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免疫诱导型
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  toxin induced
     Objective To investigate the difference of the location and expression of TIMP-1,2 liver fibrosis model in rats between immune induced and toxin induced.
     目的探讨人血白蛋白免疫诱导型及四氯化碳(CCl4)毒素诱导型所致大鼠肝纤维化模型肝组织中金属蛋白酶组织抑制因子(TIMP)定位及表达状态的差异。
短句来源
     Results Immune induced rat liver fibrosis model presented a tendency progressive aggrevation, strong expression of TIMP-1, TIMP-2 mRNA and protein and lasted for longer time, on the other hand, the toxin induced rat liver fibrosis model presented weak expression of TIMP-1, TIMP-2 mRNA and protein , and shorter period of liver fibrosis after stopping toxin attack.
     结果造模结束后,免疫诱导型模型肝组织病理改变具有进行性加重趋势,TIMP1、TIMP2mRNA及蛋白表达强度高、持续时间长; 而毒素诱导型模型具有TIMP1、TIMP2mRNA及蛋白表达强度弱、肝纤维化持续时间短等特点。
短句来源
     Conclusion The toxin induced rat liver fibrosis model was not appropriate for observation of anti-fibrotic drugs due to its fast sponteneous absorption, the immune induced rat liver fibrosis model is good for the observation of anti-fibrotic drug effects and study on the mechanism of liver fibrosis due to its slow sponteneous absorption, and has the trend of aggrevation within three months after.
     结论毒素诱导型肝纤维化模型自然吸收较快,不利于抗肝纤维化药物疗效的观察; 免疫诱导型肝纤维化模型自然吸收时间较慢,且在造模结束后1~3个月有逐渐加重趋势,有利于抗肝纤维化药物疗效观察及肝纤维化机制研究。
短句来源
  immune-induced
     Differentia of the correlation between the TIMP-1 expression level and hepatic fibrosis in immune-induced rat liver fibrosis model and CCl_4-induced rat liver fibrosis model
     免疫诱导型和CCl_4诱导型大鼠TIMP-1表达水平的差异及与肝纤维化程度相关性
短句来源
     Results The serum TIMP-1 level in immune-induced rat liver fibrosis model can reflect the severity of hepatic fibrosis and the positive in situ hybridization signal of TIMP-1 mRNA is strong;
     结果免疫诱导型大鼠肝纤维化模型制备过程中其血清TIMP1水平能较好的反映肝纤维化程度,原位杂交显示TIMP1mRNA表达较强;
短句来源
  immune induced rat
     Results Immune induced rat liver fibrosis model presented a tendency progressive aggrevation, strong expression of TIMP-1, TIMP-2 mRNA and protein and lasted for longer time, on the other hand, the toxin induced rat liver fibrosis model presented weak expression of TIMP-1, TIMP-2 mRNA and protein , and shorter period of liver fibrosis after stopping toxin attack.
     结果造模结束后,免疫诱导型模型肝组织病理改变具有进行性加重趋势,TIMP1、TIMP2mRNA及蛋白表达强度高、持续时间长; 而毒素诱导型模型具有TIMP1、TIMP2mRNA及蛋白表达强度弱、肝纤维化持续时间短等特点。
短句来源
     Conclusion The toxin induced rat liver fibrosis model was not appropriate for observation of anti-fibrotic drugs due to its fast sponteneous absorption, the immune induced rat liver fibrosis model is good for the observation of anti-fibrotic drug effects and study on the mechanism of liver fibrosis due to its slow sponteneous absorption, and has the trend of aggrevation within three months after.
     结论毒素诱导型肝纤维化模型自然吸收较快,不利于抗肝纤维化药物疗效的观察; 免疫诱导型肝纤维化模型自然吸收时间较慢,且在造模结束后1~3个月有逐渐加重趋势,有利于抗肝纤维化药物疗效观察及肝纤维化机制研究。
短句来源
  “免疫诱导型”译为未确定词的双语例句
     RESULTS:The liver fibrosis degree and level of mRNA and proteins of collagen I/III in the liver were significantly reduced in the decreasing order in oxymatrine preventive group, oxymatrine therapeutic group, and cochicine therapeutic group.
     结果:试验组肝组织结构明显好转,纤维组织增生程度明显低于肝纤维化模型组; I型、III型胶原含量及I型、III型胶原的mRNA表达均低于模型组免疫诱导型肝纤维化大鼠,其效果为试验组I(苦参素预防组)效果最好,试验组II(苦参素治疗组)次之,秋水仙碱治疗组再次之,三组均优于造模组.
短句来源
     Methods Using TIMP-2 targeting asON to inhibit the expression of TIMP-2 in fibrosis liver.
     方法免疫诱导型大鼠肝纤维化模型制备过程中,尾静脉注射针对TIMP-2的反义寡核苷酸。
短句来源
     METHODS:Rat immunogenic liver fibrosis model was induced by administration human serum albumin (HSA 200 g/L) intravenously, 80 rats were randomly divided into 5 groups.
     方法:采用免疫诱导型肝纤维化大鼠模型,80只Wister大鼠,分为5组,A预防组造模同时开始喂食双甲五灵冲剂;
短句来源
     Objective To study the effect of chinese medicine SHUANGJIAWULING on the expression of Ⅰ, Ⅲ collage using immune induced liver fibrosis rat model.
     目的 探讨中药双甲五灵冲剂对免疫诱导型肝纤维化大鼠肝组织中Ⅰ、Ⅲ型胶原蛋白及基因表达的影响。
短句来源
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  toxin induced
It was shown that G protein agonist cholera toxin induced amarathin synthesis in darkness, whereas G protein antagonist pertussis toxin inhibited red light-induced amaranthin synthesis.
      
In vitro, both concentrations of toxin induced insulin release (5?mg/l P>amp;lt;0.02, 50?mg/l P>amp;lt;0.01 vs controls), in the presence of 5.6?mM glucose.
      
Antitoxin's effect on tetanus toxin induced sphincter pupillae paralysis in the rabbit
      
The mechanisms of local tetanus or unilateral tetanus toxin induced paralysis due to intramuscular injections were studied in adult Wistar rats.
      
Using a multiple injection technique unilateral intrastriatal injections of pertussis toxin induced, after a lag phase, ipsilateral postural asymmetries which intensified upon peripheral administration of apomorphine.
      
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  immune-induced
Expression of adherent molecule and cyclin by ligustrazine in bone marrow of mice with immune-induced aplastic anemia
      
Mice with immune-induced aplastic anemia (AA) were given 5 mg ligustrazine intraperitoneally twice a day.
      
The results showed that ligustrazine could improve the expression of adherent molecule and cyclin D2 in the bone marrow of mice with immune-induced aplastic anemia, thereby promoting the growth of hematopoietic cells.
      
The permeability of the blood-testis barrier to lanthanum during the immune-induced aspermatogenesis and following vasectomy in
      
We also sequenced three gram-negative binding proteins (GNBPs) and two immune-induced peptides with strong homology to the GNBPs.
      
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AIM:To study the effect of Oxymatrine on liver fibrosis in immunogenic liver fibrosis rat model. METHODS:Rat liver fibrosis model was induced by human serum albumin (HSA), 60 Wistar rats were randomly divided into 5 groups, control group without any treatment,liver fibrosis model group,oxymatrine preventive group, oxymatrine therapeutic group,and cochicine therapeutic group.The pathological changes of liver were observed by HE and Von-Gieson staining.The expressions of mRNA and proteins of collagen I/III in...

AIM:To study the effect of Oxymatrine on liver fibrosis in immunogenic liver fibrosis rat model. METHODS:Rat liver fibrosis model was induced by human serum albumin (HSA), 60 Wistar rats were randomly divided into 5 groups, control group without any treatment,liver fibrosis model group,oxymatrine preventive group, oxymatrine therapeutic group,and cochicine therapeutic group.The pathological changes of liver were observed by HE and Von-Gieson staining.The expressions of mRNA and proteins of collagen I/III in liver were determined by in situ hybridization and immunohistochemistry. RESULTS:The liver fibrosis degree and level of mRNA and proteins of collagen I/III in the liver were significantly reduced in the decreasing order in oxymatrine preventive group, oxymatrine therapeutic group, and cochicine therapeutic group. CONCLUSION:Oxymatrine may inhibit hepatic inflammation and hepatic synthesis of collagen I/III,and thus prevent and inhibit hepatic fibrosis.

目的:探讨苦参素对实验性大鼠肝纤维化的预防与治疗作用.方法:采用人血清白蛋白免疫损伤Wistar大鼠造成肝纤维化模型,60只Wister大鼠,分为5组:造模组、秋水仙碱治疗组、试验组I(苦参素预防组)、试验组II(苦参素治疗组),另设正常对照组.动态观察大鼠肝组织病例变化,采用HE染色观察肝组织改变及Von-Gieson胶原纤维特殊染色观察肝纤维化程度,并采用免疫组织化学染色及肝组织原位杂交检测I型、III胶原含量及I型、III型胶原mRNA的表达.结果:试验组肝组织结构明显好转,纤维组织增生程度明显低于肝纤维化模型组;I型、III型胶原含量及I型、III型胶原的mRNA表达均低于模型组免疫诱导型肝纤维化大鼠,其效果为试验组I(苦参素预防组)效果最好,试验组II(苦参素治疗组)次之,秋水仙碱治疗组再次之,三组均优于造模组.结论:苦参素可减轻肝脏炎症活动、抑制肝内胶原合成,对实验性大鼠肝纤维化具有防治作用.

AIM:To explore the effect of Chinese herb Shuangjiawuling in preventing hepatic fibrosis in rat with liver fibrosis. METHODS:Rat immunogenic liver fibrosis model was induced by administration human serum albumin (HSA 200 g/L) intravenously, 80 rats were randomly divided into 5 groups. Shuangjiawuling was taken orally simultaneously with (group A), immediately after (group B), or 3 months after ( group C) administration of HAS intravenously. Colchine tablets were taken orally with the administration of HAS (group...

AIM:To explore the effect of Chinese herb Shuangjiawuling in preventing hepatic fibrosis in rat with liver fibrosis. METHODS:Rat immunogenic liver fibrosis model was induced by administration human serum albumin (HSA 200 g/L) intravenously, 80 rats were randomly divided into 5 groups. Shuangjiawuling was taken orally simultaneously with (group A), immediately after (group B), or 3 months after ( group C) administration of HAS intravenously. Colchine tablets were taken orally with the administration of HAS (group D),normal rats were used as control ( Group E ). The pathological changes of liver tissue were observed by HE and Von-Gieson staining. The hepatic mRNA and protein of TIMP-1 and TIMP-2 were analyzed by in site hybridization and immunohistochemistry. RESULTS:Hepatic fibrosis developed gradually and became obviously on the third month after administration of HAS. And strong expressions of TIMP-1 and TIMP-2 were observed, however,its expression and hepatic fibrosis were reduced dramatically following administration of Shuangjiawuling and colchine tablets.The effect of Shuangjiawuling in preventing fi- brosis was superior to that of colchine tablets (P <0.05), and its effect in group A, B, and C decreased in order.CONCLUSION:Chinese herb Shuangjiawuling can inhibit the development of hepatic fibrosis and the expression of TIMPs, and promoted the effect of the degradation of the extracellular matrix.

目的:研究在活血化淤基础上辅以软坚散节自制的双甲五灵冲剂对大鼠肝纤维化模型抗纤维化的治疗机制.方法:采用免疫诱导型肝纤维化大鼠模型,80只Wister大鼠,分为5组,A预防组造模同时开始喂食双甲五灵冲剂;B治疗组1在造模结束的同时开始喂食双甲五灵冲剂;C治疗组2在造模结束3mo后开始喂食双甲五灵冲剂;D秋水仙碱组在造模结束的同时开始喂食秋水仙碱;另设正常对照组10只.采用HE染色观察肝组织改变及Von-Gieson胶原纤维特殊染色以观察肝纤维化程度,并采用肝组织原位杂交及免疫组织化学染色观察大鼠肝脏组织中TIMP-1和TIMP-2mRNA及蛋白的表达强度.结果:免疫诱导型肝纤维化大鼠,在造模结束后肝组织学改变呈进行性加重,以造膜结束后3mo为著,其TIMP-1和TIMP-2mRNA及蛋白呈强阳性表达,而经双甲五灵冲剂治疗后的大鼠与模型组大鼠相比,肝组织结构明显好转,纤维组织明显减少,TIMP-1和TIMP-2mRNA及蛋白表达明显降低(P<0.05),并且其效果为:预防组效果最好,治疗1组较治疗2组效果好,即造模同时开始喂食双甲五灵冲剂最好,造模结束同时用药好于造模结束3mo后用药,三...

目的:研究在活血化淤基础上辅以软坚散节自制的双甲五灵冲剂对大鼠肝纤维化模型抗纤维化的治疗机制.方法:采用免疫诱导型肝纤维化大鼠模型,80只Wister大鼠,分为5组,A预防组造模同时开始喂食双甲五灵冲剂;B治疗组1在造模结束的同时开始喂食双甲五灵冲剂;C治疗组2在造模结束3mo后开始喂食双甲五灵冲剂;D秋水仙碱组在造模结束的同时开始喂食秋水仙碱;另设正常对照组10只.采用HE染色观察肝组织改变及Von-Gieson胶原纤维特殊染色以观察肝纤维化程度,并采用肝组织原位杂交及免疫组织化学染色观察大鼠肝脏组织中TIMP-1和TIMP-2mRNA及蛋白的表达强度.结果:免疫诱导型肝纤维化大鼠,在造模结束后肝组织学改变呈进行性加重,以造膜结束后3mo为著,其TIMP-1和TIMP-2mRNA及蛋白呈强阳性表达,而经双甲五灵冲剂治疗后的大鼠与模型组大鼠相比,肝组织结构明显好转,纤维组织明显减少,TIMP-1和TIMP-2mRNA及蛋白表达明显降低(P<0.05),并且其效果为:预防组效果最好,治疗1组较治疗2组效果好,即造模同时开始喂食双甲五灵冲剂最好,造模结束同时用药好于造模结束3mo后用药,三组均明显优于秋水仙碱组.结论:中药双甲五灵冲剂治疗肝纤维化的机制可能通过抑制TIMP-1和TIMP-2mRNA及蛋白的表达而降低对MMPs的抑制,从而有利于MMPs对细胞外基质的降解.

Objective To study the effect of chinese medicine SHUANGJIAWULING on the expression of Ⅰ, Ⅲ collage using immune induced liver fibrosis rat model.Methods Rat liver fibrosis was induced by the administration of 200g/L human serum albumin (HSA) by iv.Ninety rats were divided into 6 groups. Group A is as untreated control.In group B,chinese medicine SHUANGJIAWULING was taken orally at the same time with the administration of HSA. In group C,Chinese medicine SHUANGJIAWULING was taken orally immediately after the...

Objective To study the effect of chinese medicine SHUANGJIAWULING on the expression of Ⅰ, Ⅲ collage using immune induced liver fibrosis rat model.Methods Rat liver fibrosis was induced by the administration of 200g/L human serum albumin (HSA) by iv.Ninety rats were divided into 6 groups. Group A is as untreated control.In group B,chinese medicine SHUANGJIAWULING was taken orally at the same time with the administration of HSA. In group C,Chinese medicine SHUANGJIAWULING was taken orally immediately after the administration of HSA. In group D,chinese medicine SHUANGJIAWULING was taken orally at 3 months after the administration of HSA. In group E,colchine tablets was taken orally at the same time with the administration of HAS. In group F,chinese medicine BIEJIARUANGANPIAN was taken orally immediately after the administration of HSA.In group G, HSA was administrated without treatment.The pathological changes of liver tissue were observed by HE and Von-Gieson staining. The mRNA and proteins of Ⅰ, Ⅲ collage in the liver were analyzed by in situ hybridization and immunohistochemistry, respectively. Results In the immune induced liver fibrosis model rats, the fibrosis was most serious at 3 months after the administration of HAS. The expression of Ⅰ, Ⅲ collagen was the strongest at the same time. The liver fibrosis and expression of Ⅰ, Ⅲ collagen were reduced significantly in the SHUANGJlAWULING treatment rats (P<0. 05). In the SHUANGJIAWULING treatment rats, group B is better than group C for the efficacy. SHUANGJlAWULING treatment was superior to colchine tablets treatment.Conclusion Chinese medicine SHUANGJIAWULING can reduce liver fibrosis by inhibiting the expression of TIMPs expression and increase active-MMPs, then the degradation of the extracellular matrix is accelerated of Ⅰ, Ⅲ collagen mRNA and protein expression.

目的 探讨中药双甲五灵冲剂对免疫诱导型肝纤维化大鼠肝组织中Ⅰ、Ⅲ型胶原蛋白及基因表达的影响。方法  80只雌性Wistar大鼠尾静脉注射人血白蛋白 ,建立免疫损伤性肝纤维化大鼠模型后分为 6组 :B预防组造模同时开始喂食双甲五灵冲剂 ;C治疗 1组 :在造模结束的同时开始喂食双甲五灵冲剂 ;D治疗 2组 :在造模结束 3mo后开始喂食双甲五灵冲剂 ;E秋水仙碱组 :在造模结束的同时开始喂食秋水仙碱 ;F鳖甲软肝片组 :在造模结束的同时开始喂食鳖甲软肝片 ;G模型组 :以观察肝纤维化自然恢复情况 ;另设A组为正常对照组。采用HE染色及Von Gieson胶原纤维特殊染色以观察观察肝组织结构改变及肝纤维化程度 ,并采用肝组织原位杂交技术及免疫组织化学染色观察大鼠肝脏组织中Ⅰ、Ⅲ型胶原蛋白及基因的表达强度。结果 免疫诱导型肝纤维化大鼠 ,在造模结束后肝组织学改变呈进行性加重 ,以造模结束后 3mo为著 ,其Ⅰ、Ⅲ型胶原蛋白及基因呈强阳性表达 ,而经双甲五灵冲剂治疗后的大鼠与模型组大鼠相比 ,肝组织结构明显好转 ,纤维组织明显减少 ,Ⅰ、Ⅲ型胶原蛋白及基因表达明显降低 (P <0 .0 5 )...

目的 探讨中药双甲五灵冲剂对免疫诱导型肝纤维化大鼠肝组织中Ⅰ、Ⅲ型胶原蛋白及基因表达的影响。方法  80只雌性Wistar大鼠尾静脉注射人血白蛋白 ,建立免疫损伤性肝纤维化大鼠模型后分为 6组 :B预防组造模同时开始喂食双甲五灵冲剂 ;C治疗 1组 :在造模结束的同时开始喂食双甲五灵冲剂 ;D治疗 2组 :在造模结束 3mo后开始喂食双甲五灵冲剂 ;E秋水仙碱组 :在造模结束的同时开始喂食秋水仙碱 ;F鳖甲软肝片组 :在造模结束的同时开始喂食鳖甲软肝片 ;G模型组 :以观察肝纤维化自然恢复情况 ;另设A组为正常对照组。采用HE染色及Von Gieson胶原纤维特殊染色以观察观察肝组织结构改变及肝纤维化程度 ,并采用肝组织原位杂交技术及免疫组织化学染色观察大鼠肝脏组织中Ⅰ、Ⅲ型胶原蛋白及基因的表达强度。结果 免疫诱导型肝纤维化大鼠 ,在造模结束后肝组织学改变呈进行性加重 ,以造模结束后 3mo为著 ,其Ⅰ、Ⅲ型胶原蛋白及基因呈强阳性表达 ,而经双甲五灵冲剂治疗后的大鼠与模型组大鼠相比 ,肝组织结构明显好转 ,纤维组织明显减少 ,Ⅰ、Ⅲ型胶原蛋白及基因表达明显降低 (P <0 .0 5 ) ,并且其效果为预防组效果最好 ,治疗 1组较治疗 2组效果好 ,三组均明显优于秋水仙碱组。结论 中药双甲五灵冲剂可以逆转肝纤维化

 
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