Objective To investigate the expression of heme oxygenase-1 and heat shock protein (HSP) 70 in renal allograft of acute rejection in rats, to provide a theoretical base in the diagnosis and treatment of acute renal rejection, to help us explore new immunodepressives and induce immune tolerance.
Objective To establish the three-plasmid packaging cell line of the recombinant lentiviral vector encoding rat FasL gene for eukaryotic expression to meet the requisition for deep study on the effect of FasL transgene on inducing immune tolerance and protecting allografts in organic transplantation.
Conclusion Tα146-162-iMDC can ameliorate established EAMG significantly. Tα146-162-iMDC induces immune tolerance probably by antigenic specific suppression of lymphocyte proliferation and production of IFN-γ and IL-6. TGF-β does not play an important role in the tolerance induction.
The adjunct effect of cyclophosphamide on tolerance induction was observed. Results After intranasal administration of retinal S antigens, EAU was induced in two of eight(25%) rats in tolerant group, sis of six(100%) rats in control group , the difference of EAU induction rate was significant in tolerant group compared with control (P=0.0097).
Induction of immune tolerance with heart-thymus composite allotransplantation in rats
Effective induction of immune tolerance by portal venous infusion with IL-10 gene-modified immature dendritic cells leading to p
It concluded that immune tolerance to porcine cardiac myosin could be induced by anti-CD4 monoclonal antibody in vivo, and cardiac dysfunction and myocardial injury could be prevented by induction of immune tolerance.
An intensive inpatient program of induction of immune tolerance is used in Sweden.
Experimental verification of our findings may provide novel evidence of induction of immune tolerance in tumors.
The human gut offers more than 200 m2 of mucosal surface, where direct interactions between the immune system and foreign antigens take place to eliminate pathogens or induce immune tolerance toward food antigens or normal gut flora.
It has been shown that immature DC can induce immune tolerance and prolong allograft survival.
These results suggest that portal venous infusion may be an effective approach for immature DC to induce immune tolerance or hyporesponsiveness against donor antigens, and prolong allograft survival.
In the present study we investigated whether prior gene transfer to the retina, which is suspected to induce immune tolerance, could alleviate the immune response occurring after retrovirus mediated gene transfer to the liver.
We conclude that although the retina behaves as an immunoprivileged site, gene expression in the subretinal space is not sufficient to induce immune tolerance to a transgene product expressed in the liver.
Additionally, we highlight the potential importance of different routes of allergic sensitization and the role of oral tolerance induction in the pathogenesis and prevention of food allergy.
This review focuses on recent advances in tolerance induction in experimental animal models and discusses their relevance to the development of protocols for the induction and maintenance of clinical transplant tolerance.
Here, we explore the prospect of using hESCs and their derivatives for immunomodulation and tolerance induction.
Self-tolerance induction is largely a reflection of negative selection (deletion) of autoreactive T cells in the thymus.
Tolerance induction for solid organ grafts with donor-derived hematopoietic reconstitution