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剂量-反应     
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  dose-response
     A correlation for dose- response was found between cadmium dosage and LSZ (y=0.896+ 0.196x- 0.094x2,r2=0.820 5), and so was for POD (y=0.262+ 0.042x- 0.019x2, ).
     LSZ与Cd剂量间的剂量-反应关系拟合为y=0.896+0.196x-0.094x2(r2=0.8205),POD与Cd剂量间的剂量-反应关系拟合为y=0.262+0.042x-0.019x2(r2=0.7898);
短句来源
     Results In the concentration gruop of 0.062 and 0.046 μg/ml,DNA synthesis quantities were significantly different from the control group(P<0.05),However,DNA synthesis inhibition and good dose-response relationships were shown in the gruop of 0.250,0.187 and 0.125 μg/ml.
     结果八氯二丙醚浓度为0.062,0.046μg/ml时DNA合成量与对照组比差异有统计学意义,表现为合成增加(P<0.05),浓度为0.250,0.187,0.125μg/ml时,则表现为合成抑制(P<0.05),且呈剂量-反应关系(P<0.05);
短句来源
     The cumula-tive log dose-response curve of lobeline on the APD was shifted parallelly to theright by N_1-cholinergic receptor blocker hexamethonium (10μM).
     N_1 受体阻断剂六甲双铵(hexamethonium,10μM)使洛贝林对APD的剂量-反应曲线平行右移。
短句来源
     LDH enzyme activity was inhibited obviously in 100mg/L and 500mg/L dose groups; and there was a dose-response relationship between poisoning dose and LDH enzyme activity.
     100,500mg/L剂量组LDH酶活力明显受到抑制,且染毒剂量与LDH酶活力呈剂量-反应关系;
短句来源
     Study on the dose-response relationship of asbestosis prevalence
     接触石棉尘量与石棉肺发病的剂量-反应关系研究
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  dose-effect
     The SOD activity in 0.5 μmol/L Na_2AsO_2 group was significantly higher than that in the control group(P<0.01)while the SOD activity induced by 5.0 and 10.0 μmol/L Na_2AsO_2 was significantly decreased(P<0.01) if compared with the control group with the dose-effect relation of an inverted U curve.
     0.5μmol/L Na2AsO2引起SOD活力明显升高,而5.0和10.0μmol/LNa2AsO2引起SOD活力均明显降低,与对照组相比,差异有统计学意义(P<0.01),其剂量-反应关系呈倒U形曲线。
短句来源
     There was dose-effect relationship between the concentration of MTBE and hepatocytes DNA migration lengths in mice(r=0.997,P=0.003).
     肝细胞DNA迁移距离与MTBE浓度有剂量-反应关系(r=0.997,P=0.003)。
短句来源
     MTBE above 0.050 mmol/L caused greater DNA migration in cultured rat type Ⅱ pneumocytes and rat hepatocytes in vitro(P<0.05),and also with dose-effect relationship(r_ lung=0.967,r_ liver=0.963,P<0.05)).
     MTBE浓度>0.050mmol/L时,大鼠肺Ⅱ型细胞、肝细胞DNA迁移距离较阴性对照组增加,差异有统计学意义(P<0.05),且DNA迁移距离与MTBE浓度有剂量-反应关系(r肺=0.967,r肝=0.963,均P<0.05);
短句来源
     Results According to the dose-effect relation of FA toxicity to MRC-5, 100μmol/L was choosed as low dose and 10 mmol/L was choosed as high dose.
     结果 根据FA对MRC 5毒性的剂量-反应关系,选择10 0 μmol L为低剂量、10mmol L为高剂量。
短句来源
     Results The PC12 cells were exposed to lead acetate at varied concentrations for 24 hours, and the growth and proliferation of the cells are inhibited with various degrees, showing a dose-effect relationship. The IC_ 50 was detected to be (533.966±100.830) μmol/L.
     结果用不同浓度的醋酸铅处理细胞24小时,其生长增殖受到不同程度的抑制,且呈现出剂量-反应关系,其IC50值为(533.966±100.830)μmol/L。
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  dose response
     There was also a dose response relationship( r =0.886,0.787, 0.832, respectively).
     并有剂量 -反应关系 (r值分别为 0 .886、0 .787、0 .832 )。
短句来源
     The dose response relationship may be described by the log·log regression equation; log R=0.20 log C + 0.75 for E, akaara and log . R=0.22 log C+ 0.82 for E.
     二种石斑鱼对丙氨酸刺激的剂量-反应关系可用双对数回归方程表示:赤点石斑鱼为logR=0.20log C+0.75,青石斑鱼为log R=3.22 logC+0.82,其电生理阈值分别为10~(9.9) mol/1和10~(-9.6)mol/1;
短句来源
     There was significant difference in above results in the medium and high dosage groups compared with the negative control group(P<0 05 or P<0 01), and there was dose response relationship(r=-0 987,-0 895,-0 981,0 981,0 958 and 0 962,respectively,P<0 05) in these indexes.
     中、高剂量组的上述结果与阴性对照组比较 ,差异均有显著性 (P <0 0 5 ,P <0 0 1 ) ,均存在明确的剂量 -反应关系 ,相关系数依次为 :- 0 987,- 0 895 ,- 0 981 ,0 981 ,0 95 8和 0 96 2 (均P <0 0 5 )。
短句来源
     The micronucleus rates of low,middle and high dose groups(4.0‰,6.2‰,10.2‰) were significantly higher than that in negative group(1.8‰),and showed a dose response relationship.
     其低、中、高(1/8 LD50、1/4 LD50、1/2 LD50)剂量组的微核率分别为4.0‰、6.2‰、10.2‰,明显高于阴性对照组的1.8‰,并在一定范围内呈现明显的剂量-反应关系。
短句来源
     [Results] The rat type Ⅱ lung cells were treated with extract of air pollutants of RTSCDG at a single concentration of 1 02,2 03,4 06,8 13mg/ml,increase in DNA cross links and DNA single strand breaks and the dose response relationship were found after treatment ( r cross links =0 981, r breaks =0 987, P <0 01).
     [结果 ]在 1 0 2、2 0 3、4 0 6、8 13mg/ml的浓度范围内 ,颗粒提取物能引起大鼠肺Ⅱ型细胞DNA产生双链间的交联和单链断裂 ,并存在剂量 -反应关系 (r交联 =0 981,r断裂 =0 987,P <0 0 1)。
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  dosage response
     Sunflower was an ideal material for bioassay. The minimum detectable concentration for metsulfuron methyl with sunflower's root length was 0.125 μg/kg. The optimal dosage response model is y=a+b ln x.
     研究表明 ,向日葵是甲磺隆理想的生物测定试材 ,对甲磺隆的最低检出浓度达到 0 .12 5 μg/kg,其根长抑制率与除草剂浓度有高度的相关性 ,最佳的剂量 -反应模型为 y=a+b lnx
短句来源
     The allergen is mainly feather and dermatophagoides,and there is a dosage response relationship to some extent.
     结论 :羽毛加工产生的粉尘可导致机体发生由 Ig E介导的变态反应疾病 ,其变应原主要为羽毛和尘螨 ,并存在一定的剂量 -反应关系
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      dose-response
    The analysis of dose-response relationships indicated that when the hemodynamic scores in patients with hypertension were lower than 75 points, the RR of stroke at 75, 60, 45, 30 and 15 points were 2.85, 4.43, 4.54, 5.40 and 9.88, respectively.
          
    Dose-Response Functions as Estimates of the Effect of Acid Precipitates on Materials
          
    Presented and discussed are dose-response functions for structural metals and alloys (bronze, copper, weathering steel, zinc, aluminum, nickel and tin), stone materials (limestone and sandstone), paint coatings and glasses.
          
    The Classification System of ISO 9223 Standard and the Dose-Response Functions Assessing the Corrosivity of Outdoor Atmospheres
          
    A model and dose-response functions characterising the corrosivity of the outdoor atmospheres are described.
          
    更多          
      dose-effect
    No linear dose-effect relationships have been revealed for both physiological and biochemical parameters.
          
    As for individual solvents, the action of their mixtures with water obeys the "dose-effect" law, with a greater influence of small doses of absorbed vapors on the polymer structure and optical activity.
          
    The dose-effect dependence indicated stimulating effects of β-endorphin, DAGO, and DADLE on the proliferative response in the presence of phytohemagglutinin (PHA).
          
    The curve of the dose-effect dependence of C6-AHB had a breaking point within the submillimolar (10-4 M) concentration range.
          
    The phytotoxicity variation is maximum in a moderately polluted plot, where both very high and very low pollution levels were observed, which determines a substantially nonlinear dose-effect relationship.
          
    更多          
      dose response
    Thus, the three-phase (bimodal) dose response corresponds to two regimes (steady-states) of cell functioning which differ in cell sensitivity to external stimuli.
          
    In separate experiments 0.2 mg/kg+0.2 mg/kg/hr SQ 29,548 antagonized the activity of a TXA2 mimetic, U-46,619, for femoral vasoconstriction, causing 100-to-200 fold rightward shifts in dose response relationships.
          
    A dose/response relationship with dothiepin was observed.
          
    Determination of Tolerance Dose Uncertainties and Optimal Design of Dose Response Experiments with Small Animal Numbers
          
    Dose response experiments aim to determine the complication probability as a function of dose.
          
    更多          
      dosage response
    Mortality after the DD treatment, defined as the complement of the percentage of survival, was estimated for each 5 cm layer of soil to a depth of 30 cm to construct dosage response curves.
          
    Dosage response to ethanol mediates host selection by "secondary" bark beetles
          
    Dosage response of rye genes in a wheat background
          
    Thus, while overall expressed in a dominant fashion, the resistance does exhibit some allelic dosage response.
          
    The bimodal dosage response curves could be divided into a first zone of inhibition, a zone of reversed toxicity, and a second zone of inhibition.
          
    更多          


    Tachyphylaxis to ephedrine has been studied on the cat's nictitating membranes, the cat's and the rat's blood pressure. In the course of the development of tachyphylaxis to ephedrine in cats, it was found that: (1)the cumulative effect(probit) of ephedrine on nictitating membranes could be plotted linearly against its cumulative dose(log)(Fig.3), (2)the responses of nictitating membranes to supramaximal electrical stimuli on the cervical sympathetic nerve diminished, and (3) both the pressor and the nictitating...

    Tachyphylaxis to ephedrine has been studied on the cat's nictitating membranes, the cat's and the rat's blood pressure. In the course of the development of tachyphylaxis to ephedrine in cats, it was found that: (1)the cumulative effect(probit) of ephedrine on nictitating membranes could be plotted linearly against its cumulative dose(log)(Fig.3), (2)the responses of nictitating membranes to supramaximal electrical stimuli on the cervical sympathetic nerve diminished, and (3) both the pressor and the nictitating membrane responses to intravenous noradrenaline increased. Tachyphylaxis to the pressor effect of ephedrine in rats was found to be easily induced by repeated intravenous doses of 8mg/kg each at short intervals(Fig.6).After the development of tachyphylaxis to ephedrine in rats,the dose-pressor-response curve of tyramine was depressed (Fig.7), while that of noradrenaline was not altered significandy. In cats pretreated with reserpine (2.5—5mg/kg), the response of nictitating membranes was depressed significantly at the dose of 2.5mg/kg on the dose-response curve of ephedrine (Fig.4). On the contrary, the dose-pressor-response curves in reserpinized cats and rats were elevated at the last and maximal dose of ephedrine (12.5mg/kg in cats; 8mg/kg in rats) in comparing with controls in which the response to the last dose had been depressed due to the development of tachyphylaxis (Fig. 5,9). In rats pretreated with reserpine in different schedules (5mg/kg, 3—4 hours previously; 1mg/kg daily for 5 days and 7mg/kg daily for 2 days), the development of tachyphylaxis tended to be delayed and the pressor effect of the first dose of ephedrine was potentiated especially during the acute influence of a 5mg/kg dose of reserpine. Bilateral adrenalectomy made no significant difference in the results of some of the above experiments (Fig.9, Tab.4). Infusion of noradrenaline in the beginning of the rat experiments could also potentiate the pressor effect of ephedrine, but unlike reserpinization, it hastened the development of tachyphylaxis in most cases. If noradrenaline was infused after tachyphylaxis, it could partially restore the pressor effect of ephedrine injected during the infusion (Fig.8). After cocaine(2.5mg/kg, i.v.), the dose-pressor-response curve was depressed and the development of tachyphylaxis hastened (Fig.10). These results would suggest the coexistence of two important factors in the development of tachyphylaxis to ephedrine: (1) tachyphylaxis to the direct action of ephedrine is due to saturation of receptors; (2) tachyphylaxis to the indirect action of ephedrine is due to depletion of catechol amines.

    本文对于猫瞬膜,猫及大鼠血压对麻黄碱的快速耐受性进行了系統研究。在猫对麻黄碱快速耐受性产生过程中发现:(1) 麻黄碱对瞬膜的积累作用(机率)与积累剂量(对数)呈直线关系,(2) 瞬膜对电刺激交成神经的反应减弱,(3) 血压及瞬膜对静脉注射去甲腎上腺素的反应增加。与其他实驗动物相似,大鼠連续注射麻黄碱8毫克/公斤,其升压作用也易于产生快速耐受性。大鼠血压对麻黄碱产生快速耐受性后,酪胺的剂量反应曲线被压低,但去甲腎上腺素的曲线并无显著改变。猫预先注射利血平后,其瞬膜对麻黄碱的剂量反应曲线中部(2.5毫克/公斤)被压低。在猫和大鼠的剂量-升压反应曲线中,最大也卽最后一剂麻黄碱(猫:12.5毫克/公斤;大鼠:8毫克/公斤)的反应由于快速耐受性而有所降低;但用利血平后可使这个反应较对照組显著升高。大鼠预先用不同剂量利血平后,麻黄碱快速耐受性的产生趋于延緩;并且第一剂麻黄碱的升压作用,特别是在注射利血平5毫克/公斤,3—4小时后,有增强现象。切除腎上腺对上述結果似无影响。预先灌注去甲腎上腺素也可增强第一...

    本文对于猫瞬膜,猫及大鼠血压对麻黄碱的快速耐受性进行了系統研究。在猫对麻黄碱快速耐受性产生过程中发现:(1) 麻黄碱对瞬膜的积累作用(机率)与积累剂量(对数)呈直线关系,(2) 瞬膜对电刺激交成神经的反应减弱,(3) 血压及瞬膜对静脉注射去甲腎上腺素的反应增加。与其他实驗动物相似,大鼠連续注射麻黄碱8毫克/公斤,其升压作用也易于产生快速耐受性。大鼠血压对麻黄碱产生快速耐受性后,酪胺的剂量反应曲线被压低,但去甲腎上腺素的曲线并无显著改变。猫预先注射利血平后,其瞬膜对麻黄碱的剂量反应曲线中部(2.5毫克/公斤)被压低。在猫和大鼠的剂量-升压反应曲线中,最大也卽最后一剂麻黄碱(猫:12.5毫克/公斤;大鼠:8毫克/公斤)的反应由于快速耐受性而有所降低;但用利血平后可使这个反应较对照組显著升高。大鼠预先用不同剂量利血平后,麻黄碱快速耐受性的产生趋于延緩;并且第一剂麻黄碱的升压作用,特别是在注射利血平5毫克/公斤,3—4小时后,有增强现象。切除腎上腺对上述結果似无影响。预先灌注去甲腎上腺素也可增强第一剂麻黄碱的升压作用,但与利血平化不同,对多数大鼠,反可促进快速耐受性的产生。大鼠产生快速耐受性后,灌注去甲腎上腺素可部分地恢复麻黄碱的升压作用。预先静脉注射可卡因2.5毫克/公斤可压低麻黄碱的剂量反应曲线。以上一系列实验資料提示麻黄碱快速耐受性的形成由于两种重要因素:(1) 麻黄碱直接作用的快速耐受性是由于受体的饱和,(2) 麻黄碱间接作用的快速耐受性是由于介质的耗竭。

    A tincture was prepared from Erysimum cheiranthoides L. that grew wild in the Northeast of China and, after alcohol was removed by vaporization, was suspended in saline solution of suitable concentration; it was then used in experiments. Through repeated experiments on hearts (of frogs and rabbits) in situ, on perfused isolated hearts (of frogs and rabbits) and on ECG (cats), it was found that the preparation had a cardiotonic effect and, in addition to the cardiac effect, it displayed a positive glucoside...

    A tincture was prepared from Erysimum cheiranthoides L. that grew wild in the Northeast of China and, after alcohol was removed by vaporization, was suspended in saline solution of suitable concentration; it was then used in experiments. Through repeated experiments on hearts (of frogs and rabbits) in situ, on perfused isolated hearts (of frogs and rabbits) and on ECG (cats), it was found that the preparation had a cardiotonic effect and, in addition to the cardiac effect, it displayed a positive glucoside reaction as well. Judging from the fact that the active principles of the other species of the same plant were generally cardiac glucosides, it must, the authors believed, contain cardiac glucoside. The effect of the preparation was very rapid; the "log dose-response (percentage of death in probits) line" was parallel to that of k-Strophanthin; and it had no cumulative effect. Hence the authors concluded that its cardiac actions were similar to those of k-Strophanthin. One gram of the dry powder made of the aerial part of the plant was approximately equal in potency to 2.91 mg k-Strophanthin. The mouse LD_(50) (24 hr., i.p.) is 5.24±0.48gm/kg (P=0.95).

    将东北野生桂竹糖芥制成酊剂,蒸去乙醇以盐水混悬用于实驗。通过青蛙和家兔在体心、离体心以及猫心电图的实驗,确証此制剂具有强心作用;化学定性也証明它有甙类反应,据此,作者认为此植物肯定含有心甙。此制剂的“对数剂量-反应机率单位直线”与k-毒毛旋花素的相平行;无明显蓄积性并且生效甚速,故认为它的作用性貭与毒毛旋花素相似。上述結果与国外同种植物的研究資料基本相同。此植物地上部分的干粉1克相当于2.91±0.19毫克的k-毒毛旋花素(蛙法),又相当于17.9猫单位;小白鼠腹腔注射24小时的LD_(50)为5.24±0.48克/公斤(P=0.95)。

    A double antibody radioimmunoassay for detecting luteinizing hormone inrat serum was developed by using rabbit anti-ovine LH serum and radioiodinatedovine LH.In this heterogeneous system the dose-response curve of ovine LHwas parallel to that of rat LH.When ovine LH_(2-2-1)was used as a referencestandard,the sensitivity of the assay was found to be 0.1 ng per tube.The im-munoassay potency of LH_(2-2-1)was equal to that of NIH-LH-S_(18).By using ratLH-RP-1 as a reference standard,the sensitivity was found to...

    A double antibody radioimmunoassay for detecting luteinizing hormone inrat serum was developed by using rabbit anti-ovine LH serum and radioiodinatedovine LH.In this heterogeneous system the dose-response curve of ovine LHwas parallel to that of rat LH.When ovine LH_(2-2-1)was used as a referencestandard,the sensitivity of the assay was found to be 0.1 ng per tube.The im-munoassay potency of LH_(2-2-1)was equal to that of NIH-LH-S_(18).By using ratLH-RP-1 as a reference standard,the sensitivity was found to be 10 ng per tube.Since rat FSH did not show crossreaction with anti-ovirie LH serum,the inter-ference of FSH appeared to be negligible in the measurement of serum LH.By using this assay system we have studied the changes of serum LH levels inrats after ovariectomy and with treatment of progesterone and diethylstilboestroltwo months after the operation.The results confirm that sex steroid hormonespossess a negative feedback mechanism to pituitary LH secretion.The effect ofgossypol on LH secretion has also been investigated.It has been found that inadult male rats there are no significant changes either on the serum LH level or inthe response of pituitary to LRH injection following gossypol administration.The data seem to indicate that this new antifertile agent for male,gossypol,does not influence the LH secretion of pituitary.

    用兔抗羊 LH 血清和放射性碘标记的羊 LH 建立了大白鼠血清中 LH 的双抗体放射免疫测定法。在这异源的系统中羊 LH 和大鼠 LH 的剂量反应曲线是平行的。当用羊LH_(2-2-1)作参考标准时测量的灵敏度为0.1ng/管。当用大鼠 LH-RP-1作参考标准时测量的灵敏度为10ng/管。大鼠的 FSH 没有交叉反应,所以 FSH 不会干扰血清 LH 的测定。用这个系统我们研究了去卵巢以及去卵巢后给予孕酮和巳烯雌酚以后大鼠血清中LH 水平的变化。结果表明性类固醇激素对大鼠垂体 LH 的分泌具有一个负反馈的调节机制。本文中还研究了棉酚对大鼠 LH 分泌的影响。我们发现成年雄鼠服用棉酚以后血浆 LH 的水平以及垂体对 LRH 的反应均无显著的变化。结果表明新的男性抗生育药物——棉酚似乎不影响垂体的 LH 分泌功能。

     
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