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   系统性红斑狼疮(sle) 在 泌尿科学 分类中 的翻译结果: 查询用时:0.053秒
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系统性红斑狼疮sle
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  systemic lupus erythematosus(sle)
Systemic lupus erythematosus (SLE) is an autoimmune disease which occurs in over 80% in women during childbearing years.
      
The Kluver-Bucy syndrome has not been previously reported as a complication of systemic lupus erythematosus (SLE).
      
Anticardiolipin antibodies (aCL), one of a group of antiphospholipid antibodies which include the lupus anticoagulant (LA), may occur in association with systemic lupus erythematosus (SLE) and are less commonly detected in other diseases.
      
Seven patients with transverse myelopathy (TM) were found to have systemic lupus erythematosus (SLE).
      
Central nervous system (CNS) involvement in systemic lupus erythematosus (SLE) remains difficult to diagnose, particularly since structural abnormalities may not be revealed by magnetic resonance imaging (MRI).
      
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  systemic lupus erythematosus(sle)
Systemic lupus erythematosus (SLE) is an autoimmune disease which occurs in over 80% in women during childbearing years.
      
The Kluver-Bucy syndrome has not been previously reported as a complication of systemic lupus erythematosus (SLE).
      
Anticardiolipin antibodies (aCL), one of a group of antiphospholipid antibodies which include the lupus anticoagulant (LA), may occur in association with systemic lupus erythematosus (SLE) and are less commonly detected in other diseases.
      
Seven patients with transverse myelopathy (TM) were found to have systemic lupus erythematosus (SLE).
      
Central nervous system (CNS) involvement in systemic lupus erythematosus (SLE) remains difficult to diagnose, particularly since structural abnormalities may not be revealed by magnetic resonance imaging (MRI).
      
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Objective:To investigate the clinical prognosis in lupus nephritis patients with diffuse crescent formation Methodology:Fouty nine severe lupus nephritis patients with diffuse crescent formation, diagnosed by clinical, laboratory and renal histological examinations, were enrolled in this study According the protocol of immunosuppressive therapy, three groups were divided: group A ( n =12) treated with methyoprednisolone (MP) along, group B ( n =22) with MP plus cyclophosphomide (CTX), and group C (...

Objective:To investigate the clinical prognosis in lupus nephritis patients with diffuse crescent formation Methodology:Fouty nine severe lupus nephritis patients with diffuse crescent formation, diagnosed by clinical, laboratory and renal histological examinations, were enrolled in this study According the protocol of immunosuppressive therapy, three groups were divided: group A ( n =12) treated with methyoprednisolone (MP) along, group B ( n =22) with MP plus cyclophosphomide (CTX), and group C ( n =11) with MP plus mycophenolate mofetil (MMF) The effects of those immunosuppressive regimes and the clinical prognosis were observed Results:They were 47 females and 2 males, with mean of age (30 3±9 70) years old, and mean of lupus nephritis duration (15 8±18 3) months They were followed up average of (24 6±19 3) months 33 patients were more than 6 months of follow up In short term follow up, renal function, proteinuria, and anemia were improved markedly in all of groups after immunosuppressive therapy In long term follow up, there was more clinical effective in immunosuppressive regimes of MP+CTX and MP+MMF than that in regime of MP along The three years of cumulative proportion renal stable rate were higher 88% in group B and C compared with that in group C (64 0%) Conclusion:There was a good prognosis in our lupus patients with diffuse crescent formation, which may be contributed to having effective immunosuppressive induced therapy

目的 :了解新月体性狼疮性肾炎 (CLN)患者的临床转归。  方法 :临床及病理检查确诊为CLN 4 9例 ,根据不同的免疫抑制治疗方法分为三组 :A组 (n =12 ) ,甲基强的松龙 (MP)冲击治疗 ;B组 (n =2 2 ) ,MP冲击合并间断环磷酰胺 (MP +CTX)静脉治疗 ;C组 (n =11) ,MP冲击合并霉酚酸酯 (MP +MMF)治疗。观察他们的近、远期疗效和临床转归。  结果 :女性 4 7例 ,男性 2例 ,平均年龄 (30 3± 9 70 )岁 ,系统性红斑狼疮 (SLE)平均病程为(2 7 0± 2 6 1)月 ,狼疮肾炎 (LN)平均病程为 (15 8± 18 3)个月 ,平均随访时间为 (2 4 6± 19 3)个月。近期疗效 :患者血清肌酐 (SCr)从治疗前 (30 5± 2 16 ) μmol/L降至 (190± 14 6 ) μmol/L ,蛋白尿和贫血也均有不同程度的改善。临床有效者 14例 ,占 2 8 6 % ,临床缓解者 6例 ,占 12 2 %。远期疗效 :6 7 3%患者随访时间超过 6个月 ,其中B组 18例、C组 8例和A组 7例患者 ,他...

目的 :了解新月体性狼疮性肾炎 (CLN)患者的临床转归。  方法 :临床及病理检查确诊为CLN 4 9例 ,根据不同的免疫抑制治疗方法分为三组 :A组 (n =12 ) ,甲基强的松龙 (MP)冲击治疗 ;B组 (n =2 2 ) ,MP冲击合并间断环磷酰胺 (MP +CTX)静脉治疗 ;C组 (n =11) ,MP冲击合并霉酚酸酯 (MP +MMF)治疗。观察他们的近、远期疗效和临床转归。  结果 :女性 4 7例 ,男性 2例 ,平均年龄 (30 3± 9 70 )岁 ,系统性红斑狼疮 (SLE)平均病程为(2 7 0± 2 6 1)月 ,狼疮肾炎 (LN)平均病程为 (15 8± 18 3)个月 ,平均随访时间为 (2 4 6± 19 3)个月。近期疗效 :患者血清肌酐 (SCr)从治疗前 (30 5± 2 16 ) μmol/L降至 (190± 14 6 ) μmol/L ,蛋白尿和贫血也均有不同程度的改善。临床有效者 14例 ,占 2 8 6 % ,临床缓解者 6例 ,占 12 2 %。远期疗效 :6 7 3%患者随访时间超过 6个月 ,其中B组 18例、C组 8例和A组 7例患者 ,他们平均随访时间为 (30 1± 2 6 8)个月。随访终了时临床有效者 2 1例 (42 9% ) ,其中B组14例、C组 5例和A组 2例。临床缓解者 10例 (2 0 4 % ) ,其中C组 6例、B组 3例和A组 1例。比较B组和C组患者的远期疗效无明显差异 ,而优于A组。测定B组和C组患者的 3年肾功能稳定率均在 88%以上 ,明显高于

Objective To observe whether single nucleotide polymorphisms (SNPs) within the type Ⅰ interferon receptor (IFNAR) gene are associated with lupus nephritis (LN) susceptibility in Chinese population. Methods Thirteen SNPs located in IFNAR gene with high heterozygosity were chosen for genotyping on 200 nuclear families, 537 systemic lupus erythematosus (SLE) patients, including 203 LN patient and non-LN patient, and 252 normal controls using taqman MGB allelic discrimination method. Data were analysed by SDS 2.1...

Objective To observe whether single nucleotide polymorphisms (SNPs) within the type Ⅰ interferon receptor (IFNAR) gene are associated with lupus nephritis (LN) susceptibility in Chinese population. Methods Thirteen SNPs located in IFNAR gene with high heterozygosity were chosen for genotyping on 200 nuclear families, 537 systemic lupus erythematosus (SLE) patients, including 203 LN patient and non-LN patient, and 252 normal controls using taqman MGB allelic discrimination method. Data were analysed by SDS 2.1 software. Haplotypes and their frequencies were constructed and estimated by Haploview and FBAT program. Case-control study were performed between the SLE, LN, non-LN groups and normal control group. Results ①The frequency of SNP rs2243594 G allele was 29.0% in the SLE patients, significantly higher than that in the control (P<0.01). The AA genotype frequency of the SLE patients was 50.3%, significantly lower than that of the control (P<0.05). ②The SNP rs2243594 G allele frequency of the SLE LN group was 35.5%, significantly higher than that of the control (P<0.01). The AA genotype frequency of the LN patients was 39.1%, significantly lower than that of the control (61.2%) (P<0.01). ③The frequencies of haplotypes containing rs2243594 G allele were different between SLE nephritis patients and normal control group (P<0.05). ④SNP rs2243594 G allele were overtransmitted in nephritis families. Conclusion SNP rs2243594 and some haplotypes containing SNP rs2243594 within IFNAR1 are significantly associated with LN susceptibility. Genetic variation of the IFNAR gene are involved in the pathogenesis of LN.

目的研究Ⅰ型干扰素受体基因内部的单核苷酸多态性(SNP)与中国人群狼疮肾炎发病的相关性。方法选择IFNAR1和IFNAR2内部的14个SNP标记在200个核心家系,537例系统性红斑狼疮(SLE)患者(203例狼疮肾炎患者和334例狼疮非肾炎患者)和252名正常人中进行等位基因分型,以Haploview软件分析SNP分布情况,并用FBAT软件做TDT分析。结果发现中国汉族人群中①IFNAR1-SNPrs2243594等位基因频率(G)在SLE患者(29.0%)和正常人(21.2%)中差异有统计学意义(P<0.01)。AA基因型的频率在SLE患者(50.3%)低于正常对照组(61.2%,P<0.05)。②IFNAR1-SNPrs2243594等位基因频率(G)在狼疮肾炎患者(35.5%)和正常人(21.2%)两组对象的差异有统计学意义(P<0.01)。AA基因型的频率在狼疮肾炎患者(39.1%)低于正常对照组(61.2%,P<0.01)。③IFNAR1含有rs2243594G等位基因的单倍型频率在SLE肾炎患者与正常人差异有统计学意义(P<0.05)。④rs2243594G等位基因在肾炎家系中有优势传递。结论I...

目的研究Ⅰ型干扰素受体基因内部的单核苷酸多态性(SNP)与中国人群狼疮肾炎发病的相关性。方法选择IFNAR1和IFNAR2内部的14个SNP标记在200个核心家系,537例系统性红斑狼疮(SLE)患者(203例狼疮肾炎患者和334例狼疮非肾炎患者)和252名正常人中进行等位基因分型,以Haploview软件分析SNP分布情况,并用FBAT软件做TDT分析。结果发现中国汉族人群中①IFNAR1-SNPrs2243594等位基因频率(G)在SLE患者(29.0%)和正常人(21.2%)中差异有统计学意义(P<0.01)。AA基因型的频率在SLE患者(50.3%)低于正常对照组(61.2%,P<0.05)。②IFNAR1-SNPrs2243594等位基因频率(G)在狼疮肾炎患者(35.5%)和正常人(21.2%)两组对象的差异有统计学意义(P<0.01)。AA基因型的频率在狼疮肾炎患者(39.1%)低于正常对照组(61.2%,P<0.01)。③IFNAR1含有rs2243594G等位基因的单倍型频率在SLE肾炎患者与正常人差异有统计学意义(P<0.05)。④rs2243594G等位基因在肾炎家系中有优势传递。结论IFNAR基因的变异可能在狼疮肾炎发病中发挥作用。

[Objective] To explore the relationship between several serological autoantibodies with nephritis in system lupus erythematosus (SLE). [Methods] The data mainly obtained by consulting the patient from March, 2001 to July, 2005; 71 SLE patients were collected and analyzed. The comparison nephritis and non-nephritis patients in the prevalence of different specificities was performed. [Results] Anti-dsDNA, anti-ribosomal P protein (anti-P), and antibodies to lipoprotein lipase (anti-LPL) were more likely appeared...

[Objective] To explore the relationship between several serological autoantibodies with nephritis in system lupus erythematosus (SLE). [Methods] The data mainly obtained by consulting the patient from March, 2001 to July, 2005; 71 SLE patients were collected and analyzed. The comparison nephritis and non-nephritis patients in the prevalence of different specificities was performed. [Results] Anti-dsDNA, anti-ribosomal P protein (anti-P), and antibodies to lipoprotein lipase (anti-LPL) were more likely appeared in the sera of SLE nephritis patients than of non-nephritis patients; and there are strong synergistic effects of anti-LPL and anti-P, and of anti-dsDNA and anti-P (P <0.05). [Conclusions] Anti-LPL, the synergistic effects of anti-LPL and anti-P, and of anti-LPL, anti-dsDNA could be practiced as criteria for SLE nephritis diagnosis.

目的探讨3种血清学指标,抗双链DNA抗体(anti-dsDNA)、抗核糖体P蛋白抗体(anti-P)和抗脂蛋白酶抗体(anti-LPL)与系统性红斑狼疮(SLE)性肾炎的关系。方法分析该院自2001年以来71例SLE患者各主要相关血清学指标与SLE肾炎的关系。结果SLE肾炎anti-dsDNA、anti-P和anti-LPL有较高的阳性率,而且它们之间存在较高的协同相关性(P<0.05)。结论anti-LPL的升高和anti-LPL与anti-P的协同相关性,及anti-LPL与anti-dsDNA的协同相关性可以作为诊断SLE肾炎的依据。

 
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