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inhibited expression
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     Methylprednisolone may reduce the pathological damages of EAM, and this protective mechanism may be due to the inhibited expression of MMP 2 and MMP 9 and promoted expression of TIMP 1.
     甲基强的松龙能减轻EAM发病程度 ,其作用机制可能与MMP 2及MMP 9的表达下调、TIMP 1的表达上调有关
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  “inhibited expression”译为未确定词的双语例句
     Inhibited expression of TCR V_β subfamily T cells in patients with AML-M_1
     AML-M_1型患者TCR V_βT细胞家族表达抑制情况
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     Inhibited expression of ERp29 in IEC-6 cell by RNA interference
     RNAi抑制IEC-6细胞中ERp29表达
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     E_2 or P_4 of 10~(-5)mol/L inhibited expression of CD25 as a late activated molecular.
     10~(-5)mol/L的E_2和P_4还抑制了T淋巴细胞中期活化分子CD25的表达。
短句来源
     The level of P gp expression in ATRA treated cells was increased from 54.2%± 8.6% up to 98.5%±1.4% ( P <0.01), but IL 4 markedly inhibited expression of P gp down to 25.4%± 7.3% ( P <0.01).
     ATRA处理使瘤细胞P gp表达从 (5 4.2±8.6 ) %增加到 (98.5± 1.4) % ,P <0 .0 1; IL 4降低P gp表达 (2 5 .4± 7.3) % ,P <0 .0 1。
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     TSA obviously promoted the acetyl level of histone,induced expression of p21CIP1/WAF1 mRNA,and inhibited expression of cyclin A,but had no obvious influence on expression of cyclin E.
     TSA可明显提高组蛋白乙酰化水平,并诱导p21CIP1/WAF1的mRNA表达和抑制cy-clin A的mRNA表达,而对cyclin E无明显作用。
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  相似匹配句对
     The expression of E.
     研究了E.
短句来源
     The expression
     在交界瘤、良性瘤中无表达。
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     The expression of catenin was inhibited by theophylline.
     茶碱降低连接素的表达量。
短句来源
     The expression of c-Myc and cyclin D1 were inhibited.
     c-Myc、cyc lin D1的表达受到抑制。
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     and inhibited the proliferation in
     而与对照组相比,o.
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  inhibited expression
Incubation of blood with anti-CD11b inhibited expression of CD62P and increased the number of aggregates but reduced their size.
      
All of these antisense oligonucleotides inhibited expression of the 10?kb EGFR mRNA (range: 22-97% inhibition) compared to a scrambled control oligonucleotide or an untreated control.
      
Delta-sleep-inducing peptide inhibited expression of the c-fos gene in rats receiving intracerebroventricular injection of physiological saline.
      
Epithalon alone or in combination with Vilon activated expression of 194 clones (maximally by 6.61 times) and inhibited expression of 48 clones (maximally by 2.71 times).
      
Vilon alone or in combination with Epithalon activated expression of 157 clones (maximally by 6.13 times) and inhibited expression of 23 clones (maximally by 2.79 times).
      
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Our data indicated that human fetal heart cells (FHC) fail to express either HLA class I or class II antigens. Mixed lymphocyte culture or oonoanavalin A activated lymphocytes and unstimulated normal human peripheral blood lymphocytes can all induce expression of class I and class II HLA antigens on FHC. Alpha-interferon (IFN-α), interleukin 1(IL-1), IL-3, IL-4, and alpha-tumor necrosis factor (TNF-α), can all induce expression of class I but not class II HLA antigens on FHC. It is very interesting...

Our data indicated that human fetal heart cells (FHC) fail to express either HLA class I or class II antigens. Mixed lymphocyte culture or oonoanavalin A activated lymphocytes and unstimulated normal human peripheral blood lymphocytes can all induce expression of class I and class II HLA antigens on FHC. Alpha-interferon (IFN-α), interleukin 1(IL-1), IL-3, IL-4, and alpha-tumor necrosis factor (TNF-α), can all induce expression of class I but not class II HLA antigens on FHC. It is very interesting that synergistio interaction of IFN-α and TNF-α induces expression of class I and class II HLA antigens on cardiac myooytes. Immunosuppressive agenbs both cyclosporin A and FK-506 strongly inhibit expression of class I and class II HLA antigens on fetal cardiac myocytes.

我们的实验表明,正常人胚胎心肌细胞(FHC)检测不出人类白细胞抗原(HLA)。激活与未激活的正常人外周血淋巴细胞均能诱导FHC表达HLAⅠ类和Ⅱ类抗原。α干扰素(IFN-α)、白细胞介素1、3、4(IL-1、3、4)以及α肿瘤坏死因子(TNF-α),都能诱导FHC表达HLAⅠ类而不是Ⅱ类抗原。IFN-γ是Ⅰ娄和Ⅱ类抗原的诱导剂。值得注意的是,我们发现IFN-α和TNF-α联合应用时,不仅对Ⅰ类抗原的诱导起增强作用,而且能协同Ⅱ类抗原的表达。环孢霉素A(CsA)和FK-506免疫抑制剂均能抑制Ⅱ类及Ⅰ类抗原的表达。

The level of FcγR on peripheral blood mononuclear cells (PBMC) was determinedby ABC-ELISA in 43 patients with primary hepatocellular carcinoma (PHC) and in 8patients with space-occupying benign lesion (BL) in liver, twelve patients who wereoperated for PHC were followed up to detect their FcγR. Nine PBMC samples fromPHC were treated with rIFNγ. The results showed that: 1. the level of FcγR in PHCpatients was significantly lower than that in BL and in normal control;2. the expres-sion of FcγR was enhanced in...

The level of FcγR on peripheral blood mononuclear cells (PBMC) was determinedby ABC-ELISA in 43 patients with primary hepatocellular carcinoma (PHC) and in 8patients with space-occupying benign lesion (BL) in liver, twelve patients who wereoperated for PHC were followed up to detect their FcγR. Nine PBMC samples fromPHC were treated with rIFNγ. The results showed that: 1. the level of FcγR in PHCpatients was significantly lower than that in BL and in normal control;2. the expres-sion of FcγR was enhanced in postoperated PHC patients, 3. the production of IFNγin PHC patients was defective. The level of FcγR on PBMC was increased obviouslyin PHC after PBMC being treated with rIFNγ but was still lower than that in control.These results suggested: 1. FcγR dotection is helpful for distinguishing malignantfrom benign; (2) The inhibited expression of FcγR in PHC could be related to somefactors secreted by cancer tissues and also to low level of IFNγ; (3) IFNγ stimulatesthe expression of FcγR in vitro as one of the antitumour mechanism of IFNγ.

ABC-ELISA方法测定了43例肝癌及8例肝良性占位性病变患者外周血单个核细胞(PBMC)FcγR,并对其中12例肝癌切除术后病人追踪测定。用rIFNγ刺激PBMC,观察FcγR表达量的变化。结果,肝癌组FcγR水平明显低于肝脏良性占位性病变和正常对照组,而后两组比较相差不显著。手术后病人FcγR表达水平提高。肝癌病人内源性IFNγ产生缺陷。外源性IFNγ刺激后FcγR表达显著增强,但仍低于正常对照组。上述结果提示:1.FcγR对鉴别肝脏良恶性占位性病变有参考价值;2.肝癌者FcγR水平低下可能与癌组织分泌某种抑制因子及内源性IFNγ产生低下有关;3.外源性IFNγ促进FcγR表达,是其抗肿瘤机制之一。

Antisense phosphorothioate oligodeoxynueleotides respectively complementary to initial region of 2.1kb mRNA(oligomer A,14nts)and enhancer I(oligomer B,12nts)of HBV were synthesed by chemi cal synthetic method,and inhibition of these oligomers on expression of HBsAg and HBeAg in cell cul ture system was studied. The oligomer A inhibited more than 50% of HBsAg at 3μmol/L, but the oligomer B did at 6μmol/L. On the contrary,the oligomer B showed 35% inhibition on expression of HBeAg at 3μmol/L,but...

Antisense phosphorothioate oligodeoxynueleotides respectively complementary to initial region of 2.1kb mRNA(oligomer A,14nts)and enhancer I(oligomer B,12nts)of HBV were synthesed by chemi cal synthetic method,and inhibition of these oligomers on expression of HBsAg and HBeAg in cell cul ture system was studied. The oligomer A inhibited more than 50% of HBsAg at 3μmol/L, but the oligomer B did at 6μmol/L. On the contrary,the oligomer B showed 35% inhibition on expression of HBeAg at 3μmol/L,but 22% the oligomer A at the same conc. in HepG_2 cell transfected with cloned HBV DNA. However, they could only inhibit 20-35% expression of HBsAg and HBeAg at 18μmol/L in 2215 cell line. In the meantime, the results showed that the oligomer A possessed little inhibition on metabolic activity of HepG_2 cell at 40μmol/L by MTT method. The results suggest that antisense oligomers could specifically inhibit expression of HBsAg and HBeAg,and be considered as a unique class of experimental therapeutic agents against infection of hepatitis B virus.

设计合成了两个分别互补于乙肝病毒2.1kb mRNA起始区(片段A)和增强子区(片段B)的硫代磷酸的DNA片段。在经克隆HBV DNA转染HepG_2细胞建立的HBV短暂表达系统及稳定产生HBV的2215细胞中研究二者对HBsAg及HBeAg表达的抑制作用。结果表明反义寡聚物能不同程度抑制乙肝抗原表达,并与剂量呈一定正相关。在HepG_2细胞HBV短暂表达系统中,6μmol/L浓度时,片段A、B对HBsAg的抑制作用分别为60%,56.1%,对HBeAg表达的抑制水平分别为45%、48%。在2215细胞中,18μmol/L浓度时,二者对HBsAg及HBeAg的抑制作用只有20~35%左右。同时采用甲基蓝四氮唑(MTT)方法检测了反义寡聚物对HepG_2细胞活性的影响,在高浓度40μmol/L时才呈现15%左右的抑制作用,这表明其抑制乙肝抗原的表达是高选择性的。

 
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