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   阿尔茨海默 在 精神病学 分类中 的翻译结果: 查询用时:0.049秒
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  alzheimer
Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
      
Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
      
Mutations in presenilin 1 (PS1) gene are closely associated with the early onset of familial Alzheimer's disease (EOFAD).
      
Prospects of Non-drug Approaches to Alzheimer's Disease
      
According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease.
      
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  alzheimer ' s
Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
      
Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
      
Mutations in presenilin 1 (PS1) gene are closely associated with the early onset of familial Alzheimer's disease (EOFAD).
      
Prospects of Non-drug Approaches to Alzheimer's Disease
      
According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease.
      
更多          
  alzheimer s
Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
      
Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
      
Mutations in presenilin 1 (PS1) gene are closely associated with the early onset of familial Alzheimer's disease (EOFAD).
      
Prospects of Non-drug Approaches to Alzheimer's Disease
      
According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease.
      
更多          
  alzheimer s
Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
      
Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
      
Mutations in presenilin 1 (PS1) gene are closely associated with the early onset of familial Alzheimer's disease (EOFAD).
      
Prospects of Non-drug Approaches to Alzheimer's Disease
      
According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease.
      
更多          


Medified and inventory of diagnostic clinical features for dementia of the Alzheimer’s type(DAT) develpoed by Cummings and Benson. In a study of dementia of Alzheimer’s(AD)and cerebral vascular disease (VD),the results showed that the DAT inventory correctly identified 100% of DAT and VD.This DAT inventory is considered simple and facility,and might be aid for clini cians to diagnose Alzheimer’s disease.

修订Cummings和Benson设计的阿尔茨海默型痴呆诊断性临床特点调查表,用于阿尔茨海默氏病性痴呆和脑血管性痴呆。结果表明此调查表可100%地诊断两种痴呆。认为此调查表简单易行,对临床工作者在诊断阿尔茨海默病时可能有助。

Since Alzheimer′s disease seriously affects the health and life quality of old people,so that a lot of efforts have been devoted to develop new drugs for treat-ing this disease,In this paper,the efficacy,mechanism of action,dosage,dosing sche-dule,and ADRs of drugs for treatment of this disease are reviewed, they include tacrine,aniracetam,cerebrolysin,propentofylline,huperzine A,SDZ-ENA-713,E-2020,and NIK-247.

阿尔茨海默病(Alzheimer′disease,AD)是一种大脑进行性退变疾患,严重影响老年人的健康与生活质量。因此,世界各国制药界不断研制并推出抗AD新药进入临床试验,并已有几个药物上市。本文对已临床使用或正在临床试验的他克林,茴拉西坦,脑活素,丙戊茶碱,石杉碱甲,SDZ-ENA-713,E-2020,NIK-247等10多个药物的疗效、作用机制、给药剂量方案与毒副作用等作一简述。

The deposition of β-amyloid protein (β-AP) in the brain is the causative agent of Alzh-eimer's pathology. β-AP is a peptide product of the β-amyloid precursor protein (β-APP).Due to alternative splicing, there are several mRNA variants of β-APP. β-APP695, β-APP751 and P-APP770 are the main three which are different in the absence or presence of the Kunitz pro-tease inhibitor domain(KPI). RT-PCR with a pair of primers for the flank sequences of KPI can give rise to three cDNA variants corresponding to p-APP695,...

The deposition of β-amyloid protein (β-AP) in the brain is the causative agent of Alzh-eimer's pathology. β-AP is a peptide product of the β-amyloid precursor protein (β-APP).Due to alternative splicing, there are several mRNA variants of β-APP. β-APP695, β-APP751 and P-APP770 are the main three which are different in the absence or presence of the Kunitz pro-tease inhibitor domain(KPI). RT-PCR with a pair of primers for the flank sequences of KPI can give rise to three cDNA variants corresponding to p-APP695, β-APP751 and 3-APP770. In embryo rat's brain there is no detectable β-APPmRNA, whereas in the cerebral cortex and hippocampus of six-month-old rat the β-APP695 mRNA existed predominantly. In the neuro-blastoma cell line C 6 cells, p-APP695, β-APP751 and β-APP770 all appeared and the β-APP770 mRNA was the main one.

β-淀粉样蛋白(β-AP)是阿尔茨海默氏病(Alzheimer’s disease)病人老年斑的主要成分,它是β-淀粉样前体蛋白(β-APP)剪切后的产物。β-APP基因在体内存在β-APP_(695),β-APP_(751)β-APP_(770)。等几种主要的转录物,它们的区别在于Kunize丝氨酸蛋白酶抑制区(KDI)编码序列的存在和缺失。通过RT-PCR技术,用针对KPI编码区两侧序列的一种特异性引物可由总RNA样品中扩增出反映以上三种转录物的cDNA片段。实验表明,胎鼠脑组织中未检测到β-APPmRNA;6月龄大鼠海马组织,大脑皮层中只检测到β-APP_(695);在神经胶质瘤细胞系C6中存在β-APP_(695),β-APP_(751),β-APP_(770),其中β-APP_(770)占优势。

 
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