Method The models of hyperlipoidemia in SD rats and rabbits were made with 10% cholesterol containing lipid emulsion. The expression of TGF β1,2,3 and its receptor in arteries and the level of TGF β1、2、3 in serum of these animals were detected by immunohistochemistery and ELISA technics.
The end pointat which dead-stop titration determines POV of fatty emulsion was sensitive andaccurate, in comparison with amylum indicator the sensitivity(calculated on the basisof (POV)_(min) of the emulsion) being 0.032±0.001meq/l.
This paper has reported 45 high risk neonates experimentally treated by total parenteral nutrition (TPN) and 30 controlly treated by supporting treatment, which the TPN include middle and long chain fat emulsions (MCT/LCT).
The decrease of lipolytic activities occurred whether they were measured on a fat emulsion containing long-chain or medium- and long-chain triglycerides.
In experiments with rats, the differences in plasma clearing and utilisation of the lipids given were compared between animals with acute uremic acidosis and controls after intravenous injection of radioactive labelled fat emulsion.
The uptake of plasma lipids into tissue was studied in normal, starved, and alloxan-diabetic rats before and after treatment with insulin, using fat emulsion and rat chylomicrons labelled with radioactive triglyceride fatty acids.
- Fifteen minutes after intravenous injection of fat emulsion 97% of the label was recovered in lipid extracts of 8 different tissues; 67% was recovered after injection of chylomicrons.
In a second series of experiments in which Intralipid was compared with 0.9% NaCl it was demonstrated that the fat emulsion alone gave rise to considerable inflammatory changes in the veins.
Improved fatty acid and leukotriene pattern with a novel lipid emulsion in surgical patients
Ten control pigs were treated with a lipid emulsion as placebo.
A lipid emulsion containing fish oil, olive oil, or both should replace soybean-containing emulsions.
(The integrated protein secretion decreased from 20.1±1.9 g to 15.2±1.6 g, NT release dropped from 4970 to 3050 pg/180 min, and CCK from 1210 to 200 pg/180 min.) cholestyramine together with the lipid emulsion had the opposite effect.
Effects of insulin and lipid emulsion on renal haemodynamics and renal sodium handling in IDDM patients