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|  | | 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。 | |
This paper is devoted to studying a free boundary problem modeling the effects of drug resistance and vasculature on the response of solid tumors to therapy.
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It is most likely that at the first steps of MDR development YB-1 activity is necessary for propagation of resistant cell populations rather than for maintenance of drug resistance.
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Along with multiple antitumor drug resistance, MCF-7Dox cells demonstrate elevated resistance to anchorage-dependent apoptosis (anoikis) and enhanced in vitro invasive activity.
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Short Double-Stranded RNA Suppresses Multiple Drug Resistance Gene Expression in Tumor Cells
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Mechanisms of apoptosis are retained in cells with P glycoprotein-mediated drug resistance
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| | Objective:To investigate the reversal of multidrug resistance ( MDR) of gastric carcinoma cell line SGC7901/ ADM by traditional Chinese medicine tetramethylpyrazine (TMP) and verapamil (VP). Methods: MTT assay was used to investigate the cytotoxicity of the drugs against human gastric carcinoma cell line in vitro SGC7901/ADM used alone or in combination. Results: The cytotoxicity of 5 - Fu to SGC7901/ADM was enhanced by TMP and/or VP at nontoxic doses . The effect is: VP ( 100mg/L) >TMP(300mg/L) +VP(10mg/L)... | | 目的:观察中药钙通道阻滞剂川芎嗪(TMP)联合维拉帕米(VP)对胃癌耐药细胞系SGC7901/ADM多药耐 药(MDR)的逆转。方法:采用四唑氮蓝(MTY)法以川芎嗪、维拉帕米为逆转剂,观察化疗药物对SGC7901/ADM的杀伤 作用。结果:采用非细胞毒性剂量300mg/L的TMP和/或10mg/L及100mg/L的VP与5-Fu联合应用,均能提高5-Fu 的细胞杀伤作用,其结果比较为:VP(100mg/L)>TMP(300mg/L)+VP(10mg/L)>TMP(300mg/L)>VP(10mg/L)。结 论:TMP与VP具有协同逆转作用,是一种有效的中药胃癌MDR逆转剂。 | | 文摘来源 | |   |
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