In captopril-treated high-fat diet group,the level of plasma AngⅡ was decreased significantly than that of high-fat diet group [(386±57) pg/ml vs(1597±116) pg/ml,P<0.01],but was nevertheless significantly higher than that of control group [(386±57) pg/ml vs(86±6)pg/ml,P<0.01].
② Compared with control group,the percentage of CRP-positive cells in plaques were significantly increased in high-fat diet group [(42.1±11.6)% vs(1.8±0.5)%,P<0.01]. Captopril dramatically reduced the percentage of CRP-positive cells in plaques [(23±5)% vs(42±12)%,P<0.01].
Methods Rabbit model of hyperlipidemia and fatty liver were induced by high fat diet for 12 weeks, the plasma PAI 1 activity and hepatic PAI 1 mRNA expression were measured ( n =10) with colorimetry and RT PCR, another 7 rabbits were taken as normal control.
Method Wistar rats were randomly divided into normal control group (NC, n=10), diabetic with normal chow (DN,n=10), diabetes with high fat diet (DH ,n=10) and diabetes with high fat diet plus insulin therapy (DHI, n=10).
Conclusions The rat model of NAFLD could be replicated sucessfully by feeding a fat-rich diet for 24 weeks, and the mRNA and its protein of UCP2 were expressed un-regulated in livers of NAFLD. The increasing UCP2 might play a role in the reduction of ATP content in livers of the NAFLD rats.
Method:Twenty-four healthy male SD rats were randomly divided into 3 groups:control group, model group ,Chinese medicine treated group, The model rats of atherosclerosis were established by feeding with high cholesterol diet and injecting with vitamin D_2 for 6 weeks.
Methods 110 quails were randomly divided into control group, high lipid group, nicotimylsalicylic acid (NSA) 75 mg/kg group, nicotimylsalicylic acid (NSA) 150 mg/kg group, and nicotinic acid (NA) 150 mg/kg group. Models of experimental atherosclerosis in quails were built with high cholesterol diet.
The adaptation of nutrient oxidation to nutrient intake on a high-fat diet
Twelve healthy, non-obese males and females (age: 26±2, BMI: 21.4±0.5, habitual fat intake: 29±1% energy) consumed a low-fat diet for 6 days (day 1-6) followed by a high-fat diet for 7 days (day 7-13).
Fat balance was zero on day 6 but became positive after changing to the high-fat diet (1.06±0.15, 0.75±0.15, and 0.55±0.14 MJ/day for days 7, 8, and 9 respectively, p.>amp;lt;0.05), reaching a new balance on day 13, 7 days afterwards.
Effect of high-fat diet on lypolisis in isolated adipocytes from visceral and subcutaneous WAT
This study was designed in order to investigate the effect of a high-fat diet on lipolysis in isolated adipocytes.
The enrolled included control (basic chow), hyperlipidemia and fenofibrate-treated groups (high fat diet).
A respiration trial was conducted in 14 adult sows to investigate the energetic effects of a high carbohydrate and a high fat diet over a period of 21 weeks.
The model of type 2 diabetes was prepared by feeding high fat diet and injecting low dosage of streptozotocin (STZ).
The drugs did not alter the reduction in flowrate or bicarbonate concentration of pancreatic juice caused by the high fat diet alone, but, in contrast, evoked pancreatic protein hypersecretion in a number of animals.
It is also possible that smoking or high fat diet are responsible.
Nephrocalcinosis and hyperlipidemia in rats fed a cholesterol- and fat-rich diet: association with hyperoxaluria, altered kidney
Increased pH and FFA mobilization were observed with fat-rich diet, while CHO-rich diet markedly increased the respiratory exchange ratio (R).
The purpose of the study was to investigate whether a carbohydrate-rich versus fat-rich diet influenced the effect of training on the immune system.
Ten untrained young men ingested a carbohydrate-rich diet [65 energy percent (E%) carbohydrate] and ten subjects a fat-rich diet (62E% fat) while endurance training was performed 3-4 times a week for 7?weeks.
These data indicate that diet manipulation during training may influence natural immunity, and suggest that ingestion of a fat-rich diet during training is detrimental to the immune system compared to the effect of a carbohydrate-rich diet.
Preliminary results showed that APN can significantly alleviate atherosclerotic iliac artery stenosis induced by both deendothelialization and high cholesterol diet (control group, stenosis incidence 100 %, stenotic severe degree 60.
These preliminary results suggest that APN and FO can significantly alleviate stenosis induced by deendothelialization and high cholesterol diet and restenosis after angioplasty, while the former has a more marked effect.
The experimental AS rabbit models were reproduced by feeding the high cholesterol diet.
A high cholesterol diet (HCD)-induced HC rat model was made and serum lipid, urinary protein excretion (UPE) and N-aceto-β-D-glucosidase (NAG) were measured.
In this study in Vitro-and in Vivo-experiments in rabbit aortas document the distance between these contures correlating histologically with a high cholesterol diet caused a broadening of the hypoechoic space in the rabbit aortic vessel wall.