. For patients on ICS who still experience symptoms, adding a long-acting β 2 agonist improves symptom control and lung function to a greater extent than increasing the ICS dose alone. Bronchial biopsy and bronchoalveolar lavage studies have demonstrated that treatment with a combination of these two drugs results in enhanced and complementary anti inflammatory activity.
     吸入糖皮质激素 (ICS)能有效地控制气道炎症和哮喘恶化 ,对于吸入激素后仍有症状的哮喘患者 ,加用吸入长效 β2 激动剂 ,在控制哮喘症状、改善肺功能方面优于加量单用 ICS,气道活检和肺泡灌洗液检查显示两药合用具有协同或相互增强的抗炎作用
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  “inflammatory activity”译为未确定词的双语例句
     Results The correlation between serum HA, CⅣ , PⅢP and histologically assessed grade of inflammatory activity was weak (r=0.430, 0.382 and 0.300, respectively, P<0.05) .
     结果血清HA、CⅣ、PⅢP和肝脏组织炎症分级呈较弱正相关(r分别为0.430、0.382和0.300,P<0.05)。
短句来源
     [RESULTS] Compounds ZA 1, ZA 3, ZA 7, ZA 9, ZA 10 , ZA 13 , ZA 15 and ZA 16 exhibited remarkable inflammatory activity in xylene-induced mouse ear swelling model.
     [结果 ]目标化合物ZA1 、ZA3、ZA7、ZA9、ZA1 0 、ZA1 3、ZA1 5、ZA1 6 均能抑制二甲苯所致小鼠耳肿胀 ;
短句来源
     Increase in expression of eNOS was correlated with degrees of inflammatory activity and fibrosis ( r=0 6855,P<0 05;r=0 4828,P<0 05, respectively), and with decreasing PA and ALB( F=3 4101,P<0 05;F=9 1714,P<0 01 ).
     随CHB肝组织炎症程度和纤维化程度的加重 ,eNOS表达增强 (r =0 6 85 5 ,P <0 0 5 ;r =0 482 8,P <0 0 5 )。 随eNOS表达上调 ,患者PA及血清ALB下降 (F =3 410 1,P <0 0 5 ;F =9 1714,P <0 0 1)。
短句来源
     Within the group of chronic hepatitis patients, the expression of IL-18 increased with the inflammatory activity (P<0.05), and was positively correlated with serum ALT levels (r=0.92,P<0.01).
     慢性乙型肝炎组中IL-18的表达与血清丙 氨酸氨基转移酶(ALT)水平呈正相关(r=0.92,P<0.01)。
短句来源
     The relationship between the levels of serum LN,HA, PCⅢ and CⅣ and the degrees of liver tissue fibrosis was analyzed quantitatively by using SPSS11.0.Results A correlation between the levels of serum LN,HA,PCⅢ and CIV and the histologically assessed grades of inflammatory activity was found(r= 0.394,0.449, 0.443,0.351,respectively,P<0.01).
     通过 SPSS 11.0软件包分析 LN、HA、PCⅢ、CⅣ与肝组织纤维化分期及炎症分级的量化关系。 结果 LN、HA、PCⅢ、CⅣ与肝组 织学炎症分级有相关性(r 分别为0.394、0.449、0.443、0.351,P 值均<0.01);
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  inflammatory activity
The glucan failed to possess anti-inflammatory activity.
      
Relationships of inflammatory activity with biochemical parameters of the blood and sympathovagal balance of young athletes
      
The systemic inflammatory activity is supposed to be an integral factor involved in the formation of such a specific biochemical profile.
      
Hence, a decreased inflammatory activity can be involved in the regulation of some biochemical parameters and affect the sympathovagal balance of a trained body.
      
And so, atractylenolide I acted on the WBCM and TLR4 and its anti-inflammatory activity was related with antagonizing TLR4.
      
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Subcutaneous injection of lycorine at a dosage of 12 mg/kg once daily for 3 consecu- tive days induced marked involution of thymus in immature mice. Intravenous injection of a dose of 12 mg/kg of lycorine significantly depleted the adrenal ascorbic acid con- tent of the rabbit. Lycorine, at a dosage of 16 mg/kg, elicited eosinopenic response in the intact toad, but failed to induce similar response in the hypophysectomized animal. These results indicate that lycorine affected the function of the adrenal cortex...

Subcutaneous injection of lycorine at a dosage of 12 mg/kg once daily for 3 consecu- tive days induced marked involution of thymus in immature mice. Intravenous injection of a dose of 12 mg/kg of lycorine significantly depleted the adrenal ascorbic acid con- tent of the rabbit. Lycorine, at a dosage of 16 mg/kg, elicited eosinopenic response in the intact toad, but failed to induce similar response in the hypophysectomized animal. These results indicate that lycorine affected the function of the adrenal cortex presum- ably through stimulation of ACTH release. In addition, lycorine was found to possess anti-inflammatory activity on egg-white- induced oedema of the hind paw in intact rats, and on formalin-arthritis in rabbits (3mg/kg I.V.). However, lycorine failed to inhibit egg-white-induced oedema in ad- renalectomized rats. Thus, the anti-inflammatory action of lycorine is probably mediated by stimulating the pituitary-adrenal system.

作者用幼小鼠胸腺萎缩法、家兔肾上腺抗坏血酸含量降低及蟾蜍嗜酸性白血球减少等方法,证实石蒜碱具有刺激动物肾上腺皮质功能的作用;当用去除垂体蟾蜍作试验对象时,证明石蒜碱的这一作用系通过垂体而实现.此外,石蒜碱对家兔甲酸性关节炎及大鼠蛋白性关节炎显示明显的抗炎作用.

The monopotassium salt of 14-Deoxy-11, 12-didehydroandrographolide-3,19-disuccinate (DAS) neutralized with equivalentamount of sodium bicarbonate is an aqueous soluble preparation derived from andrographolide which is the principal composition of Andrographis paniculata Ness. DAS was reported to have therapeutic effect on pneumonia and upper respiratory tract infection of virus origin. We investigated its anti-inflammatory activity in mice and rats. The experimental results showed that DAS significantly...

The monopotassium salt of 14-Deoxy-11, 12-didehydroandrographolide-3,19-disuccinate (DAS) neutralized with equivalentamount of sodium bicarbonate is an aqueous soluble preparation derived from andrographolide which is the principal composition of Andrographis paniculata Ness. DAS was reported to have therapeutic effect on pneumonia and upper respiratory tract infection of virus origin. We investigated its anti-inflammatory activity in mice and rats. The experimental results showed that DAS significantly inhibited the increase of capillary permeabilities induced by various phlogistic stimulations and exudation induced by croton oil, but had no effect on granuloma formation around cotton pellet or in granuloma pouch. DAS was found to inhibit egg-white induced edema of the hind paw in intact rats but not in adrenalectomized animals. DAS induced marked involution of the thymus in immature mice and significantly depleted the content of adrenal ascorbic acid of rats. However, this action of DAS was abolished by hypophysecton(?)y. After five consecutive daily injections of DAS the ACTH content of the pituitary gland some increased with significant depletion of adrenal ascorbic acid content in rats. These results indicate that the anti-inflammatory activity of DAS is presumably due to increasing synthesis and release of ACTH of the pituitary gland.

腹腔注射或皮下注射本品128~250 mg/kg,对二甲苯、组织胺、醋酸等所致小白鼠皮肤或腹腔毛细血管通透性增高、蛋清所致大鼠足肿胀及巴豆油所致炎性渗出均有明显的抑制作用,但对肉芽组织增生无明显影响。由于去除肾上腺后其抗炎作用消失,本品也不能延长去肾上腺幼年大白鼠的生存时间,但可引起幼年小白鼠胸腺萎缩、明显降低大白鼠肾上腺中维生素C的含量,多次给药并可增加垂体前叶中ACTH的含量,因此说明本品不具有肾上腺皮质激素样作用,但能兴奋垂体——肾上腺皮质系统功能,这一作用是在于促进了垂体前叶ACTH的合成和释放。继以大白鼠肾上腺中维生素C含量降低为指标,分析了本品作用的部位,结果表明,动物去除垂体后,此作用消失,戊巴比妥钠麻醉,作用仍然存在,但在戊巴比妥钠麻醉的基础上,吗啡、地塞米松、氯丙嗪等均能完全阻断本品降低肾上腺中维生素C含量的作用,上述结果提示本品兴奋垂体——肾上腺皮质系统功能的作用部位可能在皮层下中枢。

The anti-inflammatory, antipyretic, analgesic, local anesthetic and toxic effects of Pelagonium gcravcolens were studied in this article. The LD 50 of the drug in mice given p.o. was found to be 3.66±0.24g/kg. Its toxicity is very low. It inhibited significantly the increase of capillary permeability induced by acetic acid. It also inhibited the exudation, and the inflammation on the ear induced by croton oil, but it was of no effect on granule ma. formation. This drug given p.o. elevated the cortisol level...

The anti-inflammatory, antipyretic, analgesic, local anesthetic and toxic effects of Pelagonium gcravcolens were studied in this article. The LD 50 of the drug in mice given p.o. was found to be 3.66±0.24g/kg. Its toxicity is very low. It inhibited significantly the increase of capillary permeability induced by acetic acid. It also inhibited the exudation, and the inflammation on the ear induced by croton oil, but it was of no effect on granule ma. formation. This drug given p.o. elevated the cortisol level of plasma in mice and also promoted the phagocytosis of macrophages in mice. The anti-inflammatory activity may be related to the promotion of the secretion of corticosteroids and the enhancement of the immune response. For the explanation of this phenomenon further works have to be done. Its analgesic action by the hot plate and stretching method was weaker but longer than that of Dolantin. It possesses a moderate local anesthetic activity.

本文对香竺葵油急性毒性、抗炎、镇痛解热和局麻等方面作用作了初步探讨.给小鼠一次口服香竺葵油乳剂,三天内LD50=3.66±0.24克/公斤,证明该制剂的毒性较低.本制剂局部应用和口服给药对醋酸所致的小鼠腹腔毛细血管通透性增加,巴豆油引起的耳部炎症及炎性渗出均有明显的抑制作用,但对肉芽组织增生无显著影响.由于本剂能明显提高小鼠血浆皮质醇含量,提示其抗炎作用可能与促进皮质激素分泌有关.小剂量香葵乳剂口服又证明有增强小鼠腹腔巨噬细胞吞噬功能,原因待查.用热板法和扭体反应法证明香竺葵油具有中等强度的镇痛作用,虽不能明显提高镇痛百分率但却能显著减少单位时间扭体次数,说明口服给药有延长痛反应时间的效应.但对三联菌苗致热家兔无解热作用.本制剂局部应用能使家兔角膜反射和蟾蜍离体坐骨神经动作电位明显减弱,提示有一定的表面麻醉和阻滞麻醉效能.但两者与地卡因和普鲁卡因相比,有显效慢、作用弱和持续时间长的特点.

 
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