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纤维化     
相关语句
  fibrosis
    Study on Differentially Expressed Genes in the Schistosoma Japonicum Infected Hepatic Fibrosis
    血吸虫病肝纤维化基因差异表达的研究
短句来源
    TGF-β1 Activity In Sera From Patients With Viral Hepatitis And In Association With Hepatic Fibrosis
    病毒性肝炎患者血清TGF-β1活性及其与肝纤维化关系的研究
短句来源
    PRELIMINARY RESEARCH ON RELATIONSHIP BETWEENN TNF-α AND EGG-INDUCED GRANULOMA AND HEPATIC FIBROSIS OF SCHISTOSOMIASIS JAPONICA
    TNF-α与日本血吸虫虫卵肉芽肿及肝纤维化关系的初步研究
短句来源
    Pathological Histology and Association with Serum Markers of Liver Fibrosis in Chronic Hepatitis B Patients
    慢性乙型病毒性肝炎病理组织学与血清纤维化指标关系的探讨
短句来源
    Serum TGF-β1 activity in patients with viral hepatitis and its relation with hepatic fibrosis
    病毒性肝炎患者血清转化生长因子-β1活性及其与肝纤维化的关系
短句来源
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  fibrotic
    Effect and mechanism of Bicyclol on the hepatic fibrotic patients with chronic hepatitis B
    双环醇治疗慢性乙型病毒性肝炎肝纤维化及其作用机制
短句来源
    The expression of cannabinoid receptor 1 in fibrotic liver tissues of mice infested with Schistosoma mansoni
    血吸虫性肝纤维化小鼠肝组织中内源性大麻素1受体的表达
短句来源
    The markers, such as HA,P III P, LN, IV collagen, h TIMP 1 were positively correlated with the fibrotic staging and scoring (r=0.610, 0.575, 0 607, 0.641,0.606 respectively).
    纤维化程度与血清学指标Ⅲ型前胶原肽、Ⅳ型胶原、层粘连蛋白、金属蛋白酶组织抑制物及透明质酸呈正相关,相关系数分别为0575、0607、0641、0606及061。
短句来源
    ②Serum IL-6, IL-8 levels were positively correlated with hepatic inflammatory grade and fibrotic stage.
    ②IL - 6、IL -8水平与肝组织炎症坏死程度和肝纤维化程度呈正相关 (P <0 0 1,P <0 0 1) ;
短句来源
    Compared to controls,the level of Smad3 expression in hepatic tissues of fibrotic rabbits were increased significantly. The expressions of Smad3 changed in similar way as TGF-β1 mRNA.
    与正常对照组相比 ,各期肝纤维化家兔肝组织中Smad3蛋白表达增加 ,与TGF - β1mRNA表达趋势基本一致。
短句来源
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  fibrogenesis
    THE EFFECT OF PROSTAGLANDIN E_1 ON HEPATIC FIBROGENESIS IN RATS WITH SCHISTOSOMIASIS JAPONICA
    前列腺素E_1对日本血吸虫病大鼠肝纤维化形成的影响
短句来源
    CHANGES IN SERUM TGF-β_1 AND HEPATIC FIBROGENESIS MARKERS AFTER INTERFERON-α THERAPY IN PATIENTS WITH CHRONIC HEPATITIS B
    α-干扰素治疗慢性乙型肝炎后TGF-β_1及肝纤维化指标的变化观察
短句来源
    Objective To investigate the effect of prostaglandin E 1 (PGE 1) on hepatic fibrogenesis and its mechanism in rats with schistosomiasis japonica.
    目的 探讨前列腺素 E1 (PGE1 )对日本血吸虫病肝纤维化形成的影响及其机制。
短句来源
    Conclusion PGE 1 significantly suppressed hepatic fibrogenesis in schistosomiasis japonica, whose mechanism was probably associated with suppressing of TGF-β 1 expression by PGE 1.
    结论  PGE1 对日本血吸虫病肝纤维化的形成有抑制作用 ,其机理可能与 PGE1 抑制 TGF- β1 的表达有关。
短句来源
    This suggests TGF-β_1 play a key role in liver fibrogenesis and development.
    认为 TGF-β1 在肝脏炎症、纤维化发展中起重要作用。
短句来源
更多       
  fibrosis stage
    The relationship between the serum biochemical markers and hepatic fibrosis were analyzed. Results:The level of some serum biochemical markers Alb,Glo,HA,PCⅢ,CⅣ were correlated with the hepatic fibrosis stage,and the correlation coefficient(r) were-0.299,0.282,0.595,0.387,and 0.480 respectively.
    结果:部分血清学指标与肝组织纤维化程度相关,以Alb、Glo、HA、PCⅢ、CⅣ相关性最好,相关系数分别为-0.299、0.282、0.595、0.387、0.480。
短句来源
    G has positive correlation with ALT and histological fibrosis stage(S).
    纤维化分期S与ALT、TB无相关性。
短句来源
    Methods: the serum HA,ACTA,TNF-αcontent was assayed by Elisa and RIA in 96 cases of chronic hepatitis B,and liver biopsy,inflammation classification and fibrosis stage division were carried out at the same time,then the relationship between the three indexes above and the pathological changes of the liver tissue was analysed.
    方法:采用酶联免疫吸附试验(ELISA)和放射免疫吸附试验(R IA)测定96例慢性乙肝患者血清HA、ACTA、TNF-α含量,同时进行肝组织活检,对肝组织进行炎症分级及纤维化分期,分析以上三项指标与肝组织病理变化的关系。
短句来源
    Moreover, in patients with normal transaminases, HbeAg negative group had higher degree of fibrosis stage than that of HbeAg positive group ( P <0.05).
    在转氨酶正常病例中 ,HBeAg阴性组纤维化程度较HBeAg阳性组严重 (P <0 .0 5 )。
短句来源
    Results The surface density of hepatic TGFβ_1 increased linearly with the elevation of fibrosis stage (P<0.05), there were no significant differences between every two groups of G_1, G_2, G_3 and G_4(P>0.05).
    结果 (1)按肝组织纤维化程度(S)分组,除S_2组与S_1组比较外,TGF β_1随纤维化分期加重而表达增加,F=13.46,P<0.05。
短句来源
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  fibrosis
Hepatic steatosis, lobular inflammation, hepatocytic ballooning and fibrosis were presented widespread in NAFLD liver tissues.
      
Mild perisinusoidal fibrosis and periportal fibrosis were often observed in stage 1 cases.
      
According to the statistic analysis, hepatic steatosis was positively correlated with lobular inflammation, hepatocytic ballooning and fibrosis (r = 0.587, 0.488, 0.374, respectively, all P value >amp;lt; 0.01).
      
The number of microgranulomas, lipogranulomas and apoptotic bodies increased following severity of steatosis, lobular inflammation and fibrosis.
      
We suggest that the role of portal inflammation should be emphasized besides hepatic steatosis, lobular inflammation, hepatocyte ballooning and fibrosis in diagnosis and evaluation of NAFLD.
      
更多          
  fibrotic
Fuzheng Huayu Decoction promotes protein synthesis and plays an anti-fibrotic role by anti-oxidation and accommodation of cell proliferation and transformation.
      
TGF-β1 treatment induced a fibrotic phenotype of RLE-6TN with increased expression of fibronectin (FN), α-smooth muscle actin (α-SMA) and vimentin, and decreased expression of E-cadherin (E-cad) and cytokeratin19 (CK19).
      
Although originally associated with tumorigenic processes, liver angiogenesis has also been observed in the context of different liver inflammatory, fibrotic, and ischemic conditions.
      
Histologically, an atypical infarct pattern was found, i.e., the common roundcell infiltration and the fibrotic process were surrounding but not penetrating the alcohol induced myocardial center of necrosis.
      
A prolonged treatment with daily oral doses of 1 mg/kg oxyfedrin during 30 days, did not alter the evolution of late isoproterenol-induced fibrotic heart lesions.
      
更多          
  fibrogenesis
The liver fibrogenesis was assessed using a digital image analysis instrument of Masson's trichrome stained sections.
      
It is associated with increased fibrogenesis and, in nongenotype 3 infection, with a reduced response to antiviral therapy.
      
Great progress has been made over the past 20 years in elucidating the mechanisms of hepatic fibrogenesis.
      
The recognition of the hepatic stellate cell as the fibrogenic cell of the liver, as well as the recognition of key cytokines involved in fibrogenesis, has facilitated the development of targeted antifibrotic therapies.
      
Great progress has been made over the past 20 years in elucidating the mechanisms of hepatic fibrogenesis.
      
更多          
  fibrosis stage
The genotype distribution showed no relation to the HAI, hepatitis activity (grade), and fibrosis (stage) of the liver disease.
      
IFN produced an improvement in histological activity and fibrosis stage in the second biopsy specimens irrespective of the clinical outcome when compared against untreated subjects.
      
Leptin levels increased as hepatic fibrosis stage progressed both in male and in female patients (P >amp;lt; 0.001); also, TNF levels were higher in patients with an advanced stage of fibrosis (P = 0.006).
      
Also, factors predicting significant fibrosis (stage ≥3) and cirrhosis (stage ≥5) at presentation were assessed.
      
Mean fibrosis stage decreased from 4.53 to 2.16 following treatment (P >amp;lt; 0.001).
      
更多          
  其他


28 rabbits, each infected percutaneously with 80 cercariae of Schistosoma japonicum developed pipe-stem fibrosis resembling late human schistosomiasis 4 months later. After a single oral dose of pyquiton 100mg/kg, colchicine was then given to 9 rabbits orally to treat schistosomal hepatic fibrosis in a dosage of 1 mg daily for 3 months. The remaining 19 rabbits were used in different groups of controls, namely, infected control with pyquiton 13, infected control without pyquiton 6, uninfected control 6. Liver...

28 rabbits, each infected percutaneously with 80 cercariae of Schistosoma japonicum developed pipe-stem fibrosis resembling late human schistosomiasis 4 months later. After a single oral dose of pyquiton 100mg/kg, colchicine was then given to 9 rabbits orally to treat schistosomal hepatic fibrosis in a dosage of 1 mg daily for 3 months. The remaining 19 rabbits were used in different groups of controls, namely, infected control with pyquiton 13, infected control without pyquiton 6, uninfected control 6. Liver biopsies were made before and after colchicine treatment for collagen quantitative determination and pathological observation. The results showed that collagen content was reduced from 43.07±4.25 mg/g wet weight to 15.79±2.66 mg/g wet weight, the thick fibrous bands around intrahepatic portal zone were markedly reduced, and degenerated liver cells mostly recovered. In comparison with amygdalin, hydrocortisone and other Chinese traditional medicines in our previous work, colchicine appears to be a more effective antifibrotic drug.

家兔感染日本血吸虫尾蚴4个月发生肝纤维化后,分为3组。22只兔给以吡喹酮100mg/kg,其中9只兔每日服秋水仙碱1mg, 连服3个月,13只兔不给秋水仙碱。其余6只兔不给吡喹酮,也不给秋水仙碱为感染对照。另有6只兔为正常对照。在秋水仙碱治疗前后,手术切取病兔部分肝组织作胶原定量和病理观察。 结果可见治疗后病兔肝胶原量明显减少,从43.07±4.25mg/g湿重减至15.79±2.66mg/g湿重,差异显著(P<0.05)。镜下观察可见治疗后病兔肝汇管区门静脉分支周围间质内纤维组织明显减少,肝细胞变性坏死不明显,部分肝小叶结构已恢复或接近正常,表明秋水仙碱为一较有效的抗肝纤维化药物。

During 1982-1985, the authors recorded 142 human cases of Alveolar Hydatid Disease (AHD) which were diagnosed by surgery and clinical treatment in the local hospitals from Ningxia and Xinjiang, Northwest China, of which 72 cases were male and 70 female. Acccording to the age recorded, it was found that the oldest was a 69-year patient and the youngest one was a 12-year child, while the 61 cases (47%) belonged to 30-40 age group. Nine human tissue lesions (AHD)obtained at surgery could be distinguished as two...

During 1982-1985, the authors recorded 142 human cases of Alveolar Hydatid Disease (AHD) which were diagnosed by surgery and clinical treatment in the local hospitals from Ningxia and Xinjiang, Northwest China, of which 72 cases were male and 70 female. Acccording to the age recorded, it was found that the oldest was a 69-year patient and the youngest one was a 12-year child, while the 61 cases (47%) belonged to 30-40 age group. Nine human tissue lesions (AHD)obtained at surgery could be distinguished as two main types such as giant mass type and mass-nodule type. They were rough on surface and hard in texture. The tissue sections showed that the alveolar mass was composed of numerous minute multivesicular units which measured 1-5mm in diameter. The thickened cuticular membrane was well-developed, but the germinal layer was ordinarily degenerated or absent. They were all sterile vesicles,in which no pro-toscolex had been found. The affected liver appeared to be heavy fibrous, and the reaction in the surrounding tissue was manifested by the proliferation of granulation and the formation of fibrous connective tissue, with necrosis and cavitation in the center of lesion.

1982~1985年在新疆、宁夏等地共记录人体多房棘球蚴病142例,其中男72,女70。最大年龄69岁,最小12岁,而30~40岁组65例(47%)。人体9例病理标本主要呈巨块型和巨块结节型病肝,质地坚硬。切片显示病肝纤维化,其间有大小不等的肉芽结节病变,近中央处有坏死空洞。多房蚴由许多细小泡囊组成。角质膜较厚,生发层脱落不见,缺原头节,全系不育囊。囊腔有豆渣样碎屑,无囊液。 宁夏固源流行区自然动物宿主调查发现中华鼢鼠(Myospalax fontanieri)是本虫宿主新记录,自然感染率0.3%。达乌尔黄鼠(Citellus dauricus alaschanicus)自然感染率为1.3%。二种鼠类的多房蚴发育状况良好,质软有丰富的次生泡囊和原头节。中华鼢鼠有60~80%的育囊,达乌尔黄鼠有40~60%的育囊。二者切片所见泡囊角质层薄,有断裂;生发层较厚,发育有原头节并有群多的石灰质颗粒。组织病变有炎症白细胞浸润,并有成纤维细胞和结缔组织增生以及肉芽肿病变,肝组织绝大部分被次生囊所取代。观察证明两种鼠类是我国多房棘球蚴的适宜动物宿主。 小白鼠人工感染实验阐明虫卵至多房棘球蚴的全程发育。感染孕节4...

1982~1985年在新疆、宁夏等地共记录人体多房棘球蚴病142例,其中男72,女70。最大年龄69岁,最小12岁,而30~40岁组65例(47%)。人体9例病理标本主要呈巨块型和巨块结节型病肝,质地坚硬。切片显示病肝纤维化,其间有大小不等的肉芽结节病变,近中央处有坏死空洞。多房蚴由许多细小泡囊组成。角质膜较厚,生发层脱落不见,缺原头节,全系不育囊。囊腔有豆渣样碎屑,无囊液。 宁夏固源流行区自然动物宿主调查发现中华鼢鼠(Myospalax fontanieri)是本虫宿主新记录,自然感染率0.3%。达乌尔黄鼠(Citellus dauricus alaschanicus)自然感染率为1.3%。二种鼠类的多房蚴发育状况良好,质软有丰富的次生泡囊和原头节。中华鼢鼠有60~80%的育囊,达乌尔黄鼠有40~60%的育囊。二者切片所见泡囊角质层薄,有断裂;生发层较厚,发育有原头节并有群多的石灰质颗粒。组织病变有炎症白细胞浸润,并有成纤维细胞和结缔组织增生以及肉芽肿病变,肝组织绝大部分被次生囊所取代。观察证明两种鼠类是我国多房棘球蚴的适宜动物宿主。 小白鼠人工感染实验阐明虫卵至多房棘球蚴的全程发育。感染孕节48小时后肝组织内有六钩蚴病灶。3天后虫体呈囊块,与肝组织有界限可辨。10~12天后虫体形成泡囊,有生发层细胞分化。30天后泡囊增大达1.3×1.0?

Using histochemical and immunohistochemical methods,the density of various

用组织化学和免疫组织化学法,我们观察了29例肝炎肝活检标本中的各型抗体产生细胞、巨噬细胞及补体的密度以研究局部体液免疫反应,这29例肝炎包括三型,即急性、亚急性以及慢性活动性肝炎。结果显示五型抗体产生细胞明显位于门管区及坏死和纤维化区周围。其分布变异较大。在亚重肝及慢活肝,IgE 产生细胞比 IgA 产生细胞高许多倍,而在急肝,IgM 产生细胞较高。在亚重肝,IgE 产生细胞比慢活肝中者高二倍,比急肝者高20倍。在亚重肝,IgE 产生细胞数最高,依次为 IgA 产生细胞数,恢复期下降,IgE 产生细胞的增多与肥大细胞无关。亚重肝时臣噬细胞也增高。C_3检出率及着色强度急肝75%,亚重肝62.5%,慢活肝则只为50%。HBsAg(+)、HBcAg(+)、HBsAg 及 HBcAg 均(-)组的亚重肝中五型抗体产生细胞区分无何意义,巨噬细胞也如此。总之,在乙型肝炎,细胞介导免疫与体液免疫是两类重要的免疫应答,本文对其机制进行详细陈述。

 
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