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阿尔茨海默     
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  alzheimer
     Study on the relationship among oxidative stress,mitochondrial DNA mutation and the development of Alzheimer's disease
     氧应激、线粒体DNA突变与阿尔茨海默病发生发展关系的研究
短句来源
     Study on Apolipoprotein E Gene Polymorphisms and Neuroelectrophysiology in Alzheimer's Disease
     阿尔茨海默病载脂蛋白E基因多态性及神经电生理研究
短句来源
     Aluminum-induced Alzheimer's Disease in Rats and Preventive Mechanisms of TKR
     铝致阿尔茨海默病大鼠的效应及补肾填精方的防治机制
短句来源
     Relation between Alzheimer' Disease and ERK Pathway with PKC and GDNF
     阿尔茨海默病与ERK途径和PKC及GDNF的关系
短句来源
     The Mechanism of Peripheral T Lymphocyte Transmigrating the Blood-brain Barrier in Alzheimer's Disease
     阿尔茨海默病人外周血T淋巴细胞穿过血脑屏障的机制
短句来源
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  alzheimer ' s
     Association of Family History and Polymorphism in ACT-51G/T, IL-1α-889C/T, LRP766C/T and NOS-Ⅲ298G/T with Alzheimer's Disease in Chinese Han Population
     中国汉族人群中ACT-51G/T、IL-1α-889C/T、LRP766C/T和NOS-Ⅲ298G/T基因多态性及家族史与阿尔茨海默病的关联性研究
短句来源
     Expression of HSP70 in hippocampus neurons of Alzheimer's model rats induced by Aβ_(25~35)
     Aβ_(25~35)诱导阿尔茨海默病模型大鼠海马神经元HSP70的表达
短句来源
     Results In 129 cases of senile dementia, there were 55 Alzheimer's disease(AD) , 46 vas-cular dementia (VD) and 18 mixed dementia (MD).
     结果 129例老年期痴呆中,阿尔茨海默病(Alzheimer’s disease,AD)55例,血管性痴呆(vas-cular dementia,VD)46例,混合性痴呆(mixed dementia,MD)18例。
短句来源
     Association between Interleukin-1α-889 C/T Polymorphism and Alzheimer's Disease in Chinese Han Population
     中国汉族人群白介素-1α-889C/T多态性与阿尔茨海默病的相关性
短句来源
     Analysis of the interaction of the-1385A/G polymorphisms of FGF1 gene promoter and ApoE gene in Alzheimer's disease
     阿尔茨海默病患者FGF1基因启动子-1385A/G多态与ApoE基因多态关联性分析
短句来源
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  alzheimer ′ s
     Objective The aim of this study was to evaluate the association of Gln192Arg polymorphism in paraoxonase 1 (PON1) gene with Alzheimer′s disease (AD) in Chinese Han population.
     目的探讨中国汉族人群中对氧磷酶1(PON1)基因Gln192Arg单核苷酸多态性(SNP)与阿尔茨海默病(AD)的相互关系。
短句来源
     The experimental study on an animal model of Alzheimer′s disease by intraventricular injection of the immunotoxin 192-IgG-saporin
     免疫毒素192-IgG-saporin侧脑室注射建立阿尔茨海默病动物模型的实验研究
短句来源
     Expression of CD44 antigen in brains of patients with Alzheimer′s disease
     阿尔茨海默病患者脑内CD44的表达
短句来源
     Analysis of the polymorphisms of the AACT, ERAB and NACP genes in 15 patients with Alzheimer′s disease
     阿尔茨海默病病人AACT、ERAB和NACP基因的多态性分析
短句来源
     Objective:To study the relationship between the concentration of the Tau protein in cerebrospinal fluid (CSF) and dementia and to evaluate it′s significance in diagnosis of Alzheimer′s disease (AD).
     目的 :探讨痴呆与脑脊液 ( Cerebrospinal fluid,CSF) Tau蛋白 (神经元微管相关蛋白 )含量之间的关系 ,为阿尔茨海默病 ( Alzheimer′s disease,AD)临床诊断提供生化依据。
短句来源
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  alzheimer ’ s
     Objective To investigate the association of three CETP polymorphisms (Taq1B, I405V and D442G) with sporadic Alzheimer’s disease (SAD).
     目的探讨胆固醇酯转运蛋白(CETP)基因Taq1B、I405V和D442G3个单核苷酸多态性在散发阿尔茨海默病(sporadic Alzheimer disease,SAD)发病机制中的作用。
短句来源
     Estrogen inhibiting neuritic plaque formation in hippocampus of app/ps1 double transgenic mice of Alzheimer’s disease
     雌激素对app/ps1双转基因阿尔茨海默病模型小鼠海马老年斑形成的抑制作用
短句来源
     Correlation between FGF1 gene promoter-1385 A /G polymorphisms and Alzheimer’s disease
     FGF1基因启动子-1385A/G多态性与阿尔茨海默病的关联性研究
短句来源
     Conclusions:aggregated Aβ25-35 microinjected into dorsal hippocampus could take effect on inducing abnormal phosphorylation of tau by activating GSK-3β,And constructing the Alzheimer’s disease-like rat model.
     结论:Aβ25-35通过激活GSK-3β诱导tau蛋白发生异常磷酸化,海马背侧注射Aβ25-35能建立具有AD样tau蛋白异常磷酸化的大鼠模型,为阿尔茨海默病的治疗研究提供了比较理想的实验动物模型。
短句来源
     Objective To evaluate the association of an intronic single nucleotide polymorphism(SNP) in cholesterol 24S-hydroxylase (CYP46) gene with Alzheimer’s disease(AD) in Chinese Han population.
     目的探讨胆固醇24S-羟化酶(cholesterol24-hydroxylase,CYP46)基因第二内含子单核苷酸多态性(single nucleotide polymorphism,SNP)与阿尔茨海默病(AD)的相互关系。
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      alzheimer
    Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
          
    Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
          
    Mutations in presenilin 1 (PS1) gene are closely associated with the early onset of familial Alzheimer's disease (EOFAD).
          
    Prospects of Non-drug Approaches to Alzheimer's Disease
          
    According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease.
          
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      alzheimer ' s
    Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
          
    Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
          
    Mutations in presenilin 1 (PS1) gene are closely associated with the early onset of familial Alzheimer's disease (EOFAD).
          
    Prospects of Non-drug Approaches to Alzheimer's Disease
          
    According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease.
          
    更多          
      alzheimer ′ s
    The apoE gene has been identified as a major susceptibility locus for late-onset Alzheimer′s disease (LOAD).
          


    Two hundred cases of encephalatrophy were verified by CT examinations. There were 138 cases of simple encephalatrophy, of whom 52 cases showed symptoms of dementia (26.5%). There were 62 cases of encephalatrophy caused by cerebral infarction, of whom 17 cases showed symptoms of dementia. There were close relations between encephalatrophy and Alzheimer's dementia. The manifestations of Alzheimer's dementia and dementia caused by cerebrovascular disease were also analized, proposals for clinical diagnosis of Alzheimer's...

    Two hundred cases of encephalatrophy were verified by CT examinations. There were 138 cases of simple encephalatrophy, of whom 52 cases showed symptoms of dementia (26.5%). There were 62 cases of encephalatrophy caused by cerebral infarction, of whom 17 cases showed symptoms of dementia. There were close relations between encephalatrophy and Alzheimer's dementia. The manifestations of Alzheimer's dementia and dementia caused by cerebrovascular disease were also analized, proposals for clinical diagnosis of Alzheimer's dementia being offered.

    经CT证实的脑萎缩200例。其中单纯性脑萎缩138例,有痴呆表现者52例(26.5%);脑梗塞所致脑萎缩62例,痴呆表现者17例(36.5%)。单纯性脑萎缩与阿尔茨海默氏痴呆关系较密切。通过分析阿尔茨海默氏痴呆与脑血管病性痴呆的表现,对阿尔茨海默氏痴呆的临床诊断提出意见。

    Forty patients with senile dementia were studied by the method of computer EEG topography (CET). The patients with cerebral infarction with normal intellect and the healthy elderly persons served as control. 16 cases of Alzheimer disease (AD) was group A, 24 cases of multiple infarction dementia (MID) was group B, 25 cases of cerebral infarction with normal intellect was group C, 21 cases of healthy elderly person was group D. The spectrum power of σ band and θ band in group A, B, C was higher than that in group...

    Forty patients with senile dementia were studied by the method of computer EEG topography (CET). The patients with cerebral infarction with normal intellect and the healthy elderly persons served as control. 16 cases of Alzheimer disease (AD) was group A, 24 cases of multiple infarction dementia (MID) was group B, 25 cases of cerebral infarction with normal intellect was group C, 21 cases of healthy elderly person was group D. The spectrum power of σ band and θ band in group A, B, C was higher than that in group D(P<0.05). In comparison with group D, the spectrum power of a band reduced significantly in 8 cases(50%) of group A, in nearly 10% of cases of group B and group C. The spectrum power of α_1 band was more increased in group A,B than that in group C.

    本文报告应用脑电地形图(CET)研究老年期痴呆患者40例的变化,其中阿尔茨海默病(A组)16例,多发梗塞性痴呆(B组)24例,并与脑梗塞25例(C组)、健康老年人21例(D组)进行对照研究。A、B、C三组的δ和θ频带功率高于D组(P<0.05。)A组的α频带功率低于其他组,以α_2、α_3频带降低显著。而A、B两组的α_1频带功率较D、C组增高。讨论了老年期痴呆脑电地形图的变化。

    Galanthamine is an inhibitor of acetylcholinesterase and a potent drug to treatAlzheimer's disease. According to the known pharmacological characterization of galan thamine and it's analogs, we conducted 3D-QSAR studies on this kind of compounds.The lowest energy conformations of compounds were obtained from molecular mechedcscalculations. Then these conformions were used in the CoMFA analysis and 3D-QSARwas constructed. The dondnant factor which thect activity was steric effect, whereaselectrostatic effect...

    Galanthamine is an inhibitor of acetylcholinesterase and a potent drug to treatAlzheimer's disease. According to the known pharmacological characterization of galan thamine and it's analogs, we conducted 3D-QSAR studies on this kind of compounds.The lowest energy conformations of compounds were obtained from molecular mechedcscalculations. Then these conformions were used in the CoMFA analysis and 3D-QSARwas constructed. The dondnant factor which thect activity was steric effect, whereaselectrostatic effect only played an twortam role. On the analysis of steric effect, wefound that replacement of large group was disadvatage for the activity. The electrostaticfeatures in different position were also acquired.

    雪花胺是一类重要的乙酰胆碱脂酶抑制剂,有可能发展成治疗阿尔茨海默病的药物.利用分子力学计算得到了这类化合物的优势构象,并对这些化合物进行了CoMFA研究.发现,对于雪花胺类化合物,影响其药效的主要因素是空间结构,电荷作用力的影响较小.对空间因素的进一步分析发现,对于该类分子,不宜用空阻较大的基团进行取代.由电荷影响的分析得到了在不同位置上取代基所应有的电行性质.三维定量构效关系研究为基于雪花胺的抑制剂设计提供了方案.

     
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