One important problem in material science and engineering is the computational design of material, that’s to predict properties through theoretical calculations, or optimize compositions and process parameters of material with prescribed properties. However, for most industrial materials, it’s difficult to design compositions and processes from physical principle.
The recent researches indicated that the combined directed evolution, coupling the directed evolution with rational design and computational design approaches respectively, is becoming increasingly important in protein engineering and is becoming the new direction for directed evolution.
In this paper, a previously described method for calculating design sensitivities of a fatigue performance index is used in a simple optimization of suspension damping and stiffness on a simple truck model.
Two ways of calculating design sensitivity of a structure under transient loads are discussed-direct differentiation method and adjoint variable method.
This paper describes three procedures for calculating design derivatives of the non-linear critical load.
More pronounced differences were, however, observed when comparing the amplitudes of criterion variation which can lead to errors when calculating design efficiencies.