Results Compared with the control group, ILK, α-SMA and Vimentin in renal tubular epithelial cells in Group diabetes gradually increased in immunohistochemistry (P<0.01); ILK was consistent with the pathological variation of renal interstitium and was positively correlated to α-SMA(rs=0.621,P<0.05).
Objective To investigate the effects of transforming growth factor β1(TGFβ1)on the expression of glycogen synthase kinase-3β(GSK-3β) in human kidney proximal tubular epithelial cell line(HKCs). Methods HKCs cultured in vitro were divided into four groups at random:control(C) group: the HKCs were cultured with free serum medium(FSM);
Conclusion: Renal tubule basement membrane disruption, renal tubule epithelial cells invasion into the renal interstitium, and the expression of MMP2 and MMP9 are involved in the development of renal interstitial fibrosis.
Methods: Healthy renal tubule epithelial cells were divided into normal control group(cultured in serum-free RPMI 1640 medium),anoxic group(treated with antimycin A + serum-free RPMI 1640 medium),and oxidative stress group(H_(2)O_(2)+ serum-free RPMI 1640 medium)(n=15).
The nephrotoxicity of cefotiam was determined on the basis of the number of tubular epithelial cells excreted, the malate dehydrogenase activity in the urine and the histological examination of the kidneys.
There were slight increases in the number of tubular epithelial cells excreted and in the malate dehydrogenase activity in the urine of some animals receiving 3,000 mg/kg/day of cefotiam or cephalothin.
Silencing of Bak Ameliorates Apoptosis of Human Proximal Tubular Epithelial Cells by Escherichia coli-Derived Shiga Toxin 2
Enzymehistochemistry demonstrated that lactate dehydrogenase (LDH) activity in proximal tubular epithelial cells increased but succino dehydrogenase (SDH) activity decreased.
Endogenously produced adenosine is proposed to be formed primarily by renal tubular epithelial cells and approaches the vascular smooth cells of the renal vasculature from the extracellular space, i.e.
The effect of connective tissue growth factor on human renal tubular epithelial cell transdifferentiation
However, recent findings suggest that EMT involving tubular epithelial cell is a reversible process, potentially determined by the surviving cells to facilitate the repopulation of injured tubules with new functional epithelia.
The present study was undertaken to determine the role of the ERK activation in H2O2-induced apoptosis of renal epithelial cells using opossum kidney (OK) cells, an established proximal tubular epithelial cell line.
This study was carried out to investigate the effect of aristolochic acid I (AAI) on DNA damage and cell cycle in porcine proximal tubular epithelial cell lines (LLC-PK1 cells).
In the current study, we investigated the oxalate-induced injury and up-regulation of monocyte-chemoattractant protein-1 (MCP-1) in HK-2 cells, a proximal tubular epithelial cell line derived from normal human kidney.
However, little is known about whether it is required for activation of tubular cells induced by albumin overload.
Cubilin was required for handling a greater amount of protein in nephrotic status and albumin-induced production of MCP-1 and RANTES by renal tubular cells, which further initiated tubulointerstitial inflammation in proteinuric disease.
The dystrophy developing in the kidney after cutting the sciatic nerve blocks the compensatory increase in specific accumulation of (3H)aldosterone in the cytoplasm of the renal tubular cells.
Growth factors support differentiation of newly formed tubular cells, down-regulate apoptosis, and improve renal hemodynamics.
Thus, reduced oxygen and substrate consumption, especially during cold ischemic time of renal grafts, could be of importance for the integrity of the tubular cells.