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诱导免疫耐受     
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  induction of immune tolerance
     Role of 15d-PGJ_2 in the Prevention of Rejection and the Induction of Immune Tolerance of Orthotopic Liver Transplantation in Rats
     15d-PGJ_2在大鼠肝移植抗排斥和诱导免疫耐受中的作用研究
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     New Breakthrough In Research of Dendritic Cells——induction of immune tolerance
     树突状细胞研究新突破——诱导免疫耐受
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     objective To study the role of CTLA4 Ig in the induction of immune tolerance in mice heart transplantation.
     目的 通过建立小鼠心脏移植模型 ,探讨CTLA4Ig在免疫抑制和诱导免疫耐受中的作用。
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     Application of CTLA4-Ig in the Prevention of Rejection and the Induction of Immune Tolerance of Orthotopic Liver Transplantation in Rats
     大鼠肝移植急性排斥模型的建立及CTLA4-Ig抗排斥和诱导免疫耐受的实验研究
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     Objective To explore the effect of allogeneic intra-bone marrow bone marrow transplantation(IBM-BMT) on the induction of immune tolerance.
     目的探讨异基因小鼠髓腔内骨髓移植(IBM-BMT)诱导免疫耐受的效果。
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  induce immune tolerance
     Conclusion CTLA4Ig can inhibit T cell proliferation and IL-2 excretion. Combination of CTLA4Ig and CsA can completely inhibit T cell proliferation and IL-2 excretion but can induce immune tolerance.
     结论CTLA4Ig能抑制淋巴细胞的增殖和IL-2的分泌释放,CTLA4Ig和CsA联合应用能更彻底抑制淋巴细胞增殖和IL-2的分泌释放,并诱导免疫耐受;
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     ② CTLA4-Ig treatment can Prevent rejection and induce immune tolerance in ROLT model with characters of acute rejection;
     结论CTLA4-Ig有抗排斥反应及诱导免疫耐受功能的作用;
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     ConclusionGZD could enhance the immune function in inte stinal mucosa in mice with Bi syndrome,thus it might induce immune tolerance an d immune inhibition.
     结论桂枝汤可以增强痹证小鼠肠道黏膜免疫功能 ,从而可能诱导免疫耐受和免疫抑制。
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     Objective To investigate the expression of heme oxygenase-1 and heat shock protein (HSP) 70 in renal allograft of acute rejection in rats, to provide a theoretical base in the diagnosis and treatment of acute renal rejection, to help us explore new immunodepressives and induce immune tolerance.
     目的 探讨血红素加氧酶-1(H0-1)和热休克蛋白70(HSP70)在大鼠肾移植急性排斥反应中的表达及意义,为急性排斥反应的早期诊断和治疗提供理论基础,同时也对新型免疫抑制剂的开发以及诱导免疫耐受提供一个新思路。
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     Conclusion Human bone marrow mesenchymal stem cells inhibit maturation and function of monocyte-derived dendritic cells and induce immune tolerance.
     结论骨髓间充质干细胞上清可抑制单核细胞来源的树突状细胞的成熟和功能,诱导免疫耐受
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  inducing immune tolerance
     An experimental study on CD40 and CTLA4 simulating peptides inducing immune tolerance
     CD40及CTLA4模拟小分子肽诱导免疫耐受的实验研究
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     Objective To establish the three-plasmid packaging cell line of the recombinant lentiviral vector encoding rat FasL gene for eukaryotic expression to meet the requisition for deep study on the effect of FasL transgene on inducing immune tolerance and protecting allografts in organic transplantation.
     目的建立真核细胞表达的大鼠FasL基因重组慢病毒载体三质粒包装细胞系统,为进一步研究转FasL基因在同种异体器官移植中诱导免疫耐受、保护移植物的作用奠定基础。
短句来源
     Conclusion: immature DC induced by high concentration of IL-10 combined with Tw may be applied in inducing immune tolerance.
     结论:高浓度的IL-10和雷公藤多甙联合应用诱导的未成熟DC具有诱导免疫耐受的应用价值。
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     The effect and morphology observation of oral administration insulin to NOD mice inducing immune tolerance
     NOD鼠口服胰岛素诱导免疫耐受的疗效及形态学观察
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     With further studies and developments of transplantation immunology, eliminating transplant rejection through inducing immune tolerance has become the main goal in organ transplantation.
     而随着移植免疫学的进一步研究和发展,诱导免疫耐受已经成为器官移植研究的主要目标。
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  tolerance induction
     Conclusion Tα146-162-iMDC can ameliorate established EAMG significantly. Tα146-162-iMDC induces immune tolerance probably by antigenic specific suppression of lymphocyte proliferation and production of IFN-γ and IL-6. TGF-β does not play an important role in the tolerance induction.
     结论Tα146-162-iMDC 能改善EAMG发病小鼠的临床表现,其诱导免疫耐受可能与抗原特异性的抑制淋巴细胞增殖和IFN-γ、 IL-6的分泌有关,TGF-β在耐受诱导中可能不发挥主要作用。
短句来源
     But the mechanism of tolerance induction by DBMC is not clearly understood, and the DBMC infusion accompanying organ transplantation may cause a number of possible conflicting immunological effects.
     但是,DBMC输注诱导免疫耐受的确切机制至今仍不清楚,而且在器官移植同时输注DBMC可以引起一系列冲突的免疫效应,除了可能使受体对供体致敏外,输注的DBMC还可能对受体起免疫反应,即可能诱发移植物抗宿主病(GVHD);
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     The adjunct effect of cyclophosphamide on tolerance induction was observed. Results After intranasal administration of retinal S antigens, EAU was induced in two of eight(25%) rats in tolerant group, sis of six(100%) rats in control group , the difference of EAU induction rate was significant in tolerant group compared with control (P=0.0097).
     结果用牛视网膜S抗原鼻腔滴注诱导免疫耐受后再诱导EAU,耐受组8只大鼠仅有2只发病(25%),对照组6只(100%)全部发病,耐受组大鼠发病比例明显低于对照组(P=0·0097)。
短句来源
     1Experimental research of teh immune tolerance induction by mouce splenocytes 2Living-related partial orthotopic liver transplantation:3cases review
     ⒈小鼠脾细胞诱导免疫耐受的实验研究⒉活体肝部分移植3例临床研究
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     Prevention of kidney allograft rejection in rat by immune tolerance induction
     诱导免疫耐受预防大鼠肾脏移植排斥反应的研究
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  induction of immune tolerance
Induction of immune tolerance with heart-thymus composite allotransplantation in rats
      
Effective induction of immune tolerance by portal venous infusion with IL-10 gene-modified immature dendritic cells leading to p
      
It concluded that immune tolerance to porcine cardiac myosin could be induced by anti-CD4 monoclonal antibody in vivo, and cardiac dysfunction and myocardial injury could be prevented by induction of immune tolerance.
      
An intensive inpatient program of induction of immune tolerance is used in Sweden.
      
Experimental verification of our findings may provide novel evidence of induction of immune tolerance in tumors.
      
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  induce immune tolerance
The human gut offers more than 200 m2 of mucosal surface, where direct interactions between the immune system and foreign antigens take place to eliminate pathogens or induce immune tolerance toward food antigens or normal gut flora.
      
It has been shown that immature DC can induce immune tolerance and prolong allograft survival.
      
These results suggest that portal venous infusion may be an effective approach for immature DC to induce immune tolerance or hyporesponsiveness against donor antigens, and prolong allograft survival.
      
In the present study we investigated whether prior gene transfer to the retina, which is suspected to induce immune tolerance, could alleviate the immune response occurring after retrovirus mediated gene transfer to the liver.
      
We conclude that although the retina behaves as an immunoprivileged site, gene expression in the subretinal space is not sufficient to induce immune tolerance to a transgene product expressed in the liver.
      
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  inducing immune tolerance
Transgenic edible plant organs are now available to study the feasibility of inducing immune tolerance in IDDM animals by oral administration of GAD65.
      
NIAID is supporting studies of other strategies for inducing immune tolerance.
      
Several different mechanisms may be involved in inducing immune tolerance by intrathymic inoculation.
      
  tolerance induction
Additionally, we highlight the potential importance of different routes of allergic sensitization and the role of oral tolerance induction in the pathogenesis and prevention of food allergy.
      
This review focuses on recent advances in tolerance induction in experimental animal models and discusses their relevance to the development of protocols for the induction and maintenance of clinical transplant tolerance.
      
Here, we explore the prospect of using hESCs and their derivatives for immunomodulation and tolerance induction.
      
Self-tolerance induction is largely a reflection of negative selection (deletion) of autoreactive T cells in the thymus.
      
Tolerance induction for solid organ grafts with donor-derived hematopoietic reconstitution
      
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