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中晚期胰腺癌
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  advanced pancreatic cancer
     Chemotherapy is one of the most important adjuvant treatments, especially for the advanced pancreatic cancer, the comprehensive therapies based on chemotherapy are one of the most interesting research fields.
     化疗是治疗胰腺癌的重要手段,尤其对于中晚期胰腺癌,以化疗为主的综合治疗是目前研究的重点,但多药耐药现象的存在严重阻碍了化疗药物的应用。
短句来源
     CLINICAL ANALYSIS OF INTRAOPERATIVE RADIOTHERAPY ON THE ADVANCED PANCREATIC CANCER
     中晚期胰腺癌术中放射治疗的临床分析
短句来源
     Methods 36 cases of advanced pancreatic cancer were divided into two groups,16 cases were treated with Trans-port-catheter system arterial infusion chemotherapy (group B),other 20 cases were treated with systemic chemotherapy (group A).
     方法  36例中晚期胰腺癌患者分为 2组 ,16例行经PCS区域动脉灌注化疗 (B组 ) ,另 2 0例行外周静脉全身化疗 (A组 )。
短句来源
     Meta-Analysis on Comparative Study of Curative Effect Between Interventional Therapy and Conventional Systemic Venous Chemotherapy in Moderate and Advanced Pancreatic Cancer
     中晚期胰腺癌介入治疗与外周静脉化疗疗效比较的META分析
短句来源
     Methods A total of 52 patients with local advanced pancreatic cancer treated between January 1992 and January 1996 were included in this evaluation. Treatment was either infusion chemotherapy plus concurrent radiotherapy (23cases) or pure radiotherapy (29cases).
     方法92年1月至96年1月收治52例中晚期胰腺癌,23例行动脉灌注化疗并同期放疗(综合组),29例行单纯放疗(单放组)。
短句来源
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  middle advanced pancreatic cancer
     Effect of Qi Replenishing and Blood Circulation Activating Drugs in Treatment of Middle Advanced Pancreatic Cancer with Radio and Chemotherapy
     益气活血中药在中晚期胰腺癌放化疗中的作用
短句来源
  advanced pancreatic carcinoma
     Objective To retrospectively analyze the effectiveness of transarterial infusion chemotherapy of gemcitabine and 5-fluorouracil for management of advanced pancreatic carcinoma.
     目的回顾性分析经动脉灌注国产盐酸吉西它滨(Gemcitabine hydrochloride,商品名泽菲)和5-氟尿嘧啶(5-fluorouracil,5-Fu)治疗中晚期胰腺癌临床疗效。
短句来源
     Methods Gemcitabine and 5-fluorouracil was administered to 20 patients with advanced pancreatic carcinoma via an interarterial catheter.
     方法20例中晚期胰腺癌患者接受动脉灌注泽菲和5-Fu化疗。
短句来源
     Methods:Gemeitabine was administered to 38 patients with advanced pancreatic carcinoma via interarterial catheter.
     方法 :38例中晚期胰腺癌患者接受动脉灌注健择治疗 ,其中 2 8例曾行胆道支架置入术。
短句来源
     Analysis of Survival Factors of Advanced Pancreatic Carcinoma by Cox Proportional Hazard Model
     影响中晚期胰腺癌预后因素的Cox回归分析
短句来源
     Methods Of 51 advanced pancreatic carcinoma patients, 25 received gemcitabine combined with 5-fluorouracil via transarterial continuous infusion chemotherapy (group A).
     方法51例中晚期胰腺癌,其中25例采用经动脉持续灌注吉西他滨和5-Fu方案,26例采用经外周静脉灌注吉西他滨和5-Fu方案。
短句来源
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  “中晚期胰腺癌”译为未确定词的双语例句
     CLINICAL ANALYSIS OF ~(125)I IMPLANTS ON 23 PATIENTS WITH UNRESECTABLE PANCREATIC CARCINOMA
     ~(125)Ⅰ放射粒子治疗中晚期胰腺癌23例临床分析
短句来源
     Methods between April 2002 and April 2004,23 pancreatic cancer patients with middle or terminal stage were treated by 3 3-dimensional conformal radiotherapy with high dose and low fraction,third weekly,3.5 GY~4.5 GY perfection?
     方法:2002年4月,对23例不能手术的中晚期胰腺癌患者三维适形放疗,采用高剂量低分割的方法。 每周3次,3.5 GY~4.5 GY,肿瘤总剂量55 GY~65GY。
短句来源
     Tree-Dimensional Conformal Radiotherapy for Advanced with Pancreatic Cancer in 23 Patients
     三维适形放射治疗中晚期胰腺癌23例近期疗效观察
短句来源
     Results The results showed that the 95% confidence interval of integrated RD of survival rated for 1 year and clinical benefit response(CBR) on the curative effect between interventional therapy and conventional systemic venous chemotherapy were 0.0168 and 0.1834 ,0.2325 and 0.4367 respectively,all of which excluded zero.
     结果 中晚期胰腺癌介入治疗与外周静脉化疗对比研究的 1年生存率和临床受益率合并率差的 95 %可信区间分别为 0 .0 168,0 .183 4和 0 .2 3 2 5 ,0 .43 67,均不包括“0”。
短句来源
     Conclusion There were significant differences (Ρ<0.05)in the survival rate of 1 year and clinical benefit response(CBR) between interventional therapy and conventional systemic venous chemotherapy for modemte and advanced pancreatic cancers.
     结论 中晚期胰腺癌介入治疗与外周静脉化疗 1年生存率和临床受益率之间的差异具有显著性 (Ρ <0 .0 5 ) ,即介入治疗较外周静脉化疗更能提高中晚期胰腺癌的 1年生存率和临床受益率
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  advanced pancreatic cancer
Concurrent Chemoradiotherapy for Advanced Pancreatic Cancer
      
This study presents the results of intraoperative NCPB in 29 patients with advanced pancreatic cancer, 5 of whom had no pain preoperatively.
      
Intraoperative NCPB is a safe, easy procedure which can provide long lasting pain control in most patients with advanced pancreatic cancer.
      
Comparative study of gemcitabine plus cisplatin and gemcitabine plus fluorouracil in the treatment of advanced pancreatic cancer
      
Therapeutic evaluation on advanced pancreatic cancer Treated by Integrative Chinese and western medicine - Clinical analysis of
      
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  advanced pancreatic carcinoma
Maintenance Chemotherapy after Chemoradiation Improves Survival of Patients with Locally Advanced Pancreatic Carcinoma
      
Treatment of advanced pancreatic carcinoma with a combination of protracted infusional 5-fluorouracil and weekly carboplatin: A
      
Phase II trial of uracil/tegafur (UFT) plus leucovorin in patients with advanced pancreatic carcinoma: A University of Chicago p
      
Based on these encouraging preclinical results we initiated a phase II clinical trial in which patients with advanced pancreatic carcinoma were treated with retinoic acid in combination with interferon-α.
      
In summary, these studies suggest that retinoids might be beneficial in the treatment of advanced pancreatic carcinoma patients based on their pleiotropic effects on tumor cell biology.
      
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In this paper the experimental study and clinical preliminary observation of chemosensitivity test on 5 cases of pancreatic carcinoma in vitro are reported. The major drug of clinical treatment of pancreatic carcinoma was 5-FU. The results showed only two cases had good correlativity. The results of chemosensitivity test showed that drug sensitivity inten- sity was ordinally 5-FU, MMC, ADR and TSPA. A close correlation between clinical chemotherapy treatment and chemosensitivity test in vitro was found in 4...

In this paper the experimental study and clinical preliminary observation of chemosensitivity test on 5 cases of pancreatic carcinoma in vitro are reported. The major drug of clinical treatment of pancreatic carcinoma was 5-FU. The results showed only two cases had good correlativity. The results of chemosensitivity test showed that drug sensitivity inten- sity was ordinally 5-FU, MMC, ADR and TSPA. A close correlation between clinical chemotherapy treatment and chemosensitivity test in vitro was found in 4 patients out of 5. The survival time was over one year and the clinical response rate was 80%. This method could help select drug for clinical treatment and specify the application of the drug, which will surely improve the survival rate.

本文对5例胰腺癌患者的自身肿瘤组织行体外化疗药物敏感性检测,分析其实验结果与临床药物治疗的相关性。本文药敏预测提示,仅2例对氟脲嘧啶显示出很好的相关性。其余3例相关性较差。其敏感药依次是丝裂霉素、阿霉素、噻替哌。在药敏指导下化疗半年后随访,5例患者中有4例药物测定结果与临床效果一致,均已存活1年以上,治疗有效率达80%。作者认为:尤其对中晚期胰腺癌患者,在药敏指导下化疗可提高生存率。

Abstract A retrospective study of 75 patients proven pancreatic carcinoma was made. Comparing the CT findings with surgical operated results was done. The sensetivity and specificity of CT were 97. 3 % and 84%, respctively. 12 patients were resectable. The author opinions: (1) or scan is a important method in diagnosis of pancreatic carcinoma,but early pan Panareatic c ̄rna is difficult tO detect with CT: (2 ) Percutaneous biopey or la ̄omy is n ̄ for the patient with non Speckic CT findings; (3) Althouth there...

Abstract A retrospective study of 75 patients proven pancreatic carcinoma was made. Comparing the CT findings with surgical operated results was done. The sensetivity and specificity of CT were 97. 3 % and 84%, respctively. 12 patients were resectable. The author opinions: (1) or scan is a important method in diagnosis of pancreatic carcinoma,but early pan Panareatic c ̄rna is difficult tO detect with CT: (2 ) Percutaneous biopey or la ̄omy is n ̄ for the patient with non Speckic CT findings; (3) Althouth there were false-negative,CT contrast scan is helful for assessing resectability of pancre atic carcinoma.

总结我院经CT检查和手术病理证实的75例胰腺癌。对照CT表现和手术结果,CT阳性率97.3%(73/75),定性诊断84%(63/75),误诊4.5%(3/75),不典型表现9.3%(7/75)。75例中手术完全切除肿溜12例(16%),姑息切除4例。笔者认为:(1)CT是诊断中晚期胰腺癌的重要手段,但早期诊断仍然困难;(2)对CT表现不典型的病变需经皮穿刺活检或手术确诊;(3)CT增强扫描对胰腺癌可否手术切除的估价有重要的参考价值,但应注意假阴性存在。

Objective To analyze the treatment results of un resectable local pancreatic cancer by arterial infusion chemotherapy plus concurrent radiotherapy or radiotherapy alone.Methods A total of 50 patients with local advanced pancreatic cancer from January 1992 through October 1995 were treated either by arterial infusion chemotherapy (C) plus concurrent radiotherapy (R) (22 cases) or by radiotherapy alone (28 cases). Radiation given was the same in the two groups of patients (50~60 Gy in 5 to 6 weeks, 1.8~2 Gy/Fx,5...

Objective To analyze the treatment results of un resectable local pancreatic cancer by arterial infusion chemotherapy plus concurrent radiotherapy or radiotherapy alone.Methods A total of 50 patients with local advanced pancreatic cancer from January 1992 through October 1995 were treated either by arterial infusion chemotherapy (C) plus concurrent radiotherapy (R) (22 cases) or by radiotherapy alone (28 cases). Radiation given was the same in the two groups of patients (50~60 Gy in 5 to 6 weeks, 1.8~2 Gy/Fx,5 Fx/wk). Infusion chemotherapy was performed once every 4 weeks, consisting of 5 fluorouracil 1.0 g, mitomycin C 10 mg, cisplatin 60 mg. An average of 2.3 cycles was given to each patient.Results Although the remission rate of jaundice and pain did not show significant difference between the two groups, patients in C+R treatment group had longer period of symptomatic remission ( P <0.05). The response rate (CR+PR) was 68.2% in C+R treatment group and 35.7% in R treatment group, respectively. The 1 , 2 , and 3 year survival rate was 75.3%, 36.8%, 25.4% in C+R treatment group, and 51.3%, 22.6%, 8.7% in R treatment group, respectively.Conclusion Arterial infusion chemotherapy combined with concurrent radiotherapy is a treatment of choice for patients with local unresectable cancer of the pancreas.

目的 分析中晚期胰腺癌动脉灌注化疗并同期放疗与单纯放疗的疗效。方法 对1992 年1 月至1995 年10 月行动脉灌注化疗并同期放疗( 综合组) 的22 例和单纯放疗( 单放组) 的28例中晚期胰腺癌的疗效进行比较分析,两组临床资料具可比性。单放组每周照5 次,每次DT1-8 ~2-0Gy,总量50~60 Gy5~6-7 周;综合组动脉灌注化疗,每次5Fu1.0 g、MMC10 mg、DDP60 mg,每4 周一次,平均2-3 次人,同期放疗方案同单放组。结果 腹痛、黄疸的症状缓解率两组之间差异无显著性,但单纯放疗组黄疸改善时间较短(P< 0-05) ;有效率(CR+ PR)综合组为68-2% ,单放组为35-7% ;1 ,2,3 年生存率综合组和单放组分别为75-3 % 、36-8% 、25-4% 和51-3% 、22-6% 、8-7 % ,综合组明显好于单放组。结论 对不能手术切除的中晚期胰腺癌,行动脉灌注化疗并同期放疗较单纯放疗能获得较高的生存率

 
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