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原发性肾癌
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  primary renal cell carcinoma
     Expression of mdr-1 gene product in primary renal cell carcinoma and its clinical significance
     原发性肾癌mdr-1基因产物的表达及临床意义
短句来源
     Bilateral primary renal cell carcinoma:Report of 5 cases
     双侧原发性肾癌5例报告
短句来源
     Methods:The specimens were from 49 patients with primary renal cell carcinoma by radical nephrectomy. MVD was evaluated by immunohistochemistry using the labeled strentavidin-biotin-preoxidase method with a monoclonal antibody directed against factor Ⅷ-related antigen(FⅧ-RAg).
     方法 :应用Ⅷ因子相关抗原单克隆抗体进行免疫组化SABC法染色 ,检测 49例原发性肾癌根治性切除术标本中MVD ,并以 10例正常肾组织为对照。
短句来源
  “原发性肾癌”译为未确定词的双语例句
     Expression of multidrug resistance-associated protein and P-glucoprotein in human renal carcinoma
     多药耐药相关蛋白和P-糖蛋白在原发性肾癌中的表达及其临床意义
短句来源
     Our study was to investigate whether the expression of the PTP BAS in RCC tissues detected by Northern blot was associated with the development and the progress of the RCC on the level of mRNA.
     本研究旨在通过应用Northern Blot技术,分析原发性肾癌组织PTP BAS基因的表达情况,从mRNA表达水平研究原发性肾癌发生过程中是否有PTP BAS表达水平的改变,并初步探讨PTP BAS基因与原发性肾癌发生的关系。
短句来源
     Conclusions:Bilateral primary renal carcinoma lacks typical clinical manifestations.
     结论:双侧原发性肾癌早期无特殊临床表现,主要依靠影像学检查诊断。
短句来源
     Methods Using a sensitive semiquantitative reverse transcription polymerase chain reaction (RT PCR) assay, we examined 20 renal cell carcinomas and 10 normal kidneys for the expression of both MDR1 and MRP genes.
     ②方法 应用定量逆转录聚合酶链反应 (RT PCR) ,检测 2 0例原发性肾癌组织、10例正常人肾脏组织新鲜标本MDR1和MRP基因的mRNA表达水平。
短句来源
     MVD was evaluated immunohistochemically using the labeled streptavidin-biotin-peroxidase method with a monoclonal antibody directed against factor Ⅷ-related antigen (FⅧ-RAg).
     方法 应用Ⅷ因子相关抗原 (FⅧ -RAg)单克隆抗体进行免疫组化SABC法染色 ,检测 49例原发性肾癌根治性切除术标本中MVD。
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  相似匹配句对
     Primary Carcinoma of fhe fallopian tube
     原发性输卵管
短句来源
     Primary gallbladder carcinoma
     原发性胆囊
短句来源
     Bilateral primary renal cell carcinoma:Report of 5 cases
     双侧原发性5例报告
短句来源
     Results In renal cell carcinoma.
     结果 在中.
短句来源
     The progress of the immune therapy of renal cell carcinoma
     免疫治疗进展
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  primary renal cell carcinoma
The presence of a primary renal cell carcinoma was recognized only after surgical removal of the metastatic tumor.
      
Renal artery changes in patients with primary renal cell carcinoma
      
Resection of metastases from primary renal cell carcinoma, Wilms' tumor, and adrenocortical carcinoma is indicated.
      
Background: Solitary metastases from a primary renal cell carcinoma (RCC) occur in >amp;lt;10% of patients with metastatic RCC.
      
A new cell line, SS78, was established from a primary renal cell carcinoma of a Caucasian male.
      
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  primary renal cell carcinoma (rcc)
Background: Solitary metastases from a primary renal cell carcinoma (RCC) occur in >amp;lt;10% of patients with metastatic RCC.
      


The response of renal cell carcinoma (RCC)to chemotherapy has been a perplex problem.To probe into the principles of drug-resistance in primary RCC,the expression of mdr-1 gene product, the intrinsic drug-resistence related p-glycoprotein,was studied with labelled strep-avidin biotin (ISAB)immunohis tochemical method in 34 cases of RCC and 20 normal kidneys. The results were that p-glycoprotein was expressed in all normal kidneys,especially in proximal tubule,and in 85.3%cases of RCC.No statistical correlation...

The response of renal cell carcinoma (RCC)to chemotherapy has been a perplex problem.To probe into the principles of drug-resistance in primary RCC,the expression of mdr-1 gene product, the intrinsic drug-resistence related p-glycoprotein,was studied with labelled strep-avidin biotin (ISAB)immunohis tochemical method in 34 cases of RCC and 20 normal kidneys. The results were that p-glycoprotein was expressed in all normal kidneys,especially in proximal tubule,and in 85.3%cases of RCC.No statistical correlation was found between the staining density of p-glycoprotein and the grade,and stage of RCC.The results suggested that renal tubule was the site where p-glycoprotein expressed at high levels,so that RCC arised from renal tubule would also express p-glycoprotein at high levels. To remove the influence of multidrug resistance conducted by p-glycoprotein would be the key point to increase the effect of chemotherapy in RCC.

为探讨肾癌的耐药规律,我们应用LSAB免疫组织化学方法研究了34例原发性肾癌,20例正常肾组织多药耐药基因(mdr-1)产物P-糖蛋白(P-GP)的表达情况。结果表明:100%的正常肾组织有P-GP的表达,以肾近曲小管的表达最强,远曲小管次之。85.3%的肾癌组织有P-GP的表达。Ridit统计学检验显示P-GP的表达与肾癌的组织分级、病理分期无关。研究显示:肾小管是P-GP高表达的组织,因此起源于肾小管的肾细胞癌表现高耐药性。消除P-GP介导的多药耐药机制的影响是提高肾癌化疗效果的关键。

Tumor-infiltrating lymphocytes (TIL) isolated from two renal cell carcinoma were cultured in vitro in the presence of rh IL-2.The results showed that TIL was expanded 32-203 times and exhibited specific strong cytotoxic activity against autologous fresh renal tumor target cells (up to 53% and 640%).Phenotype characterization of the preparations showed that the CD3,CD4 and CD8 phenotype expressions of non-induced TIL cells did not change in the process of cultivation. Whereas,the CD3 expression and the CD/CD8ratio...

Tumor-infiltrating lymphocytes (TIL) isolated from two renal cell carcinoma were cultured in vitro in the presence of rh IL-2.The results showed that TIL was expanded 32-203 times and exhibited specific strong cytotoxic activity against autologous fresh renal tumor target cells (up to 53% and 640%).Phenotype characterization of the preparations showed that the CD3,CD4 and CD8 phenotype expressions of non-induced TIL cells did not change in the process of cultivation. Whereas,the CD3 expression and the CD/CD8ratio increased significantly to 95% and 1.65 respectively in the culture of activated TIL at 32th day.

对两例原发性肾癌患者手术切除肿瘤组织中肿瘤浸润性淋巴细胞(TIL)进行了体外分离与培养。结果表明:TIL体外扩增倍数分别达32~203倍,对自体肿瘤靶细胞的最高杀伤活性达53%和64%,且呈现一定的靶细胞特异性。免疫组化分析结果:未经激活的TIL细胞其膜抗原(CD3,CD4,CD8)的表达动态变化不大,但经IL-2激活的TIL细胞随着培养无数的增加,其CD3细胞数比例及CD4/CD8比值上升明显,在培养至32天时分别达95%和1.65。

The expression of mdrl mRNA was studied in 2 normal kidneys,18 renal cell carcinomas(RCC)and 1 transitional cell carcinoma of renal pelvis by reverse transcription-polymerase chain reaction(RT-PCR).The results showed that mdrl gene was expressed in all the 2 normal kidneys and in 83.3%(15/18)of RCC while no mdrl gene was detected in the other 3 RCC and 1 pelvic tumor.No correlation was found statistically between the expression of mdrl gene and the grade of RCCs(P=0.51),The high expression of mdrl gene in primary...

The expression of mdrl mRNA was studied in 2 normal kidneys,18 renal cell carcinomas(RCC)and 1 transitional cell carcinoma of renal pelvis by reverse transcription-polymerase chain reaction(RT-PCR).The results showed that mdrl gene was expressed in all the 2 normal kidneys and in 83.3%(15/18)of RCC while no mdrl gene was detected in the other 3 RCC and 1 pelvic tumor.No correlation was found statistically between the expression of mdrl gene and the grade of RCCs(P=0.51),The high expression of mdrl gene in primary RCC might be the causative factor of its intrinsic drug resistance.RT-PCR was a sensitive,specific and rapid technique in the detection of mdrl gene for clinical specimens.

用逆转录-多聚酶链反应(RT-PCR)技术研究了2例正常肾、18例原发性肾癌和1例肾盂癌mdrlmRNA表达状况,结果显示2例正常肾和15例(83.3%)肾癌表达mdrlmRNA基因,另3例肾癌和1例肾盂癌无此基因表达。mdrl基因的表达与肾癌的分级无关(P=0.51)。原发性肾癌mdrl基因的高表达奠定了肾癌内在性耐药的基础。比较不同的基因检测手段显示RT-PCR是简便、快速、灵敏、特异的检测mdrl基因的方法,适于推广。

 
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