Results At the dose of 0.3,0.5 ml Xianchen Fenci Jing had marked inhibitory effect on mouse ear edema than control group(P<0.01) and at the dose of 0.9,1.5 ml it had raised the inhibitory rate on rat paw edema(P<0.01).
After inflammation for 3 hours in rats, the foot swelling was decreased significantly It was(1.148±0.214),(0.660±0.368),(0.760±0.494),(0.745 ±0.404)mm,P < 0.05 or P < 0.01 in the saline group, indomethacin group and 10 g/kg and 20 g/kg aqueous extracts of dioscorea collettii var group, respectively .
② The secondary foot swelling degree in rats with adjuvant arthritis:Compared with the model group,the swelling degree after 9 to 23 days were significantly inhibited in the clerodendrum bungei low and high dose groups and hydrocortisone group(P< 0.01).
In order to determine the roles of PRL and sex hormones in the development of AA, we compared the rates of foot swelling in female AA rats ( FEMALE/AA) ovariecto-mized female AA rats (OVX/AA) and male AA rats (MALE/AA) , and we also determined whether lymphocytes response from AA rats is altered by PRL in vitro.
Results TFOD could inhibite carrageen- induced paw swelling in rats, 30.0mg· kg- 1 within being effective after1/2 hour and within 1 hour, and 60.0mg· kg- 1 being the most effective after 1/2 hour and in 1 hour, and still being effective after 4 hours.
RESULTS: There were significant secondary inflammatory reactions in AA rats. The morphology of synoviocytes from AA rats was changed, companying the elevation of the level of IL-1,TNFα, and PGE_2 produced by synoviocytes from AA rats. GCS(60 and 120mg/kg, ig, 8d) suppressed secondary inflammatory paw swelling, pain response, and polyarthritis index.
High- and moderate-dose CSC reduced fever in rat fever models induced by baker's yeast and reduced the pedal swelling in rats induced by carrageenin (P < 0.05 or P < 0.01 compared with the model group), which was similar to that of Chuanxinlian Tablets (P > 0.05).
Methods Experiments such as carrageenin inducing rat pedal swelling,cotton-pellet inducing rat granuloma and acetic acid inducing mice peritonitis were carried out to observe the effect of different extracts of CO on inflammation.
Method Such as carrageenin inducing rat pedal swelling,acetic acid inducing mice peritonitis and cotton-pellet inducing rat granuloma were carried out to observe the anti-inflammatory effects of Tongbizhitong capsule.