Methods Sixty BALB/c mice were divided randomly into four groups: control group (tap water, NC), iodine excess group (3000μg/L I,EI+),selenium supplement group (200μg/L Se, Se+) and iodine excess plus selenium(3000μg/L+ I 200μg/L Se, EI+Se+) group.
Methods: Sixty BALB/c mice were divided randomly into four groups; control group (tap water, NC), iodine excess group (3 000μg/L I, EI+), selenium group (200μg/L Se, Se+) and iodine excess plus selenium (3 000μg/L I + 200μg/L Se, EI+Se+) group.
In 2001 WHO, UNICEF and ICCIDD reedited the standard of iodine intake, defining 100 - 199μg/L of median urinary iodine as iodine adequate, 200 -300μg/L as iodine sufficient and over 300μg/L as iodine excess.
Epidemiology study carried out in our group suggests that the incidence of clinical and subclinical hypothyroidism in areas with excessive iodine ( MUI 374μg/L and 614 μg/L) is much higher than that in areas with adequate intake ( MUI 103μg/L).
A review with 17 references is given on the effect of iodine on human health including the property and the distribution of iodine,the medical application of iodine,diseases caused by iodine-deficiency and excessive iodine,and the treatment of abnormal iodine.
People who are mobilized and agreed to provide fasting vein blood and urine were included as the research objects, 1103 people (male284, female819) in mild iodine deficiency area, 1584 people (375male, 1209female) in more than adequate iodine area, andl075 people (275male,female 799) in excessive iodine area.
Conclusion Iodine-excess intake can decrease the selenium level and IDI activity of mice liver, which maybe is the reason to increase the serum TT4 level and lead to goiter, and selenium can alleviate that.
The universal salt iodination has been carried out in our country since 1996. After that it past a 5 - year period of iodine excess through 1996 to 2001, and then nearly 4 - year of iodine sufficient since 2002. Whether the sufficient to excess iodine intake is safe or not is still unknown.
5'-deiodinase and 5-deiodinase activities in the cerebrum were significantly higher and lower in excess iodine group than that in control group respectively. Supplementing Se 200 to 400 μg/L was effective.
The addition of selenium alleviated the toxic effects of iodine excess on the activities of D1 and GSHPx.
Applying this method for the analysis of Antarctic meteorites, an "iodine excess" in some of these samples compared to the normal iodine concentration in non-Antarctic meteorites could be confirmed.
Urinary iodine excretion was between 12-22 (n=3) and 40-42.5 (n=5) μg/dL tn 10 eutopic neonates (2 not assessed).Conclusion: Parental consanguinity and iodine excess could be the causative factors for the high incidence of CH.
Effects of chronic iodine excess in a cohort of long-term American workers in West Africa.
Transient cases might be caused by transplacental passage of TSH receptor blocking antibodies, or iodine excess.
Effect of excess iodine supplement on serum total proteins, electrophoretic patterns and body weight of Fayoumi chickens
Total proteins and their major fractions were determined in the serum of 135 males and females of Fayoumi chickens, 65 were used as controls and 70 were treated with excess iodine in the form of KI.
Exceptions are patients suffering from thyroid storm (impending early relapse after plasmapheresis due to excess iodine) or from acute Cushing's syndrome (intractable potassium loss and alkalosis whom we have successfully transferred to surgery.
A modified Bridgman method is described, which makes it possible to prepare homogeneous BiTeI crystals using excess iodine.
Black Tl4HgI6 crystals, prepared in the presence of excess iodine, are shown to consist of a nearly racemic mixture of two structures differing in polarity.