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   癌基因p53 的翻译结果: 查询用时:0.818秒
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癌基因p
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  gene p 53
     Objective To explore the association between the polymorphism of metabolic genes(GSTT1、GSTM1、CYP1A1) and tumor suppression gene p53 coden 72 and human longevity.
     目的:探讨代谢相关基因GSTT1、GSTM1、CYP1A1及抑癌基因p53第4外显子第72位密码子(codon72)与人类长寿的关系。
短句来源
     This paper reviews advance s of tumor suppressor gene p53,DCC,nm23,TIMP,p21,p16,bcl X etc al in tumor su ppressor gene therapy for malignant tumors.
     就抑癌基因p53,DCC,nm23,TIMP,p21,p16,bcl X等在恶性肿瘤基因治疗方面的研究进展作一综述。
短句来源
     Interaction of suppressor gene p53 and oncogene   mdm2 in human glandular lung cancer cell line GLC82
     抑癌基因p53与癌基因mdm2在肺腺癌细胞系GLC-82中的相互作用
短句来源
     Methods Expression of tumor supressor gene P53 and oncogene ras,c-erbB-2 were detected by immunohistochemical Sp methods in 62 cases of gastric cancer.
     方法 :应用免疫组化Sp法检测 62例胃癌中抑癌基因P5 3、癌基因ras和c -erbB -2的蛋白表达。
短句来源
     THE RELATIONSHIP BETWEEN SALIVARY GLAND TUMOUR AND OVEREXPRESSION OF ONCOGENE C-MYC,TUMOUR SUPPRESSOR GENE P53,INFECTION OF HUMAN PAPILLOVIRUS.
     涎腺肿瘤与癌基因c-myc、抑癌基因P53和人类乳头状病毒感染的关系
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  oncogenes p 53
     A Study on Expressions of Oncogenes P53, P21, C-erbB-2 and EGFR in Hepatocellular Carcinoma
     肝细胞癌癌基因P53,P21,C-erbB-2及EGFR表达的研究
短句来源
  “癌基因p53”译为未确定词的双语例句
     Expression and Significance of EBV,P53,P21 and P16 in Esophageal Carcinoma
     EBV与癌基因P53、P21、P16在食道癌中表达与意义
短句来源
     CD44v6,EGFR,nm23- H1 and p53 protein expression were studied in 84 cases of papillary thyroid carcinoma using ABC immunohis - tochemical method.
     利用免疫组化ABC法,研究甲状腺乳头状腺癌,甲状腺腺瘤和正常甲状腺组织中的肿瘤转移相关基因蛋白CD44v6,EGFR,转移抑制基因nm23-H1和抑癌基因p53蛋白的原位表达。
短句来源
     Expression of P53 and detection of P53 exon-8 in epithelial ovarian tumor
     上皮性卵巢肿瘤中抑癌基因P53的表达及第8外显子突变的检测
短句来源
     Expression of gene bcl-2 and p53 in tissue of cervical carcinoma
     癌基因bcl-2及抑癌基因p53在宫颈癌组织中的表达及临床意义
短句来源
     Expression and significance of NF-κBp65、p53 protein in cervical squamous carcinoma and precancerous lesions
     NF-κBp65、抑癌基因p53在宫颈鳞癌、癌前病变中的表达及其意义
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  gene p 53
For a quarter of a century the gene p53 has attracted close attention of scientists who deal with problems of carcinogenesis and maintenance of genetic stability.
      
Mutations in the tumor suppressor gene p53 often lead to disarrangement of the cell cycle and of genetic integrity control of cells that may contribute to tumor development.
      
The apoptosis and the expression of tumor suppressor gene p53 in hypercholesterolemia (HC)-induced renal injury were investigated in rats.
      
We propose a common etiology to these canceres via tumor suppressor gene p53.
      
Background: The p73 gene is structurally related to the tumor suppressor gene p53.
      
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  oncogenes p 53
The recessive oncogenes p53 and Rb also provide potentially convenient targets for the screening of individuals at high risk for lung cancer.
      
  oncogene p 53
Induction of the metastatic phenotype by transfection of the nuclear oncogene p53: Increases in cytoplasmic diacylglycerol level
      
Lesional skin is characterized by pathological overexpression of proinflammatory cytokines such as IL-8 and its receptor and the decreased presence of negative regulatory control factors like the anti-oncogene p53.
      
As discussed above, it is known that the oncogene P53 regulates several metabolic pathways.
      
It has been recently shown that the oncogene P53 may regulate metabolic pathways by several novel genes, including PGAM.
      


The changes of several oncogenes and suppressor genes in the specimens of cancerous and juxtacancerous tissues of 42 cases of gastric cancer were studied with Southern blot hybridization and PCR-RELP method.The probes used were c-Ha-ras,K-ras,N-ras,N-myc,c-myc,hst,EGFR,c-erbB-2,p53 and Rb.Amplification,rearrangement,and deletion of c-Ha-ras were detected in 8/33 (25.8%) cases of gastric cancer (amplification or rearrangement of hst and c-erbB-2 in 11/42 (26.6%) and 12/42 (29.2%) cases respectively (amplification...

The changes of several oncogenes and suppressor genes in the specimens of cancerous and juxtacancerous tissues of 42 cases of gastric cancer were studied with Southern blot hybridization and PCR-RELP method.The probes used were c-Ha-ras,K-ras,N-ras,N-myc,c-myc,hst,EGFR,c-erbB-2,p53 and Rb.Amplification,rearrangement,and deletion of c-Ha-ras were detected in 8/33 (25.8%) cases of gastric cancer (amplification or rearrangement of hst and c-erbB-2 in 11/42 (26.6%) and 12/42 (29.2%) cases respectively (amplification of EGFR in 21.4% of cas-esideletion or rearrangement of p53 and Rb in S/30 (30%) and 2/15 (13%) cases respectively) and amplification or rearrangement of N-ras (0/33),K-ras (1/26),N-myc (1/26),and c-myc (1/ 35) was only rarely encounted.The point mutation in codon 248 and 249 of p53 in gastric cancer was analyzed.2 cases of the 42 harbored point mutation in codon 248 of p53.These findings suggest that e-Ha-ras,hst,c-erbB-2,EGFR and p53 may be the hot point genes in the occurrence and development of gastric cancer.

本文采用Southern杂交技术分析了42例胃癌及癌旁组织中癌基因c-Ha-ras、K-ras、N-ras、c-myc、N-myc、hst、EGFR、c-erbB-2和抑癌基因p53和Rb的变化;使用PCR-RFLP方法分析了p53基因第248和249位密码子的点突变。结果显示,胃癌组织中有多种癌基因激活和抑癌基因失活,但多集中在c-Ha-ras、c-erbB-2、hst、EGFR和p53基因。这些结果表明,多种癌基因和抑癌基因可能参与了胃癌的发生和发展。

Immunocytochemical study was carried out on the bone marrow smears of 26 patients with leukemia with the use of monoclonal antibody against ras oncogene product P_(21).The results showed; It was positive in granulocytic leukemia and negative in lymphatic leukemia.The expression of ras oncogene product P_(21) was more prominant in granulocytic leukemia than that in normal granulocyte and was also increased during the differentiation stage of premature granulocyte. Thus, we conclude that ras oncogene might closely...

Immunocytochemical study was carried out on the bone marrow smears of 26 patients with leukemia with the use of monoclonal antibody against ras oncogene product P_(21).The results showed; It was positive in granulocytic leukemia and negative in lymphatic leukemia.The expression of ras oncogene product P_(21) was more prominant in granulocytic leukemia than that in normal granulocyte and was also increased during the differentiation stage of premature granulocyte. Thus, we conclude that ras oncogene might closely correlated with cell proliferation and play a more important role in the development of granulocytic leukemia than that in lymphatic leukemia.

采用ras癌基因产物P_(21)的单克隆抗体对26例白血病骨髓涂片进行免疫细胞化学研究。结果表明:粒细胞白血病为阳性,且较正常白细胞ras癌基因P_(21)表达明显增高。在幼稚的粒细胞分化阶段,P_(21)表达亦增高。淋巴细胞白血病为阴性。我们认为,ras癌基因与细胞增殖可能有密切关系。并可能在粒细胞白血病的成因上,较淋巴细胞白血病占有更重要的位置。

The characteristics of ductal adenocarcinoma of colon under eieciror: microscopy were stout and dense microvill, with small roots buried in the top of cytoplasm. The ullrarnorphological changes of carcinomatous infiltration was similar to the picture observed in vitro cultivation of cancer cells.In 104 cases out of 159, there was an over expression of ras oncogenes P21, indicating that carcinoma of colon was related to activation of ras oncogenes. Examination with monoclonal antibodies yielded a positive rate...

The characteristics of ductal adenocarcinoma of colon under eieciror: microscopy were stout and dense microvill, with small roots buried in the top of cytoplasm. The ullrarnorphological changes of carcinomatous infiltration was similar to the picture observed in vitro cultivation of cancer cells.In 104 cases out of 159, there was an over expression of ras oncogenes P21, indicating that carcinoma of colon was related to activation of ras oncogenes. Examination with monoclonal antibodies yielded a positive rate of 83.4%- 95.7%, indicating that most of the carcinomas had colon related antigens. This phenomenon should play an important role in raising the diagnostic accuracy, and it also should serve as an indicator of effective treatment. In 62 cases of mucoid adenocarcinoma and 30 cases of signet ring cell carcinoma, there was a marked reduction of mueoitin sulfate with an increase in sialic acid mucus. The letter was a glycoprotein containing hydroxyl mucus, and it facilitated the separation of cancer cells to infiltrate and metastasize.in 134 cases, AgNOR was quantified, and there were 13.05± 1.48 granules in each mucleas. There was more abundant AgNOR in undifferentiated cancer, while the number of AgNOR fluctuated between 10.56 to 11.83 in papillary adenocarcinoma, ductal adenocarcinoma, and mucoid adenocarcinoma. indicating the qunantity of AgNOR was related to degree of malignancy in colonic carcinoma.

用多种较先进技术对大肠癌进行研究。结果证明,(1)电镜下所观察到的癌细胞微绒毛粗大、密集、小根深埋在胞质顶部是大肠管状腺癌的超微结构标志。人体内癌细胞侵袭方式的微细形态变化与体外器官培养中所见相似。(2)ras癌基因P21检测,159例大肠癌中104例(65.4%)过量表达,提示大肠癌与ras癌基因活化有密切关系。5种单抗测试的122例中阳性率在83.4%~95.7%之间,说明大多数含有大肠癌肿瘤相关抗原。对提高诊断与治疗水平有重要作用。62例粘液腺癌和30例印戒细胞癌,硫酸粘液显著减少,唾酸粘液明显增多。后者为含羧基酸粘液的糖蛋白,有利于癌细胞脱离群体,向周围侵袭及扩散。(3)134例核仁组成区相关嗜银蛋白(AgNoR)定量检测,每个核颗粒数为13.05±1.48((?)±s)。未分化癌AgNOR量多(19.24),而乳头状腺癌、管状腺癌、粘液腺癌波动在10.56~11.83之间,提示AgNOR定量与大肠癌恶性程度有关。

 
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