RESULTS The CD 50 value was increased by 29.50%(ip) and 25.70%(ig) after zhidian compound capsule was administrated,with obvious anticonvulsion effects induced by sodium Glutamate and the LD 50 value of 1.41±0.01g·kg -1 (95% confidense vange);
To investigate the effect of sodium glutamate on the retention of aluminum,iron,calcium,zinc in tissues,24 SD rats were divided into 4 groups with 6 rats each one which were respectively gavaged with l ml of following solution:distilled water,1.2 mmol AlCl 3,1.2 mmol AlCl 3+1.2 mmol sodium citrate (Al+CitNa),and 1.2 mmol AlCl 3+1.2 mmol sodium glutamate (Al+GluNa)during 50 days.
Piperine and its derivatives (Antiepilepsirine, 7302, 7306, 7446, 7448) belong to a new class of anticonvulsants. In doses less than TD_(50) they were found to be able to protect rats and mice from seizures produced by maximal electroshock, metrazol, picrotoxin, strychnine, tubocurarine and sodium glutamate, and reduce the mortality of animals to various extends.
AIM: To study the effects of KN-62, an inhibitor of Ca2 + -calmodulin dependent protein kinase Ⅱ (CCDPKⅡ ), on the damage of cortical neurons and mechanisms of the loss of CCDPK Ⅱ activity induced by sodium glutamate (Glu).
Methods: Using a established model of traumatic brain edema in cats, we injected the solutions of sodium glutamate into cerebellomedullary cistern of cats 20 min post-traumatic brain injury and measured the contents of brain tissue water, cation in the bilateral cerebral hemispheres 6 h posti-njury.
METHODS: In primary cortical cultures from 16-d-old fetal rat, neuronal viability and contents of nitrite in the bathing medium after transient exposure to sodium glutamate (Glu) were measured;
The repeated batch fermentations were conducted (every 96 hours) using the optimized alginate beads, employing the production medium with 3% wt/vol maltose and 0.6% wt/vol sodium glutamate along with minerals salts solution.
The effect of maltose (4%, 3%, 2%, and 1% wt/vol) and sodium glutamate (0.6%, 0.3%, 0.15%, and 0.075%) wt/vol) concentration on neomycin production was also studied.
The responses were identified from their latent and refractory periods, the presence of summation, and the dependence of the firing index on sodium glutamate application to the recorded neuron.
Many investigators gave different opinions on the question whether the increase of the ammonia content of brain is the cause or effect in the course of the convulsion.In the present paper,the experiments show the ammonia con- tent of different regions of the brain in the convulsive rats was markedly in- creased.When sodium glutamate and strychnine were injected intraperitoneally simultaneously,convulsion happened as usual in spite of the decrease of the brain ammonia content except for diencepha...
Piperine and its derivatives (Antiepilepsirine, 7302, 7306, 7446, 7448) belong to a new class of anticonvulsants. In doses less than TD_(50) they were found to be able to protect rats and mice from seizures produced by maximal electroshock, metrazol, picrotoxin, strychnine, tubocurarine and sodium glutamate, and reduce the mortality of animals to various extends. They appeared to have a wide anticonvulsive spectrum. Their action resembled diphenylhydantoin (DPH) in protecting rats and mice from ...
The present paper reports the central and peripheral actions of d1-3-n-butyl-phthalide in animals. Beside the anticonvulsant action, Ag-1 was also found to be able to protect mice and rats from seizures induced by sodium glutamate, spasm induecd by i.c.v, acetycholine and tremorine spasm as well as electroshock. No change of EEG patterns was shown in 13 unanesthetized normal rabbits after ip injection of Ag-1 50, 120, 200 and 250 mg/kg. After a single iv of metrazol 20 mg/kg to rabbits, bursts o...
sodium glutamate
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