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人膀胱癌    
相关语句
  human bladder
    Establishment of a human bladder cancer cell line with multidrug resistance──BIU-87/ ADM
    人膀胱癌BIU-87细胞系多重抗药性的形成
短句来源
    Establishment of doxorubicin-resistant human bladder cancer cell line ( BIU-87/ADM )and its mechanism of multidrug resistance
    人膀胱癌阿霉素耐药株BIU-87/ADM的建立及其耐药机理的研究
短句来源
    A doxorubicin (3driamycin,ADM)-resistant human bladder transitional cell carcinoma cell line, BIU-87/ADM was established by exposing the BIU-87 parent cells to a high concentration of ADM for a short period and then maitained in a culture medium with alow concentration of ADM increasing the dose stepwise over a period of 6 months.
    应用阿霉素(ADM),大剂量短暂冲击结合低浓度持续递增法,逐步诱导人膀胱癌移行上皮细胞系BIU-87,在体外持续培养6个月,获得了具有多重抗药性的BIU-87/ADM细胞。 该细胞能在浓度为2.0g/L的ADM中持续增殖。
短句来源
    Microarray technique has been used to study biomarker for human bladder cancer, to study fingerprints of gene regulation associated with cadmium chloride, benzo(a) pyrene and trichloroethylene.
    例如微阵列技术已用于研究人膀胱癌的生物标记以及氯化镉、苯并(a)芘和三氯乙烯相关基因调控的指纹。
短句来源
  human bladder cancer
    Establishment of a human bladder cancer cell line with multidrug resistance──BIU-87/ ADM
    人膀胱癌BIU-87细胞系多重抗药性的形成
短句来源
    Establishment of doxorubicin-resistant human bladder cancer cell line ( BIU-87/ADM )and its mechanism of multidrug resistance
    人膀胱癌阿霉素耐药株BIU-87/ADM的建立及其耐药机理的研究
短句来源
    Microarray technique has been used to study biomarker for human bladder cancer, to study fingerprints of gene regulation associated with cadmium chloride, benzo(a) pyrene and trichloroethylene.
    例如微阵列技术已用于研究人膀胱癌的生物标记以及氯化镉、苯并(a)芘和三氯乙烯相关基因调控的指纹。
短句来源
  human bladder cancer cell
    Establishment of a human bladder cancer cell line with multidrug resistance──BIU-87/ ADM
    人膀胱癌BIU-87细胞系多重抗药性的形成
短句来源
    Establishment of doxorubicin-resistant human bladder cancer cell line ( BIU-87/ADM )and its mechanism of multidrug resistance
    人膀胱癌阿霉素耐药株BIU-87/ADM的建立及其耐药机理的研究
短句来源
  human bladder cancer
    Establishment of a human bladder cancer cell line with multidrug resistance──BIU-87/ ADM
    人膀胱癌BIU-87细胞系多重抗药性的形成
短句来源
    Establishment of doxorubicin-resistant human bladder cancer cell line ( BIU-87/ADM )and its mechanism of multidrug resistance
    人膀胱癌阿霉素耐药株BIU-87/ADM的建立及其耐药机理的研究
短句来源
    Microarray technique has been used to study biomarker for human bladder cancer, to study fingerprints of gene regulation associated with cadmium chloride, benzo(a) pyrene and trichloroethylene.
    例如微阵列技术已用于研究人膀胱癌的生物标记以及氯化镉、苯并(a)芘和三氯乙烯相关基因调控的指纹。
短句来源
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  human bladder
TBARS, Carnitine, and Reduced Glutathione Levels in Human Bladder Carcinoma
      
Select cytocompatibility experiments (specifically adhesion and long-term growth studies) were performed on these scaffolds using human bladder smooth muscle cells (BdSMCs).
      
Construction and expression of a human-mouse chimeric antibody against human bladder cancer
      
Objective: To construct and express a human-mouse chimeric antibody against human bladder cancer.
      
Method: The variable region genes of anti-human bladder cancer monoclonal antibody BDI-1 were cloned by RT-PCR.
      
更多          
  human bladder cancer
Construction and expression of a human-mouse chimeric antibody against human bladder cancer
      
Objective: To construct and express a human-mouse chimeric antibody against human bladder cancer.
      
Method: The variable region genes of anti-human bladder cancer monoclonal antibody BDI-1 were cloned by RT-PCR.
      
Conclusion: The constructed chimeric antibody was expressed successfully in eukaryotic cells, and the chimeric antibody had desired affinity against human bladder cancer cells.
      
The effects of EPI-CDMN associated with external pulsed electromagnetic fields (PEMFs) (10 mT) on killing human bladder cancer BIU-87 cells were studied by MTT assay and Annexin-V/PI double-labeled flow cytometry technique, respectively.
      
更多          
  human bladder cancer cell
Preliminary study of the in vitro growth inhibition of human bladder cancer cell line BIU-87 by arsenic trioxide
      
The growth inhibition rates of human bladder cancer cell line BIU87 by various concentrations of As2O3 were detected by using MTT method.
      
Adenovirus-mediated transfer of p53 and p16 inhibiting proliferating activity of human bladder cancer cell EJin vitro andin vivo
      
Implantation of human bladder cancer cell lines in the bladder wall of nude rats results in tumor formation, providing an excellent model to test this.
      
Effector cells in natural cytotoxicity against human bladder cancer cell lines
      
更多          
  human bladder cancer
Construction and expression of a human-mouse chimeric antibody against human bladder cancer
      
Objective: To construct and express a human-mouse chimeric antibody against human bladder cancer.
      
Method: The variable region genes of anti-human bladder cancer monoclonal antibody BDI-1 were cloned by RT-PCR.
      
Conclusion: The constructed chimeric antibody was expressed successfully in eukaryotic cells, and the chimeric antibody had desired affinity against human bladder cancer cells.
      
The effects of EPI-CDMN associated with external pulsed electromagnetic fields (PEMFs) (10 mT) on killing human bladder cancer BIU-87 cells were studied by MTT assay and Annexin-V/PI double-labeled flow cytometry technique, respectively.
      
更多          


A

用化学偶联法将抗人膀胱癌单克隆抗体分子偶联到阿霉素白蛋白毫微球上,构建了一个有靶向杀伤性的免疫毫微球,即:阿霉素白蛋白载单克隆抗体毫微球(ADR-NP-Ab)。改变阿霉素毫微球和单克隆抗体的反应分子比,确定了制备该免疫毫微球的最佳条件。经免疫荧光检测及显微照像分析证明,免疫毫微球可有效地和人膀胱癌细胞结合。体外杀伤试验表明,此免疫毫微球对靶细胞EJ有高度特异杀伤活性,而对无关的人直肠癌Lovo细胞则无明显作用。

A doxorubicin (3driamycin,ADM)-resistant human bladder transitional cell carcinoma cell line, BIU-87/ADM was established by exposing the BIU-87 parent cells to a high concentration of ADM for a short period and then maitained in a culture medium with alow concentration of ADM increasing the dose stepwise over a period of 6 months.The BIU-87/ADM cells became resistant to adriamycin,the resistance being 21 times stronger than their parent cells at IC50 and exhibited cross-resistance to epirubucun,vincristine and...

A doxorubicin (3driamycin,ADM)-resistant human bladder transitional cell carcinoma cell line, BIU-87/ADM was established by exposing the BIU-87 parent cells to a high concentration of ADM for a short period and then maitained in a culture medium with alow concentration of ADM increasing the dose stepwise over a period of 6 months.The BIU-87/ADM cells became resistant to adriamycin,the resistance being 21 times stronger than their parent cells at IC50 and exhibited cross-resistance to epirubucun,vincristine and etoposide but not to cisplatin,mitomycin, methotraxate and 5-fluorouracil.When BIU-87/ADM was cultured in the absence of ADM for 8 weeks,90 % of its drug-resistance property still persisted.BIU-87/ADM expressed the phenotype of multidrug resistance with relative stability and could serve as an ideal model for the study of multidrug resistance in human bladder transitional cell carcinoma.

应用阿霉素(ADM),大剂量短暂冲击结合低浓度持续递增法,逐步诱导人膀胱癌移行上皮细胞系BIU-87,在体外持续培养6个月,获得了具有多重抗药性的BIU-87/ADM细胞。该细胞能在浓度为2.0g/L的ADM中持续增殖。通过测定抗癌药物50%抑制浓度(IC_(50))发现,BIU-87/ADM细胞对阿霉素的敏感性下降了21倍,同时对表阿霉素(4-epi)、长春新碱(VCR)、足叶乙甙(VP-16)也具有显著的交叉抗药性,对顺铂(DDP)、丝裂霉素(MMC)、5-氟尿嘧啶(5-Fu)和氨甲喋呤(MTX)无抗药性;BIU87/ADM细胞在脱离阿霉素诱导第8周时,其抗药性仍保持在90%以上,结果表明:BIU-87/ADM细胞具有多重抗药性(MDR)表型,且抗药性较稳定,是研究人膀胱移行细胞癌MDR机制和筛选抗药性逆转剂的理想模型。

A human bladder cancer cells line resistant to doxorubicin, BIU-87/ADM,has been established in vitro by exposing BIU-87 parent cell to progressively higher concentrations of the drug over a period of 8 months. The cell line has been characterized in terms of growth kinetics, morphology, cross-resistance to other anticancerous agents, pharmacokinetics of ADM and expression of p-glycoprotein(P-gp)which is closely related to the MDR phenotype, The BIU-87/ADM cell was 6.3 times more resistant to doxorubicin than...

A human bladder cancer cells line resistant to doxorubicin, BIU-87/ADM,has been established in vitro by exposing BIU-87 parent cell to progressively higher concentrations of the drug over a period of 8 months. The cell line has been characterized in terms of growth kinetics, morphology, cross-resistance to other anticancerous agents, pharmacokinetics of ADM and expression of p-glycoprotein(P-gp)which is closely related to the MDR phenotype, The BIU-87/ADM cell was 6.3 times more resistant to doxorubicin than the BIU-87 parent cells. BIU-87/ADM exhibited cross-resistance to doxorubicin derivatives(epirubicin, daunorubicin),vincristine and etoposide, but not to cisplatin and mitomycin C, Compared to the parent cells, the resistant cells have a slower growth rate and lower confluent density. Unlike the BIU-87 parent cells, about 75% of the BIU 87/ADM cells showed a positive reaction with monoclonal antibody against P-gp,JSB-1. Intracellular drug accumulation studies with fluorescence spectrometry indicated that the resistance exhibited by the BIU-87/ADM line was mainly caused by an increased active efflux, These results suggest that MDR is an important phenomenon in bladder cancer and that more than one pathway of MDR may be present in human bladder cancer cell lines. BIU-87/ADM may be a useful model for the development of new chemotherapeutic strategies in overcoming drug-resistance in the treatment of bladder cancer.

人膀胱癌细胞株BIU-87为亲本,经递增阿霉素(ADM)剂量的方法,历时8个月,建立了一株耐药亚株BIU-87/ADM.此细胞株对ADM的耐受程度较亲本细胞提高了6.3倍,对柔红霉素(DNR)、表阿霉素、长春新碱和鬼臼乙叉甙有明显的交叉耐药性,但对顺铂、丝裂霉素无交叉耐药性。与亲本细胞相比,耐药亚株生长慢,倍增期延长,汇合密度低,异形性明显,有巨细胞形成。进一步研究表明,耐药亚株对DNR蓄积减少;免疫化学显示,75%的耐药细胞P-gp过表达。因而耐药细胞内DNR低聚集主要是P-gp膜泵功能增强介导产生细胞内药物外溢增多所致,是其产生耐药性的主要原因。但并非所有BIU-87/ADM均表达P-gp,其他耐药机理的共存是有可能的。BIU-87/ADM及其亲本细胞为寻求逆转人膀胱癌耐药的新型化疗增敏剂或综合化疗方案提供了良好的实验模型。

 
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