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卵巢癌
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  ovarian cancer
    Nonlinear pharmacokinetics of paclitaxel in ovarian cancer patients
    紫杉醇在卵巢癌化疗病人中的非线性药物动力学(英文)
短句来源
    Objectives: (1) To investigate the effects of raloxifene on the growth of Human breast cancer cell lines MCF-7, MDA-MB-231, human normal breast epithelial cell line HBLIOO and human ovarian cancer cell line SKOV3;
    研究雷洛昔芬(raloxifene,RLX)在体外对人乳腺癌细胞株MDA-MB-231、MCF-7、人乳腺癌细胞株HBL100以及卵巢癌细胞株SKOV3生长的影响,探讨可能的机理。
短句来源
    Methods: JAR cellular line of choriocarcinoma and SKOV3 and 3AO cellular lines of ovarian cancer were treated with ubenimex at different concentrations(0.5 g/L,1 g/L,5 g/L,10 g/L,15 g/L,20 g/L), and the growth inhibition was analyzed by MTT assay. The changes of DNA structure were observed under fluorescence microscope with the fluorescence staining of ethidium bromide.
    方法:应用MTT比色法观察不同浓度的乌苯美司(0.5g/L、1g/L、5g/L、10g/L、15g/L、20g/L)对人绒毛膜癌JAR细胞、卵巢癌3AO细胞和SK-OV3细胞的生长抑制作用,溴乙啶和丫啶橙荧光染色荧光显微镜观察凋亡细胞DNA结构改变。
短句来源
    Study on Folate Receptor-mediated Mitoxantrone Albumin Nanoparticles Drug Delivery System Targeting for Ovarian Cancer Cell
    叶酸受体介导的米托蒽醌白蛋白纳米粒靶向卵巢癌细胞给药系统的研究
短句来源
    The effects of raloxifene on the growth of HBL100 was studied by MTT assay and inverted microscopy. Part three: Compared with tamoxifen, 17β- E_2 and progesterone, the effects of raloxifene on human ovarian cancer cell line SKOV3 were studied by MTT assay.
    第三部分:MTT法了解雷洛昔芬对人卵巢癌细胞株SKOV3生长情况的影响,免疫组化法了解雷洛昔芬对Ki-67表达的影响,并与他莫西芬、17 β-雌二醇和孕酮进行了比较。
短句来源
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  ovarian carcinoma
    All compounds prepared in this study were tested for their cytotoxicity against PC-3 (prostate cancer), A549 (lung cancer), HO-8910 (ovarian carcinoma), Hela (cervical carcinoma) and 4 leukemic cell lines (HL60, K562, P388 and resistant HL60).
    分别选取人前列腺癌细胞PC-3,人肺癌细胞A549,人卵巢癌细胞HO-8910,人宫颈癌Hela细胞,人白血病细胞HL60、K562以及鼠P388淋巴白血病细胞对所合成的化合物进行了抗肿瘤生物活性体外筛选试验,MTT法测试其IC_(50)。
短句来源
    Conclusion: The recombinant fusion protein 183B 2ScFvPE38 keeps the activity of both components and may be of great use in the future to deal with ovarian carcinoma.
    结论 :抗卵巢癌单链免疫毒素 183B2 ScFvPE38具有良好的免疫学活性及生物学活性 ,可能有良好的应用前景
短句来源
    Methods The in vitro cytotoxic effect of Plain-L and PEG-L against ovarian carcinoma A2780 and human colon carcinoma HCT-8 cells were studied by MTT assay method.
    方法采用噻唑蓝(MTT)比色法测定Plain L与PEG L对人卵巢癌细胞A2780和人结肠直肠癌细胞HCT 8的抑制作用;
短句来源
    Vector construction and high level expression of single chain immunotoxin against ovarian carcinoma
    抗卵巢癌单链免疫毒素的载体构建及高效表达
短句来源
    It is concluded that the traditional Chinese medicine Gusongbao might increase the immunologic function, regulate calcium phosphorus metabolism, maintain bone density and improve osteoporosis can be used in therapy and prevention of osteoporosis and is especially suitable for ovarian carcinoma, carcinoma of endometrium and mammary cancer, in which administration of should be cautious or contraindicated.
    结果指出,中药骨松宝可提高免疫功能,调节钙磷代谢,保持骨质密度,改善骨质疏松程度,可用于治疗和预防骨质疏松,尤其对雌激素禁忌或慎用者(卵巢癌和子宫内膜腺癌、乳腺癌)更为理想
短句来源
  ovary cancer
    of ovary cancer treated with the drug alone was 2/2 and together with cisplatin was 38.1%(8/21);
    卵巢癌单药治疗2/2有效,与顺铂联合应用的有效率为38.1%(8/21);
短句来源
    CONCLUSION:The efficacy of Anzatax in treatment of advanced breast and ovary cancer are confirmed and its effect in treatment of NSCLC need to be further observed.
    结论:安素泰对晚期卵巢癌、乳腺癌疗效肯定,对NSCLC的疗效有待进一步确定。
短句来源
  “卵巢癌”译为未确定词的双语例句
    ESTABLISHMENT OF ADRIAMYCIN-RESISTANT HUMAN OVARIANCARCINOMA CELL
    人卵巢癌细胞阿霉素耐药株的建立及其耐药机制的探讨
短句来源
    Method plasma concentrations of 125I-Folate-PGA were investigated in BALB/c mice, single-photon-emmission computed tomography (SPECT) and quantitative biodistribution studies was performed compared with that of 125I-PGA in SKOV3 tumor-bearing BALB/c mice.
    方法:采用125I标记法和TCA沉淀法研究Folate-PGA偶联酶在BALB/c小鼠的药代动力学性质; 以人卵巢癌SKOV3裸鼠为模型进行125I-Folate-PGA的生物分布研究和SPECT显像。
    Objective: To construct an expression vector for co_expression of single chain Fv antibody (OC183B 2) and peudomonas exotoxin(PE38).
    目的 :构建抗卵巢癌单链抗体 183B2 ScFv与假单孢外毒素 (peudononasexotoxin ,PE38)的融合蛋白表达载体并制备抗人卵巢癌单链免疫毒素蛋白 183B2 ScFvPE38,为卵巢癌导向治疗打下基础。
短句来源
    Methods The in vitro anti angiogenic effect of artesunate was tested on models of angiogenesis: proliferation, migration and tube formation of human umbilical vein endothelial (HUVE) cells;
    方法 用人脐静脉内皮细胞 (HUVEC)的生长、迁移及小管形成实验研究药物的体外抗血管生成作用 ; 用人卵巢癌裸鼠移植瘤模型和免疫组化法研究药物的体内抗血管生成作用。
短句来源
    Methods: The recombinant vectors carrying hTERT promoter and HSV tk gene was constructed and transfected into SKOV3 cells.
    方法 :将hTERT启动子调控的HSV tk基因重组逆转录病毒载体成功转染人卵巢癌SKOV3细胞 (SKOV3/tk细胞 ) ,用MTT法观察SKOV3/tk细胞对GCV、TPT的敏感性 ;
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  ovarian cancer
Of them, α-1-acid glycoprotein and clusterin are expressly down-regulated in breast cancer, whereas transthyretin is decreased specifically in ovarian cancer.
      
BRCA1 mutations are associated with a higher risk of breast (BC) and ovarian cancer in women.
      
Biochip analysis of BRCA1/2 and CHEK2 common mutations in ovarian cancer and primary multiple tumors involving the ovaries (Russ
      
Ovarian cancer (OC) is among the leading causes of cancer-related mortality in women.
      
The RA538 cDNA was transferred into human ovarian cancer cell line SK-OV-3 and human melanoma cell line WM-983A by its recombinant adenoviral vector constructed through homologous recombination.
      
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  ovarian carcinoma
Semiquantitative RT-PCR revealed elevated transcription of RHOA in tumors (45 cases of breast cancer, renal cell carcinoma, and epithelial ovarian carcinoma; p >amp;lt; 10-4).
      
20,29-Dihydro-20,29-dichloromethylenebetulinic acid proved to be the most cytotoxic toward human melanoma of the Colo 38 and Bro lines and human ovarian carcinoma of the CaOv line (IC50 10 μM).
      
Expression of the human fast-twitch skeletal muscle troponin I cDNA in a human ovarian carcinoma suppresses tumor growth
      
To explore the efficiency and mechanism of ovarian carcinoma gene therapy with the human fast-twitch skeletal muscle troponin I gene (Tnl-fast), Tnl-fast cDNA was transferred into human ovarian adenocarcinoma cell-line SK-OV-3.
      
Our study, to our knowledge, shows the slowed down growth of the primary ovarian carcinoma, suggested that grafts were self-inhibitory by halting angiogenesis.
      
更多          
  ovary cancer
Growth-inhibitory effects of curcumin on ovary cancer cells and its mechanisms
      
It was concluded that curcumin could significantly inhibit the growth of ovary cancer cells.
      
Exogenous CAR expression had a potential role in inhibiting the malignant metastasis phenotype of ovary cancer cells.
      
To explore the role and possible mechanism of apoptosis and caspase-3 activity in the development of multicellular drug resistance of ovary cancer.
      
Cases were 254 patients with histologically confirmed epithelial ovary cancer.
      
更多          


Ungeremine (Ⅱ, AT-1840), an alkaloid from Ungernia minor, was partially synthesized from lycorine. It was shown to possess marked inhibitory action against EAC, P-388, L-1210, Lewis lung carcinoma and Yoshida ascites sarcoma. Some related compounds (Ⅳ~ⅩⅣ) were prepared and screened on EAC in mice to study the SAR. It seems that the presence of phenolic betaine in the molecule of Ⅱ bears some relationship to its antitumour acitivity. From this point of view, 9-demethylberberine and 9-demethytpalmatine (ⅫⅠ and...

Ungeremine (Ⅱ, AT-1840), an alkaloid from Ungernia minor, was partially synthesized from lycorine. It was shown to possess marked inhibitory action against EAC, P-388, L-1210, Lewis lung carcinoma and Yoshida ascites sarcoma. Some related compounds (Ⅳ~ⅩⅣ) were prepared and screened on EAC in mice to study the SAR. It seems that the presence of phenolic betaine in the molecule of Ⅱ bears some relationship to its antitumour acitivity. From this point of view, 9-demethylberberine and 9-demethytpalmatine (ⅫⅠ and ⅩⅣ), two betaine type compounds, were thus prepared from antitumour inactive berberine and palmatine. The screening results supported the above betaine hypothesis.Ungeremine had been tried on 464 patients with various types of advanced neoplastic diseases. Preliminary data showed that it could improve the general conditions and relieve pain. In 15.7% cases the tumour mass was reduced markedly to less than half of their original volumes. No serious side effect was observed.

恩其明(ungeremine,Ⅱ,AT-1840)对小鼠艾氏腹水癌,L_(1210)、P_(388)、Lewis肺癌以及大鼠吉田肉瘤腹水型有明显抑制作用。为了研究其构效关系合成了有关化合物Ⅳ~ⅩⅣ。 Ⅱ_a已推荐临床试用,经464例各种中晚期肿瘤患者的J临床观察,有效率(肿瘤缩小1/2以上)为15.7%,对卵巢癌、胃癌等肿瘤有一定疗效,且副反应低,对血象、心、肝、肾等主要脏器均无明显影响。

Lycobetaine (AT-1840),developed by Chinese medicinal chemists,is a new structure type of anticancer agent without obvious toxicity and side-effects,and the therapeutic effect is good in treatment of ovarial cancer and gastric cancer.The anti-cancer effects of open-ring analogs 2 of Lycobetaine were found in our previous studies.In this study,analog 2 was used as a guide compound,and some open-ring analogs of lyco- betaine were designed and synthesized in order to study their anticancer antivity and the metabolism...

Lycobetaine (AT-1840),developed by Chinese medicinal chemists,is a new structure type of anticancer agent without obvious toxicity and side-effects,and the therapeutic effect is good in treatment of ovarial cancer and gastric cancer.The anti-cancer effects of open-ring analogs 2 of Lycobetaine were found in our previous studies.In this study,analog 2 was used as a guide compound,and some open-ring analogs of lyco- betaine were designed and synthesized in order to study their anticancer antivity and the metabolism in organic tissue.There were no obvious anticancer effects when the compounds 6a and 6b were screened against tumor in mice bearing EAC.

石蒜内铵(lycobetaine,AT—1840)是我国学者首先发现的新结构类型的抗肿瘤药物,对卵巢癌、中晚期胃癌有较好的疗效。石蒜内铵开环类似物Ⅱ具有明显的抗癌作用。本文工作是以化合物Ⅱ做为导向化合物,进一步设计合成了一些类似化合物。以期用以寻找结构简单、作用更强的抗肿瘤物质,为进行这类化合物的抗癌机理研究,并对其在生物组织中的代谢活性研究等提供有意义的化合物。

Eleven patients with malignant tumor testified by pathologywere given with HD-DDP IP and STS (sodium thiosulfate). Among them 7patients were ovarian cancer, 1 Krukenberg tumor, 1 mesothelioma, 1 bigspread mass in postperitoneum of embryo carcinoma of testis and 1 undiffe-renteated carcinoma. This group of patients were treated total 32 courses.The highest dose was 280mg/m~2. Hydration and manmital were given beforeand after DDP treatment. Nephrotoxicity exhibited serum creatine slightincrease temorarily. When...

Eleven patients with malignant tumor testified by pathologywere given with HD-DDP IP and STS (sodium thiosulfate). Among them 7patients were ovarian cancer, 1 Krukenberg tumor, 1 mesothelioma, 1 bigspread mass in postperitoneum of embryo carcinoma of testis and 1 undiffe-renteated carcinoma. This group of patients were treated total 32 courses.The highest dose was 280mg/m~2. Hydration and manmital were given beforeand after DDP treatment. Nephrotoxicity exhibited serum creatine slightincrease temorarily. When STS was given as the protective agent the crea-tine level did not show increase obviously, even the dosage of DDP reach280mg/m~2. No one showed renal damage in all cases. Marrow toxicity showed that white blood cells decreased temporarily, but no one ceasedtreatment because of leukopenia, Efficiency: 8 of evaluable patients, 7 had part response (PR), givingresponse rate 87. 5% (7/8). Pharmacokinetic study showed that the concentration changes of totalPt in peritoneal cavity has a feature of the first order elimination kinetics,as the linal modal of the first compartment. The results of pharmacokine-tic datum in plasma and peritoneal cavity exhibited: 1. The area underthe curve of total Pt in peritoneal cavity was 4 times larger than that inplasma. 2. The area under the curve of total Pt in peritoneal cavity inc-reased with a higher DDP dosage, but it was not influenced by the use ofSTS. 3. Peak level in the peritoneal was 22 times higher than in plasma.

本文采用大剂量顺铂(DDP)腹腔灌注加静脉给硫代硫酸钠(STS)解毒的“双路”,化疗,治疗11例经病理证实的恶性肿瘤患者,其中:卵巢癌7例,Krukenbers’s瘤、腹膜间皮瘤、睾丸胚胎癌腹腔内及肝转移、腹腔低分化癌各一例,共32疗程,最大剂量为280mg/m~2,灌注前后水化及用甘露醇利尿。结果:3例无可测病灶,8例可做疗效评定,其中7例PR,有效率为87.5%(7/8)。血清肌酐一过性轻度增高,用STS时,未见明显增高,剂量达280mg/m~2也未发生肾损害。骨髓毒性表现暂时性白细胞下降,但均未因白细胞减少而停止治疗。血及腹腔药物浓度测定结果:腹腔总铂浓度的变化符合一级动力学特征,为线性一房室模型。全部药动学参数结果为:1.腹腔DDP曲线下面积比血浆大4倍。2.腹腔DDP曲线下面积随DDP剂量增加而增加,并不受加用STS影响。3.腹腔峰浓度比血浆高22倍。肿瘤局部给大剂量抗癌药物,全身给该药物的解救剂称“双路”化治疗。

 
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