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慢性炎症状态     
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  chronic inflammatory state
     Objective To identify the relationship among chronic inflammatory state, malnutrition and cardiovascular diseases in peritoneal dialysis patients.
     目的 探讨腹膜透析患者慢性炎症状态与营养不良及心血管病的关系。
短句来源
     Objective To identify the effect of peritoneal transport features and chronic inflammatory state in the abdominal cavity on nutritional status in patients with peritoneal dialysis.
     目的探讨腹膜转运特性及腹腔慢性炎症状态对腹膜透析患者营养状况的影响。
短句来源
     Conclusion Chronic inflammatory state is present in abdominal cavity of CAPD patients,which is closely related to malnutrition.
     结论CAPD患者腹腔内存在慢性炎症状态,其与营养不良有密切关系。
短句来源
     Influence of chronic inflammatory state on hemodialysis patients receiving intravenous iron replenishment
     慢性炎症状态对血液透析病人补铁治疗的影响
短句来源
     In addition,the metabolic syndrome associated with the chronic inflammatory state often accompanies cytokine abnormalities which may influence tumor progression.
     此外,代谢综合征与慢性炎症状态相关,其细胞因子的异常可影响肿瘤的生长。
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  chronic inflammation state
     Chronic inflammation state,malnutrition and cardiovascular disease in peritoneal dialysis patients
     腹膜透析患者慢性炎症状态与营养不良及心血管病的关系
短句来源
  chronic inflammatory status
     Conclusion The chronic inflammatory status is in CAPD patients in deed. The inflammation-symbolized factor-CRP is related with the PDE concentra tion of glucose and peritonitis times. The de-function of peritoneal transport mechanism is concerned with the rise of TGF-β 1,IL-6,TNF and CRP.
     结论 CAPD患者体内确实存在慢性炎症状态 ,其炎症标志性因子CRP与腹透液葡萄糖浓度、腹膜炎次数有关 ,CAPD患者腹膜物质转运功能丧失与TGF β1 、IL 6、TNF、CRP升高有关。
短句来源
     Conclusion The development of depression in MHD patients was correlated with the times of arterio-venous fistula operation, anemia and chronic inflammatory status.
     结论MHD患者动-静脉内瘘手术的次数及肾性贫血、体内慢性炎症状态与抑郁症的发生有关。
短句来源
  inflammation state
     Chronic inflammation state,malnutrition and cardiovascular disease in peritoneal dialysis patients
     腹膜透析患者慢性炎症状态与营养不良及心血管病的关系
短句来源
     Persistent inflammation state might be responsible for the elevation of serum CRP level in hemodialysis patients.
     结论:MHD患者持续存在不同强度的慢性炎症状态,其血清CRP有上升趋势,慢性炎症状态是心血管疾病和死亡的强预测因素。
短句来源
     Conclusions Persistent inflammation state might be responsible for the elevation of serum CRP level in patients with diabetic nephropathy. Serum CRP level is correlative with renal function damage.
     结论 DN患者持续存在不同强度的慢性炎症状态 ,提示病人血清中CRP水平与肾功能减退具有相关关系
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      chronic inflammatory state
    Experimental evidence suggests that both insulin resistance and NAFLD result from a chronic inflammatory state.
          
    The incidence of the ulcerative state is brought on by repetitive postural trauma, which causes a chronic inflammatory state, characterized by hypertrophy of skin layers and diffuse, intense inflammatory infiltrate throughout the ulcer.
          
    The natural history is one of a chronic inflammatory state, characterized by intermittent flares of disease activity.
          
    The presence of IL-10 in middle ear effusions may be one of the causes of a lack of clinical features of acute inflammation and may lead to a chronic inflammatory state.
          
    These findings imply that SLPI contributes to host protection against inflammatory cell and destructive enzymes in the chronic inflammatory state of cholesteatoma by affecting the innate immune system.
          
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      chronic inflammatory status
    The chronic inflammatory status and the need of a longstanding therapy expose the patient to several extraintestinal manifestations.
          


    Objective To identify the relationship among chronic inflammatory state, malnutrition and cardiovascular diseases in peritoneal dialysis patients. Methods Cardiovascular diseases and dialysis regime in 90 clinically stable continuous ambulatory peritoneal dialysis (CAPD) patients were investigated. Then, dietary energy intake (DEI) and protein intake (DPI) through dietary diaries were measured. The serum albumin (Alb), prealbumin(PA), transferring (TF), lean body mass (LBM), LBM% and the normalized protein equivalent...

    Objective To identify the relationship among chronic inflammatory state, malnutrition and cardiovascular diseases in peritoneal dialysis patients. Methods Cardiovascular diseases and dialysis regime in 90 clinically stable continuous ambulatory peritoneal dialysis (CAPD) patients were investigated. Then, dietary energy intake (DEI) and protein intake (DPI) through dietary diaries were measured. The serum albumin (Alb), prealbumin(PA), transferring (TF), lean body mass (LBM), LBM% and the normalized protein equivalent of total nitrogen appearance (nPNA) were examined or calculated. Subjective global assessment (SGA) was also evaluated. Serum interleukin-6 (IL-6), tumor necrotic factor-α(TNF-α) and C-reactive protein (CRP) were measured as markers of chronic inflammation. Serum leptin and plasma NPY were detected too. Results Serum IL-6 and TNF-α levels of CAPD cases were (17. 17±27.72) pg/ml and (34. 21±25. 92) pg/ml, which were significantly higher as compared to control group. Serum CRP level in CAPD patients was (9. 88±20. 93)mg/L. There were 24 patients(26. 67% ) with CRP above normal level. 55 patients(61. 11% ) had cardiovascular diseases. The patients with angina pectoris, old myocardial infarction and chronic heart failure had higher CRP levels than those without above complications ( P < 0. 05) . At least one marker of chronic inflammation in malnourished patients respectively diagnosed with Alb, PA, LBM% and SGA increased significantly( P < 0. 01-0. 05). Patients with CRP higher than 8 mg/L had lower DEI, DPI levels than those with normal CRP( P < 0. 05) . Serum TNF-α level was negatively correlated to DEI( r = - 0. 34) and DPI( r = - 0. 32) respectively ( P < 0. 01) . Serum leptin and NPY were not correlated to nutritional indexes and intake of energy and protein. Conclusions Chronic inflammatory state is really present in CAPD patients, which is possibly related to the cardiovascular diseases. The low intake of protein and energy induced by chronic inflammation may result in malnutrition, which is not dependent on leptin.

    目的 探讨腹膜透析患者慢性炎症状态与营养不良及心血管病的关系。方法 记录90例稳定的持续性不卧床腹膜透析(CAPD)患者的心血管并发症和透析处方。通过食谱调查计算平均每日每公斤体重的热卡(DEI)和蛋白质(DPI)。测定或计算营养指标:血白蛋白(Alb)、前白蛋白(PA)和转铁蛋白(TF)、瘦体重(LBM)、瘦体重%(LBM%)和标准化的氮出现率相当蛋白(nPNA)。进行主观综合性营养评估(SGA)。分别以Alb、PA、LBM%和SGA作为营养不良的判定标准,将本组患者分为营养良好和营养不良组。测定慢性炎症指标:血清白介素-6(IL-6),肿瘤坏死因子-α(TNF-α)和C-反应蛋白(CRP)。测定血清瘦素和血浆神经肽Y(NPY)水平。结果 本组CAPD患者的血IL-6为(17.17±27.72)pg/ml,TNF-α(34.21±25.92)pg/ml,均显著高于正常对照。血CRP(9.88±20.93)mg/L,有24例(26.67%)超过正常参考值(8 mg/L)。本组患者合并心绞痛、陈旧性心肌梗死(心梗)或慢性心力衰竭(心衰)者共55例(61.11%),其中仅并发心绞痛或陈旧心梗者、仅并发...

    目的 探讨腹膜透析患者慢性炎症状态与营养不良及心血管病的关系。方法 记录90例稳定的持续性不卧床腹膜透析(CAPD)患者的心血管并发症和透析处方。通过食谱调查计算平均每日每公斤体重的热卡(DEI)和蛋白质(DPI)。测定或计算营养指标:血白蛋白(Alb)、前白蛋白(PA)和转铁蛋白(TF)、瘦体重(LBM)、瘦体重%(LBM%)和标准化的氮出现率相当蛋白(nPNA)。进行主观综合性营养评估(SGA)。分别以Alb、PA、LBM%和SGA作为营养不良的判定标准,将本组患者分为营养良好和营养不良组。测定慢性炎症指标:血清白介素-6(IL-6),肿瘤坏死因子-α(TNF-α)和C-反应蛋白(CRP)。测定血清瘦素和血浆神经肽Y(NPY)水平。结果 本组CAPD患者的血IL-6为(17.17±27.72)pg/ml,TNF-α(34.21±25.92)pg/ml,均显著高于正常对照。血CRP(9.88±20.93)mg/L,有24例(26.67%)超过正常参考值(8 mg/L)。本组患者合并心绞痛、陈旧性心肌梗死(心梗)或慢性心力衰竭(心衰)者共55例(61.11%),其中仅并发心绞痛或陈旧心梗者、仅并发慢性心衰者或伴以上两种并发症者的血CRP均分别显著高于未合并以上心血管疾病者(P<0.05)。在各营养不良组,至少有一个慢性炎症指标的升高,且有显著性意义(P<0.01~0.05)。血CRP升高组较CRP正常组的DEI、DPI水平显著为低(P<0.0

    Objective To investigate the effect of peritoneal dialysate efflu ent(PDE) level of TGF-β 1 and related factors on the peritoneal transport mec hanism. Methods We measured TGF-β 1,IL-6,TNF,CRP of plasma or PDE in CA PD patients,meanwhile added up the concentration of glucose,exchanged volume and t imes;abdomen retaining time of PDE,peritonitis times,KpT/V and Cpcr were calcula ted. Results The plasma levels of IL-6,TNF and CRP in CAPD patients wer e significantly higher than those of IL-6,TNF and CRP...

    Objective To investigate the effect of peritoneal dialysate efflu ent(PDE) level of TGF-β 1 and related factors on the peritoneal transport mec hanism. Methods We measured TGF-β 1,IL-6,TNF,CRP of plasma or PDE in CA PD patients,meanwhile added up the concentration of glucose,exchanged volume and t imes;abdomen retaining time of PDE,peritonitis times,KpT/V and Cpcr were calcula ted. Results The plasma levels of IL-6,TNF and CRP in CAPD patients wer e significantly higher than those of IL-6,TNF and CRP in normal controls (P< 0.05~0.01);As far as the CAPD patients whose (KpT/V+Cpcr)/2 in the twelfth mont h was 10% lower than those in the third month were concerned,the PDE level of T GF-β 1,IL-6,TNF,the concentration of glucose and peritonitis times were obvi ously higher than those of TGF-β 1,IL-6,TNF,CRP, the concentration of glu cose,and peritonitis times in controlled subjects (P<0.005~0.01). A positiv e cor relation was found between the PDE level of TGF-β 1 and those of IL-6,TNF,CR P and the concentration of glucose (P< 0.05 ~0.01).The PDE level of TGF- β 1 ha d no correlation with peritonitis times.The PDE level of CRP had a good correlat ion with the concentration of glucose and peritonitis times (P<0.05~0.01). I t had no correlation with exchanged volume,number of times and the interval in a bdominal cavity. Conclusion The chronic inflammatory status is in CAPD patients in deed.The inflammation-symbolized factor-CRP is related with the PDE concentra tion of glucose and peritonitis times. The de-function of peritoneal transport mechanism is concerned with the rise of TGF-β 1,IL-6,TNF and CRP.

    目的 研究不卧床持续性腹膜透析 (CAPD)患者腹透液中转移生长因子 β1 (TGF β1 )水平及影响因素对腹膜小分子物质清除功能的影响。方法 测定CAPD患者血浆中和腹透液中TGF β1 、IL 6、TNF、CRP(C反应蛋白 )水平 ;同时统计CAPD患者腹透液葡萄糖含量、交换量、次数、留腹时间及腹膜炎次数 ;计算CAPD患者KpT V、Cpcr。结果 CAPD患者血浆中IL 6、TNF、CRP水平均明显高于正常健康人 ,P <0 .0 5~ 0 .0 1;透析第 12月 (KpT V +Cpcr) 2较第 3月下降超过 10 %的CAPD患者其腹透液中TGF β1、IL 6、TNF、CRP、葡萄糖浓度、腹膜炎次数均较对照组明显升高 ,P <0 .0 5~ 0 .0 1;腹透液中TGF β1 与IL 6、TNF、CRP、腹透液中葡萄糖浓度呈正相关 ,P <0 ..0 5~ 0 .0 1,与腹膜炎次数无关 ;腹透液中CRP与葡萄糖浓度、腹膜炎次数呈正相关 ,P <0 .0 5~ 0 .0 1,与腹膜交换量、次数、留腹时间无关。结论 CAPD患者体内确实存在慢性炎症状态 ,其炎症标志性因子CR...

    目的 研究不卧床持续性腹膜透析 (CAPD)患者腹透液中转移生长因子 β1 (TGF β1 )水平及影响因素对腹膜小分子物质清除功能的影响。方法 测定CAPD患者血浆中和腹透液中TGF β1 、IL 6、TNF、CRP(C反应蛋白 )水平 ;同时统计CAPD患者腹透液葡萄糖含量、交换量、次数、留腹时间及腹膜炎次数 ;计算CAPD患者KpT V、Cpcr。结果 CAPD患者血浆中IL 6、TNF、CRP水平均明显高于正常健康人 ,P <0 .0 5~ 0 .0 1;透析第 12月 (KpT V +Cpcr) 2较第 3月下降超过 10 %的CAPD患者其腹透液中TGF β1、IL 6、TNF、CRP、葡萄糖浓度、腹膜炎次数均较对照组明显升高 ,P <0 .0 5~ 0 .0 1;腹透液中TGF β1 与IL 6、TNF、CRP、腹透液中葡萄糖浓度呈正相关 ,P <0 ..0 5~ 0 .0 1,与腹膜炎次数无关 ;腹透液中CRP与葡萄糖浓度、腹膜炎次数呈正相关 ,P <0 .0 5~ 0 .0 1,与腹膜交换量、次数、留腹时间无关。结论 CAPD患者体内确实存在慢性炎症状态 ,其炎症标志性因子CRP与腹透液葡萄糖浓度、腹膜炎次数有关 ,CAPD患者腹膜物质转运功能丧失与TGF β1 、IL 6、TNF、CRP升高有关。

    Objective: To investigate serum C-reactive protein level and its correlation with cardiovascular disease in maintenance hemodialysis (MHD) patients. Methodology: This study included 41 MHD adult patients (elder than 18 years) who were followed-up for more than 12 months in our dialysis center. The effects of active rheumatic disease, neoplasm and drugs (non-steroid anti-inflammation drugs, angiotensin converting enzyme inhibitors, statins) were ruled out. Histories of cardiovascular disease, sex age, blood...

    Objective: To investigate serum C-reactive protein level and its correlation with cardiovascular disease in maintenance hemodialysis (MHD) patients. Methodology: This study included 41 MHD adult patients (elder than 18 years) who were followed-up for more than 12 months in our dialysis center. The effects of active rheumatic disease, neoplasm and drugs (non-steroid anti-inflammation drugs, angiotensin converting enzyme inhibitors, statins) were ruled out. Histories of cardiovascular disease, sex age, blood pressure, height , body weight, type of dialysis membrane were recorded. Serum were sampled for the determination of serum albumin, pre-albumin, urea total cholesterol, low-density lipoprotein, fibrinogen, CRP assay. Body weight and CRP were determined after 1 year again. Variability of CRP and its correlation with cardiovascular disease were evaluated. Results: Good correlation exists between 2 serial CRP measurement (pearson r=0.6661, P<0.01), and serum CRP level tended to increase after 1 years follow-up. Patients in elevated serum-CRP group had higher incidence of cardiovascular disease and higher mortality rate (7/8 and 4/8), as compared with patients in normal CRP group (3/33 and 4/33). The prominent causes of death were heart failure and cerebral hemorrhage in patients group with elevated serum CRP. Conclusion: It is concluded that serum CRP level can be used as a strong predictor of cardiovascular diseae in maintenance hemodialysis patients. Persistent inflammation state might be responsible for the elevation of serum CRP level in hemodialysis patients.

    目的:评价维持性血液透析(MHD)患者C-反应蛋白(CRP)的稳定性以及和心血管疾病的关系。 方法:选择在我院血液透析中心治疗的MHD患者41例,所有患者年龄18岁以上;均稳定透析3个月以上;无活动性风湿性疾病;无肿瘤证据或肿瘤术后无肿瘤复发证据;预计1年内不进行肾移植;可能影响血清CRP的药物(非类固醇类消炎药、血管紧张素转换酶抑制剂、他汀类降脂药等)维持不变。记录所有患者的心血管疾病病史、性别、年龄、血压、身高、体重、使用的透析膜类型,同时透析前采血白蛋白、前白蛋白、尿素、血清总胆固醇、低密度脂蛋白、纤维蛋白原和CRP、透析后采血测定血浆尿素和下次透析前尿素,计算Kt/V和nPCR。1年后重复体重和CRP测定。采血时机在1个月内无临床显性感染。评价CRP的稳定性以及和心血管疾病/死亡的关系。 结果:两次CRP测定呈显著相关性(pearson r=0.6661, P<0.01),且有上升趋势。CRP升高组患者持续处于较高水平,其心血管疾病比例(7/8)和死亡比例(4/8)明显高于CRP正常组(分别为3/33和4/33)。死亡的主要原因是心力衰竭和脑出血。 结论:MHD患者持续存在不同强度的慢性炎...

    目的:评价维持性血液透析(MHD)患者C-反应蛋白(CRP)的稳定性以及和心血管疾病的关系。 方法:选择在我院血液透析中心治疗的MHD患者41例,所有患者年龄18岁以上;均稳定透析3个月以上;无活动性风湿性疾病;无肿瘤证据或肿瘤术后无肿瘤复发证据;预计1年内不进行肾移植;可能影响血清CRP的药物(非类固醇类消炎药、血管紧张素转换酶抑制剂、他汀类降脂药等)维持不变。记录所有患者的心血管疾病病史、性别、年龄、血压、身高、体重、使用的透析膜类型,同时透析前采血白蛋白、前白蛋白、尿素、血清总胆固醇、低密度脂蛋白、纤维蛋白原和CRP、透析后采血测定血浆尿素和下次透析前尿素,计算Kt/V和nPCR。1年后重复体重和CRP测定。采血时机在1个月内无临床显性感染。评价CRP的稳定性以及和心血管疾病/死亡的关系。 结果:两次CRP测定呈显著相关性(pearson r=0.6661, P<0.01),且有上升趋势。CRP升高组患者持续处于较高水平,其心血管疾病比例(7/8)和死亡比例(4/8)明显高于CRP正常组(分别为3/33和4/33)。死亡的主要原因是心力衰竭和脑出血。 结论:MHD患者持续存在不同强度的慢性炎症状态,其血清CRP有上升趋势,慢性炎症状态是心血管疾病和死亡的强预测因素。

     
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