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阴性精神分裂症
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  negative symptoms
     Objective:To study the relationship between cerebrospinal(CSF)levels of serotonin(5-HT),5-hydroxyindoleacetic acid(5HIAA),norepinephrine(NE),3-methoxy-4-hydrophenylethylene(MHPG)and clinical manifestations of schizophrenia. Method:CSF levels of the above neurotransmitters and metabolites were determined with high pressure liquid chromatography in 42 schizophrenic patients with positive,25 with negative symptoms and 10 normal control.
     应用高压液相色谱(HPLC)对42例阳性精神分裂症、25例阴性精神分裂症和10例健康正常对照组脑脊液中(CSF)5—羟色胺(5—HT)、5—羟吲哚乙酸(5—HIAA)、去甲肾上腺素(NE)、3—甲基—4—羟基苯乙二醇(MHPG)进行测试。
短句来源
     Results:CSF level of NE,MHPG,ratio of 5HIAA/MHPG of schizophrenic patients with positive symptoms were significantly lower than that of normal control. The 5HT/NE ratio was significantly higher in patients with positive than negative symptoms.
     并以5—HT/NE、5—HIAA/MHPG为其相互作用指标,结果发现,阳性精神分裂症NE、MHPG、5—HIAA/MHPG显著低于正常对照组,而且NE、5—HIAA显著低于阴性精神分裂症,但是5—HT/NE则显著高于阴性精神分裂症
短句来源
     The post DST plasma cortisol level at 4:00 pm and 11:00 pm were both significantly lower in subjects with positive than negative symptoms.
     阳性精神分裂症 D S T 后下午4 时和11 时两个时点血浆皮质醇水平均低于阴性精神分裂症
短句来源
     Results:The baseline plasma cortisol level at 8:00 am before DST was significantly higher in subjects with positive than negative symptoms.
     结果: 阳性精神分裂症 D S T 前晨8 时基础血浆皮质醇水平显著高于阴性精神分裂症
短句来源
     Method:Eighteen negative schizophrenia and 15 positive schizophrenia were treated with clozapine,11 negative schizophrenia and 13 positive schizophrenia were treated with risperidone,negative symptoms,positive symptons,cognitive function were assessed separately before and after treatment.
     方法 :对 18例阴性精神分裂症和 15例阳性精神分裂症采用氯氮平治疗 ; 对 11例阴性精神分裂症和 13例阳性精神分裂症采用利培酮治疗。
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  negative schizophrenia
     A study on the relationship of negative schizophrenia cognitive function improvement with HVA and 5-HIAA.
     阴性精神分裂症认知功能改善与HVA和5-HIAA的关系
短句来源
     Methods 21 patients matching Andreason′s negative schizophrenia criteria received SPECT and WCST, and were treated with clozapine for eight weeks. There were 28 and 12 normal subjects as WCST and SPECT control group respectively.
     方法 对 2 1例符合Andreason阴性精神分裂症标准的患者 (以下简称患者组 )于氯氮平治疗前后进行威斯康星卡片分类测验 (WCST)和单光子发射计算机断层扫描(SPECT)检查 ,以 40名正常人为对照组 (其中 2 8名为WCST对照组 ,12名为SPECT对照组 )。
短句来源
     The results showed that CSF HVA level of negative schizophrenia patients was lower than those of both positive schizophrenia patients and normal controls. It is suggest that the active of CSF dopamine of negative schizophrenia is lower.
     阴性精神分裂症HVA水平与正常人和阳性患者相比显著降低,提示精神分裂症阴性患者,多巴胺(DA)活动降低。
短句来源
     Method:Eighteen negative schizophrenia and 15 positive schizophrenia were treated with clozapine,11 negative schizophrenia and 13 positive schizophrenia were treated with risperidone,negative symptoms,positive symptons,cognitive function were assessed separately before and after treatment.
     方法 :对 18例阴性精神分裂症和 15例阳性精神分裂症采用氯氮平治疗 ; 对 11例阴性精神分裂症和 13例阳性精神分裂症采用利培酮治疗。
短句来源
     ②negative schizophrenia, which is subdivided into defective and degenerated types;
     ②阴性精神分裂症分为缺陷型和衰退型。
短句来源
  “阴性精神分裂症”译为未确定词的双语例句
     Objective:To explore the relationship of negative schizophrenic cognitive function improvement with HVA and 5 HIAA.
     目的 :探讨阴性精神分裂症认知功能的改善与 HVA和 5-HIAA变化的关系。
短句来源
     Conclusion:The great part of negative schizophrenic cognitive function improvement has marked correlation with change of DA and 5 HT.
     结论 :大部分阴性精神分裂症认知功能的改善与 DA和 5-HT浓度变化无明显相关
短句来源
     We determined the levels of tryptophan ( TRP ) ,serotonin ( 5-HT ) ,5-hydroxyin-doleacetic acid(5-HIAA)in CSF of 67 patients with schizophrenia and 10 healthy voluteer controls,and introduced the concept of 5-HT relative metabolism rate (RMR) presented by 5-HI-AA/5-HT. The patients were devived into positive type (type Ⅰ)and negative type (type Ⅱ)by Andreasen's definition.
     本文应用高效液相色谱(HPLC)对67例精神分裂症及10例健康对照组脑脊液中色氨酸(TRP)、五羟色胺(5-HT)、五羟吲哚乙酸(5-HIAA)进行测试,同时引入5-HT相对代谢率概念用5-HIAA/5-HT表示,并以Andreasen分型标准划分42例阳性精神分裂症和25例阴性精神分裂症
短句来源
     Conclusion These findings suggest that the negative and positive subtype of schizophrenics possibly display different basis of neurobiology. [
     结论阳性、阴性精神分裂症可能有不同的神经生物学基础。
短句来源
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  negative symptoms
The most prevalent disturbed behaviours in the sample reflected the negative symptoms of schizophrenia and showed no change over the year.
      
Discharged patients were less disturbed at the beginning of the study and had fewer negative symptoms throughout.
      
Further aspects tested were the sequence of onset and the influence of substance abuse on the course of schizophrenia, primary and secondary negative symptoms, structural models and symptom clusters from onset until 5 years after first admission.
      
Results:?Schizophrenics' normative needs for care in the clinical sector are dominated by positive and negative symptoms, psychopharmacological side effects and psychosocial distress.
      
Results For the baseline data highly significant differences were found between best-ever groups and negative symptoms (non-manual vs.
      
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  negative schizophrenia
It is important that 14.6% (17 cases) of Schneider-negative schizophrenia consisted of research-diagnosable affective disorder, with mania making up 5.2% and depression 9.4% of this figure.
      


Using high pressure liquid chromatography,the CSF homovanillic acid(HVA)level of 25 posi- tive,21 negative schizophrenia patients and 8 normal controls were analysed.The results showed that CSF HVA level of negative schizophrenia patients was lower than those of both positive schizophrenia patients and normal controls.It is suggest that the active of CSF dopamine of negative schizophrenia is lower.The results also showed that the CSF HVA level was positive correlation with impulse,bizarre behaviour,and negative...

Using high pressure liquid chromatography,the CSF homovanillic acid(HVA)level of 25 posi- tive,21 negative schizophrenia patients and 8 normal controls were analysed.The results showed that CSF HVA level of negative schizophrenia patients was lower than those of both positive schizophrenia patients and normal controls.It is suggest that the active of CSF dopamine of negative schizophrenia is lower.The results also showed that the CSF HVA level was positive correlation with impulse,bizarre behaviour,and negative correlation with apathy,no correlation with disturbance thinking.

用高压液相色谱仪(HPLC)测定46例阳性和阴性精神分裂症患者腰段脑脊液中高香草酸(HVA)水平,结果发现;阴性精神分裂症HVA水平与正常人和阳性患者相比显著降低,提示精神分裂症阴性患者,多巴胺(DA)活动降低。HVA水平与兴奋、行为怪异等症状呈正相关,与情感平淡呈负相关,与思维障碍不相关,提示思维障碍不能用某一递质系统的变化来解释。

We determined the levels of tryptophan ( TRP ) ,serotonin ( 5-HT ) ,5-hydroxyin-doleacetic acid(5-HIAA)in CSF of 67 patients with schizophrenia and 10 healthy voluteer controls,and introduced the concept of 5-HT relative metabolism rate (RMR) presented by 5-HI-AA/5-HT.The patients were devived into positive type (type Ⅰ)and negative type (type Ⅱ)by Andreasen's definition.It was shown that there were not any differences in levels of 5-HT and 5-HIAA in CSF and RMR of 5-HT between schizophrenic patients and controls,but...

We determined the levels of tryptophan ( TRP ) ,serotonin ( 5-HT ) ,5-hydroxyin-doleacetic acid(5-HIAA)in CSF of 67 patients with schizophrenia and 10 healthy voluteer controls,and introduced the concept of 5-HT relative metabolism rate (RMR) presented by 5-HI-AA/5-HT.The patients were devived into positive type (type Ⅰ)and negative type (type Ⅱ)by Andreasen's definition.It was shown that there were not any differences in levels of 5-HT and 5-HIAA in CSF and RMR of 5-HT between schizophrenic patients and controls,but the level of TRP in CSF of schizophrenics was significantly lower than that of controls.And it was also found that the levels of 5-HIAA,RMR in the positive patients were significantly lower than those in the negative patients.The heterogenity of 5-HT function in schizophrenia was dicussed.

本文应用高效液相色谱(HPLC)对67例精神分裂症及10例健康对照组脑脊液中色氨酸(TRP)、五羟色胺(5-HT)、五羟吲哚乙酸(5-HIAA)进行测试,同时引入5-HT相对代谢率概念用5-HIAA/5-HT表示,并以Andreasen分型标准划分42例阳性精神分裂症和25例阴性精神分裂症。结果发现,精神分裂症患者脑脊液中TRP明显低于正常对照组,阳性(Ⅰ型)分裂症5-HIAA以及5-HIAA/5-HT明显低于阴性(Ⅱ型)精神分裂症,并对精神分裂症的5-HT代谢障碍假说及其异质性进行了讨论。

The levels of norepinephrine(NE) and 3-methoxy-4 -hydroxyphenylethyleneglycol(MHPG) in CSF of 42 patients with postive schizophrenia and 25 patients with negative schizophrenia and 10 mormal controls were determined by high pressure liquid chromatography(HPLC).Ane concept of NE relative metabolite rate(RMR),which was expressed by ratio of MHPG to NE,was introduced. The result showed that levels of MHPG in CSF were significantly lower in 67 schizophrenic pound taht levels of NE and MHPG in CSF of 42 positive...

The levels of norepinephrine(NE) and 3-methoxy-4 -hydroxyphenylethyleneglycol(MHPG) in CSF of 42 patients with postive schizophrenia and 25 patients with negative schizophrenia and 10 mormal controls were determined by high pressure liquid chromatography(HPLC).Ane concept of NE relative metabolite rate(RMR),which was expressed by ratio of MHPG to NE,was introduced. The result showed that levels of MHPG in CSF were significantly lower in 67 schizophrenic pound taht levels of NE and MHPG in CSF of 42 positive patients were lower significantly than those of 10 normal controls (x2=4.7519,df=1,P<0.05; x2=5.0530,df=1,P<0.01).Furthermore.we found that level of NE in CSF nad ratio of MHPG to NE of 42 positive schizophrenic patients were lower significantly than those of 25 negative patients.These results indicate that some schizophrenic patients have a low central NE function and heterogeneity in central NE function.The relationship schizophrenia are discussed in the paper.

本文采用高压液相色谱(HPLC)对42例阳性精神分裂症、25例阴性精神分裂症及10例健康对照组进行了脑脊液中去甲肾上腺素(NE)及其代谢产物3-甲基-4-羟基苯乙二醇(MHPG)的测定,同时引入NE相对代谢率(MHPG/NE)加以比较,研究结果提示:67例精神分裂症脑脊液中MHPG明显低于正常对照组,42例阳性精神分裂症脑脊液中NE及MHPG亦明显低于正常对照组,同时还发现,阴性精神分裂症相对代谢率MHPG/NE也明显低于阳性精神分裂症.本文针对以上结果、结合NE与多巴胺(DA)的相互关系进行了讨论,同时分析了精神分裂症的异质性问题。

 
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