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protein bcl
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  蛋白bcl
     Conclusions Apoptosis related protein Bcl 2 and Bax take part in the regulation of apoptosis in DRG after peripheral nerve injury.
     结论 细胞凋亡相关蛋白Bcl 2和Bax参与外周神经损伤后背根节细胞凋亡的调节。
短句来源
     The phosphorylation of anti apoptotic protein bcl 2 may be the key of the procedure,and other involved proteins include c Raf 1,PKA upstream and caspase 3,PARP downstream.
     其中抗凋亡蛋白bcl 2的磷酸化似乎起关键性作用 ,在其上游包括c Raf 1和PKA ,下游还有caspase 3、PARP等都可能参与这一诱导凋亡过程。
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     To investigate the mechanism and clinical significance of bcl 2 gene in gastric carcinoma malignant transformation process with anti apoptosis protein bcl 2 expression,distribution in gastric carcinoma and adjacent tissue.
     通过抗凋亡蛋白bcl 2在胃癌、癌旁组织中的表达与分布 ,探讨bcl 2基因在胃癌恶性转化过程中的作用机制和临床意义。
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     Apoptosis related protein Bcl 2 is related to TCM syndromes development.
     细胞凋亡相关蛋白 Bcl-2与证候形成有关。
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     Objective To evaluate the expression of proliferative antigen Ki 67 and apoptosis antagonizing protein Bcl 2 as well as their clinical significance in non Hodgkin′s lymphoma(NHL).
     目的 探讨增殖相关抗原Ki 6 7和抗凋亡蛋白Bcl 2的检测 ,观察其在非霍奇金淋巴瘤(NHL)中的表达及临床意义。
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  基因bcl
     Expression of apoptosis suppressing protein Bcl 2 in the benign and malignant skin tumors
     抗凋亡基因Bcl-2在皮肤良恶性肿瘤中的表达
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     To study apoptosis antagonizing protein BcL 2 and proto oncogene protein C fos expression and distribution in ovarian epithelial tumor,expression of BcL 2 and C fos protein was examined by immunohistochemistry in 42 epithelial tumors of ovary.
     探讨抗凋亡基因BcL2 和原癌基因Cfos 在卵巢上皮性肿瘤发生发展中的作用及其临床意义,采用单克隆抗体免疫组化技术对42 例卵巢上皮组织进行BcL2 和Cfos 蛋白表达的检测。
短句来源
     Methods: Changes of the expression of protein Bcl 2 or Bax were observed in CA 1 region of gerbil hippocampus following HBOT on ischemia reperfusion 3 days using the method of labelled streptavidin biotin (LSAB)immunohistochemistry stai ning.
     方法 :采用“双侧颈总动脉阻断法”前脑缺血模型 ,对沙土鼠前脑缺血 2 0min后再灌注 3d ,并用 0 .15MPa和 0 .2 5MPa压力的高压氧治疗 (6 0min/d ,连续 3d)后 ,应用免疫组化LSAB方法 ,观察高压氧对海马CA1,区神经元凋亡相关基因bcl 2和bax的蛋白表达的影响。
短句来源
     Objective:To study the role of the expression of the apoptosis relating protein bcl 2 and the expression of bax protein with the clinicopathologic charateristic and the survival probablity in human lung cancer cases.
     目的 :探讨凋亡相关基因bcl 2和bax在人肺癌组织中的表达情况及其与肺癌的各种临床病理特征和预后的关系。
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  “protein bcl”译为未确定词的双语例句
     Expression of apoptosis suppressing protein Bcl 2 in cutaneous basal cell carcinoma
     凋亡抑制蛋白Bcl-2在皮肤基底细胞癌中的表达
短句来源
     Purpose To study the relationships between the expressions of cyclin D1 protein, bcl 2 and fas protein and apoptosis and proliferation of R S/H cells in Hodgkins lymphoma (HL).
     目的 :探讨cyclinD1蛋白与霍奇金淋巴瘤 (HL)R S/H细胞凋亡及增殖的关系。
短句来源
     3 and 5 days after CO exposure, the expression of protein Bcl 2 significantly increased ( P <0.05).
     HBO治疗组凋亡神经元明显减少 ,Bcl 2蛋白表达增多 ,尤以染毒后 3和 5d明显 (P <0 .0 5 ) .
短句来源
     Results:The numbers of positive cardiac myocyte nuclear and its percentage in IP group decreased significantly(P<0.05 or 0.01) compared with that of I/R group The numbers of protein bcl xl positive cardiomyocyte and its percentage in IP group were bigger(P<0.01) than that of I/R group.
     结果 :IP组TUNEL法阳性心肌细胞核数量及阳性心肌细胞核占总心肌细胞核数的百分比均明显少于I/R组 (P <0 .0 5或 0 .0 1) ; IP组表达bcl xl蛋白阳性的心肌细胞数及阳性心肌细胞占心肌细胞总数的百分比均明显高于I/R组 (P <0 .0 1)。
短句来源
     There was significantly statistic difference between the expression of p53 protein and bcl 2 and the metastatic status of lymph node( P <0 05),but no statistic difference between expressions of p53 protein, bcl 2 and Bax.
     p5 3与bcl 2的表达与肺癌淋巴结转移之间有显著统计意义 (P <0 0 5 ) ,p5 3的表达与bcl 2和Bax表达之间无统计学显著意义。
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  protein bcl
Furthermore, we could demonstrate that TIEG2 decreases the levels of the anti-apoptotic protein Bcl-XL and inhibits transcription driven by the Bcl-XL promoter.
      
Subchronic exposure to HD resulted in significantly increased expression of both anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bax and Caspase-3 in cerebral cortex and cerebellum, which exhibited a dose-dependent pattern.
      
Furthermore, salsolinol decreased the levels of the anti-apoptotic protein Bcl-2, and increased pro-apoptotic protein Bax, while enhancing the release of cytochrome-c from mitochondria.
      
In particular, as demonstrated by densitometric analysis, after exposure to both platinum compounds the total amount of the anti-apoptotic protein Bcl-2 was significantly reduced.
      
The optical density of the detection product of the antiapoptotic protein Bcl-2 was also studied in cells of the supraoptic and paraventricular (PVN) nuclei.
      
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Immunohistochemical double-labelling technique was applied in the present work to investigate the localization and distribution of anti-apoptosis protein Bcl-2 in 12 cases of bone marrow with reactive hyperplasia.The results exhibited that the hematopoietic cells labelled bv lectin UEA-1 were completely isolated from those reacted with monoclonal antibodies against Bcl-2 protein. These data establish that in bone marrow hematopoietic cells which were intensely stained for Bcl-2 originate...

Immunohistochemical double-labelling technique was applied in the present work to investigate the localization and distribution of anti-apoptosis protein Bcl-2 in 12 cases of bone marrow with reactive hyperplasia.The results exhibited that the hematopoietic cells labelled bv lectin UEA-1 were completely isolated from those reacted with monoclonal antibodies against Bcl-2 protein. These data establish that in bone marrow hematopoietic cells which were intensely stained for Bcl-2 originate in myeloid or lymphoid linage rather than erythroid or megakaryocytic linage.

通过双际记免疫组织化学技术,探讨了抗细胞凋亡的Bcl-2蛋白在12例反应性骨髓组织中的定位与分布。结果显示,bcl-2特异性单克隆抗体与荆豆素UEA-1标记的骨髓造血细胞彼此分离、互不重叠。提示人骨髓中Bcl-2蛋白阳性造血细胞源自粒系或淋巴系,而不是红系或巨核系。

objectiveApoptosis-antagonizing protein Bcl-2 expression,distribution in non-Hodgkn's lymphoma (NHL) and its clinical significanec were studied.Methods Four-stage peroxi-dase antiperoxidase complex (PAP) methodwas applied to comparatively investigate the expression and distribution of Bcl-2 protein in formalin-fixed,paraffin-dmbebded lymph node tissue comprising 12 cases of reactive follicular hyperplasia and 71 cases of NHL.Results (1) Bcl-2 protein was detect-ed in 93.0% cases...

objectiveApoptosis-antagonizing protein Bcl-2 expression,distribution in non-Hodgkn's lymphoma (NHL) and its clinical significanec were studied.Methods Four-stage peroxi-dase antiperoxidase complex (PAP) methodwas applied to comparatively investigate the expression and distribution of Bcl-2 protein in formalin-fixed,paraffin-dmbebded lymph node tissue comprising 12 cases of reactive follicular hyperplasia and 71 cases of NHL.Results (1) Bcl-2 protein was detect-ed in 93.0% cases of NHL with T-or B-lymphocytic phenotype.(2) Bcl-2 protein was restricted in centrocytes but not in centroblasts in 8 of 9 cases of NHL stemed from germinal centers.(3) A sig-nificant increase in Bcl-2 protein expression was found in 5 of 10 cases of diffuse large B-lymphocytic NHL showing plasmacytoid differentiation.(4) In 7 cases of follicular NHL the neoplastic nodules were stuongly labeled for Bcl-2 protein and only scattered positive cells were seen in its periphery;On the contrary ,in reactive lymphoid follicles Bcl-2 protein was predominantly anchored in mantle zones whereas germinal center cells were unstained. Conclusion (1) Bcl-2 protein is expressed in NHL of T-or B-cell origin. (2)Bcl-2 protein expresion appears to be associated with differentiation stages of NHL.(3) Immunohistochemical staining for Bcl-2 protein conduces to differentiate between reactive and neoplastic follicles.

研究抗凋亡蛋白Bcl-2在非霍奇金淋巴瘤(NHL)中的表达、分布及其临床意义。方法采用4重PAP免疫组织化学法,对比分析了12例反应性淋巴滤泡增生与71例NHL的常规石蜡包埋淋巴结组织中Bcl-2蛋白的表达与分布。结果(1)93.0%T、B淋巴细胞性NHLBcl-2蛋白阳性。(2)8/9例滤泡中心起源的弥漫型NHL中,Bcl-2蛋白局限于中心细胞,而中心母细胞多为阴性。(3)5/10例呈浆细胞样分化趋势的弥漫性大B细胞NHL,Bcl-2蛋白表达增强。(4)7例滤泡型NHL中,Bcl-2蛋白主要定位于瘤性滤泡中央,而其周围则相对稀疏。相反,生理性淋巴滤泡中,Bcl-2蛋白则主要分布于套区,生发中心均为阴性。结论T、B淋巴细胞NHL均能表达Bcl-2;Bcl-2表达可能与NHL分化水平相关;Bcl-2蛋白免疫组化染色有助于鉴别反应性淋巴滤泡增生过长与滤泡型淋巴瘤。

To investigate the expression of the apoptosis-suppressing protein Bcl-2 in head and neck neoplasm and the relationship between Bcl-2 and p53 oncoprotein, 90 malignant tumours and 20 benign diseases were studied with immunohistochemical LSAB(labeled streptavidin biotin) method. The results indicated that 48. 9% (44/90) cases of head and neck malignant tumours were Bcl-2 positive, and all benign diseases were negative. The expression rate of Bcl-2 in head and neck squamous carcinoma (59....

To investigate the expression of the apoptosis-suppressing protein Bcl-2 in head and neck neoplasm and the relationship between Bcl-2 and p53 oncoprotein, 90 malignant tumours and 20 benign diseases were studied with immunohistochemical LSAB(labeled streptavidin biotin) method. The results indicated that 48. 9% (44/90) cases of head and neck malignant tumours were Bcl-2 positive, and all benign diseases were negative. The expression rate of Bcl-2 in head and neck squamous carcinoma (59. 6%) was obviously higher than adenocarcinoma (24. 8%),undifferentiated tumour (33. 3 %) and malignant lymphoma (P<0.05). The expression rate of Bcl-2 in p53-positive tumours was significantly higher in p53-negative neoplasm. The positive rate of Bcl-2 oncoprotein was not connected with clinical stage and pathological grade. The positive staining intensity was significantly related with clinical stage. This study suggested that Bcl-2 oncoprotein may play an important role in the development of head and neck tumour.

为了探讨Bcl-2蛋白在头颈恶性肿瘤发生、发展中的作用及与抑癌基因P53的关系,采用免疫组化链霉菌素生物素技术(LSAB法),对90例头颈恶性肿瘤和20例良性病变组织中Bcl-2、P53蛋白进行了检测。结果显示;48.9%的头颈恶性肿瘤表达Bcl-2蛋白,而20例良性病变全部防性。Bcl-2在头颈鳞癌的表达率(59.6%)明显高于腺癌(34.8%)、末分化癌(33.3%)和恶性淋巴瘤(P<0.05)。在P53阳性肿瘤中Bcl-2蛋白的表达率更高。Bcl-2蛋白的阳性率与肿瘤的临床分期和病理分级无关,而阳性细胞着色强度与临床分期密切相关(P<0.01),随着疾病的进展着色逐渐增强。结论:bcl-2基因产物可能在头颈肿瘤,特别是头颈鳞癌的发生及发展中起着重要的作用。

 
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