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慢性丙肝
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  chronic hepatitis c
     Clinical observation of serum IL-18,IL-10,sIL-2R,TNF-α levels in the patients with chronic hepatitis C before and after antiviral treatment
     慢性丙肝患者抗病毒治疗前后血清IL-18、IL-10、sIL-2R、TNF-α水平变化的临床观察
短句来源
     Results 2.7±1.16,4.8±1.68 and 5.2±2.85 SSCP bands were detected in the patients with acute hepatitis C, chronic hepatitis C and HCC respectively.
     结果 急性丙肝、慢性丙肝和HCC患者中 ,SSCP电泳条带数分别为 2 .7± 1.16、4.8± 1.6 8和 5 .2± 2 .85。
短句来源
     The levels of CD + 3, CD + 4, CD + 4/CD + 8 in acute and chronic hepatitis C with anti-HCV(+) were lower and CD + 8 was higher than those in normal controls (P<0.01).
     急慢性丙肝患者与正常对照组相比 ,外周血CD+ 3 ,CD+ 4百分率降低 ,CD+ 8百分率增高 ,CD+ 4/CD+ 8比值下降 (从P <0 .0 5降至P <0 .0 1) .
短句来源
     Diagnostic value of RIBA and RIA 2 in detection of anti HCV in chronic hepatitis C
     慢性丙肝RIBA与RIA-2检测抗-HCV的价值
短句来源
     The prevalence of SENV-D and/or gENV-H (SENV-D/H) infections in healthy adults and patients with acute hepatitis A, chronic hepatitis B, chronic hepatitis C and non A-E hepatitis were 30.7%, 37.5%, 64.8%, 57.1% and 44.7%, respectively.
     SENV D和/或H型在健康成人、急性甲肝、慢性乙肝、慢性丙肝和非甲-戊型肝炎患者中的总感染率分别为30.7%、37.5%、64.8%、57.1%和 44.7%。
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  “慢性丙肝”译为未确定词的双语例句
     Results The mean level of HCV-RNA and expressive levels of IL-8,IP-10,Mig mRNA in peripheral blood of HCV chronic infection were 2.09×10~(6)copies/ml,and(1.243 7±0.071 2),(0.682 8±0.073 8),(0.668 3±0.075 4),with significant difference with those of normal controls(P<0.01).
     结果慢性丙肝患者HCV-RNA平均水平2.09×106拷贝/m l,IL-8、IP-10、M igmRNA表达水平分别为(1.243 7±0.071 2)、(0.682 8±0.073 8)、(0.668 3±0.075 4),与正常对照相比,差异有显著性(P<0.01)。
短句来源
     Methods Totally 89 patients with hepatitis C were included in this study and 46 patients were treated with PEG-INF-2a (180 μg or 135 μg/week) and RBV 900 mg/d, 43 patients were treated with IFNα-2a (5 MIU/qod)and RBV 900 mg/d.
     方法观察了89例慢性丙肝患者,对46例慢性丙肝患者予PEGIFNα-2a(180μg或135μg/周)联合利巴韦林(RBV)900mg/d抗病毒治疗,对照组为43例慢性丙肝患者予IFNα-2a(5MIU/隔天)联合RBV900mg/d抗病毒治疗。
短句来源
     Results The SENV-H positive rate was 24.4% in healthy donors, 32.7% in acute hepatitis A patients,45.2% in chronic hepatitis B patients,65.0% in hepatitis C patients, 43.9% in hepatitis non A-E patients.
     结果SENV-H感染率在无偿献血者中为24.4%,在急性甲肝、慢性乙肝、慢性丙肝和非甲-非戊型肝炎患者中分别为32.7%、45.2%、65.0%和43.9%。
短句来源
     Between subgroup of post- transfusion case and sporadic case of CHC,frequency and mean titer of ANA/SMA were 25.6% vs 66. 7%(P<0.05)and l:20 vs l:100(P<0.001),respectivety.
     在输血后慢性丙肝和散发性慢性丙肝中,ANA/SMA阳性率分别为25.6%和66.7%(P<0.05),ANA/SMA平均滴度分别为1:20和1:100(p<0.001)。
短句来源
     Posi- tive rate of anti-GoR in CHC,CHB and healthy person group was 58. 3%,3.3%and0%respectuvely,it indicates that anti- GOR was closely related to HCV infection(P<.005).
     抗-GOR阳性率在慢性丙肝、慢性乙肝及健康人组中分别为58.3%,3.3%和0%,即抗-GOR与HCV感染密切相关(P<0,005)。
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  相似匹配句对
     Clinical Study on Chronic Hepatitis C Treated by "Liver-Clearing Granule
     清冲剂治疗慢性炎的研究
短句来源
     the toxic action of PZA on liver is greater than that of other antitubercular drugs.
     ?
短句来源
     HLA-DR Expression in Chronic Active Hepatitis C
     慢性活动性组织HLA-DR的表达
短句来源
     Changes of cytokines in the serums of patients with chronic hepatitis C before and after therapy with interferon-alpha
     慢性患者干扰素治疗前后血清细胞因子的变化
短句来源
     Clinical study on HCV RNA in PBMC of patients with chronic viral hepatitis C treated with interferon alpha 2b
     α2b干扰素治疗慢性患者的临床研究
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  chronic hepatitis c
Neurological manifestations of chronic hepatitis C
      
Response to treatment of chronic hepatitis C with interferon α in patients infected with HIV-1 is associated with higher CD4+ ce
      
The aim of this study was to assess the efficacy and tolerance of interferon α (IFN α) treatment of chronic hepatitis C in HIV-seropositive patients.
      
The results indicate that IFN α treatment of chronic hepatitis C in HIV-seropositive patients is successful in a considerable number of cases.
      
HCV genotypes in patients with chronic hepatitis C in Croatia
      
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T cell subsets in peripheral blood of 35 chronic patients with hepatitis C have been investigated through monoclonal antibody and APAAP assay. The results showed that the percentage of cells in patient group with hepatitis C had no difference and cells and OKT4/OKT8 ratio were lower than that of the control group.The percentage of cells and OKT4/OKT8 ratio in HBsAg negative patient group with hepatitis C were significantly lower than that of the control group. No difference was observed in the percentage of...

T cell subsets in peripheral blood of 35 chronic patients with hepatitis C have been investigated through monoclonal antibody and APAAP assay. The results showed that the percentage of cells in patient group with hepatitis C had no difference and cells and OKT4/OKT8 ratio were lower than that of the control group.The percentage of cells and OKT4/OKT8 ratio in HBsAg negative patient group with hepatitis C were significantly lower than that of the control group. No difference was observed in the percentage of OKT8 cells. The percentages of cells in HBsAg positive patient group with hepatitis C were significantly lower in comparison with control group and chronic active patient group with hepatitis B, but the OKT4/OKT8 ratio showed no difference. The percentage of cells was significantly lower as compared with HBsAg negative patient group with hepatitis C. These results indicated that T cell subsets in peripheral blood in patients with hepatitis C were obviously out of balance and the percentage of cells was significantly lower in hepatitis C patients co-infected with HBV.

应用单克隆抗体和APAAP法对35例慢性丙型肝炎患者的外周血T淋巴细胞亚群的分布进行了检测。结果表明慢性丙肝患者OKT_3 ̄+细胞与正常对照无显著差异,而OKT_4 ̄+、OKT_8 ̄+细胞及OKT_4/OKT_8比值均低于正常对照。结果还表明HBsAg阴性的丙肝患者细胞和OKT_4/OKT_8比值明显低于正常对照,而OKT_8 ̄+细胞差别不显著。合并HBsAg阳性的丙肝患者OKT_4 ̄+、OKT_8 ̄+细胞均显著低于正常对照和慢性活动性乙型肝炎患者,而OKT_4/OKT_8比值的差异则不显著,OKT_8 ̄+细胞还显著低于HBsAg阴性的丙肝患者。提示慢性丙型肝炎患者外周血T淋巴细胞亚群分布存在明显的失衡现象;合并HBsAg阳性对OKT_8 ̄+细胞有明显影响。

Using polymerase chain reaction and recombination DNA technique,the core gencs(HCV-Y1 and HCV-Y2)of hepatitis C virus genome were cloned in sera from patients with acute-and chronic-hepatitis C in the inshore Nantong area of the Yangtze River.The core genes of HCV were expressed in E.Coli,and highly homeology of their nucleotide sequences were shown to compare with the other isolatcs.They are similar to HCV type Ⅱ like HCV-J and HCV-T.These data should be useful in genetic classification of HCV,detection of...

Using polymerase chain reaction and recombination DNA technique,the core gencs(HCV-Y1 and HCV-Y2)of hepatitis C virus genome were cloned in sera from patients with acute-and chronic-hepatitis C in the inshore Nantong area of the Yangtze River.The core genes of HCV were expressed in E.Coli,and highly homeology of their nucleotide sequences were shown to compare with the other isolatcs.They are similar to HCV type Ⅱ like HCV-J and HCV-T.These data should be useful in genetic classification of HCV,detection of antibody to HCV for early diagnosis of HCV infection.

以基因扩增及重组DNA技术,从长江下游南通地区急性丙肝和慢性丙肝患者血清中成功地克隆了丙肝病毒核心蛋白基因(HCV-Y1和HCV-Y2)。该段基因在大肠杆菌内已得到高效表达,它们的序列分析发现核苷酸组成的同源性为93.2%,与已报告的HCV株比较属于HCV-Ⅱ型。这对于我国HCV的基因分型以及开发丙肝核心蛋白抗体检测,早期诊断丙肝感染都具有良好的应用前景。

Hepatitis C virus (HCV) is a positive strand RNA virus. It replicates through a negative strand RNA as the intermediator which in turn is used as the template in the subsequent amplification of the positive strand genomic RNAs. Replicative form as detected by nested PCR procedure was monitored in 17 patients with chronic hepatitis C treated with interferon. Positive strand RNA of HCV was found in all the 17 patients and negative strand was foun in 13 before interferon treatment. At the end of therapeutic course...

Hepatitis C virus (HCV) is a positive strand RNA virus. It replicates through a negative strand RNA as the intermediator which in turn is used as the template in the subsequent amplification of the positive strand genomic RNAs. Replicative form as detected by nested PCR procedure was monitored in 17 patients with chronic hepatitis C treated with interferon. Positive strand RNA of HCV was found in all the 17 patients and negative strand was foun in 13 before interferon treatment. At the end of therapeutic course of interferon for 12 weeks,9 were responders and 8 were non-responders. In the responder group the positive strand became nondetectable in 4 and also 3 out of 13 negative strand ones became nondetectable the same. In contrast, in non-responder group both positive and negative strands there were no change however. These results demonstrate that active infectionand replication of HCV is present in patients with chronic hepatitis C and interferon seems able to exert an inhibitory effect on this process. It suggests that detection of negative strand RNA of HCV may be a useful marker for evaluating and predicting the effect of treatment.

利用套式逆转录多聚酶链反应(RT-PCR)方法,对17例慢性丙肝患者进行了血清丙肝病毒正、负链RNA的检测,并且动态观察了其对干扰素治疗的反应。结果发现治疗前17例患者血清中正链RNA均阳性,13例血清负链RNA亦阳性(反应组8例,无反应组5例)。治疗后反应组中4例血清正链RNA阴转,3例负链RNA阴转;无反应组中血清正、负链RNA状况无变化。提示患者血清中有正、负链RNA复制复合体存在,体内有活跃的病毒复制;干扰素对丙肝病毒及复制活动有抑制作用。负链RNA作为病毒复制活动的直接标志,对评估和预测丙肝治疗的疗效有一定的意义。

 
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