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p基因的
相关语句
  p gene
    The Relationship between Expression of HBV P Gene and Integration of HBV P Gene and X Gene in PBMCs of HCC Patients
    HCC患者PBMCs中HBV逆转录酶P基因的表达与X、P基因整合的研究
短句来源
    Objective To investigate the mechanism of HBVDNA integration and the nosogenesis of hepatocellular carcinoma by detecting the expression of HBV P gene and the integration of HBV P , X gene in PBMCs of HCC patients.
    目的:研究在原发性肝细胞癌(HCC)患者外周血单个核细胞(PBMCs)中乙型肝炎病毒(HBV)DNA多聚酶/逆转录酶P基因的表达与X、P基因整合的关系,阐明HBV的整合机制以及肝细胞癌的发病机制。
短句来源
    MTBE could induce high expression of c myc gene,and had no effect on the expression of GST P gene.
    点杂交结果显示,MTBE可明显诱导大鼠肝组织中c-myc基因的高表达,而对GST-P基因的表达未见明显影响。
短句来源
    No expression of HBV P gene and no integration of X gene or P gene was found in PBMCs in the control and healthy volunteers groups.
    HBVDNA阳性7例中X整合率为71.4%(5/7),P整合率为14.3%(1/7),P基因的mRNA表达率为1 4.3%(1/7); HBVDNA阴性33例中X整合率为78.8%(26/33),P整合率为巧.
短句来源
    Conclusion The integration of X gene was significantly higher than P gene in PBMCs of HCC patients .
    2%(5/33),P基因的mRNA表达率为9.1%(3/33)。 统计学分析显示在I+H、IH期原发性肝癌中,其X、P基因整合率及P基因的表达率差别均无统计意义(P>0.05);
短句来源
  “p16基因的”译为未确定词的双语例句
    INTEGRATION OF HBV X AND P GENES IN PBMCs IN PATIENTS WITH PRIMARY HEPATOCELLULAR CARCINOMA
    原发性肝细胞癌病人PBMCs中HBV X、P基因的整合
短句来源
    THE mRNA EXPRESSION OF GENE P IN HBV REVERSE TRANSCIPTASE OF PBMCs,THE INTEGRATION OF GENE X AND THEIR RELATIONS TO PRIMARY HEPATOMA
    PBMCs中HBV逆转录酶P基因的mRNA表达X基因的整合与肝细胞癌变的关系
短句来源
    Dot hybridization method was used to explore the expression of c myc gene and GST P(glutathione S transferase P) gene in the of MTBE treated rats.
    采用点杂交方法,从RNA水平检测了MTBE亚慢性染毒大鼠肝组织中原癌基因c-myc基因和功能基因GST-P基因的表达情况。
短句来源
    PCR was used to determine the integration of HBV P and X gene.
    分别设计HBV X基因、P基因PCR引物,检测HCC病人PBMCs基因组中HBV的X基因和P基因的整合情况。
短句来源
    ConclusionThe integration of HBV X and P exists in peripheral blood mononuclear cells,and the expression of X gene plays a major role in the occurrence of primary liver cancer.
    结论PBMCs中存在HBV X、P基因的整合,X基因片段的整合及表达是HCC发生的主要因素。
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  p gene
The results obtained underlined the high similarity (>amp;gt;99%) of the entire sakacin P gene cluster from the L.
      
Transcription initiation signals were derived from the mating pheromone α-factor (MFα1p) and alcohol dehydrogenase (ADC1p) gene promoters.
      
Fayette) cotyledonary nodes were transformed with bean pod mottle virus (BPMV) coat protein precursor (CP-P) gene via Agrobacterium-mediated transformation.
      
Southern blot hybridization verified the integration of the BPMV CP-P gene.
      
Extracts from plants transformed with the CPO-P gene significantly reduced Aspergillus flavus colonies by up to 100% compared with extracts from control plants transformed with pBI121.
      
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To explore preliminaryly the mechanism of golden Syrian hamster

本实验采用Northern印迹杂文方法研究了甲基丙烯酸环氧丙酯(GMA)对金仓鼠胚胎(SHE)细胞原癌基因C─myc和重要功能基因谷胱甘肽S─转移酶p(GST─p)表达的影响.结果表明GMA促进了这些基因的表达,其中GST─p基因在作用2h表达即见增高,5h后达到高水平,直至12h仍维持这一高水平;c─myc基因在12h后出现高水平.本文讨论了GMA诱导上述基因表达的改变与细胞转化之间的可能关系.

The exon 5 , 6 , 7 of p53 gene in frozen breast cancer specimen was detected. Using PCR-SSCP method , the abnormal shifting of the single stranded DNA ( ssDNA ) was identified in 15 out of 30 cases. The distribution of mutation among these cases were 1. according to stage of diseaae , stage Ⅱ 7 / 14 , stage Ⅲ 6 / 11 , stage Ⅳ 2 / 2; 2 . according to pathological type , infiltrative ductal carcinoma 13/26 , papillary adeno carcinoma 1 / 1 , intraductal carcinoma 1 / 1 ; 3. According to axillary nodal status ,...

The exon 5 , 6 , 7 of p53 gene in frozen breast cancer specimen was detected. Using PCR-SSCP method , the abnormal shifting of the single stranded DNA ( ssDNA ) was identified in 15 out of 30 cases. The distribution of mutation among these cases were 1. according to stage of diseaae , stage Ⅱ 7 / 14 , stage Ⅲ 6 / 11 , stage Ⅳ 2 / 2; 2 . according to pathological type , infiltrative ductal carcinoma 13/26 , papillary adeno carcinoma 1 / 1 , intraductal carcinoma 1 / 1 ; 3. According to axillary nodal status , positive axillary lympho node 11/18,megative axillary lympho mode 4/12.The result indicates that the mutation of p53 gene is intimatly related to clinical stage and pathological type . The carcinoma with positive p53 gene mutation in more invassive , recurred and metastaticl.

应用聚合酶链式反应-单链构象多态性分析(PCK-SSCP)法检测30例乳腺癌组织中P基因的5、6、73个外显子。结果显示,15例有异常电泳带,表明这些病例相应的DNA片段发生突变。结合临床分析发现:在(1)Ⅱ期7/14例、Ⅲ期6/11例、Ⅳ期2/2例,(2)浸润性导管癌13/26例、乳头状腺癌1/1例、导管内癌1/1例,(3)腋窝淋巴结阳性11/18例、腋窝淋巴结阴性4/12例中发现P基因突变。提示P基因突变与临床分期及病理改变有关,有P53基因突变的原发病灶具有较强的侵袭能力,易复发和转移。

Methyl tertiary butyl ether (MTBE) is a new gasoline additive, which is used to increase the combustion of gasoline and to reduce the emission of harmful exhausts from automobile. The mechanism for the carcinogenesis of MTBE in animals is not clear.Immunohistochemistry method was used to detect the effect of MTBE on the expression of c myc and p21 proteins in NIH 3T 3 cells. Dot hybridization method was used to explore the expression of c myc gene and GST P(glutathione S transferase P) gene in the of MTBE treated...

Methyl tertiary butyl ether (MTBE) is a new gasoline additive, which is used to increase the combustion of gasoline and to reduce the emission of harmful exhausts from automobile. The mechanism for the carcinogenesis of MTBE in animals is not clear.Immunohistochemistry method was used to detect the effect of MTBE on the expression of c myc and p21 proteins in NIH 3T 3 cells. Dot hybridization method was used to explore the expression of c myc gene and GST P(glutathione S transferase P) gene in the of MTBE treated rats.The results showed that MTBE could enhance the expression of c myc protein,but had no effect on p21 protein. MTBE could induce high expression of c myc gene,and had no effect on the expression of GST P gene.These results suggest that the high expression of c myc gene induced by MTBE might be one of the mechanisms of its carcinogenicity in animal.

甲基叔丁基醚(MTBE)是一种新型的汽油添加剂,被用来提高汽油燃烧效率,减少汽车尾气中有害物质的排放。MTBE具有一定的动物致癌性,但其机制目前并不清楚。本研究采用免疫组织化学方法,检测了MTBE对体外培养的NIH3T3细胞中c-myc和p21蛋白表达的影响;采用点杂交方法,从RNA水平检测了MTBE亚慢性染毒大鼠肝组织中原癌基因c-myc基因和功能基因GST-P基因的表达情况。免疫组化结果显示,MTBE可诱导c-myc基因的高表达,对p21蛋白的表达未见明显影响。点杂交结果显示,MTBE可明显诱导大鼠肝组织中c-myc基因的高表达,而对GST-P基因的表达未见明显影响。上述结果提示,MTBE可诱导细胞中c-myc基因表达活性增高,可能是其动物致癌性的机制之一。

 
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