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慢性肝炎和慢性重型肝炎
相关语句
  severe chronic viral hepatitis b
     An Appraisal of the Therapeutic Effectiveness of Traditional Chinese Medicines in the Treatment of Severe Chronic Viral Hepatitis B
     中药治疗慢性肝炎和慢性重型肝炎疗效评价
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  “慢性肝炎和慢性重型肝炎”译为未确定词的双语例句
     METHODS: Experimental study on expression of perfurin in chronic severe patients: To detect the expression of perfurin in PBMC and liver tissue of healthy peoples, chronic hepatitis B and chronic severe hepatitis B and to observe the regulation of CHISHAO YINCHEN FANG for perfurin with RT-PCR.
     方法:慢重肝患者穿孔素表达特征的实验研究:采用RT-PCR方法检测正常人、慢性肝炎和慢性重型肝炎外周血单个核细胞穿孔素的表达特征;
  相似匹配句对
     Reevaluation of the typing criteria for patients with chronic severe hepatitis
     慢性重型肝炎分类的研究
短句来源
     Study on the mechanisms of treating chronic severe hepatitis with plasma exchange
     血浆置换治疗慢性重型肝炎
短句来源
     Use of Artificial liver System in the Treatment of Chronic Severe Hepatitis
     血浆交换治疗慢性重型肝炎
短句来源
     The Analysis of MELD in the 156 Severe Hepatitis
     慢性重型肝炎MELD评分分析
短句来源
     Analysis of prognostic factor in chronic severe hepatitis
     慢性重型肝炎预后因素分析
短句来源
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>=AIMS:To study the expression of perfurin in PBMC and liver tissue and explore its therapeutic organism; To observe the effect of CHISHAO YINCHEN FANG for chronic severe hepatitis B, which belongs to accumulation of damp -heat and tangling of heat and blood stasis in TCM; and to observe the regulation effect of CHISHAO YINCHEN FANG to perfurin.METHODS: Experimental study on expression of perfurin in chronic severe patients: To detect the expression of perfurin in PBMC and liver tissue of healthy peoples, chronic...

>=AIMS:To study the expression of perfurin in PBMC and liver tissue and explore its therapeutic organism; To observe the effect of CHISHAO YINCHEN FANG for chronic severe hepatitis B, which belongs to accumulation of damp -heat and tangling of heat and blood stasis in TCM; and to observe the regulation effect of CHISHAO YINCHEN FANG to perfurin.METHODS: Experimental study on expression of perfurin in chronic severe patients: To detect the expression of perfurin in PBMC and liver tissue of healthy peoples, chronic hepatitis B and chronic severe hepatitis B and to observe the regulation of CHISHAO YINCHEN FANG for perfurin with RT-PCR. And then further detection of the Expression of perfurin in PBMC of patients with chronic hepatitis B was done with flow cytometer. To study the correlation between the expression of perfurin in liver tissue in chronic severe hepatitis B patients and illness state. Observation of therapeutic effects; Patients of chronic severe hepatitis B(67 cases), which belongs to accumulation of damp-heat and tangling of heat and blood stasis syndrome in TCM, was divided into two groups randomly (respectively CHISHAO YINCHEN FANG group with 34 cases, western medicine group with 33 cases)treated for 28 days. After 28 days, the liver functions, signs and symptoms, complication, fatality rate and effective rate were observed. RESULTS; The result of the Expression of perfurin in PBMC in patients with hepatitis B with the flow cytometer show that CD16+56+ Perform+ CD3- and CD4- Perform- CD8+ cells were decreased; the CD16- Perforin+CD3- cells, CD16- Perforin+CD3- cells, CD56- Perforin+CD3- cells and CD4- Perforin + CD8+ cells were also decreased in patients with chronic severe hepatitis B, but increased in patients with hepatitis B, which indicate that these cells were helpful for severe hepatitis, however, the CD4+ Perform-CD8- cells and CD4+ Perform- CD8+ cells, which were increased only in patients with chronic severe hepatitis B, may result in the occurrence of the severe hepatitis. The expression of perfurin in liver tissue of patients with chronic severe hepatitis B were the most in group (TBIL: 171-342μmol/L), more in group (TBIL : 342 -513μmol/L)and less in group(TBIL: >513μmol/L). After the treatment for 4 weeks, the difference of TBIL, DBIL and PA (pre-albumin) in two groups were significant (P<0. 05). After the treatment for 2 weeks, the difference of PT (Prothrombin time) in two groups were significant (P<0. 01). The scores of symptoms (jaundice, anorexia, nausea vomiting, dry and bitter mouth, epigastric distention and oppression, fidgety and constipation) were significant (P<0. 05) after the treatment. The fatality rates of the two groups were respectively 17. 7% (CHISHAO YINCHEN FANG group), 39. 4%. (Western medicine group); and the effective rate were 61. 8% (CHISHAO YINCHEN FANG group) and 36. 4% (western medicine group), the difference were significant (P<0. 05). The difference of the Expression of perfurin mRNA in PBMC in patients with chronic severe hepatitis B were significant (P<0. 05) before and after the treatment. CONCLUSION :The correlation between the expression of perfurin and the patient's condition in patients with chronic hepatitis B was negative; and also was negative in patients with chronic severe hepatitis B. CHISHAO YINCHEN FANG was effective for chronic severe hepatitis B which belongs to accumulation of damp -heat and tangling of heat and blood stasis syndrome in TCM, which can improve the symptoms and the liver functions, especially for the improvement of TBIL, PA and PT; And can decrease the occurrence of complications and fatality rates, increase the survival rates and treatment effective rates without the occurrence of side effects. The CHISHAO YINCHENFANG can regulate the expression of perfurin in patients with chronic severe hepatitis B, and worth to be explored further.

目的:研究慢重肝患者外周血单个核细胞和肝组织穿孔素的表达特征,探讨其发病机理;观察赤芍茵陈方治疗中医为热毒瘀肝型慢性重型乙型肝炎(以下简称慢重肝)患者的临床疗效,以及对穿孔素的干预作用。方法:慢重肝患者穿孔素表达特征的实验研究:采用RT-PCR方法检测正常人、慢性肝炎和慢性重型肝炎外周血单个核细胞穿孔素的表达特征;流式细胞仪三色标记方法进一步检测分析乙肝病毒感染者外周血单个核细胞穿孔素的表达特征;研究慢重肝患者肝组织中穿孔素的表达和病情的关系。疗效观察:选取慢性重型乙型肝炎,中医为热毒瘀肝型患者67例,随机分为赤芍茵陈方治疗组34例和西药综合治疗对照组33例,治疗28天。观察两组患者肝功能、症状体征变化和并发症、病死率和有效率情况,检测治疗组赤芍茵陈方干预慢重肝外周血PBMC穿孔素表达的作用。结果:慢重肝患者穿孔素表达特征的实验研究部分:RT-PCR方法检测结果表明:外周血淋巴细胞穿孔素PCR扩增阳性表达正常人组最多,慢性乙型肝炎组病人较多,慢性重型乙型肝炎组病人最少;流式细胞仪三色标记方法进一步分析乙肝病毒感染者外周血单个核细胞穿孔素的表达特征,数据表明:肝病时CD16+56+Perforin+...

目的:研究慢重肝患者外周血单个核细胞和肝组织穿孔素的表达特征,探讨其发病机理;观察赤芍茵陈方治疗中医为热毒瘀肝型慢性重型乙型肝炎(以下简称慢重肝)患者的临床疗效,以及对穿孔素的干预作用。方法:慢重肝患者穿孔素表达特征的实验研究:采用RT-PCR方法检测正常人、慢性肝炎和慢性重型肝炎外周血单个核细胞穿孔素的表达特征;流式细胞仪三色标记方法进一步检测分析乙肝病毒感染者外周血单个核细胞穿孔素的表达特征;研究慢重肝患者肝组织中穿孔素的表达和病情的关系。疗效观察:选取慢性重型乙型肝炎,中医为热毒瘀肝型患者67例,随机分为赤芍茵陈方治疗组34例和西药综合治疗对照组33例,治疗28天。观察两组患者肝功能、症状体征变化和并发症、病死率和有效率情况,检测治疗组赤芍茵陈方干预慢重肝外周血PBMC穿孔素表达的作用。结果:慢重肝患者穿孔素表达特征的实验研究部分:RT-PCR方法检测结果表明:外周血淋巴细胞穿孔素PCR扩增阳性表达正常人组最多,慢性乙型肝炎组病人较多,慢性重型乙型肝炎组病人最少;流式细胞仪三色标记方法进一步分析乙肝病毒感染者外周血单个核细胞穿孔素的表达特征,数据表明:肝病时CD16+56+Perforin+CD3-细胞和CD4-Perforin-CD8+细胞明显下降,与病情相关,CD16-Perforin+CD3-细胞、CD16-Perforin+CD3-细胞和CD56-Perforoin CD3-细胞及CD4-Perforin+CD8+细胞仅在重肝时下降,而在慢乙肝静止期反而上升,说明上述细胞有抗重症肝炎作用,而CD4+Perforin-CD8-和CD4+Perforin-CD8+仅因在重肝时上升,可能有致重症化作用;总胆红素介于171-342μmol/L的慢重肝病人肝组织穿孔素表达最多,总胆红素342-513/μmol/L的病人居中,总胆红素>513μmol/L的病人最少。疗效部分:两组治疗四周总胆红素和直接胆红素有显著差异(P<0.05);治疗四周前白蛋白有显著差异(P<0.05);治疗两周和治疗四周凝血酶原时间都有极显著差异(P<0.01);两组治疗后身目发黄、纳呆、恶心呕吐、口干苦、脘闷腹胀、烦躁和大便秘结有显著差异(P<0.05);治疗4周时治疗组患者的病死率为17.7%,较对照组患者的39.4%为低(P<0.05);治疗组患者的有效率为61.8%,较对照组患者的36.4%提高(P<0.05)。赤芍茵陈方治疗组慢重肝患者外周血PFPmRNA表达治疗前比治疗后有显著差异(P<0.05)。结论:实验部分显示:乙肝病毒感染患者穿孔素表达和病情有关;慢重肝的病情程度和穿孔索的表达也有关系。赤芍茵陈方对中医辩证为热毒瘀肝型慢性重型乙型肝炎患者能有效改善肝功能,特别是退黄、升高前白蛋白和降低凝血酶原时间效果显著,缓解临床症状,能有效减少并发症和病死率,提高存活率和治疗有效率,无明显毒副作用,赤芍茵陈方具有调节慢重肝患者穿孔素表达的作用,临床运用安全可靠,值得进一步深入研究。

 
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