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   bcl鄄2 的翻译结果: 查询用时:0.635秒
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bcl鄄
相关语句
  bcl-2
     cDDP and TPT increased the expression of fas in 3AO(P<0.01), but decreased the expression of bcl-2 apparently(P<0.01);
     cDDP和TPT可使fas在3AO中的表达明显升高(P<0.01),bcl鄄2明显降低(P<0.01);
短句来源
     cDDP and TPT had significant influence on the expression of fas(P<0.01), but no influence on the expression of bcl-2(P>0.05).
     cDDP和TPT对fas表达影响较为显著(P<0.01)熏对bcl鄄2无显著影响(P>0.05)。
短句来源
     Results: The expressions of bcl-2 and fas in 3AO/cDDP cell line were decreased than those in 3AO cell line(P<0.01).
     结果:与3AO相比,fas与bcl鄄2在3AO/cDDP中的表达明显降低(P<0.01);
短句来源
     Results The apoptosis of neuron in hippocampus was increased,the expression of bax was raised while bcl-2 was reduced (51.83±2.54 and 12.57±2.09; 14.82±0.79 and 58.97±2.80,P < 0.01).
     结果缺碘子代大鼠较同龄正常组大鼠海马神经细胞bax表达增多,分别为51.83±2.54和12.57±2.09; bcl鄄2表达减少,分别为14.82±0.79和58.97±2.80,两组间比较,差异有非常显著意义(P< 0.01)。
短句来源
     The positive staining rate of p27 and bcl-2 was significantly lower in POEC than that in normal ovarian tissue and ovarian benign tumor (P=0.01 and P=0.001).
     [结果]p27和bcl鄄2在恶性卵巢上皮癌组织阳性表达率明显低于卵巢正常组织和良种肿瘤组织(P=0.01,P=0.001)。
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  bc l-2
     cDDP and TPT increased the expression of fas in 3AO(P<0.01), but decreased the expression of bcl-2 apparently(P<0.01);
     cDDP和TPT可使fas在3AO中的表达明显升高(P<0.01),bcl鄄2明显降低(P<0.01);
短句来源
     cDDP and TPT had significant influence on the expression of fas(P<0.01), but no influence on the expression of bcl-2(P>0.05).
     cDDP和TPT对fas表达影响较为显著(P<0.01)熏对bcl鄄2无显著影响(P>0.05)。
短句来源
     Results: The expressions of bcl-2 and fas in 3AO/cDDP cell line were decreased than those in 3AO cell line(P<0.01).
     结果:与3AO相比,fas与bcl鄄2在3AO/cDDP中的表达明显降低(P<0.01);
短句来源
     Results The apoptosis of neuron in hippocampus was increased,the expression of bax was raised while bcl-2 was reduced (51.83±2.54 and 12.57±2.09; 14.82±0.79 and 58.97±2.80,P < 0.01).
     结果缺碘子代大鼠较同龄正常组大鼠海马神经细胞bax表达增多,分别为51.83±2.54和12.57±2.09; bcl鄄2表达减少,分别为14.82±0.79和58.97±2.80,两组间比较,差异有非常显著意义(P< 0.01)。
短句来源
     The positive staining rate of p27 and bcl-2 was significantly lower in POEC than that in normal ovarian tissue and ovarian benign tumor (P=0.01 and P=0.001).
     [结果]p27和bcl鄄2在恶性卵巢上皮癌组织阳性表达率明显低于卵巢正常组织和良种肿瘤组织(P=0.01,P=0.001)。
短句来源
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  b cl-2
     cDDP and TPT increased the expression of fas in 3AO(P<0.01), but decreased the expression of bcl-2 apparently(P<0.01);
     cDDP和TPT可使fas在3AO中的表达明显升高(P<0.01),bcl鄄2明显降低(P<0.01);
短句来源
     cDDP and TPT had significant influence on the expression of fas(P<0.01), but no influence on the expression of bcl-2(P>0.05).
     cDDP和TPT对fas表达影响较为显著(P<0.01)熏对bcl鄄2无显著影响(P>0.05)。
短句来源
     Results: The expressions of bcl-2 and fas in 3AO/cDDP cell line were decreased than those in 3AO cell line(P<0.01).
     结果:与3AO相比,fas与bcl鄄2在3AO/cDDP中的表达明显降低(P<0.01);
短句来源
     Results The apoptosis of neuron in hippocampus was increased,the expression of bax was raised while bcl-2 was reduced (51.83±2.54 and 12.57±2.09; 14.82±0.79 and 58.97±2.80,P < 0.01).
     结果缺碘子代大鼠较同龄正常组大鼠海马神经细胞bax表达增多,分别为51.83±2.54和12.57±2.09; bcl鄄2表达减少,分别为14.82±0.79和58.97±2.80,两组间比较,差异有非常显著意义(P< 0.01)。
短句来源
     The positive staining rate of p27 and bcl-2 was significantly lower in POEC than that in normal ovarian tissue and ovarian benign tumor (P=0.01 and P=0.001).
     [结果]p27和bcl鄄2在恶性卵巢上皮癌组织阳性表达率明显低于卵巢正常组织和良种肿瘤组织(P=0.01,P=0.001)。
短句来源
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  “bcl鄄2”译为未确定词的双语例句
     Objective To study the effect of alcohol on apoptosis and apoptosis-associated genes-Bcl-2 and Bax of cardiac muscle cell.
     目的研究乙醇对心肌细胞凋亡及凋亡相关基因Bcl鄄2和Bax表达的影响。
短句来源
     Apoptin,the chicken anemia virus-derived protein,induces apoptosis in a p53-independent and bcl-2-stimulated manner in transformed and tumorigenic human cells. It is a potential agent for tumor therapy.
     来源于鸡贫血病毒(CAV)的凋亡素(apoptin)能选择性地诱导肿瘤细胞和转化细胞的凋亡,对正常人二倍体细胞无影响,而且它诱导的凋亡不依赖p53介导,不被bcl鄄2抑制,使其成为一种有前景的抗肿瘤制剂。
短句来源
     Multivariate analysis showed: stage, grade, residual tumor dimension after primary surgery and p27 expression demonstrated the significant impacts on survival(P<0.05).
     分期、分化程度、术后残留大小和p27表达是影响预后的重要因素,未发现bcl鄄2的表达与卵巢癌的预后相关。
短句来源
     Three groups were reperfused at 24,48,72 and 168 h respectively. Apoptotic cells were detected by TUNEL technique.
     3组分别于再灌注24、48、72、168h断头取脑,海马石蜡切片,原位末端标记法(TUNEL)测定海马CA1区锥体细胞凋亡阳性数及免疫组化法测定Bcl鄄2反应强度。
短句来源
     Methods:Human ovarian cancer cell line HO-8910,cultured in vitro,was treated with 1.25-20 μg/ml curcumin for 6~24 h. Morphological changes of cells were observed with invert microscope, and growth inhibition rates of HO-8910 cells were measured with MTT method. The cell cycle distribution and apoptosis were detected by flow cytometic analysis.
     方法:选用人卵巢癌细胞株HO鄄8910进行体外培养,以1.25-20μg/ml姜黄素分别处理HO鄄8910细胞6鄄24h,倒置相差显微镜观察细胞形态,MTT法检测细胞增殖,流式细胞仪检测凋亡和细胞周期,SABC免疫组化检测细胞凋亡相关蛋白Fas、Fas鄄L、Bcl鄄2及Bax的表达。
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  bcl-2
The rCBF of the right frontal lobe and hippocampus was also detected by the PerifluxPF model laser Doppler flowmetry, and the expressions of c-fos or c-jun or Bcl-2 and Bax were also measured by immune histochemistry S-P method accordingly.
      
Furthermore, Bax and Bcl-2 positive cells were all increased over time in the operation group, and the expression ratio of Bax/Bcl-2 in the operation group was significantly higher than that in the false operation group (P >amp;lt; 0.01).
      
In conclusion, rCBF decrease can impair the learning and memory function in rats, which may be related to the increase of the expression ratio of c-fos or c-jun or Bcl-2 or Bax in the frontal cortex and hippocampus.
      
In the second experiment, the protein expression of the FHIT and other apoptosis related proteins (Bax, Bcl-2 and Survivin) were measured in human CRC by TMA.
      
Both TUNEL and TMA experiments demonstrated significantly inhibited apoptosis by down-regulation of Bax and the up-regulation of Survivin and Bcl-2.
      
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To explore the value of apoptosis induced by chemotherapeutic agents in vitro for predicting of chemotherapeutic response in the patients with acute myeloid leukemia.Apoptosis induced by chemotherapeutic agents in vitro was detected by Tunel assay,and the level of bcl-2expression was measured by immunohistochemistry.The relationship between apoptosis of leukemic cells in vitro and chemotherapeutic effect in vivo was analyzed in42patients with acute myeloid leukemia.Apoptotic rate of30patients with complete remission(CR)induced...

To explore the value of apoptosis induced by chemotherapeutic agents in vitro for predicting of chemotherapeutic response in the patients with acute myeloid leukemia.Apoptosis induced by chemotherapeutic agents in vitro was detected by Tunel assay,and the level of bcl-2expression was measured by immunohistochemistry.The relationship between apoptosis of leukemic cells in vitro and chemotherapeutic effect in vivo was analyzed in42patients with acute myeloid leukemia.Apoptotic rate of30patients with complete remission(CR)induced by any one of daunorubicin(DNR)or cytosine arabinoside(Ara-C)was higher than apoptotic rate of12patients with nor-remission(NR).The expression of bcl-2in the patients with CR was lower than the expression in the patients with NR(P<0.05).Overall apoptotic rate induced by DNR and Ara-C in vitro could be a quantitive index as to predict clinical response to regimen of DA in patients with acute myeloid leukemia.[Conclusion]Apoptot-ic level induced by chemotherapeutic agents in vitro could be an important index to predict chemothera-peutic sensitivity of the patients with acute myeloid leukemia.

[目的]探讨急性髓系白血病(AML)患者体外化疗药物诱导白血病细胞凋亡在化疗疗效预测中的价值。[方法]应用TdT介导的脱氧核苷酸切口和末端标记法(Tunel)、单克隆抗体免疫组化检测等方法研究42例初治AML患者体外化疗药物诱导白血病细胞凋亡、bcl鄄2表达与临床化疗疗效的关系。[结果]42例AML患者中,30例获完全缓解(CR)者,bcl鄄2表达显著低于12例未缓解(NR)者(P<0.05);CR患者柔红霉素(DNR)和阿糖胞苷(Ara鄄C)体外诱导白血病细胞凋亡率均分别高于NR患者,差异有显著性(P均<0.05);体外DNR和Ara鄄C两药诱导白血病细胞的总凋亡率,可以作为临床预测AML患者DA方案疗效的定量指标。[结论]体外化疗药物能否有效地诱导白血病细胞凋亡是判断AML患者化疗敏感性的重要指标。

Bcl-2and bax are important controlling genes for apoptosis.Super expression of bcl-2makes cell survival longer,but super expression of bax makes cell apoptosis.Both of them play an important role in the carcinogenesis and development of gastric carcinoma.The relationships between bcl-2,bax genes and gastric carcinoma were reviewed in this article.

bcl-2、bax是细胞凋亡的重要调控基因,bcl鄄2的超表达使细胞生存期延长,而bax的超表达则使细胞凋亡。二者不同程度的表达在胃癌的发生、发展中起重要作用。该文就bcl鄄2,bax与胃癌关系作一综述。

Anticancer drugs exert their cytotoxic effect by triggering apoptosis.The mech-anism on it includes:①Anticancer drugs can activate Fas/FasL(CD95/Apo-1)signaling system.The Fas agonistic monoclonal antibody(mAb)can decrease the tumor cells sensi-tivity to drugs.Apoptosis is induced by pathway:DR4?DR5/TRAIL.②Many genes par-ticipate the drug induced apoptosis.Wild-type p53(WT p53)restricts cell proliferation,while mutant p53surpresses apoptosis.Overexpression of bcl-2is always related to tumor multidrugs resistance.When...

Anticancer drugs exert their cytotoxic effect by triggering apoptosis.The mech-anism on it includes:①Anticancer drugs can activate Fas/FasL(CD95/Apo-1)signaling system.The Fas agonistic monoclonal antibody(mAb)can decrease the tumor cells sensi-tivity to drugs.Apoptosis is induced by pathway:DR4?DR5/TRAIL.②Many genes par-ticipate the drug induced apoptosis.Wild-type p53(WT p53)restricts cell proliferation,while mutant p53surpresses apoptosis.Overexpression of bcl-2is always related to tumor multidrugs resistance.When it exerts effect,coordination with other members of the fami-ly,such as bax,is usually needed.③Although different stimulus can induce apoptosis by different pathway,the most common way is the activation of Caspase-3.Some anticancer drugs can directly activate Caspase.

抗肿瘤药物通过诱导肿瘤细胞凋亡而发挥其抗肿瘤活性,其作用机制的研究主要有:①激活Fas/FasL(CD95/Apo鄄1)信号系统,抗Fas/Apo鄄1抗体则能降低药物诱导凋亡的敏感性。通过DR4、DR5/TRAIL途径诱导细胞凋亡。②众多基因参与了细胞凋亡。野生型p53抑制细胞增殖,突变型p53抑制细胞凋亡。bcl鄄2基因过表达与肿瘤多药耐药有关,bcl鄄2发挥其抑制凋亡的效应需要与其家族的其它成员如bax相互协调。③Caspase鄄3的活化诱导凋亡。有些细胞毒药物可直接活化Caspase促使细胞凋亡。

 
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