Methods Drug utilization index (DUI) was used to analyze the prescriptions of antipyretic analgesic and anti-inflammatory drugs to out-patients in the fourth quarter of 2001. Results and Conclusion In 71.4% of the prescriptions, the DUI ranged from 0.9 to 1.1, indicating basically justified utilization of antipyretic analgesic and anti-inflammatory drugs in Nanfang Hospital though with occasional abuses of somiton tablets.
Our results showed that the drugs that can cause nephropathy included aminoglycoside antibiotics(43.10%) , cephalosporins(13.79%), antipyretic analgesics (29-31%), sulfonamides (8.62%) and anti-tuberculosis agents (3-45%).
RESULTS: A total of 67 categories were found to be sensitized drugs, leading the top five places were penicillins (23.8%), Chinese herbal medicine and Chinese patent medicine (17.6%), antipyretic analgesics (13.8%) , sulfanilamide group (10.9%) and cephalosporins (9.5%), respectively.
patient-controlled analgesia (PCA) was determined for the opioid piritramide (a pure μ-receptor agonist) and the antipyretic analgesic metamizole (Dipyrone) in three groups of patients following abdominal surgery.
In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.
Ibuprofen and, to a minor extent, the other antipyretic analgesic drugs also diminished the stimulus induced flare reaction around the stimulated skin sites.
The clearance of the antipyretic-analgesic drug acetaminophen, biotransformed in humans by glucuronide and sulfate conjugation, was evaluated in 32 healthy young and elderly volunteers.