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浅表膀胱癌
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  superficial bladder cancer
     The role of cell adhesion, multidrug resistance and cell proliferation in short-term recurrent cases with T_1G_3 superficial bladder cancer
     细胞黏附、多药耐药及细胞增殖在T_1G_3型浅表膀胱癌近期复发中的作用
短句来源
     LARGE DOSE OF MITOMYCIN c INTRAVESICAL INSTILLATION INTHE PREVENTION OF SUPERFICIAL BLADDER CANCER RECURRENCE
     大剂量丝裂霉素C膀胱灌注预防浅表膀胱癌复发的研究
短句来源
     Long-term Prognostic Value of the First Recurrence-free Period in Patients with Superficial Bladder Cancer
     首次无复发间期在浅表膀胱癌患者中的远期预后价值
短句来源
     Conclusions Minimum adhesion, strong drug resistance and maximum proliferation are the main factors that promote short-term recurrence of superficial bladder cancer and also the inherent reasons for easy recurrence and high malignancy of T 1G 3 tumors.
     结论 黏附性低、耐药性强和增殖旺盛是促使T1G3 型浅表膀胱癌近期复发的主要因素 ,同时也是导致T1G3 肿瘤易复发、高恶性度的内在原因。
短句来源
     ObjectiveTo evaluate the long-term prognostic value of the first recurrence-free period (RFP) in patients with superficial bladder cancer (SBC).
     【目的】评价首次无复发间期 (recurrence freeperiod ,RFP)在浅表膀胱癌患者中的远期预后价值。
短句来源
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  superficial bladder carcinoma
     Objective To investigate the relationship of protein kinase C-alpha(PKCα) expression /activation with tumor differentiation and resistance to chemotherapy drugs in superficial bladder carcinoma.
     目的探讨蛋白激酶C(PKC)α与浅表膀胱癌细胞分化及内源性耐药的关系。
短句来源
     Conclusions Only BCG instillation and combined instillation of BCG and other drugs could effectively lower recurrence of superficial bladder carcinoma after surgical operation.
     结论BCG灌注或者联合其他灌注方法能有效降低浅表膀胱癌术后的复发率。
短句来源
     Methods Literatures in the relationship between different instillation methods and recurrence of superficial bladder carcinoma issued from January 1989 to February 2005 were retrieved and the effects were quantitatively estimated with fixed-effect model and random-effect model by meta-analysis.
     方法应用M ETA分析固定效应模型和随机效应模式对1989年1月至2005年2月有关浅表膀胱癌不同灌注方法与膀胱癌术后复发的文献进行综合定量评价。
短句来源
     The role of protein kinase C alpha in recurrence of superficial bladder carcinoma
     蛋白激酶Cα对浅表膀胱癌分化及阿霉素内源性耐药的作用
短句来源
     The Role of PKC-alpha on Differentiation and the Inherent Resistance to ADM in Superficial Bladder Carcinoma
     蛋白激酶C-alpha对浅表膀胱癌分化及阿霉素内源性耐药的作用
短句来源
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  “浅表膀胱癌”译为未确定词的双语例句
     A human RT4 bladder cancer cell line stably expressing green fluorescent protein(GFP)-PKCα (RT4/PKCα) was established.
     应用人浅表膀胱癌细胞系RT4细胞,建立能够稳定表达PKCα绿色荧光蛋白(GFP)的人膀胱癌细胞系RT4/PKCαGFP。
短句来源
     Methods:The local secretion of IL2 and TNFα was examined in the urine of patients before and after intravesical instillation of BCGCWS.
     方法:通过酶联免疫吸附法(ELISA),检测浅表膀胱癌患者BCGCWS灌注后,尿中细胞因子(IL2和TNFα)的变化情况。
短句来源
     Methods Expression of PKCα was measured by Western-blot analysis in 76 samples including tumor and normal tissues, respectively.
     方法采用蛋白印迹法检测76例临床标本(浅表膀胱癌及正常组织)中PKCα的表达水平,对所有患者行标准化疗后随访4~24个月,分析PKCα表达及活化与复发的关系。
短句来源
     Observation of the effectiveness of bladder filling with MMC in preventing recurrence of superficial carcinoma of the bladder
     大剂量丝裂霉素C膀胱内灌注预防浅表膀胱癌术后复发疗效观察
短句来源
     BCG CWS has been used in clinical study for preventing the recurrence of superficial transitional cell carcinoma.
     为了提高膀胱癌的治疗效果,采用BCGCWS(细胞壁骨架)行膀胱内灌注,防治浅表膀胱癌复发。
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  superficial bladder cancer
Presently, one of the most potent immunotherapies is the application of bacillus Calmette Guerin (BCG) to prevent recurrences of the superficial bladder cancer.
      
It could as possibly prove to be an effective intravesical treatment agent for superficial bladder cancer.
      
Substantial changes have been made in the therapeutic options for the management of superficial bladder cancer in the past 5 years.
      
Treatment goals for superficial bladder cancer are complete removal of the initial tumor, prevention of disease recurrence, and inhibition of progression to invasive disease.
      
This article reviews the pros and cons of a second staging TURBT and how it may impact the management of high-grade, low-stage superficial bladder cancer.
      
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  superficial bladder carcinoma
(Bacillus Calmette Guérin) has proven to be effective in the prophylaxis of recurrence of superficial bladder carcinoma after transurethral resection and in the treatment of carcinoma in situ (C.I.S.) in man.
      
The main problems presented by superficial bladder carcinoma, its high recurrence rate and multifocal appearance, require treatment of the bladder as a whole.
      
Photodynamic therapy (PDT) is one such experimental treatment for superficial bladder carcinoma, involving the administration of a photosensitizer that accumulates in the tumor tissue, and subsequent irradiation of the tumor with light.
      
The results show that ALA-induced photosensitization has a high potential for photodynamic therapy (PDT) of superficial bladder carcinoma.
      
In intravesical therapy for superficial bladder carcinoma urothelial cells may, through the production of cytokines, contribute to the bacillus Calmette-Guérin (BCG)-induced local immunological reaction and associated antitumor efficacy.
      
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BCG CWS has been used in clinical study for preventing the recurrence of superficial transitional cell carcinoma.53 patients were randomized into two groups:BCG CWS group and BCG group.The protocol of immunoprophylaxis included 6 weekly instillation of 5mg BCG CWS in 50ml normal saline via a catheter.Immunotherapy was given once monthly for at least two years.Results:Followup (from 6 to 32 months with a median 26.3 months) consisted of cystoscopy and cytology with cold cup biopsies carried out every 3 months...

BCG CWS has been used in clinical study for preventing the recurrence of superficial transitional cell carcinoma.53 patients were randomized into two groups:BCG CWS group and BCG group.The protocol of immunoprophylaxis included 6 weekly instillation of 5mg BCG CWS in 50ml normal saline via a catheter.Immunotherapy was given once monthly for at least two years.Results:Followup (from 6 to 32 months with a median 26.3 months) consisted of cystoscopy and cytology with cold cup biopsies carried out every 3 months for 2 years.It showed that in three patients (12.0%) recurrence occumed after the instillation of BCG CWS.During the instillation the rate of toxic side effects was very low.The intravesical BCG CWS appears to be an effective prophylaxis against recurrence.It is supperior to BCG vaccine with fewer complication,but with similar effective rate ( P >0.05).Long term result needs further investigation.BCG CWS can be preserved even longer without changing its antitumor property and is easily available for rural hospitals.

为了提高膀胱癌的治疗效果,采用BCGCWS(细胞壁骨架)行膀胱内灌注,防治浅表膀胱癌复发。53例膀胱癌患者手术后分为BCGCWS组和BCG组。BCGCWS组(25例)5mgBCGCWS加无菌生理盐水50ml注入膀胱,BCG组(28例)75mgBCG加生理盐水50ml注入膀胱。每周1次,连续6周,以后每月一次连续两年。随访6~32个月,中位数26个月。两组比较肿瘤复发率无显著性差异,BCGCWS组毒副反应比BCG组明显减少。结论:BCGCWS能有效地防治浅表膀胱癌复发,毒副反应低,并具有保存期长,使用方便的特点。

Objective:To address the antitumor mechanism and to monitor the immunological response of patients following interavesical (BCGCWS eleton) treatment.Methods:The local secretion of IL2 and TNFα was examined in the urine of patients before and after intravesical instillation of BCGCWS. By using an enzymelinked immunosorbant assay (ELISA) technique to determine the levels of cytokines the difference between pre and postCWS mean urinary levels of IL2 and TNFα. Results:It showed that the levels of IL2 and...

Objective:To address the antitumor mechanism and to monitor the immunological response of patients following interavesical (BCGCWS eleton) treatment.Methods:The local secretion of IL2 and TNFα was examined in the urine of patients before and after intravesical instillation of BCGCWS. By using an enzymelinked immunosorbant assay (ELISA) technique to determine the levels of cytokines the difference between pre and postCWS mean urinary levels of IL2 and TNFα. Results:It showed that the levels of IL2 and TNFα increased significantly from (36.9±15.9) ng/L and (47.8±24.1) μg/L to (154.0±31.9) ng/L and (609.9±239.8) μg/L, respectively (P<0.001).Conclusions:The BCGCWS can induce T lymphocytes and actiwated macrophages to cytokines in response to a specific antiginic stimulation. Prophylactic intravesical treatment with BCGCWS is an effective therapy method for recurrent superficial bladder carcinoma.

目的:为了解BCGCWS(细胞壁骨架)对膀胱局部免疫抗肿瘤机理而进行研究。方法:通过酶联免疫吸附法(ELISA),检测浅表膀胱癌患者BCGCWS灌注后,尿中细胞因子(IL2和TNFα)的变化情况。结果:IL2灌注前(36.9±15.9)ng/L,灌注后(154.0±319)ng/L;TNFα灌注前(478±241)μg/L,灌注后(6099±2398)μg/L。灌注前后比较有显著性差异(P<0001)。结论:BCGCWS能激活巨噬细胞致敏淋巴细胞分泌细胞因子IL2和TNFα,发挥局部免疫抗肿瘤作用,对防治浅表膀胱癌的复发起重要作用

Objective: To evaluate the exfoliative urine cytology in diagnosis of transitional cell carcinoma(TCC) of bladder. Methods: 105 patients suffered from TCC of bladder were selected with randomization from 1990 to 2000. The positive rate of exfoliative urine cytology in different stage, grade, size, number, postion of tumor were calculated. Results:The general positive rate of exfoliative urine cytology was 65.7%. The positive rate was 100% in Tis stage, 59.4% in Ta and T1 stage, 65.7% in invasive TCC,...

Objective: To evaluate the exfoliative urine cytology in diagnosis of transitional cell carcinoma(TCC) of bladder. Methods: 105 patients suffered from TCC of bladder were selected with randomization from 1990 to 2000. The positive rate of exfoliative urine cytology in different stage, grade, size, number, postion of tumor were calculated. Results:The general positive rate of exfoliative urine cytology was 65.7%. The positive rate was 100% in Tis stage, 59.4% in Ta and T1 stage, 65.7% in invasive TCC, 48% in grade below Ⅱ, 71.3% in grade more than Ⅱ, 67.6% in multiple tumors, 62.2% in single tumor, 67.6% in tumor which involving trigone or neck of bladder, 61.3% in tumor not involving these regions, 67.6% in size of tumor more than 2cm, 60.5% in size less than 2cm respectively. The recurrence rate was 39.1% in patients with positive exfoliative urine cytology and 33.3% in the patients with negative. Conclusion: There are no influence of TCC stage on cytopositivity except for Tis stage. A good association was observed between grade of TCC and cytopositivity( P <0.05). There are no significant association was observed between size, number, position, of the tumor and cytopositivity( P >0.05). The recurrence of TCC also has no relationship with cytopositivity( P >0.05).

目的 :探讨膀胱移行细胞癌与尿脱落细胞阳性率之间的关系。方法 :随机选择 1990年~ 2 0 0 0年在本院住院手术的膀胱移行细胞癌患者 10 5例 ,根据不同的分期、分级、大小、肿瘤数目分别计算尿脱落细胞阳性率。结果 :尿脱落细胞阳性率 6 5 .7% ;Tis期、浅表膀胱癌和浸润性膀胱癌尿脱落细胞阳性率分别为 10 0 %、5 9.4%和 6 5 .7% ;肿瘤分级Ⅱ级以下尿脱落细胞阳性率 48% ,Ⅱ级以上者为 71.3% ;多发、单发膀胱癌尿脱落细胞阳性率分别为 6 7.6 %、6 2 .2 % ;肿瘤累及膀胱三角或颈部尿脱落细胞阳性率为 6 7.6 % ,未累及者 6 1.3% ;肿瘤直径大于或等于 2cm尿脱落细胞阳性率为 6 7.6 % ,直径小于 2cm者 6 0 .5 % ;脱落细胞阳性患者中肿瘤的复发率为 39.1% ,阴性患者中复发率为 33.3%。结论 :除Tis期外 ,肿瘤分期对尿脱落细胞阳性率无明显影响 ;高分级肿瘤尿脱落细胞阳性率较低分级肿瘤明显为高 (P <0 .0 5 ) ;肿瘤大小、部位、数目、复发率和尿脱落细胞阳性率无明显关系。

 
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