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apoptosis tumor
相关语句
  细胞凋亡一样
     RESULTS:As FasL induced apoptosis,tumor necrosis factor α could obviously induce the apoptosis of MG63 osteogenic cells,mesenchymal stem cells and osteoblasts in concentration and time dependent manner.
     结果:和FasL诱导细胞凋亡一样,肿瘤坏死因子α能引起MG63骨肉瘤细胞,间充质干细胞和成骨细胞的凋亡,并表现为明显的浓度依赖和时间依赖。
短句来源
  “apoptosis tumor”译为未确定词的双语例句
     ING1 gene (Inhibitor of growth 1 gene), a recently identified candidate tumor suppressor gene, encode the protein P33ING1b. P33ING1b protein is involved in restriction of cell growth and proliferation, apoptosis, tumor anchorage independent growth, cellular senescence, maintenance of genomic stability, and modulation of cell cycle checkpoints.
     ING1基因(Inhibitor of growth 1 gene)是近年来克隆出来的一个新的肿瘤抑制基因,其表达产物P33~(ING1b)蛋白具有抑制细胞生长、促进细胞凋亡、参与细胞衰老调控等作用。
短句来源
     In addition,they are other evidences prude that acidic ribosomal phosphoproteins P0、P1、P2 areinvolved in apoptosis,tumor and immunological disease.
     此外,酸性核糖体磷酸化蛋白P0、P1、P2还与细胞凋亡、肿瘤和免疫性疾病的发生、发展密切相关。
短句来源
     Result:Among 648 tumor-related genes, 97 (15.0%) showed aberrant expression, including 20 up-regulated, and 77 down-regulated. The abnormal genes were associated with cell proliferation,apoptosis,tumor adhesion,invasion,metastasis,signal transudation and tumor immunity, et al. Some unknown genes related to BTCC are also detected simultaneously in this study.
     结果:648个肿瘤相关基因中差异表达基因共97条,占总数的15.0%,其中20条表达增高,77条表达降低,551条表达在正常范围,表达异常的基因涉及细胞增殖、凋亡、信号传递、肿瘤粘附、侵袭、转移、肿瘤免疫等方面,同时检测到一些与BTCC相关的未知基因。
短句来源
     SP immunohistochemical method was performed to detect expression of Fas, FasL and CD45RO, the apoptosis tumor cells were determined by TUNEL technique.
     结果:1 .Fas表达结果:①在正常肺组织中,Fas阳性表达主要位于细胞膜,肺癌组织中Fas阳性表达位于胞浆和/或胞膜,腺癌中Fas表达以胞浆为主。
短句来源
     Nuclear factor of kappa B was the key gene which regulated the genes transcription, which could be activated by many factors, and could control many genes expressions, for example Immunologic reaction, embryogenesis, apoptosis, tumor genesis, metastasis, physiologic reaction, pathologic reaction.
     核转录因子NF-κB(nuclear factor of kappa B) 是调节细胞基因转录的关键因子。 NF-κB具有多向性调节作用,可在多种因素作用下被激活,参与调控多种基因的表达;
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  相似匹配句对
     Tumor radiosensitivity and apoptosis
     肿瘤辐射敏感性与细胞凋亡
短句来源
     Apoptosis and tumor treatment
     细胞凋亡与肿瘤治疗
短句来源
     Apoptosis
     细胞凋亡
短句来源
     Apoptosis:
     延长,凋亡指数增加;
短句来源
     Snail and Tumor
     Snail与肿瘤
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Objective To investigate the retrovirus-mediated gene killing effect on murine bladder cancer in vivo by simple instillation.Methods The orthotopic rat bladder cancer was established in female Wistar rats by intravesical administration of the carcinogen, N-methyl-nitrosourea (MNU). A retrovirus vector containing HSV-tk gene was transurethrally instilled into the bladder. GCV was injected intraperitoneally the next day after instillation for 6d.The distribution of the gene was examined by reverse transcriptase...

Objective To investigate the retrovirus-mediated gene killing effect on murine bladder cancer in vivo by simple instillation.Methods The orthotopic rat bladder cancer was established in female Wistar rats by intravesical administration of the carcinogen, N-methyl-nitrosourea (MNU). A retrovirus vector containing HSV-tk gene was transurethrally instilled into the bladder. GCV was injected intraperitoneally the next day after instillation for 6d.The distribution of the gene was examined by reverse transcriptase -polymerase chain reaction (RT-PCR). Tumor incidence and tumor weight, defined as the weight of the tumored bladder, were determined on day 6 and 10 after GCV intraperitoneal injection for 6d.Apoptosis of tumor cells were detected with in situ DNA nick end labeling (TUNEL).Results The suicide gene transferred into the tumor cells and expressed successfully by instillation of retrovirus vector containing HSV-tk was conformed by RT-PCR. Significant difference was observed between the weight of the tumored bladder or the quantity of the apoptosis tumor cells treated by HSV-tk/GCV system rats and the control rats.Conclusions Our study shows that transurethral instillation of retrovirus vector could transfer the HSV-tk gene to the rat bladder tumor cells effectively. HSV-tk/GCV system can acts as a candidate treatment for bladder cancer therapy. Inducing apoptosis of tumor cells might be the important mechanism of HSV-tk/ GCV system.

目的 探讨经尿道膀胱灌注由逆转录病毒介导的HSV tk基因对大鼠膀胱肿瘤的治疗作用。方法 N 甲基亚硝基脲(MNU)膀胱灌注诱导雌性Wistar大鼠膀胱肿瘤。经尿道HSV tk基因膀胱灌注后 ,RT PCR检测肿瘤组织中tk基因表达 ;TUNEL法检测肿瘤细胞凋亡 ;荷瘤膀胱总重量检测。结果 HSV tk基因经尿道膀胱灌注后 ,RT PCR检测膀胱肿瘤组织有tk基因mRNA表达 ;TUNEL法凋亡检测 ,荷瘤膀胱总重量测定 ,提示治疗组与对照组有显著差异。结论 经尿道膀胱灌注逆转录病毒载体 /HSV tk可转导tk基因 ;联合GCV治疗 ,肿瘤生长被显著抑制 ;诱导肿瘤细胞凋亡可能是其作用机理之一。

Objective To investigate cationic liposome-TK complexes killing effect on murine bladder cancer in vivo by simple instillation.Methods The orthotopic rat bladder cancer model was established in female Wistar rats by intravesical administration of the carcinogen, N-methyl-nitrosourea(MNU). Cationic liposome-Tk complexes was transurethrally instilled into the bladder. GCV was injected intraperitoneally the next day after instillation for 6 days. The distribution of the gene was examined by reverse transcriptase-polymerase...

Objective To investigate cationic liposome-TK complexes killing effect on murine bladder cancer in vivo by simple instillation.Methods The orthotopic rat bladder cancer model was established in female Wistar rats by intravesical administration of the carcinogen, N-methyl-nitrosourea(MNU). Cationic liposome-Tk complexes was transurethrally instilled into the bladder. GCV was injected intraperitoneally the next day after instillation for 6 days. The distribution of the gene was examined by reverse transcriptase-polymerase chain reaction(RT-PCR). Tumor incidence and tumor weight, defined as the weight of the tumored bladder, were determined on day 6 and 10 after GCV intraperitoneal injection for 6 days. Apoptosis of tumor cells were detected with in situ DNA nick end labeling (TUNEL).Results The sucide gene transferred into the tumor cells and expressed successfully by instillation of cationic liposome-TK complexes was conformed by RT-PCR. Significant difference was observed between the weight of the tumored bladder or the quantity of the apoptosis tumor cells treated by HSV-TK/GCV system rats and the control rats. Conclusions The study shows that transurethral instillation of cationic liposome-TK complexes can transfer the HSV-TK gene to the rat bladder tumor cells effectively. HSV-TK/GCV system can act as a candidate treatment for bladder cancer therapy. Inducing apoptosis of tumor cells might be the important mechanism of HSV-TK/GCV system.

目的 观察阳离子脂质体介导的 HSV- TK基因经尿道膀胱灌注对大鼠膀胱肿瘤体内杀伤作用。方法  N-甲基亚硝基脲 (MNU)膀胱灌注诱导雌性 Wistar大鼠膀胱肿瘤。经尿道 HSV- TK基因膀胱灌注后 ,RT- PCR检测肿瘤组织中 TK基因表达 ;TUNEL法检测肿瘤细胞凋亡 ;荷瘤膀胱总重量测定。结果  HSV- TK基因经尿道膀胱灌注后 ,RT-PCR检测膀胱肿瘤组织有 TK基因 m RNA表达 ;TUNEL法凋亡检测 ,荷瘤膀胱总重量测定 ,提示治疗组与对照组差异有显著性。结论 经尿道膀胱灌注阳离子脂质体 - TK复合物可转导 TK基因 ;联合 GCV治疗 ,肿瘤生长被抑制 ;诱导肿瘤细胞凋亡可能是 HSV- TK/ GCV系统作用机理之一。

 
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