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基因     
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  gene
    Experimental studies on restenosis after angioplasty and myocardial ischemia by gene therapy of vascular endothelial growth factor
    血管成形术后再狭窄及心肌缺血应用hVEGF基因治疗的实验研究
短句来源
    Relationship between G_s a,Gβ_3 Gene Polymorphism and essential hypertension or response to Erbesartan
    Gsα和Gβ3基因多态性与原发性高血压及厄贝沙坦治疗反映的关系
短句来源
    Prevention of vein graft restenosis with widl-type P53 gene transfection and laser irradiation
    野生型P53基因转染和低能量激光照射防治移植静态再狭窄的实验研究
短句来源
    Cloning,Sequence Analysis,Expression Feature and Biological Function Prediction of a Nove1 Leukemia-associated Gene LRP16
    一个新的白血病相关基因—LRP16的克隆、序列分析、表达特征及其生物学功能推测
短句来源
    Adenovirus-mediated gene transfer of vascular endothelial growth factor B induces angiogenesis in chronic ischemic myocardium
    腺病毒介导血管内皮生长因子B基因转染慢性缺血心肌血管新生的研究
短句来源
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  genes
    Experimental Study of Co-expression of Double Genes for Preventing Arterial Restenosis
    双基因共表达预防血管再狭窄的实验研究
短句来源
    The Effects of GNB3 and eNOS Genes Polymorphism and Related Environmental Factors on Hypertension and Stroke
    GNB3、eNOS基因多态性和相关环境因素对高血压和脑卒中的影响
短句来源
    A Study on the Relationship of Polymorphism of ACE and ATIR Genes and Essential Hypertension
    血管紧张素转换酶基因多态性、血管紧张素Ⅱ受体-1基因多态性与原发性高血压关系的研究
短句来源
    Effects of NHE-1 Hammerhead Ribozyme on Apoptosis and Expression of Apoptosis-associated Genes in Pulmonary Artery Smooth Muscle Cells of Rats in Vitro
    Na~+/H~+交换器-1核酶对缺氧大鼠肺动脉平滑肌细胞凋亡及凋亡相关基因表达的影响
短句来源
    Expression Profiling of Calcium Channel Correlated Genes in Spontaneously Hypertensive Rats Using RNA Array
    自发性高血压大鼠钙离子通道相关基因表达谱的RNA阵列研究
短句来源
更多       
  genetic
    Genetic Relationship Study between Essential Hypertension and ACE Gene, AGT Gene in Tibetan Population
    藏族群体中原发性高血压与ACE,AGT基因的遗传相关性研究
短句来源
    Clinical And Genetic Diagnosis o β-Thalassemia ──Report of 8 cases in Yuxi Region,Yunnan
    玉溪地区8例β-地中海贫血的临床及基因诊断
短句来源
    Clinical and Genetic Analysis of β-mediterranean Anemia
    景洪地区6例β-地中海贫血的临床和基因分析
短句来源
    Genetic Analysis of Mouse T-cell Lymphomas after Longterm Passage in Syngeneic Mice
    小鼠T细胞淋巴瘤在同基因鼠内传代的遗传学分析
短句来源
    ALLELE TYPES AND GENETIC GENETIC ANALYSIS OF Rb p68RS2.0 LOCUS IN HAN POPULATION OF GUANGZHOU AND LEUKEMIA
    广州地区汉族人群和白血病患者Rb基因P68RS2.0区的遗传多态性
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更多       
  mdk
    PCR. The MDK promoter/enhancer (MDKp) sequence with runt domain binding sites was amplified from the human genome DNA and directionally cloned into pGL3-Basic Luciferase reporter vectors to construct the MDKp-pGL3-B expression plasmids.
    从基因组DNA中PCR扩增一段含Runt结合顺序的MDK基因启动子/增强子序列(MDKp),定向克隆到pGL3-Basic质粒,构建MDKp-pGL3-Basic Luciferase报告基因表达载体;
短句来源
    Objective: To explore the changes of gene express profile of the Kasumi-1 cell line which showed growth arrest, differentiation and apoptosis when treated by histone deacetylase inhibitor, phenylbutyrate (PB); and to determine the role of AMLl and AMLl-ETO fusion protein in MDK gene transcription.
    研究目的:探讨组蛋白脱乙酰基酶抑制剂苯丁酸钠诱导人类白血病细胞系Kasumi-1生长抑制、分化和凋亡的基因表达谱改变和AML1、AML1-ETO对MDK基因转录的调节作用。
短句来源

 

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      gene
    NEW TECHNOLOGY FOR DRUG DISCOVERY BASED UPON INSERTION OF LIGANDS INTO GENE SEQUENCES BY NUCLEAR RECEPTOR PROTEINS
          
    A gene regulatory mechanism has been proposed in which steroid hormones and certain other drugs bind to nuclear receptor proteins followed by transfer to DNA where they are inserted between base pairs.
          
    Polymerase chain reaction was used to amplify a 439-bp fragment of a 65,000-kDa (Mr) heat shock protein gene (hsp65) of Mycobacterium.
          
    Cloning of an APETALA3 homologous gene (PtAP3) from Populus tomentosa and genetic transformation of its sense and anti-sense con
          
    A pair of primers were designed according to published literature on Populus trichocarpa gene (PTD), and PtAP3, an AP3 homologous gene from Populus tomentosa was isolated by PCR using genomic DNA of the male clone of P.
          
    更多          
      genes
    Simultaneous introduction of multiple genes into plants is a critical step in plant genetic engineering to manipulate multiple functional genes in metabolic engineering and trait stacking.
          
    It is important to construct a bidirectional promoter for transforming two or more genes into plants simultaneously.
          
    The transient expression of the gusA and gfp genes were detected by histochemical staining for GUS and by fluorescence microscopy for GFP.
          
    At present, this procedure can be used to evaluate the genetic effect of individual major genes (up to two to three major genes), the collective genetic effect of polygene, and their heritability value.
          
    Molecular mapping of two semidwarf genes in an indica rice variety Aitaiyin3 (Oryza sativa L.)
          
    更多          
      genetic
    More particularly, Genetic Algorithms, Artificial Neural Networks and Fuzzy Logic methods seem to be the most promising tools to speed up and optimize the search for new leads and focused libraries.
          
    Herein we describe the 3D QSAR study of 4-anilinoquinoline-3-carbonitrile by Genetic Function Approximation (GFA) and Comparative Molecular Field Analysis (CoMFA).
          
    In this paper a hybrid algorithm which combines the pattern search method and the genetic algorithm for unconstrained optimization is presented.
          
    The algorithm is a deterministic pattern search algorithm, but in the search step of pattern search algorithm, the trial points are produced by a way like the genetic algorithm.
          
    Novel Quantum Genetic Algorithm and Its Applications
          
    更多          
      mdk
    Ziel dieser Studie war es, die H?ufigkeit von Empfehlungen für rehabilitative Ma?nahmen, die der Medizinische Dienst der Krankenversicherung (MDK) in den Pflegegutachten an die Pflegekasse ausspricht, und deren Umsetzung zu untersuchen.
          
    Aufgaben und Funktion des Medizinischen Dienstes der Krankenversicherung (MDK)
          
    Der Medizinische Dienst der Krankenversicherung (MDK) wirkt an der Seite der Gesetzlichen Krankenversicherung (GKV) als interessenunabh?ngiger sozialmedizinischer Beratungs- und Begutachtungsdienst an der Gestaltung des Gesundheitswesens mit.
          
    Die komplexen sozialmedizinischen Rahmenbedingungen und Grundlagen für die Arbeit des MDK werden mit Bezug auf aktuelle Themen in der Dermatologie dargestellt.
          
    Kritischer Kommentar zur "Arbeitshilfe für die Umsetzung der Vereinbarung über Psychiatrische Institutsambulanzen" des MDK-Kompe
          
    更多          


    15 cases of hemoglobin E ( HbE), including 12 cases of HbE-β-thal-assemia and 3 cases of HbE, were reported. Clinical, laboratorial and genetic studies revealed that HbE could be divided into two groups, HbE and HbE-β-thalassemia, the latter being further divided into two types according to HbE contents. HbE-β-thalassemias with HbE content above 45% showed severe clinical symptoms and laboratory findings, while that with HbE content below 45% not,the latter type being called HbE -β+-thalassemia. Ultrastruc-tural...

    15 cases of hemoglobin E ( HbE), including 12 cases of HbE-β-thal-assemia and 3 cases of HbE, were reported. Clinical, laboratorial and genetic studies revealed that HbE could be divided into two groups, HbE and HbE-β-thalassemia, the latter being further divided into two types according to HbE contents. HbE-β-thalassemias with HbE content above 45% showed severe clinical symptoms and laboratory findings, while that with HbE content below 45% not,the latter type being called HbE -β+-thalassemia. Ultrastruc-tural studies showed that erythroblasts in bone marrow were irregular inshape with electronic dense inclusion bodies and suggested intramedullary hemolysis. Investigation of family history revealed that this disease was autosomal codominant in mode of inheritance. Authors suggested that this HbE gene might be brought from Guangdong to Sichuan Province more than 300 years ago.

    在四川发现的15例HbE,根据临床表现、实验室检查及血红蛋白分析,将其分为两类,第一类是HbE复合β地中海贫血,第二类是HbE。前者又依HbE含量高于或低于45%,分为一、二型。一型中部分病例为HbE复合β°地中海贫血,二型属HbE复合β~+地中海贫血。在HbE复合β°地中海贫血骨髓中见到电子密度高的包涵体,而成熟红细胞中则无,这是原位溶血的依据。家系调查证实,此病属共显性遗传。该地此病的遗传基因,可能是300年前广东客家人移川时带入的。

    II s'agit d'une discussion sur les travaux de recherche dans lesquels nous avons évalué la fonction du système co-transport des globules rouges par la mesure de l'augmentation nette d'influx Na~+ (ΔNa), comme nous avons su que cette fonction est sensible stimulée par K~+ extracellulaire, mais non sensible à l'ouabaine.En étudiant les valeurs ΔNa du pedigree de 30 familles (144 personnes), nous trouvons: (1) en comparant ayes le coefficient d'héréd(?)té idéale de Mendal, il n'y a pas de différence statistique...

    II s'agit d'une discussion sur les travaux de recherche dans lesquels nous avons évalué la fonction du système co-transport des globules rouges par la mesure de l'augmentation nette d'influx Na~+ (ΔNa), comme nous avons su que cette fonction est sensible stimulée par K~+ extracellulaire, mais non sensible à l'ouabaine.En étudiant les valeurs ΔNa du pedigree de 30 familles (144 personnes), nous trouvons: (1) en comparant ayes le coefficient d'héréd(?)té idéale de Mendal, il n'y a pas de différence statistique nette sur les proportion de nombres d'anomalie entre les descendants ayant un parent anormal, deux parents anormaux et deux parents normaux; (2) l'anomalie de ΔNa se trouve à travers trois générations successives; (3) existence de deux pics sur la courbe de distribution de fréquence ΔNa montre l'existence de deux groupes de qualités différentes: (4) la statistique montre une relation intime entre les valeurs ΔNa des cas observés et le développement d'hypertension essentielle. Annsi, la thèse a pour conclusion que par la loi de dominance simple de Mendal, les défauts héréditaires du système co-transport cellulaire pourront avoir une relation intime avec l'hypertension essentielle. Il pouvra nous fourni d'information importante sur la prédiction, prévention, classification génétique, diagnostic differentiel etc.

    本文以细胞外K~+刺激、哇巴因不敏感的Na~+内向净增流量(△Na)估计红细胞协同转运功能,通过对30个家系、144人作谱系调查发现:①双亲中一方、双方异常的家系子代△Na异常率与盂德尔理想遗传比值间无显著统计学差异;②在家系的连续三代人中均见有△Na异常者;③△Na频数分布曲线呈现双峰,提示存在两个不同“质”的群体;④受测者△Na值与原发性高血压的发生间经统计学测验关系十分密切。我们认为,按盂德尔显性单基因遗传规律传递的细胞膜协同转运功能缺陷与原发性高血压密切有关。它对预报、预防、遗传分型及鉴别诊断等可能有重要启示。

    With restriction endonuclease mapping and blot hybridization methods, arrangements of a-globin genes in 21 patients with hemoglobin H disease in Guangdong Province were determined. Results showed that 10 cases were compounds of nondeletion gene and a-thal 1 gene (ααT/--); 1 case was a homozygote of nondeletion genes (ααT/ααT); 6 cases were compounds of rightward deletion α-thal 2 gene and a-thal 1 gene (-α/--); 4 cases were compounds of leftward deletion a-thal 2 gene and a-thal 1 gene (-α/--).

    以限制性内切酶及印迹杂交技术,用α-珠蛋白基因探针分析广东地区21例HbH病病人的α-珠蛋白基因在染色体上的排列,结果10例为非缺失型与α-地贫1的双重杂合子,1例为非缺失型纯合子,6例为右侧缺失型α-地贫2与α-地贫1双重杂合子,4例为左侧缺失型α-地贫2与α-地贫1双重杂合子。

     
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