Indomethacin is a kind of non-steroidal anti-inflammatory drug(NSAID),which has antipyretic analgesic and anti-inflammatory activities by inhibiting the synthesis of prostaglandin.
This paper analyzed 12518 OPD prescription of Huashan Hospital during January, 1994 to December, 1994. The results showed that antipyretic analgesic, NSAIDs precriptions accounted for 12.1% of the total precriptions, of which, 93. 92% precriptions can be seen using these drugs alone, and DUI of the most drugs less than 1, so drugs abuse in dosage were insignificant。
The western medicine accounted for 48.6%(53/109),among which the most chief drugs were anti-inflammatory,antipyretic,antituberculotic and antithyroid drugs.
patient-controlled analgesia (PCA) was determined for the opioid piritramide (a pure μ-receptor agonist) and the antipyretic analgesic metamizole (Dipyrone) in three groups of patients following abdominal surgery.
In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.
Ibuprofen and, to a minor extent, the other antipyretic analgesic drugs also diminished the stimulus induced flare reaction around the stimulated skin sites.