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virus a
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     Hepatitis B Virus
     乙型肝炎病毒
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     Virus"of Marriage
     捕杀婚姻的“病毒”
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     Virus counter
     病毒计数器
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     (e) infection by virus;
     病毒说:细菌感染或多病原说;
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     On Jewish Virus
     计算机病毒“犹太人”
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  virus a
Potato virus A is studied by atomic force microscopy.
      
Geometric characteristics of potato virus A are determined by computer-aided analysis of the images obtained.
      
Identification of the Protease-Binding Domain in the N-Terminal Region of Influenza Virus A Matrix Protein M1
      
A region responsible for protease binding by influenza virus A matrix protein M1 was identified.
      
The receptor properties of influenza virus A/USSR/90/77 isolates are studied.
      
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Serum samples collected from man, swine, rabbit, duck and chickenin West Sichuan in September 1979 were examined by haemagglutinationinhibition (HI) test for antibodies to human influenza A viruses(A(H_(sw1)N_1), A(H_1N_1), A(H_2N_2) and A(H_3N_2) ). The number ofthe samples tested from man and domestic sera were 114, 252, 84, 102,and 102 respectively, and some of the domestic sera positive with HIantibodies were retested by single radial haemolysis method (SRH) forfurther determination of whether the...

Serum samples collected from man, swine, rabbit, duck and chickenin West Sichuan in September 1979 were examined by haemagglutinationinhibition (HI) test for antibodies to human influenza A viruses(A(H_(sw1)N_1), A(H_1N_1), A(H_2N_2) and A(H_3N_2) ). The number ofthe samples tested from man and domestic sera were 114, 252, 84, 102,and 102 respectively, and some of the domestic sera positive with HIantibodies were retested by single radial haemolysis method (SRH) forfurther determination of whether the HI antibodies presented in HI testwere specific. Different sera showed different positive rates of HI anti-body to the four influenza antigens. Of the four subtypes, HI antibodiesin the swine sera HI antibody to the A(H_3N_2) antigen was the highest(17.5%), the presence of the antibody also was demonstrated by SRHmethod, The results suggested that not only in other countries but alsoin West Sichuan the influenza A virus (H_3N_2) already circulated amongthe swine population. HI antibody to the A(H_1N_1) antigen of the chick-en sera was 19.7%, two of 12 samples of positive sera by SRH test waspositive presumedly. The percentage and the level of all HI antibodies tothe four antigen of the rabbit sera were pretty high (25%, 98.8%, 98.8%and 90.4%) but by the SRH reaction no one of the positive sera showedthe evidence of any antibody. It suggested that the rabbit was possiblyuninfected with the human influenza A viruses.

本文报告用血凝抑制试验检查人和猪、鸭、鸡、兔血清中的人类流感病毒(A/Hsw_1N_1,A/H_1N_1,A/H_2N_2和A/H_3N_2)抗体,并用血抑抗体滴度较高的动物血清作单扩溶血试验复核,两种试验的结果悬殊很大,最后对这些结果的意义加以讨论。

Two vaccines of Corynebacterium parvum "Shanghai 7705" and "Beijing 7903" were made from strains of C. parvum No. 76-27 and 77-1 separately in China. One single intravenous injection of the vaccine into mice could protect them from toxic death of intravenous infection of influenza virus A3.Jing-fang 75-39, induce serum y-interferon, activate peritoneal phagocytosis and enhance the anti-influenza virus antibody. The optimal, protection time was 24 hrs post-vaccination, not correlated with the peak of serum...

Two vaccines of Corynebacterium parvum "Shanghai 7705" and "Beijing 7903" were made from strains of C. parvum No. 76-27 and 77-1 separately in China. One single intravenous injection of the vaccine into mice could protect them from toxic death of intravenous infection of influenza virus A3.Jing-fang 75-39, induce serum y-interferon, activate peritoneal phagocytosis and enhance the anti-influenza virus antibody. The optimal, protection time was 24 hrs post-vaccination, not correlated with the peak of serum interferon level at 6 hrs post-vaccination, but was coincided with the peak of peritoneal phagocytosis 24 hrs after vaccination. The intraperitoneal injection of silica before vaccination may render the phagocytosis ineffective and lower the protection against influenza virus infection, but not the induction of serum IF in mice. These results suggested that the protection power of vaccinated mice against influenza virus infection was closely related to the activation of phagocytosis by Corynebacterium parvum vaccine.Intraperitoneal vaccination gave low protection and subcutaneous vaccination none.

我国分离的厌氧棒菌制成的菌苗北京7903和上海7503两批样品,静脉注入小鼠20mg/kg一次,对6~48小时后经静脉感染流感病毒所致死亡有保护作用,可减少小鼠死亡率。最佳保护时间为注射后24小时,保护率87.6~100%。静脉注射菌苗后6小时出现血清干扰素,高峰达320~640u/ml,18小时降低,持续24小时以上,其性质可能为γ-干扰素。静脉注射菌苗6~72小时间,激活巨噬细胞活性,高峰时间在注射后24小时。腹腔巨噬细胞吞噬鸡红细胞的%和吞噬指数,比对照组高,P<0.01。静脉注射菌苗对流感病毒抗体生成有促进作用,可使血清流感病毒血凝抑制抗体增高3~4倍。腹腔及皮下注射菌苗保护率低,腹腔注射后未测出血清干扰素。 小鼠静脉注射棒菌菌苗后抗流感病毒的最佳保护时间,与血清干扰素高峰时间不一致,但与腹腔巨噬细胞吞噬功能高峰一致。给小鼠腹腔注射石英粉尘,破坏巨噬细胞吞噬功能,也降低菌苗对流感病毒感染的保护作用,但对血清干扰素滴度无显著影响,提示厌氧棒菌菌苗抗流感病毒作用,与激活巨噬细胞的关系密切。

The epidemiological, clinical, virological and serological investigations on a hand-foot-mouth disease (HFMD) were carried out in the 22 kindergartens in Beijing from Oct. 1983 to Dec. 1984. The mobi-dity rate was 20.8%(282/1353). 95% of the patients were under 5 years of age. Two epidemic peaks were found in April and July respectively. Coxsackie virus A16 was isolated from the specimens of the patients with the HFMD (9 shares of stool, 8 shares of throat swab and 2 shares of vesicular fluid). A significant...

The epidemiological, clinical, virological and serological investigations on a hand-foot-mouth disease (HFMD) were carried out in the 22 kindergartens in Beijing from Oct. 1983 to Dec. 1984. The mobi-dity rate was 20.8%(282/1353). 95% of the patients were under 5 years of age. Two epidemic peaks were found in April and July respectively. Coxsackie virus A16 was isolated from the specimens of the patients with the HFMD (9 shares of stool, 8 shares of throat swab and 2 shares of vesicular fluid). A significant rise in the neutralizing antibody tilers against the virus isolated was found in 11 out of the 16 serum-paired samples (68.7%).

1983年10月~1984年12月,对北京22个幼儿园发生的手足口病进行了流行病学、临床学、病毒学和血清学方面的调查研究。其患病率为20.8%(282/1353),95%的病例发病年龄在5岁以下。4月份和7月份出现两个流行高峰。自病人大便、咽拭子和水疱液中分离到科萨奇A16病毒。在16例病人双份血清中,证明11例对分离株的中和抗体效价有意义升高。

 
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