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   诱导免疫耐受 在 内分泌腺及全身性疾病 分类中 的翻译结果: 查询用时:0.027秒
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诱导免疫耐受
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  induction of immune tolerance
    Conclusion GAD protected the NOD female mice from getting diabetes and insulitis. Its mechanism may be related to induction of immune tolerance by increasing the GAD65 expression in islets.
    结论 GAD可预防NOD小鼠胰岛炎和糖尿病的发生 ,其机制可能与使胰岛GAD6 5表达增加诱导免疫耐受有关。
短句来源
    Objective To probe into the method and mechanism of the prevention and treatment of IDDM in mice by induction of immune tolerance with the autoantigen insulin.
    目的探讨自身抗原诱导免疫耐受防治1型糖尿病(IDDM)的方法及机制。
短句来源
    Conclusion:The thymus may be an ideal site for islet transplantation and may play an important role in the induction of immune tolerance.
    结论:胸腺可能为胰岛移植的理想部位,而且在诱导免疫耐受中具有重要作用。
短句来源
    Recently, studies on the protection of islet grafts function have made a certain progress through the improvement of donor pancreas procurement and preservation, islet isolation and purification, inhibition of non-specific and instant blood-mediated inflammatory reaction, induction of immune tolerance and gene-modified islet transplantation.
    近年来通过改善供体胰腺组织的保存、胰岛分离和纯化方法,抑制非特异性炎症反应,减轻经血液介导的瞬时炎症反应,诱导免疫耐受和基因修饰胰岛移植等措施,移植胰岛的功能保护研究取得了一定进展。
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  “诱导免疫耐受”译为未确定词的双语例句
    Methods Immune tolerance was estab- lished by subcutaneously injection of the bovine insulin (100μg) in IFA (emulsified 1:1) in streptozotocin(STZ) induced type 1 diabetes mellitus(T1DM) model.
    方法在链脲佐菌素(STZ)所致1型糖尿病模型(type 1 diabetes mellitus,T1DM)内采用胰岛素与IFA混合乳剂皮下注射的方式诱导免疫耐受
短句来源
    Objective To study the treatment effect of adjuvant arthritis(AA) in Wistar rats by oral administration of type Ⅱ collagen (CⅡ). To detect the expression of IL-2 in lymphoid tissue and pathological changes of joint in the process of treating.
    目的探讨口服Ⅱ型胶原(typeⅡcollagen,CⅡ)对大鼠佐剂性关节炎(adjuvant arthritis,AA)的治疗作用,研究口服诱导免疫耐受过程中淋巴器官IL-2水平的变化及大鼠骨关节的病理改变。
短句来源
    Effects of oral tolerance induced by anministration of type Ⅱcollagen on immunopathololgy and Th cell subsets of adjuvant arthritis
    口服Ⅱ型胶原诱导免疫耐受对佐剂性关节炎免疫病理和Th亚群的作用
短句来源
    Suppression of adjuvant arthritis in rats by oral administration of collagen
    口服胶原蛋白诱导免疫耐受对大鼠佐剂性关节炎的治疗作用
短句来源
    Oral Tolerance Induced by Type Ⅱ Collagen and 1a-Hydroxyvitamin D_3 Inhibiting Rat Adjuvant-Induced Arthritis
    Ⅱ型胶原和1a-羟基维生素D3联合诱导免疫耐受防治大鼠佐剂性关节炎
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  induction of immune tolerance
Induction of immune tolerance with heart-thymus composite allotransplantation in rats
      
Effective induction of immune tolerance by portal venous infusion with IL-10 gene-modified immature dendritic cells leading to p
      
It concluded that immune tolerance to porcine cardiac myosin could be induced by anti-CD4 monoclonal antibody in vivo, and cardiac dysfunction and myocardial injury could be prevented by induction of immune tolerance.
      
An intensive inpatient program of induction of immune tolerance is used in Sweden.
      
Experimental verification of our findings may provide novel evidence of induction of immune tolerance in tumors.
      
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Healthy Kunming mice(divided into A and B groups) were injected in haperitoneally with STZ (3 0mg·kg-1/d)for 5 days,Group A was pregavaged with bovine PZI(1mg,3/w for 6Ws)and group B was normally fed as controls. After 22w of STZ ip,DM appeared in both A and B groups (10%vs 90%)and insulitis scores were 0 vs 3-4 degrees respectively. Another heaklthy mice C group received fresh splenic cells (2× 107)from A group for 10 days and then STZ twice at an interval of 7 weeks. Blood sugars were observed for 6 months....

Healthy Kunming mice(divided into A and B groups) were injected in haperitoneally with STZ (3 0mg·kg-1/d)for 5 days,Group A was pregavaged with bovine PZI(1mg,3/w for 6Ws)and group B was normally fed as controls. After 22w of STZ ip,DM appeared in both A and B groups (10%vs 90%)and insulitis scores were 0 vs 3-4 degrees respectively. Another heaklthy mice C group received fresh splenic cells (2× 107)from A group for 10 days and then STZ twice at an interval of 7 weeks. Blood sugars were observed for 6 months. No DM appeared in group C. Our results showed that oral bovine PZI induced immunotolerance protected mice from STZ-insulitis and DM.

正常昆明株小鼠口服牛胰岛素(A组)6周(1mg,3次/周)与对照组(B组)均接收STZ注射(30mg·kg-1/日×5日),22周后糖尿病发病率(10%~90%)及胰岛病理检查(胰岛炎计分0~3.4级)差异显著。接受A组小鼠新鲜脾细胞(2×107)的正常C组,免疫10天后共接收STZ(同上)2次(间隔7周),共观察6个月。糖尿病发生率为0。提示口服牛胰岛素诱导了免疫耐受,保护胰岛免受STZ引起的胰岛炎及糖尿病。

Objective:To improve the therapeutic effects of experimental autoimmune encephalomyelitis

目的:口服髓鞘碱性蛋白(myelinbasicprotein,MBP)与T细胞疫苗接种(Tcelvaccination,TCV)联合应用诱导免疫耐受,以提高特异性的免疫疗法对实验性自身免疫性脑脊髓膜炎(experimentalautoimmuneencephalomyelitis,EAE)的防治效果。方法:从gpSCH/CFA诱发EAE的DA大鼠体内取淋巴细胞,体外再以MBP刺激,并用rIL2促进增殖,反复数个循环,可获得MBP特异的T淋巴细胞系。将此T细胞系经照射(15Gy)灭活处理后,静脉接种至同基因正常DA大鼠体内,同时给此DA大鼠多次口服MBP诱导耐受,最后以脊髓匀浆/完全福氏佐剂(SCH/CFA)攻击经上述处理的大鼠,以观察其EAE的发病情况。结果:单独口服MBP诱导耐受及单独TCV处理的DA大鼠对随后诱发的EAE的抑制率分别为67%和50%,而将二者联合应用,则抑制率可达80%。结论:口服MBP与MBP特异的T细胞疫苗接种联合应用,可获得更深程度的耐受效果,多种手段联合应用可能成为临床今后通过诱导耐受防治自身免疫病的新策略。

Objective To establish on animal model of experimental autoimmune encephalomyelitis (EAE), and to investigate the therapeutic effect of orally administrated myelin basic protein (MBP) on EAE. Methods With guinea pig spinal cord homogenate in complete Freund's adjuvant (CFA GPSCH) or MBP in complete Freund's adjuvant (CFA MBP) and Bordetella pertussis vaccine (BPV) was injected intradermally to induce EAE in Wistar rats. To investigate the suppression of clinical and histological manifestations of the disease...

Objective To establish on animal model of experimental autoimmune encephalomyelitis (EAE), and to investigate the therapeutic effect of orally administrated myelin basic protein (MBP) on EAE. Methods With guinea pig spinal cord homogenate in complete Freund's adjuvant (CFA GPSCH) or MBP in complete Freund's adjuvant (CFA MBP) and Bordetella pertussis vaccine (BPV) was injected intradermally to induce EAE in Wistar rats. To investigate the suppression of clinical and histological manifestations of the disease when animals were fed with MBP before or after disease induction. Results With CFA GPSCH or CFA MBP and BPV, we succeeded in the induction of EAE in Wistar rats, and the incidence of EAE was more than 90%. The clinical expression of the disease was suppressed whether animals were fed with MBP before or after sensitization, the incidence of EAE was dramatically decreased in animals which were fed with MBP before disease induction, and the duration of disease was shortened significantly in animals which were fed with MBP after onset of the disease. Histological examination revealed a marked reduction of perivascular infiltrates in rats fed with MBP either before or after sensitization to MBP. In addition, DTH responses to whole MBP were suppressed and the suppression of in vitro proliferative responses to MBP were observed to be antigen specific. Conclusions EAE can be prevented and cured by oral administration of MBP to induce specific immunologic tolerance.

目的建立实验性自身免疫性脑脊髓炎(EAE)动物模型,探讨口服自身抗原诱导免疫耐受对大鼠EAE的防治作用。方法在普通Wistar大鼠经1次足跖真皮内注射完全弗氏佐剂-豚鼠全脊髓匀浆或完全弗氏佐剂-髓鞘碱性蛋白乳剂加百日咳疫苗诱发EAE疾病;另在大鼠致炎前及发病后口服髓鞘碱性蛋白(MBP),观察其对EAE的防治作用。结果在Wistar大鼠成功地诱发了EAE,发病率将近90%。大鼠在致炎前口服MBP,可明显推迟EAE发病时间,降低EAE发病率,使神经组织病理改变明显改善。大鼠发生EAE后给予MBP,可明显控制发病动物的病情,使病程缩短及减轻患鼠神经组织的炎症程度。另外,在耐受鼠由MBP引起的迟发型超敏反应(DTH)以及体外针对MBP的淋巴细胞增殖反应也明显受到抑制。结论口服MBP可引起特异性的免疫耐受,从而产生对实验性自身免疫性脑脊髓炎的防治作用

 
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