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infection hcv
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  传播hcv
     OBJECTIVE To investigate the p re valence of HCV core antigen in blood donors with negative HCV antibody and evalu ate the residual risk of posttransfusion infection HCV after HCV antibody detect ion.
     目的观察丙型肝炎病毒(HCV)抗体阴性献血人群HCV核心抗原的流行情况,初步评估经HCV抗体检测后输血传播HCV的潜在风险。
短句来源
     CONCLUSIONS The residual risk of posttra nsfusion infection HCV is very little after HCV antibody detection.
     结论结果提示抗HCV检测后,经血液传播HCV的潜在风险已经很低。
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  “infection hcv”译为未确定词的双语例句
     The results indicate that chronic hepatopathy is mainly caused by HBV infection, HCV infection gets the second place in the disease, and HCV infection has close relations with blood transfusion.
     提示HBV感染是引起慢性肝病的主要病因,HCV次之。 HCV感染与输血有密切关系。
短句来源
     Conclusion IDU was one of the highest risk factors for infection HCV and HIV in heroin addicts.
     IDU的HCV和HIV混合感染率 (4 5 % )高于nIDU(0 4 % ,P <0 0 1)。
短句来源
     The duration of HCV infection, HCV genotype and HCV viremia are important determinants for the evolution of HCV quasispecies heterogeneity.
     感染时间长、基因 1型感染及高水平的血清HCVRNA水平预示体内存在较多的HCV准种。
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     Methods 86 young patients with primary hepatocellular carcinoma,69 males and 17 females, age 21 to 40, average 35 and 122 elderly patients, 98 males and 24 females, age 60 - 84, average 67, all with primary hepatocellular carcinoma, were enrolled in the study. The clinical menifestation, family history of primary hepatocellular carcinoma, alcohol drinking, HBV infection, HCV infection, ALT, AFP, AFU, liver cirrhosis, tumor thrombus in portal vein and tumor types were studied and compared respectively between two groups.
     方法 分析86例青年肝癌患者(年龄<40岁)的临床特点,包括临床症状体征、肝癌家族史、饮酒史、HBV感染率、HCV感染率、ALT异常、AFP阳性、AFU阳性、合并肝硬化、门静脉癌栓以及肝癌类型,并与同期122例老年肝癌患者(年龄>60岁)进行比较。
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     To combie quantitatively the results of case control studies about the effect of HBV infection, HCV infection and dual infection on the risk of primary hepatocellular carcinoma (PHC)in Chinese and assess the value of Gibbs sampling in meta analysis.
     【目的】对中国人乙型肝炎病毒 (HBV)、丙型肝炎病毒 (HCV)及其双重感染与原发性肝癌关系的病例 对照研究结果进行定量综合 ,探讨Gibbs抽样方法在meta分析中的应用价值。 【方法】制订meta分析的文献纳入和剔除标准 ,经分析筛选 ,有 16个研究纳入。
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     source of HCV infection.
     本文亦提示 HCV携带者可能为危险的传染源.
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     infection;
     感染 ;
短句来源
     b infection.
     b的感染提供依据。
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     HCV, HBV Infection and Hepatocellular Carcinoma
     HCV HBV感染与肝细胞性肝癌
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  infection hcv
Hepatitis C virus infection (HCV), is a major cause of liver disease worldwide, and are frequently resistant to the interferon alpha treatment.
      
Chronic hepatitis C infection (HCV) accounts for approximately 50% of the cases of hepatocellular carcinoma (HCC) in the United States.
      
Hepatitis C viral infection (HCV) results in liver damage leading to inflammation and fibrosis of the liver and increasing rates of hepatic decompensation and hepatocellular carcinoma (HCC).
      
In this cross-sectional observational study, one hundred thirty patients with chronic HCV infection (HCV RNA positive by PCR) and 61 healthy controls were enrolled from a tertiary care teaching medical center.
      
The viremic rate was highest in HCV infection (HCV RNA by PCR/anti-HCV) (83.2%), with HGV infection (HGV RNA/total HGV marker) (21.7%) intermediate, and HBV infection (hepatitis B surface antigen by RIA/anti-HBc) (5.3%) lowest (P >amp;lt; 0.05).
      
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Objective To evaluate the prevalence of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections among heroin addicts with different types of taking drug and to assess the association of various peptide antibody of HCV with the expression of HCV-RNA. Methods The sera of 496 heroin addicts and 165 controls were assayed by reverse transcriptase-polymerase chain reaction (RT-PCR) using established primers for HCV-RNA, enzyme linked immunosorbent assay (ELISA) for...

Objective To evaluate the prevalence of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections among heroin addicts with different types of taking drug and to assess the association of various peptide antibody of HCV with the expression of HCV-RNA. Methods The sera of 496 heroin addicts and 165 controls were assayed by reverse transcriptase-polymerase chain reaction (RT-PCR) using established primers for HCV-RNA, enzyme linked immunosorbent assay (ELISA) for HCV-Ab and HIV-Ab and protein chip for peptide antibody of HCV.Results HCV infection was detected in 31.7% of injection drug users (IDU), 5.6% of non injection drug users (nIDU) and 2.4% of normal controls. Prevalence of infection in IDU was significantly higher than nIDU and controls (P<0.01). There was no significant difference between nIDU and controls (P>0.05). Anti-NS 5 was significantly associated with HCV-RNA (P<0.01). Compare to the nIDU and controls, the IDU group presented a higher prevalence of HIV (5.7% vs. 0.4% and 0, P<0.01), the coinfections of HCV and HIV (4.5% vs. 0.4% and 0, P<0.01). Conclusion IDU was one of the highest risk factors for infection HCV and HIV in heroin addicts. The prevalence of coinfections HCV and HIV was significantly higher in IDU than in nIDU. Anti-NS 5 of HCV was significantly associated with HCV-RNA. The protein chip was an efficient technique and may be used clinically.

目的 调查海洛因依赖者不同吸毒方式 ,丙型肝炎病毒 (HCV)和人类免疫缺陷病毒(HIV)感染及合并感染状况 ;探讨HCV不同肽段抗体与HCV RNA活动的相关性。方法 对 4 96例海洛因依赖者和 16 5名对照组血清进行逆转录聚合酶链反应检测HCV RNA ,酶联免疫吸附试验检测HCV Ab和HIV Ab ,蛋白芯片技术检测HCV多肽段抗体。结果 在海洛因依赖者中 ,HCV感染率在静脉注射组 (IDU)为 31 7% ,非静脉注射组 (nIDU)为 5 6 % ,对照组为 2 4 %。IDU与nIDU和对照组比较差异有非常显著性 (均P <0 0 1) ,而nICU与对照组比较差异无显著性 (P >0 0 5 )。蛋白芯片技术检测显示 ,抗 NS5与HCV RNA呈较好的相关性 (P <0 0 1)。在海洛因依赖者中 ,IDU的HIV感染率(5 7% )高于nIDU(0 4 % ,P <0 0 1)和对照组 (0 )。IDU的HCV和HIV混合感染率 (4 5 % )高于nIDU(0 4 % ,P <0 0 1)。结论 在海洛因依赖者中注射用药是感染HCV和HIV的高危险因素 ,ID...

目的 调查海洛因依赖者不同吸毒方式 ,丙型肝炎病毒 (HCV)和人类免疫缺陷病毒(HIV)感染及合并感染状况 ;探讨HCV不同肽段抗体与HCV RNA活动的相关性。方法 对 4 96例海洛因依赖者和 16 5名对照组血清进行逆转录聚合酶链反应检测HCV RNA ,酶联免疫吸附试验检测HCV Ab和HIV Ab ,蛋白芯片技术检测HCV多肽段抗体。结果 在海洛因依赖者中 ,HCV感染率在静脉注射组 (IDU)为 31 7% ,非静脉注射组 (nIDU)为 5 6 % ,对照组为 2 4 %。IDU与nIDU和对照组比较差异有非常显著性 (均P <0 0 1) ,而nICU与对照组比较差异无显著性 (P >0 0 5 )。蛋白芯片技术检测显示 ,抗 NS5与HCV RNA呈较好的相关性 (P <0 0 1)。在海洛因依赖者中 ,IDU的HIV感染率(5 7% )高于nIDU(0 4 % ,P <0 0 1)和对照组 (0 )。IDU的HCV和HIV混合感染率 (4 5 % )高于nIDU(0 4 % ,P <0 0 1)。结论 在海洛因依赖者中注射用药是感染HCV和HIV的高危险因素 ,IDU中HCV和HIV混合感染率最高。抗NS5与HCV RNA活动性有关。蛋白芯片是一种高效的检测技术 ,具有临床实用价值。

Objective To investigate the significance of serum HCV RN A load and the risk factors of transmission between chronic hepatits C (CHC) pat ients and their spouse infections.Methods The anti-HCV was detected in serum,urine,tear an d sperm from CHC patients with EIA.HCV RNA was detected by FQ-PCR technology fo r CHC patients and their spouses as well.Results The incidences of anti-HCV in serum,urine,tear,a nd sperm from CHC patients and their spouses were 94.26% (115/122),42.8%(21/49...

Objective To investigate the significance of serum HCV RN A load and the risk factors of transmission between chronic hepatits C (CHC) pat ients and their spouse infections.Methods The anti-HCV was detected in serum,urine,tear an d sperm from CHC patients with EIA.HCV RNA was detected by FQ-PCR technology fo r CHC patients and their spouses as well.Results The incidences of anti-HCV in serum,urine,tear,a nd sperm from CHC patients and their spouses were 94.26% (115/122),42.8%(21/49 ),11.9%(5/42),47.22%(17/36) and 22.5%(27/120),and the incidences of HCV RNA w e re 88.15%(67/122),55.10%(27/49),19.04%(8/42),66.67%(24/36)and 25.83%(31/1 20 ),respectively.But all of cross-references were negative.The incidence of anti -H CV and HCV RNA in female group of spouses was 5.06%(11/73),78.08%(57/73);the incidence of anti-HCV and HCV RNA in female group of spouses was up to 29.78% (14/47),89.36%(42/47),While serum of CHC patients HCV RNA load≥105 copies/m l, their spouse HCV RNA positive incidence was?29.19%(21/69),but their spouses H C V RNA positive incidence was?19.4%(11/57) as in the serum of CHC patients HCV RNA load<105 copies/ml.The rates of HCV RNA were 13.33%(2/15),22.22%(4/18) , 32.00%(8/25) and 55.32%(27/47) of spouse married ages less 10,from 11-20,21-30 ?to 31-54?years,respectively. Conclusion HCV can be transmitted between the spouse and CHC patient.The female spouse is more easily infected than the male spouse of CH C patients.When CHC patients peripheral serum HCV RNA load≥105 copies/ml,the infected riskness of their spouse is higher than that of the spouses of periphe ral serum HCV RNA load<105copies/ml.The incidence of spouse infection HCV is positive correlation with the ma rried age.

目的 研究慢性丙型肝炎(CHC)患者外周血浆病毒载体量、危险因素与其配偶感染的关系。方法 应用酶免法(EIA)及FQ -PCR法检测12 2例CHC患者的血浆、尿液、泪液和精液及其配偶血浆抗丙型肝炎病毒(抗-HCV)及HCVRNA含量。结果 CHC患者血浆、尿液、泪液和精液及其配偶血浆抗-HCV检出率分别为94 . 2 6 %(115 / 12 2 ) ,4 2. 8% (2 1/ 4 9) ,11 .19% / (5 / 4 2 ) ,4 7 .2 2 % (17/ 35 )和2 2 . 5 0 % (2 7/ 12 0 ) ;HCVRNA的检出率分别为88 .15 % (6 7/ 12 2 ) ,5 5 . 10 % (2 7/ 4 9) ,19 .0 4 % (8/ 4 2 ) ,6 6 . 6 7% (2 4 / 36 )和2 5 . 83% (31/ 12 0 ) ,对照组均无抗-HCV及HCVRNA检出。男性配偶的抗-HCV、HCVRNA的检出率分别为15 .0 6 % (11/ 73) ,78. 0 8% (5 7/ 73) ;女性配偶的抗-HCV、HCVRNA的检出率分别为2 9. 78% ...

目的 研究慢性丙型肝炎(CHC)患者外周血浆病毒载体量、危险因素与其配偶感染的关系。方法 应用酶免法(EIA)及FQ -PCR法检测12 2例CHC患者的血浆、尿液、泪液和精液及其配偶血浆抗丙型肝炎病毒(抗-HCV)及HCVRNA含量。结果 CHC患者血浆、尿液、泪液和精液及其配偶血浆抗-HCV检出率分别为94 . 2 6 %(115 / 12 2 ) ,4 2. 8% (2 1/ 4 9) ,11 .19% / (5 / 4 2 ) ,4 7 .2 2 % (17/ 35 )和2 2 . 5 0 % (2 7/ 12 0 ) ;HCVRNA的检出率分别为88 .15 % (6 7/ 12 2 ) ,5 5 . 10 % (2 7/ 4 9) ,19 .0 4 % (8/ 4 2 ) ,6 6 . 6 7% (2 4 / 36 )和2 5 . 83% (31/ 12 0 ) ,对照组均无抗-HCV及HCVRNA检出。男性配偶的抗-HCV、HCVRNA的检出率分别为15 .0 6 % (11/ 73) ,78. 0 8% (5 7/ 73) ;女性配偶的抗-HCV、HCVRNA的检出率分别为2 9. 78% (14 / 4 7)、89 .36 % (42 / 4 7)。当CHC患者外周血浆HCVRNA≥10 5copies/ml时,其配偶HCVRNA的检出率为2 9. 1% (2 1/ 6 9) ;当CHC患者外周血浆HCVRNA <10 5copies/ml时,其配偶HCVRNA的检出率为19 4. 7% (11/ 5 7)。配偶婚龄<10 ,11~2 0 ,2 1~30 ,31~5 4年的4个组HCVRNA的检出率分别为13 .33% (2 / 15 )、2 2 . 2 2 % (4/ 18)、32 . 0 0 % (8/ 2 5 )和5 5. 32 % (2 7/ 4 7)。结

OBJECTIVE To investigate the p re valence of HCV core antigen in blood donors with negative HCV antibody and evalu ate the residual risk of posttransfusion infection HCV after HCV antibody detect ion. METHODS HCV antibody and HCV core antigen were detected by ELISA;alanine aminotransferase was detected by kinetics metho d;HCV RNA was detected by real time PCR technique. RESULTS Three samples had positive HCV co re antigen in 1 758 blood donors with negative HCV...

OBJECTIVE To investigate the p re valence of HCV core antigen in blood donors with negative HCV antibody and evalu ate the residual risk of posttransfusion infection HCV after HCV antibody detect ion. METHODS HCV antibody and HCV core antigen were detected by ELISA;alanine aminotransferase was detected by kinetics metho d;HCV RNA was detected by real time PCR technique. RESULTS Three samples had positive HCV co re antigen in 1 758 blood donors with negative HCV antibody,the prevalence rat e of HCV core antigen was 0.17%.HCV RNA was negative in three samples with pos itive HCV core antigen. CONCLUSIONS The residual risk of posttra nsfusion infection HCV is very little after HCV antibody detection.

目的观察丙型肝炎病毒(HCV)抗体阴性献血人群HCV核心抗原的流行情况,初步评估经HCV抗体检测后输血传播HCV的潜在风险。方法抗HCV抗体和HCV核心抗原检测采用ELISA试剂盒,丙氨酸氨基转移酶检测采用速率法,HCV RNA检测采用实时荧光PCR检测试剂盒。结果在抗HCV检测阴性的1 758份无偿献血者标本中,HCV核心抗原检测有3份阳性,阳性率为0.17%;HCV核心抗原阳性的3份样本HCV RNA检测为阴性。结论结果提示抗HCV检测后,经血液传播HCV的潜在风险已经很低。

 
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