助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   myc癌基因 的翻译结果: 查询用时:0.052秒
图标索引 在分类学科中查询
所有学科
肿瘤学
眼科与耳鼻咽喉科
更多类别查询

图标索引 历史查询
 

myc癌基因     
相关语句
  myc oncogene
     Co operative Expression of P 53 、 ras P 21 and C myc Oncogene proteins in Brain Astrocytomas
     脑星形细胞瘤P~(53)、ras-P~(21)、C-myc癌基因蛋白协同表达的观测
短句来源
     Ocular metastasis of neuroblastoma and amplification of N myc oncogene
     神经母细胞瘤眼部转移与N-myc癌基因扩增的临床意义
短句来源
     Detection of c myc Oncogene Amplification During Induced Differentiation of HL 60 Cells
     应用PCR检测HL-60细胞诱导分化前后c-myc癌基因的扩增
短句来源
     Conclusion (1) Hypoxia may lead to activation of C myc oncogene and increase of FGF b expression in lung tissue.
     结论(1)缺氧可激活C-myc癌基因以及增强FGF-b的表达;
短句来源
     Methods The relationship between molecular chaperone Grp94 and c myc oncogene expression in the human colorectal carcinoma cell line CCL229, CX 1 and retinoic acid (RA) induced CCL229 by both of digoxin labelled c myc cDNA probe spot bybridization and RT PCR with endoplasmic reticulum molecular chaperone Grp94 proximal 3′ end oligonucletide primers was investigated.
     方法应用地高辛标记c-myccDNA探针的斑点杂交,和以Grp94基因近3′端一对寡核苷酸为引物的RT-PCR技术,比较了人大肠癌细胞系CCL229、CX-1以及经维甲酸诱导的CCL229细胞中Grp94和c-myc癌基因在表达上的关系。
短句来源
更多       
  myc gene
     Expression of P53 and c myc gene in human adrenal tumors
     肾上腺肿瘤P53及c-myc癌基因表达研究
短句来源
     Hypomethylation of c myc gene in multifocal type was significant as compared with unifocal type ( P <0.05). It is also found that c N ras gene hypomethylation had a strong correlation with tumor size ( P <0.01).
     也发现伴卫星灶的肝癌患者其c-myc癌基因低甲基化发生率较高(P<0.05),并且肿瘤直径越大,c-N-ras基因低甲基化倾向越明显(P<0.01)。
短句来源
     Conclusion Overexpression of C myc gene is an important factor in the development of HCC;
     ④结论C-myc癌基因过度表达是肝癌癌变过程中的重要因素;
短句来源
  myc oncogenes
     THE INTEGRATION RATE OF HBV X,S,PreS, C GENES IN PRIMARY HEPATOCELLULAR CARCINOMA AND RELATION TO THE EXPRESSION OF RAS AND MYC ONCOGENES
     原发性肝癌中 HBV X、S、Pre-S、C 基因片段整合与 ras、myc 癌基因表达的关系
短句来源
     The existing status of HBV in 66 cases HCC was detected by digoxigenin labelled HBV DNA probe. The 32 cases,with only integrated HBV DNA,were selected and used to study the integration rate of HBV X,HBV S,HBV PreS and HBV C genes and the expression of ras and myc oncogenes.
     用地高辛标记的HBV基因组探针检测了66例肝细胞性肝癌(HCC)中HBV的存在状态,从中筛选出32例仅有HBVDNA整合的HCC作为研究对象,进一步检测了HBVX基因、S基因、Pre-S、C基因DNA片段的整合情况,并探讨了HBV4种基因亚片段整合与ras、myc癌基因表达的关系。
短句来源
  myc genes
     The cells were continuously cultivated in vitro and the dynamic characteristics of Haras, Kiras and cmyc genes expression in the oval cells were detected using RNADNA slot blot hybridization.
     在培养过程中,通过RNADNAslotblot杂交方法,动态观察Haras、Kiras和cmyc癌基因的表达变化。
短句来源
     (2) There was significant enhanced expression of ras and myc genes in penile cancer and cervical cancinomas compared with genital warts.
     ②C-Ha-ras及C-myc癌基因在阴茎癌及宫颈癌中表达较生殖器疣中均显著增强(P<0.001);
短句来源

 

查询“myc癌基因”译词为其他词的双语例句

     

    查询“myc癌基因”译词为用户自定义的双语例句

        我想查看译文中含有:的双语例句
    例句
    为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。
      myc oncogene
    In melanoma, HLA class I expression is suppressed by overexpression of the c-myc oncogene.
          
    Expression of the avian gag-myc oncogene in Saccharomyces cerevisiae
          
    N-myc Oncogene amplification in a pediatric case of glioblastoma multiforme
          
    The DNA extracted from a fresh tumor sample at diagnosis was processed by Southern blot analysis and hybridized with a 2.0 kb N-myc oncogene probe recognizing the first intron and the second exon of the human gene.
          
    Aneuploid flow cytometry, low serum ferritin and NSE levels, few or no copies of the N-myc oncogene, favorable histology and primary tumors affecting the neck, pelvis and mediastinum have an improved prognosis.
          
    更多          
      myc gene
    Silencing of c-myc gene expression using enzymatically and chemically synthesized siRNAs
          
    The expression of c-myc gene was found pronouncedly reduced by Western blot analysis.
          
    However, the inhibition of PTPase activity may block the induction oftnf-β gene and c-myc gene transcription by IL-2 and ultimately results in cell death.
          
    HeLa cells overexpressing Bcl-2 partly resist As2O3 induced apoptosis, which might be relative to preventing the cells from As2O3 caused G2/M block, downregulation of c-myc gene expression and inhibition of viral gene expression was also noted.
          
    CSF-1 can induce the c-myc gene expression via Ras and Ets-related proteins.
          
    更多          
      myc oncogenes
    Tumor formation by a murine macrophage cell line immortalized in vitro by v-raf and v-myc oncogenes
          
    Murine bone marrow cells immortalized in vitro by the J2 recombinant retrovirus bearing the v-raf and v-myc oncogenes have the functional and phenotypic characteristics of macrophages.
          
    Previous studies on the involvement of oncogenes in prostatic carcinogenesis, using primary human prostatic tumors, have shown that the ras and myc oncogenes might be related to the progression of this disease.
          
    Tumor induction by ras and myc oncogenes in fetal and neonatal brain: modulating effects of developmental stage and retroviral d
          
    The effect of infection with a retrovirus carryingv-raf/v-myc oncogenes (J2 virus) on the in vitro proliferation of human large granular lymphocytes (LGL) was investigated.
          
    更多          
      myc genes
    The regulation of c-myc protein, product of c-myc/genes, was studied in four glioma cell lines by Northern blot, pulse-chase dot blot, immunoblot and immunoprecipitation analyses.
          
    However, cells without DMs were also present in which the c-myc genes were found integrated into any of several distinct chromosomes (mainly 7q+, 4 and 4q+, and 1).
          
    When only cells with integrated genes were present, this cell line was still highly tumorigenic indicating that the localization of the c-myc genes in DMs was not required for these cells to be tumorigenic in nude mice.
          
    In accordance with immunohistochemical findings, in situ hybridization demonstrated a significant level of expression of PDGF-B, PDGF-A receptor, PDGF-B receptor, and c-myc genes in proliferating intimal cells of the thoracic and abdominal aortas.
          
    Fourteen cases of DCIS and 11 of DCIS with minimal invasion were analysed for mRNA levels of β-actin, EGFR, c-cerbB2, MTS1, k-ras, RB, BRCA1, cyclin E, and c-myc genes.
          
    更多          


    Expression of c-myc oncogene of myeloma cells and their changes after hybridization in homo-and hetero-cellular cybrid and hybrid were studied with Northern-blot and dot-blot techniques, using cloned c-myc gene as a probe. Results indicated that c-myc oncogene transcripts could not be detected in cybrids of mouse X mouse (BW-RM), mouse X rabbit (BW-RR) and human X mouse (HMy-RM) hybridization. However, weak transcription of this oncogene was shown to be active in cybrids after 15th passages with a tendency of...

    Expression of c-myc oncogene of myeloma cells and their changes after hybridization in homo-and hetero-cellular cybrid and hybrid were studied with Northern-blot and dot-blot techniques, using cloned c-myc gene as a probe. Results indicated that c-myc oncogene transcripts could not be detected in cybrids of mouse X mouse (BW-RM), mouse X rabbit (BW-RR) and human X mouse (HMy-RM) hybridization. However, weak transcription of this oncogene was shown to be active in cybrids after 15th passages with a tendency of increasing expression activity noted during later subcultures. Similarly, no detectable c-myc gene transcript was seen in 4th and 7th subcultures of hetero-cellular hybrids (mouse plasmocytoma Sp 2/0 X rat erythroblasts, SP-ER), suggesting that "cy-toplasmic factor" of erythroid cells could inhibit or reduce expression of originally active c-myc, the inhibition being nonspecific in both cybrid and hybrid and reduction of expression of oncogene closely related to decrease or reversion of malignancy of tumor cells. Mechanisms of regulatory effects of erythroid cell cytoplasmic factors and molecular basis for oncogene repression in tumor cells were discussed.

    本实验用Northern杂交方法,以c-myc癌基因为探针,对人和小鼠骨髓瘤细胞以及杂交后的同种和异种胞质体杂交细胞和异种杂交细胞进行了癌基因表达的核酸分子杂交分析。结果表明,在小鼠-小鼠,小鼠-兔及人-小鼠的胞质体杂交细胞(BW-RM,BW-RR,HMy-RM)中均未检测到myc癌基因的表达产物。但自15代以后开始出现微弱或可测的表达活性,并随传代而有上升的趋向。同样,在小鼠浆细胞瘤(Sp2/o)与大鼠有核红细胞(ER)的异种杂交中,杂交细胞(SpER)的第4代和第7代细胞中亦未检查到myc基因转录物。表明细胞杂交后,myc基因受到了抑制。这种抑制作用似无种属特异性。这一结果提示红系细胞内“胞质因子”对肿瘤细胞原来活化的myc基因具有抑制作用,并与杂交细胞的恶性下降有关。论文对胞质因子对癌基因表达的调控作用及其分子生物学机理进行了讨论。

    A human promyelocytic leukemia cell mutant (HL-60-AR) with characteristics of resistance to 8-azagunine and deficient in hy-poxanthine and guanine phosphoribosyltrans-ferase had been established from HL-60 cell line in our laboratory.The previous study showed that HL-60-AR mutant cells main-tained the basic biological characteristics and potence of differentiation induced by various compounds of their parental HL-60 cells.In order to investigate the dependence of inducer presence for HL-60-AR cell differentiation,the...

    A human promyelocytic leukemia cell mutant (HL-60-AR) with characteristics of resistance to 8-azagunine and deficient in hy-poxanthine and guanine phosphoribosyltrans-ferase had been established from HL-60 cell line in our laboratory.The previous study showed that HL-60-AR mutant cells main-tained the basic biological characteristics and potence of differentiation induced by various compounds of their parental HL-60 cells.In order to investigate the dependence of inducer presence for HL-60-AR cell differentiation,the present experiment was designed that HL-60-AR cells were washed for 3 times to re-move inducer after treatment for various pe-riod,and suspended in medium without indu-cer,then assayed expression of cell differen-tiated characters.Meanwhile,the cultures in which inducer was removed were passaged se-veral generations and assayed to determine the passage hereditary stablization of cell dif-ferentiated characters. Experimental results showed that when HL-60-AR cells incubated in medium without inducer after they had a previous treatment with 10~(-6)M RA for 24 hours,the cell dif-ferentiated characters could be continuous ex-pression and the number of differentiated cells was progressively increased.The increase of NBT reduction positive cells and cell mem-brane C_3 complement receptor positive cells de-tected by YC rosette formation was indepen-dent on the duration of incubation between cells and RA,but it does depend on the ad-ditive duration of cell exposure to RA-contai-ning medium and RA-free medium.The cells which exposed to RA for 24 hours and rein-cubated in RA-free medium for another 120 hours showed kinetics of numbers of differen-tiated cells similar to cells exposed RA for 144 hours (Fig.3,4).This result indicated that cellular commitment to differentiation re-quired an approximately 24 hour exposure to RA.Following this,committed cells continued to differentiate.However,cell differentiated characters induced by DMSO was unstable and reversible. A notable result happened when RA-induced cells were suspended in conventional culture medium and passaged for 3 times,the number of differentiated cells could be de-tected as high as 50 percent.Taken togather the results indicate that after exposure to RA for 24 hours,a significant cell differentiation could be required and cell in populations re-moved from RA thereafter continued to diffe-rentiate.The expression of differentiated cha-racters was irreversible and heritable,exten-ding from parent to daughter cells. It was showed that a cell proliferative arrest could be assayed as HL-60-AR cell dif-ferentiation.The differentiated cells decreasedcell DNA synthesis and number of colony-forming in soft agar medium,and lost the ability of tumor-producing in nude mice.A rapid decrease of c-myc oncogene expression detected by molecular hybridization at the ear-ly stage of RA-treatment indicated that the inhibition of c-myc gene expression might provide some clues for explaining the primary-process and molecular mechanism of HL-60-AR cell differentiation.

    HGPRT~-人早幼粒白血病细胞突变株(HL-60-AR)与RA保温一定时间后,洗去药物继续培养,细胞分化性状(NBT还原能力、细胞膜C_3补体受体及形态变化)不但继续存在,而且能持续表达。撤去RA后连续传代培养,至少在传三代后细胞分化性状仍高度表达。然而,DMSO对HL-60-AR细胞的作用特点明显不同于RA。HL-60-AR细胞分化伴随增殖能力的降低。核酸分子杂交结果表明,细胞c-myc癌基因表达受抑先于细胞分化性状的获得和增殖能力的下降。

    Poly (A)~+ RNA from mouse 615 hepatoma(H615, H22) and normal mouse 615 liver(N615) was isolated by guanidinium chlorideand the Oligo (dT) cellulose affinity chro-matography method. RNA was denaturedby the formaldehyde-formamide methodand performed with the agarose electro-phoresis. After the Northern blot transferthe nitrocellulose filters were hybridizedwith ~(32)P-labeled H-ras, N-ras, Ki-ras andC-myc probes. The results showed thatthere was an expression of H-ras in H615,but a very weak expression in N615....

    Poly (A)~+ RNA from mouse 615 hepatoma(H615, H22) and normal mouse 615 liver(N615) was isolated by guanidinium chlorideand the Oligo (dT) cellulose affinity chro-matography method. RNA was denaturedby the formaldehyde-formamide methodand performed with the agarose electro-phoresis. After the Northern blot transferthe nitrocellulose filters were hybridizedwith ~(32)P-labeled H-ras, N-ras, Ki-ras andC-myc probes. The results showed thatthere was an expression of H-ras in H615,but a very weak expression in N615.

    作者用盐酸胍法从615系小鼠原发性可移植性肝癌(H651、H22)实体瘤组织及正常615系小鼠肝组织(N615)中制备总RNA,经Oligo(dT)纤维素亲和层析法纯化得到 poly(A)~+RNA,再经兔网织红血球溶胞物体系测活及电泳鉴定后,作Northern 印迹和经α-~(32)P-标记的H-ras、Ki-ras及C-myc癌基因分子探针杂交,发现:仅H615中有H-ras基因的明显表达信号,N615中仅有弱表达。

     
    << 更多相关文摘    
    图标索引 相关查询

     


     
    CNKI小工具
    在英文学术搜索中查有关myc癌基因的内容
    在知识搜索中查有关myc癌基因的内容
    在数字搜索中查有关myc癌基因的内容
    在概念知识元中查有关myc癌基因的内容
    在学术趋势中查有关myc癌基因的内容
     
     

    CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
    版权图标  2008 CNKI-中国知网
    京ICP证040431号 互联网出版许可证 新出网证(京)字008号
    北京市公安局海淀分局 备案号:110 1081725
    版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社