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  “2鄄l”译为未确定词的双语例句
     This study was designed to investigate cell apoptosis induced by (O, O-diisopropyl phosphoryl-L-tryptophan)2-L-lysine methyl ester <(DIPP-L-Trp)2-L-L ys-OCH3>, and its mechanism in K562 cells.
     本研究探讨二异丙基磷酰化二肽甲酯[(O,O鄄diisopropylphosphoryl鄄L鄄tryptophan)2鄄L鄄lysinemethylester,(DIPP鄄L鄄Trp)2鄄L鄄Lys鄄OCH3]诱导K562细胞凋亡的作用及其可能的机制。
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     METHODS: K562 cells were double stain ed by AnnexinV-FITC and propidium iodide (PI) to detect (DIPP-L-Trp)2-L-Lys-OCH3 -induced apoptosis by flow cytometry (FCM).
     方法:AnnexinV鄄FITC和PI双染法检测(DIPP鄄L鄄Trp)2鄄L鄄Lys鄄OCH3诱导的K562细胞凋亡。
短句来源
     After treatment of different concent rations of (DIPP-L-Trp)2-L-Lys-OCH3, K562 cells were stained by rhodamine123 and PI to detect changes in membrane potential (Δψm), or stained by 2',7'-dichlor ofluorescein diacetate (DCFH-DA) to detect reactive oxygen species (ROS) of mito chondrial by FCM.
     以罗丹明123(Rhodamine123)及2蒺,7蒺鄄二氯荧光素乙二酯(2蒺,7蒺鄄dichlorofluoresceindiacetate,DCFH鄄DA)为细胞染色剂,采用流式细胞术检测以不同浓度(DIPP鄄L鄄Trp)2鄄L鄄Lys鄄OCH3处理后K562细胞线粒体膜电位(Δψm)和活性氧(reactiveoxygenspecies,ROS)的变化。
短句来源
     RESULTS: When treated with 50 μg/ml of (DIPP-L-Trp)2-L-Lys-OC H3 for 24 h, apoptosis rate of K562 cells was 61.9%, Δψm was decreased in 93.6 % of K562 cells,and ROS production was decreased.
     结果:50μg/ml(DIPP鄄L鄄Trp)2鄄L鄄Lys鄄OCH3作用细胞24h,AnnexinV鄄FITC和PI双染检测表明,有61.9%的细胞出现早期凋亡现象。
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     2) The 3 species in Roegneria, i. e. R.
     2)R.
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     v2, G.
     v2、G.
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     2l ?
     2l?
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     The sporopollen includes Osmundacidites sp., Deltoidospora sp., Leiotriletes sp., Punctatisporites sp., Ilexpollenites sp., Quercoidites sp., Caryapollenites sp., Betulaceoipollenites sp., Sporopollis?
     ,Betulaceoipollenitessp. ,Sporopollis?
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     Conclusion: MMP-1 and MMP-3 may have important role in triggering pulmonary vascular remodeling and take part in the whole process.
     结论:MMP1和MM
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  2-l
The ramified regions consist of linear α-1,2-L-rhamno-α-1,4-D-galacturonan as the core.
      
Partial acid hydrolysis and digestion with pectinase demonstrated that comaruman composed of the backbone comprised regions of linear α-1,4-D-galactopyranosyl uronan interconnected by numerous residues of α-1,2-L-rhamnopyranose.
      
The excitation of (HCLCO + O) generally follows the Eley-Rideal mechanism, that is O + CO-L → CO2-L +hv or CO + O-L→ CO2-L +hv, where L denotes a lattice.
      
The highest rates of this process were recorded in summer: 0.95-2.60 mg S2-/dm3 per day in bottom sediments and up to 0.49 mg S2-/l per day in the water column.
      
The rate of sulfate reduction varied from 0.002 to 18.940 μg S2- l-1 day-1 and the rate of methanogenesis from 0.012 to 16.235 μg CH4 l-1 day-1.
      
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Objective:To assess the safety and effect of different intravenous chemotherapeutic regimens in patients with gastric carcinomas following curative gastrectomy.Methods:A systematic review of relevant randomized controlled trials(RCTs)was performed.RCTs were identified from Medline and Embase(1980~2002/8),and the Chinese Biomedicine Database(1990~2002/8).Literature references were checked at the same time.Randomized and quasirandomized trials with confirmed cases of curative gastrectomy were included,comparing...

Objective:To assess the safety and effect of different intravenous chemotherapeutic regimens in patients with gastric carcinomas following curative gastrectomy.Methods:A systematic review of relevant randomized controlled trials(RCTs)was performed.RCTs were identified from Medline and Embase(1980~2002/8),and the Chinese Biomedicine Database(1990~2002/8).Literature references were checked at the same time.Randomized and quasirandomized trials with confirmed cases of curative gastrectomy were included,comparing the effect of curative gastrectomy followed by intravenous chemotherapy with that of gastrectomy alone.Results:Seventeen trials involving2915patients were included.Metaanalysis was done with random effects model.Heterogeneity and sensitivity analyses were performed also.The effect of curative gastrectomy intravenous chemotherapy combined with post-operative was better than surgery alone(odds ratio0.66,95%CI0.51~0.85).There was significant difference between the two groups by utest(P=0.002).Sensitivity analyses revealed the same difference(odds ratio0.79,95%CI0.64~0.98).There were nine trials which detailed the sideeffects by the WHO toxicity grade standard.The sideeffects were haematologic and biochemical toxicity,debilitating nausea and vomiting.There were five patients died of chemotherapeutic toxicity.Conclusions:Based on the present review,curative gastrectomy followed by post-operative intravenous chemotherapy produces a positive therapeutic effect on gastric cancer.

目的:评价胃癌根治术后接受不同药物、剂量(经静脉)化疗的疗效和安全性。方法:应用国际Cochrane协作网的系统评价方法,研究文献中关于胃癌根治术后接受不同药物、剂量(经静脉)化疗组与单纯根治手术组疗效比较的随机和半随机试验进行了系统评价。结果:17个试验包括2915例病人,经异质性检验,χ2=37.58,P=0.0017,17个试验存在异质性;采用随机效应模型(D鄄L)法进行meta分析,合并效应量OR=0.66,95%可信区间为0.51~0.85,经u检验,P=0.002,说明胃癌根治术后接受不同药物、剂量(经静脉)化疗组的疗效优于单纯根治手术组。17篇文章中有9篇对化疗药物的毒性反应按WHO分度标准进行描述,副作用主要有胃肠道症状、骨髓抑制、心脏毒性、血液毒性等,5例病人死于化疗相关毒性事件。结论:胃癌根治术后接受化疗可能有一定效果,毒性事件发生率较低;在接受根治性切除术后,全身静脉化疗对提高胃癌病人的5年生存率可能有一定的作用。

To evaluate the relationship between bone marrow dissemination and distant metastases in operable breast cancer.The clinical trails published between Jan.1, 1990 and Mar.1,2003 on bone marrow dissemination in operable breast cancer were identified through Medline database.Relevant data,which accorded with the criteria of this paper,was abstracted. The results were pooled using Meta-analysis to estimate the impact of bone marrow dissemination on distant metastases in breast cancer.Sixty-three clinical trails...

To evaluate the relationship between bone marrow dissemination and distant metastases in operable breast cancer.The clinical trails published between Jan.1, 1990 and Mar.1,2003 on bone marrow dissemination in operable breast cancer were identified through Medline database.Relevant data,which accorded with the criteria of this paper,was abstracted. The results were pooled using Meta-analysis to estimate the impact of bone marrow dissemination on distant metastases in breast cancer.Sixty-three clinical trails on bone marrow dissemination in breast cancer were found,but only 9 of them that met with our inclusion criteria were identified. In the random effects model,P>0.05;odds ratio,2.85;95%confidence interval,1.68 to 4.82.[Conclusions]Bone marrow dissemination closely associated with distant metastases in operable breast cancer.Specific detection and large sample clinical trails are needed for revealing its definite significance.

[目的]探讨可手术乳腺癌患者骨髓播散与远处转移相关性。[方法]在Medline数据库中检索有关可手术乳腺癌骨髓播散方面的文献,选择符合本研究纳入标准的文献作为研究对象,对骨髓播散与远处转移的相关性进行Meta分析。[结果]共检索出63篇相关文献,其中符合纳入标准的文献9篇。骨髓播散对远处转移的影响,在随机效应模型下(D鄄L法)的齐性检验P>0.05,合并后OR=2.85,95%可信区间1.68~4.82。[结论]骨髓播散与可手术乳腺癌患者的远处转移密切相关;对这一问题的明确阐述尚需开发灵敏而特异的检测方法及大样本长期临床随访资料的积累。

Objective To study the effect of NG-nitro-L-argininemethyl-ester(L-NAME)on rat myocardial injury induced by adriamycin(ADM).Methods Eighty-five male Wistar rats were randomly divided into three groups:ADM group,ADM+L-NAME group and control group.MDA,SOD,nitric oxide(NO)and inducible nitric oxide synthase(iNOS)in myocardium and serum were detected and the pathological study was performed.Results The extent of myocardial injury in ADM+L-NAME group(16.7%)was significantly lower than that of ADM group(43.3%)with...

Objective To study the effect of NG-nitro-L-argininemethyl-ester(L-NAME)on rat myocardial injury induced by adriamycin(ADM).Methods Eighty-five male Wistar rats were randomly divided into three groups:ADM group,ADM+L-NAME group and control group.MDA,SOD,nitric oxide(NO)and inducible nitric oxide synthase(iNOS)in myocardium and serum were detected and the pathological study was performed.Results The extent of myocardial injury in ADM+L-NAME group(16.7%)was significantly lower than that of ADM group(43.3%)with P<0.05.Compared with ADM group,the contents of MDA in serium and myocardium of ADM+L-NAME group decreased significantly while the activity of SOD increased significantly.Compared with control group,the contents of nitric oxide and iNOS activity of myocardium in ADM group increased significantly.Conclusion L-NAME has protective effect on rat myocardial injury induced by ADM.The mechanism of the protective effect might related to the suppression of the iNOS activity which decreases the nitric oxide in myocardium.

目的研究一氧化氮合酶抑制剂N鄄硝基鄄L鄄精氨酸甲基酯(L鄄NAME)对阿霉素(ADM)致大鼠心肌损伤的保护作用。方法85只雄性Wistar大鼠,随机分为ADM组、ADM+L鄄NAME组及对照组。实验第30天,光镜下观察心肌形态结构病理改变;测定血清及心肌组织中的脂质过氧化物(MDA)和超氧化物歧化酶(SOD)活性;测定心肌组织中的一氧化氮(NO)及诱导型一氧化氮合酶(iNOS)的活性。结果光镜下ADM + L鄄NAME组大鼠心肌病理损害程度较ADM组轻,ADM + L鄄NAME和ADM两组心肌坏死灶的检出率分别为16.7%和43.3%,二者比较差异显著意义(P< 0.05)。与ADM组比较,ADM + L鄄NAME组血清、心肌组织中的MDA显著降低,而SOD活性显著增加;与对照组比较,ADM组心肌中NO和iNOS的活性均显著升高。结论L鄄NAME对ADM致大鼠心肌损伤有保护作用,其机理可能与抑制iNOS活性使心肌组织NO减少有关。

 
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